Search

Your search keyword '"Selingue, Erwan"' showing total 6 results
Start Over Author "Selingue, Erwan" Search Limiters Full Text
6 results on '"Selingue, Erwan"'

3. Efficient PD-L1 imaging of murine glioblastoma with FUS-aided immunoPET by leveraging FcRn-antibody interaction

Author

Chevaleyre, Céline, primary, Novell, Anthony, additional, Tournier, Nicolas, additional, Dauba, Ambre, additional, Dubois, Steven, additional, Kereselidze, Dimitri, additional, Selingue, Erwan, additional, Jego, Benoit, additional, Maillère, Bernard, additional, Larrat, Benoit, additional, Nozach, Hervé, additional, and Truillet, Charles, additional

Published
2023
Full Text
View/download PDF

4. Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

Author

Maté de Gérando, Anastasie, primary, d’Orange, Marie, additional, Augustin, Emma, additional, Joséphine, Charlène, additional, Aurégan, Gwénaelle, additional, Gaudin-Guérif, Mylène, additional, Guillermier, Martine, additional, Hérard, Anne-Sophie, additional, Stimmer, Lev, additional, Petit, Fanny, additional, Gipchtein, Pauline, additional, Jan, Caroline, additional, Escartin, Carole, additional, Selingue, Erwan, additional, Carvalho, Kévin, additional, Blum, David, additional, Brouillet, Emmanuel, additional, Hantraye, Philippe, additional, Gaillard, Marie-Claude, additional, Bonvento, Gilles, additional, Bemelmans, Alexis-Pierre, additional, and Cambon, Karine, additional

Published
2021
Full Text
View/download PDF

5. Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state.

Author

Gérando, Anastasie Maté de, d'Orange, Marie, Augustin, Emma, Joséphine, Charlène, Aurégan, Gwénaelle, Gaudin-Guérif, Mylène, Guillermier, Martine, Hérard, Anne-Sophie, Stimmer, Lev, Petit, Fanny, Gipchtein, Pauline, Jan, Caroline, Escartin, Carole, Selingue, Erwan, Carvalho, Kévin, Blum, David, Brouillet, Emmanuel, Hantraye, Philippe, Gaillard, Marie-Claude, and Bonvento, Gilles

Subjects
ASTROCYTES, TAU proteins, ADENO-associated virus, TRANSGENIC mice, GENETIC transformation, CHRONIC traumatic encephalopathy, FRONTOTEMPORAL lobar degeneration, PROTEIN metabolism, PROTEINS, RESEARCH, NERVE tissue proteins, HIPPOCAMPUS (Brain), NEURONS, ANIMAL experimentation, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, CELLS, NEURODEGENERATION, MICE
Abstract

Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes, the origin of astrocytic tau is still elusive. Here, we used innovative gene transfer tools to model tauopathies in adult mouse brains and to investigate the origin of astrocytic tau. We showed in our adeno-associated virus (AAV)-based models and in Thy-Tau22 transgenic mice that astrocytic tau pathology can emerge secondarily to neuronal pathology. By designing an in vivo reporter system, we further demonstrated bidirectional exchanges of tau species between neurons and astrocytes. We then determined the consequences of tau accumulation in astrocytes on their survival in models displaying various status of tau aggregation. Using stereological counting of astrocytes, we report that, as for neurons, soluble tau species are highly toxic to some subpopulations of astrocytes in the hippocampus, whereas the accumulation of tau aggregates does not affect their survival. Thus, astrocytes are not mere bystanders of neuronal pathology. Our results strongly suggest that tau pathology in astrocytes may significantly contribute to clinical symptoms. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

6. Abstract 2797: Liver cancer patient-derived xenografts to improve disease management in childhood and adolescence: perspectives and challenges of personalized medicine.

Author

Cairo, Stefano, primary, Gorse, Aurore, additional, Nicolle, Delphine, additional, Selingue, Erwan, additional, Gauthier, Frédéric, additional, Chardot, Christophe, additional, Fadel, Elie, additional, Elias, Dominique, additional, Orbach, Daniel, additional, Guettier, Catherine, additional, Beurdeley, Arnaud, additional, Yvonnet, Vanessa, additional, Deas, Olivier, additional, Fabre, Monique, additional, Brugières, Laurence, additional, Branchereau, Sophie, additional, and Judde, Jean-Gabriel, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results