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1,396 results on '"Sharma, Prashant"'

1. Rayleigh Taylor Instability in Multiple Finite-Thickness Fluid Layers

Author

Sharma, Prashant

Subjects
Physics - Fluid Dynamics, Physics - Geophysics, Physics - Plasma Physics
Abstract

We develop a general transfer-matrix formalism for determining the growth rate of the Rayleigh-Taylor instability in a fluid system with spatially varying density and viscosity. We use this formalism to analytically and numerically treat the case of a stratified heterogeneous fluid. We introduce the inviscid-flow approximation in our transfer-matrix formalism to find analytic solutions in the limit of uniform kinematic viscosity for a stratified heterogeneous fluid. We discuss the applicability of these results and the no-acceleration approximation that also yields analytical solutions in the large viscosity limit., Comment: 8 pages, 3 figures

Published
2024

4. Current redistribution model of anomalous resistance behaviour in superconductor-topological insulator heterostructures

Author

S., Abhirami, Amaladass, Edward Prabu, Sharma, Prashant, K., Vinod, V., Thanikaiarasu A., and Mani, Awadhesh

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Other Condensed Matter
Abstract

Anomalous resistance upturn and downturn have been observed on the topological insulator (TI) surface in superconductor-TI (NbN-Bi1.95Sb0.05Se3) heterostructures at ~ mm length scales away from the interface. Magnetotransport measurements were performed to verify that the anomaly is caused due to the superconducting transition of the NbN layer. The possibility of long range superconducting proximity effect due to the spin-polarized TI surface state was ruled out due to the observation of similar anomaly in NbN-Au and NbN-Al heterostructures. It was discovered that the unusual resistance jumps were caused due to current redistribution at the superconductor-TI interface on account of the geometry effects. Results obtained from finite element analysis using COMSOL package has validated the proposed current redistribution (CRD) model of long range resistance anomalies in superconductor-TI and superconductor-metal heterostructures., Comment: 37 pages (including references), 17 figures

Published
2022

6. The constraint of plasma power balance on runaway avoidance

Author

McDevitt, Christopher J., Tang, Xian-Zhu, Fontes, Christopher J., Sharma, Prashant, and Chung, Hyun-Kyung

Subjects
Physics - Plasma Physics
Abstract

In a post-thermal-quench plasma, mitigated or unmitigated, the plasma power balance is mostly between collisional or Ohmic heating and plasma radiative cooling. In a plasma of atomic mixture $\{n_\alpha\}$ with $\alpha$ labeling the atomic species, the power balance sets the plasma temperature, ion charge state distribution $\{n_\alpha^i\}$ with $i$ the charge number, and through the electron temperature $T_e$ and ion charge state distribution $\{n_\alpha^i\},$ the parallel electric field $E_\parallel.$ Since the threshold electric field for runaway avalanche growth $E_{av}$ is also set by the atomic mixture, ion charge state distribution and its derived quantity, the electron density $n_e,$ the plasma power balance between Ohmic heating and radiative cooling imposes a stringent constraint on the plasma regime for avoiding and minimizing runaways when a fusion-grade tokamak plasma is rapidly terminated.

Published
2022
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8. PLOD: An Abbreviation Detection Dataset for Scientific Documents

Author

Zilio, Leonardo, Saadany, Hadeel, Sharma, Prashant, Kanojia, Diptesh, and Orăsan, Constantin

Subjects
Computer Science - Computation and Language
Abstract

The detection and extraction of abbreviations from unstructured texts can help to improve the performance of Natural Language Processing tasks, such as machine translation and information retrieval. However, in terms of publicly available datasets, there is not enough data for training deep-neural-networks-based models to the point of generalising well over data. This paper presents PLOD, a large-scale dataset for abbreviation detection and extraction that contains 160k+ segments automatically annotated with abbreviations and their long forms. We performed manual validation over a set of instances and a complete automatic validation for this dataset. We then used it to generate several baseline models for detecting abbreviations and long forms. The best models achieved an F1-score of 0.92 for abbreviations and 0.89 for detecting their corresponding long forms. We release this dataset along with our code and all the models publicly in https://github.com/surrey-nlp/PLOD-AbbreviationDetection, Comment: Accepted at LREC 2022, 8 pages

Published
2022

10. An Ensemble Approach to Acronym Extraction using Transformers

Author

Sharma, Prashant, Saadany, Hadeel, Zilio, Leonardo, Kanojia, Diptesh, and Orăsan, Constantin

Subjects
Computer Science - Computation and Language
Abstract

Acronyms are abbreviated units of a phrase constructed by using initial components of the phrase in a text. Automatic extraction of acronyms from a text can help various Natural Language Processing tasks like machine translation, information retrieval, and text summarisation. This paper discusses an ensemble approach for the task of Acronym Extraction, which utilises two different methods to extract acronyms and their corresponding long forms. The first method utilises a multilingual contextual language model and fine-tunes the model to perform the task. The second method relies on a convolutional neural network architecture to extract acronyms and append them to the output of the previous method. We also augment the official training dataset with additional training samples extracted from several open-access journals to help improve the task performance. Our dataset analysis also highlights the noise within the current task dataset. Our approach achieves the following macro-F1 scores on test data released with the task: Danish (0.74), English-Legal (0.72), English-Scientific (0.73), French (0.63), Persian (0.57), Spanish (0.65), Vietnamese (0.65). We release our code and models publicly., Comment: Published at SDU@AAAI-22

Published
2022

11. Cognition-aware Cognate Detection

Author

Kanojia, Diptesh, Sharma, Prashant, Ghodekar, Sayali, Bhattacharyya, Pushpak, Haffari, Gholamreza, and Kulkarni, Malhar

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

Automatic detection of cognates helps downstream NLP tasks of Machine Translation, Cross-lingual Information Retrieval, Computational Phylogenetics and Cross-lingual Named Entity Recognition. Previous approaches for the task of cognate detection use orthographic, phonetic and semantic similarity based features sets. In this paper, we propose a novel method for enriching the feature sets, with cognitive features extracted from human readers' gaze behaviour. We collect gaze behaviour data for a small sample of cognates and show that extracted cognitive features help the task of cognate detection. However, gaze data collection and annotation is a costly task. We use the collected gaze behaviour data to predict cognitive features for a larger sample and show that predicted cognitive features, also, significantly improve the task performance. We report improvements of 10% with the collected gaze features, and 12% using the predicted gaze features, over the previously proposed approaches. Furthermore, we release the collected gaze behaviour data along with our code and cross-lingual models., Comment: Published at EACL 2021

Published
2021

12. Observation of fast current redistribution in an imploding plasma column

Author

Stollberg, Christine, Kroupp, Eyal, Mikitchuk, Dimitry, Sharma, Prashant, Bernshtam, Vladimir, Cvejic, Marko, Doron, Ramy, Stambulchik, Evgeny, Maron, Yitzhak, Fruchtman, Amnon, Ochs, Ian E., Fisch, Nathaniel J., and Shumlak, Uri

Subjects
Physics - Plasma Physics
Abstract

Spectroscopic measurements of the magnetic field evolution in a Z-pinch throughout stagnation and with particularly high spatial resolution reveal a sudden current redistribution from the stagnating plasma (SP) to a low density plasma (LDP) at larger radii, while the SP continues to implode. Based on the plasma parameters it is shown that the current is transferred to an increasing-conductance LDP outside the stagnation, a process likely to be induced by the increasing impedance of the SP. Since an LDP often exists around imploding plasmas and in various pulsed-power systems, such a fast current redistribution may dramatically affect the behavior and achievable parameters in these systems., Comment: 6 pages, 5 figures, resubmitted to PRL

Published
2021

15. Zeptosecond dynamics in atoms: fact or fiction?

Author

Nandi, T., Sharma, Prashant, Chatterjee, Soumya, Mitra, D., Mishra, Adya P, Azuma, Y., Koike, F., and Kheifets, A. S.

Subjects
Physics - Atomic Physics
Abstract

Photon exchange due to nuclear bremsstrahlung during nuclear collisions can cause Coulomb excitation in the projectile and the target nuclei. The corresponding process originated in nuclear timescales can also be observed in atomic phenomenon experimentally if it delayed by at least with an attosecond or longer timescales. We have found that this happens due to a mechanism involving the Eisenbud-Wigner-Smith time delay process. We have estimated photoionization time delays in atomic collisions utilizing the nonrelativistic version of random phase approximation with exchange and Hartree-Fock methods. We present three representative processes in which we can observe the phenomena in attosecond timescales even though they originate from excitations in the zeptosecond timescales. Thus the work represents an investigation of parallels between two neighboring areas of physics. Furthermore the present work suggests new possibilities for atomic physics research near the Coulomb barrier energy, where the laser is replaced by nuclear bremsstrahlung., Comment: 6 pages, 4 figures

Published
2021

16. De novo variants in DENND5B cause a neurodevelopmental disorder

Author

Acosta, Maria T., Adams, David R., Alvarez, Raquel L., Alvey, Justin, Allworth, Aimee, Andrews, Ashley, Ashley, Euan A., Afzali, Ben, Bacino, Carlos A., Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bellen, Hugo J., Bennett, Jimmy, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Briere, Lauren C., Brown, Gabrielle, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen Peter, Chanprasert, Sirisak, Chao, HsiaoTuan, Chinn, Ivan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Cole, F. Sessions, Colley, Heather A., Cope, Heidi, Corona, Rosario, Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D’Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G., Delgado, Margaret, Dell'Angelica, Esteban C., Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L., Douine, Emilie D., Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Falk, Marni, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Fu, Jiayu, Gahl, William A., Glass, Ian, Goddard, Page C., Godfrey, Rena A., Grajewski, Alana, Gropman, Andrea, Halley, Meghan C., Hamid, Rizwan, Hanchard, Neal, Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Huang, Yan, Hutchison, Sarah, Introne, Wendy, Isasi, Rosario, Izumi, Kosuke, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Jean-Marie, Orpa, Jobanputra, Vaidehi, Kaitryn, Emerald, Ketkar, Shamika, Kiley, Dana, Kilich, Gonench, Kobren, Shilpa N., Kohane, Isaac S., Kohler, Jennefer N., Korrick, Susan, Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., LeBlanc, Kimberly, Lee, Brendan H., Levitt, Roy, Lewis, Richard A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Maghiro, AudreyStephannie, Mahoney, Rachel, Malicdan, May Christine V., Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McConkie-Rosell, Allyn, McCray, Alexa T., McGee, Elisabeth, Might, Matthew, Miller, Danny, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo, Morimoto, Marie, Mulvihill, John J., Nakano-Okuno, Mariko, Nelson, Stanley F., Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Pallais, J. Carl, Papp, Jeanette C., Parker, Neil H., Petcharet, Leoyklang, Phillips, John A., III, Posey, Jennifer E., Potocki, Lorraine, Swerdzewski, Barbara N. Pusey, Quinlan, Aaron, Rao, Deepak A., Raper, Anna, Raskind, Wendy, Renteria, Genecee, Reuter, Chloe M., Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenthal, Elizabeth, Rossignol, Francis, Ruzhnikov, Maura, Sabaii, Marla, Sacco, Ralph, Sampson, Jacinda B., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Schoch, Kelly, Scott, Daryl A., Seto, Elaine, Sharma, Prashant, Shashi, Vandana, Shelkowitz, Emily, Sheppeard, Sam, Shin, Jimann, Silverman, Edwin K., Sinsheimer, Janet S., Sisco, Kathy, Smith, Edward C., Smith, Kevin S., Solnica-Krezel, Lilianna, Solomon, Ben, Spillmann, Rebecca C., Stergachis, Andrew, Stoler, Joan M., Sullivan, Kathleen, Sullivan, Jennifer A., Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tan, Queenie K.-G., Tan, Amelia L.M., Tarakad, Arjun, Taylor, Herman, Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Ungar, Rachel A., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Walker, Melissa, Walley, Nicole M., Wambach, Jennifer, Wan, Jijun, Wang, Lee-kai, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Weisz Hubshman, Monika, Wener, Mark, Wenger, Tara, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Worley, Kim, Yamamoto, Shinya, Zhang, Zhe, Zuchner, Stephan, Scala, Marcello, Tomati, Valeria, Ferla, Matteo, Lena, Mariateresa, Cohen, Julie S., Fatemi, Ali, Brokamp, Elly, Koziura, Mary E., Nicouleau, Michael, Rio, Marlene, Siquier, Karine, Boddaert, Nathalie, Musante, Ilaria, Tamburro, Serena, Baldassari, Simona, Iacomino, Michele, Scudieri, Paolo, Bellus, Gary, Reed, Sara, Al Saif, Hind, Russo, Rossana Sanchez, Walsh, Matthew B., Cantagrel, Vincent, Crunk, Amy, Gustincich, Stefano, Ruggiero, Sarah M., Fitzgerald, Mark P., Helbig, Ingo, Striano, Pasquale, Severino, Mariasavina, Salpietro, Vincenzo, Pedemonte, Nicoletta, and Zara, Federico

Published
2024
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17. Effects of natural antimicrobial compounds propolis and copaiba on periodontal ligament fibroblasts, molecular docking, and in vivo study in Galleria mellonella

Author

Pedrinha, Victor Feliz, Santos, Letícia Martins, Gonçalves, Carolina Passarelli, Garcia, Maíra Terra, Lameira, Osmar Alves, Queiroga, Carmen Lucia, Marcucci, Maria Cristina, Shahbazi, Mohammad-Ali, Sharma, Prashant Kumar, Junqueira, Juliana Campos, Sipert, Carla Renata, and de Andrade, Flaviana Bombarda

Published
2024
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18. Exploring a novel model for projectile charge state distribution inside a solid-target

Author

Chatterjee, Soumya, Sharma, Prashant, Mitra, D., and Nandi, T.

Subjects
Physics - Atomic Physics
Abstract

For the first time, we report a theoretical methodology to predict charge state distribution of projectile ions inside a solid-target. The method utilizes either a simple Fermi gas model or an ab initio theoretical method and a certain parameterization of width for the Lorentzian charge state distributions. Results obtained from the two approaches are comparable, but the former has a certain edge over the latter. The projectile charge state distribution inside a solid-target plays a significant role in estimating electron capture cross-sections and then to describe the observed K-shell ionization dynamics. The electron capture process plays a certain role in L-shell ionization dynamics too, but in a test case of Si on Au target the subshell charge sharing contributes a more vital role than the electron capture. Thus, we have validated the present model as a reliable as well as useful for many solid-target based applications viz. tumour therapy, biophysics, accelerators, material science etc., Comment: 7 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:2103.08299

Published
2021

19. Significance of high charge state of projectile ions inside the target and its role on electron capture leading to target ionization phenomenon

Author

Chatterjee, Soumya, Sharma, Prashant, Claudia, Montanary, Mitra, D., and Nandi, T.

Subjects
Physics - Atomic Physics
Abstract

The K x-ray spectra of different targets (Cu, Zn, and Ge) induced by 3 to 5 MeV/u Si projectile ions have been measured to determine the K-shell ionization cross-section. A significant difference is observed between the measurements and theoretical estimates, with the latter being about 50% below the experimental results. This underestimation} is attributed to the charge-exchange from target K-shell to projectile K- and L-shells. Such observation can only be possible if the projectile ions attain up to H- and He-like charge states. Corresponding projectile charge state fractions have been evaluated from the Lorentzian charge state distribution, where mean charge state is taken from the Fermi gas model [Phys. Rev. Lett. 30, 358 (1973)] and width from the Novikov and Teplova approach [Phys. Lett. A378, 1286-1289 (2014)]. The sum of the direct ionization cross-section and K-K + K-L capture cross-sections gives a good agreement with the measured cross-sections. Furthermore, we have validated this methodology with available data for Si-ion on Ti target. Such results may be useful in many solid target based applications., Comment: 13 pages, 12 figures

Published
2021
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29. HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder

Author

Ambrose, J.C., Arumugam, P., Bevers, R., Bleda, M., Boardman-Pretty, F., Boustred, C.R., Brittain, H., Brown, M.A., Caulfield, M.J., Chan, G.C., Giess, A., Griffin, J.N., Hamblin, A., Henderson, S., Hubbard, T.J.P., Jackson, R., Jones, L.J., Kasperaviciute, D., Kayikci, M., Kousathanas, A., Lahnstein, L., Lakey, A., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., Maleady-Crowe, F., McEntagart, M., Minneci, F., Mitchell, J., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A.C., O‘Donovan, P., Odhams, C.A., Patch, C., Perez-Gil, D., Pereira, M.B., Pullinger, J., Rahim, T., Rendon, A., Rogers, T., Savage, K., Sawant, K., Scott, R.H., Siddiq, A., Sieghart, A., Smith, S.C., Sosinsky, A., Stuckey, A., Tanguy, M., Taylor Tavares, A.L., Thomas, E.R.A., Thompson, S.R., Tucci, A., Welland, M.J., Williams, E., Witkowska, K., Wood, S.M., Zarowiecki, M., Acosta, Maria T., Adams, David R., Alvarez, Raquel L., Alvey, Justin, Allworth, Aimee, Andrews, Ashley, Ashley, Euan A., Afzali, Ben, Bacino, Carlos A., Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bellen, Hugo J., Bennet, Jimmy, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Briere, Lauren C., Brown, Gabrielle, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Chinn, Ivan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Cole, F. Sessions, Colley, Heather A., Cope, Heidi, Corona, Rosario, Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D'Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G., Delgado, Margaret, Dell'Angelica, Esteban C., Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L., Douine, Emilie D., Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Falk, Marni, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Fu, Jiayu, Gahl, William A., Glass, Ian, Goddard, Page C., Godfrey, Rena A., Grajewski, Alana, Halley, Meghan C., Hamid, Rizwan, Hanchard, Neal, Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Huang, Yan, Hutchison, Sarah, Introne, Wendy, Isasi, Rosario, Izumi, Kosuke, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Jean-Marie, Orpa, Jobanputra, Vaidehi, Kaitryn, Emerald, Ketkar, Shamika, Kiley, Dana, Kilich, Gonench, Kobren, Shilpa N., Kohane, Isaac S., Kohler, Jennefer N., Korrick, Susan, Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., LeBlanc, Kimberly, Lee, Brendan H., Levitt, Roy, Lewis, Richard A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Maghiro, AudreyStephannie, Mahoney, Rachel, Malicdan, May Christine, Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McConkie-Rosell, Allyn, McCray, Alexa T., McGee, Elisabeth, Might, Matthew, Miller, Danny, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo, Morimoto, Marie, Mulvihill, John J., Nakano-Okuno, Mariko, Nelson, Stanley F., Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Pallais, J. Carl, Papp, Jeanette C., Parker, Neil H., Petcharet, Leoyklang, Phillips, John A., III, Posey, Jennifer E., Potocki, Lorraine, Swerdzewski, Barbara N., Quinlan, Aaron, Rao, Deepak A., Raper, Anna, Raskind, Wendy, Renteria, Genecee, Reuter, Chloe, Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenthal, Elizabeth, Rossignol, Francis, Ruzhnikov, Maura, Sabaii, Marla, Sacco, Ralph, Sampson, Jacinda B., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Schoch, Kelly, Scott, Daryl A., Seto, Elaine, Sharma, Prashant, Shashi, Vandana, Shelkowitz, Emily, Sheppeard, Sam, Shin, Jimann, Silverman, Edwin, Sinsheimer, Janet, Sisco, Kathy, Smith, Edward, Smith, Kevin, Solnica-Krezel, Lilianna, Solomon, Ben, Spillmann, Rebecca, Stergachis, Andrew, Stoler, Joan, Sullivan, Kathleen, Sullivan, Jennifer, Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tan, Queenie K.-G., Tan, Amelia L., Tarakad, Arjun, Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia, Toro, Camilo, Tran, Alyssa A., Ungar, Rachel A., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Walker, Melissa, Walley, Nicole M., Wambach, Jennifer, Wan, Jijun, Wang, Lee-kai, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Weisz, Monika, Wener, Mark, Wenger, Tara, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Yamamoto, Shinya, Zhang, Zhe, Zuchner, Stephan, Niggl, Eva, Bouman, Arjan, Hoogenboezem, Remco M., Wallaard, Ilse, Park, Joohyun, Admard, Jakob, Wilke, Martina, Harris-Mostert, Emilio D.R.O., Elgersma, Minetta, Bain, Jennifer, Balasubramanian, Meena, Banka, Siddharth, Benke, Paul J., Bertrand, Miriam, Blesson, Alyssa E., Clayton-Smith, Jill, Ellingford, Jamie M., Gillentine, Madelyn A., Goodloe, Dana H., Haack, Tobias B., Jain, Mahim, Krantz, Ian, Luu, Sharon M., McPheron, Molly, Muss, Candace L., Raible, Sarah E., Robin, Nathaniel H., Spiller, Michael, Starling, Susan, Thiffault, Isabelle, Vetrini, Francesco, Witt, Dennis, Woods, Emily, Zhou, Dihong, Elgersma, Ype, and van Esbroeck, Annelot C.M.

Published
2023
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34. Enhancing Mechanical and Thermal Properties of Polymer Matrix Nanocomposites through Tailored Nanomaterial Architectures

Author

Ingole Sunil B., Sharma Prashant, Verma Rajan, Chowdhury Sohini, Patil Pravin P., Dwivedi Shashi Prakash, and Khan Akhilesh Kumar

Subjects
tailored nanomaterial architectures, nanocomposites, mechanical properties, green initiatives, thermal stability, Environmental sciences, GE1-350
Abstract

This research explores the custom-made design of nanomaterial designs to improve the mechanical and thermal properties of polypropylene (PP) framework nanocomposites. Functionalized multiwalled carbon nanotubes (f-MWCNTs) and polyvinylpyrrolidone-modified nano-silica (PVP-SiO2) were deliberately consolidated into the PP matrix, illustrating improved scattering and interaction at the atomic level. Morphological examination uncovered a uniform dissemination of nanofillers, driving to upgrade mechanical properties. Tensile tests illustrated a dynamic increment in Young’s Modulus and Tensile Strength with higher concentrations of nanofillers, especially in definitions NC3 and NC4. Thermal analysis, counting differential checking calorimetry (DSC) and thermogravimetric analysis (TGA), demonstrated hoisted glass move temperatures and upgraded warm solidness. Comparative execution with related works highlighted the special commitments of this ponder, emphasizing green activities, sustainability, and progressions in multifunctionality. The nanocomposites display promising results, with NC3 appearing with a Young’s Modulus of 2.5 GPa and Tensile Strength of 35 MPa, whereas NC4 accomplished a Young’s Modulus of 3.0 GPa and Tensile Quality of 40 MPa. These discoveries emphasize the potential of tailored nanomaterial models for creating high-performance and environmentally capable polymer network nanocomposites.

Published
2024
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35. Unusual charge exchange by swift heavy ions at solid surfaces

Author

Nandi, Tapan, Sharma, Prashant, and Kumar, Pravin

Subjects
Physics - Atomic Physics
Abstract

We have employed x-ray spectroscopy to probe the charge changing process only in the bulk of the foil when swift heavy ions pass through it. In contrast, the electromagnetic methods take into account integral effect of the charge changing process in the bulk as well as the charge exchange phenomenon at the surface of the foil. Thus, the difference between the mean charge states so measured from the two methods disentangles the charge exchange phenomenon at the surface from the charge changing process in the bulk and, provides opportunities to refine the understanding of ion-surface interactions. Very surprisingly, up to tens of electrons per event participate in the charge exchange phenomenon during swift heavy ion-surface interactions. This finding has been validated with a series of experiments using several ions (z = 22-35) in the energy range of 1.5-3.0 MeV/u and also verified theoretically with Fermi-gas model. Interestingly, such unusual charge exchange phenomenon could play significant role in x-ray emission of many astrophysical environments, infrared emission bands from range of environments in galaxies, accelerator physics, ion energy losses in solids, heavy ion cancer treatments, inner shell ionization by heavy ions, and surface modifications in nano scale.

Published
2019

36. Structuring an unordered text document

Author

Yadav, Shashank, Shimpi, Tejas, Chowdary, C. Ravindranath, Sharma, Prashant, Agrawal, Deepansh, and Agarwal, Shivang

Subjects
Computer Science - Information Retrieval, Computer Science - Computation and Language
Abstract

Segmenting an unordered text document into different sections is a very useful task in many text processing applications like multiple document summarization, question answering, etc. This paper proposes structuring of an unordered text document based on the keywords in the document. We test our approach on Wikipedia documents using both statistical and predictive methods such as the TextRank algorithm and Google's USE (Universal Sentence Encoder). From our experimental results, we show that the proposed model can effectively structure an unordered document into sections.

Published
2019

41. De novo variants in DENND5B cause a neurodevelopmental disorder

Author

Scala, Marcello, primary, Tomati, Valeria, additional, Ferla, Matteo, additional, Lena, Mariateresa, additional, Cohen, Julie S., additional, Fatemi, Ali, additional, Brokamp, Elly, additional, Bican, Anna, additional, Phillips, John A., additional, Koziura, Mary E., additional, Nicouleau, Michael, additional, Rio, Marlene, additional, Siquier, Karine, additional, Boddaert, Nathalie, additional, Musante, Ilaria, additional, Tamburro, Serena, additional, Baldassari, Simona, additional, Iacomino, Michele, additional, Scudieri, Paolo, additional, Rosenfeld, Jill A., additional, Bellus, Gary, additional, Reed, Sara, additional, Al Saif, Hind, additional, Russo, Rossana Sanchez, additional, Walsh, Matthew B., additional, Cantagrel, Vincent, additional, Crunk, Amy, additional, Gustincich, Stefano, additional, Ruggiero, Sarah M., additional, Fitzgerald, Mark P., additional, Helbig, Ingo, additional, Striano, Pasquale, additional, Severino, Mariasavina, additional, Salpietro, Vincenzo, additional, Pedemonte, Nicoletta, additional, Zara, Federico, additional, Acosta, Maria T., additional, Adams, David R., additional, Alvarez, Raquel L., additional, Alvey, Justin, additional, Allworth, Aimee, additional, Andrews, Ashley, additional, Ashley, Euan A., additional, Afzali, Ben, additional, Bacino, Carlos A., additional, Bademci, Guney, additional, Balasubramanyam, Ashok, additional, Baldridge, Dustin, additional, Bale, Jim, additional, Bamshad, Michael, additional, Barbouth, Deborah, additional, Bayrak-Toydemir, Pinar, additional, Beck, Anita, additional, Beggs, Alan H., additional, Behrens, Edward, additional, Bejerano, Gill, additional, Bellen, Hugo J., additional, Bennett, Jimmy, additional, Bernstein, Jonathan A., additional, Berry, Gerard T., additional, Bivona, Stephanie, additional, Blue, Elizabeth, additional, Bohnsack, John, additional, Bonner, Devon, additional, Botto, Lorenzo, additional, Briere, Lauren C., additional, Brown, Gabrielle, additional, Burke, Elizabeth A., additional, Burrage, Lindsay C., additional, Butte, Manish J., additional, Byers, Peter, additional, Byrd, William E., additional, Carey, John, additional, Carrasquillo, Olveen, additional, Cassini, Thomas, additional, Chang, Ta Chen Peter, additional, Chanprasert, Sirisak, additional, Chao, HsiaoTuan, additional, Chinn, Ivan, additional, Clark, Gary D., additional, Coakley, Terra R., additional, Cobban, Laurel A., additional, Cogan, Joy D., additional, Coggins, Matthew, additional, Cole, F. Sessions, additional, Colley, Heather A., additional, Cope, Heidi, additional, Corona, Rosario, additional, Craigen, William J., additional, Crouse, Andrew B., additional, Cunningham, Michael, additional, D’Souza, Precilla, additional, Dai, Hongzheng, additional, Dasari, Surendra, additional, Davis, Joie, additional, Dayal, Jyoti G., additional, Delgado, Margaret, additional, Dell'Angelica, Esteban C., additional, Dipple, Katrina, additional, Doherty, Daniel, additional, Dorrani, Naghmeh, additional, Doss, Argenia L., additional, Douine, Emilie D., additional, Earl, Dawn, additional, Eckstein, David J., additional, Emrick, Lisa T., additional, Eng, Christine M., additional, Falk, Marni, additional, Fieg, Elizabeth L., additional, Fisher, Paul G., additional, Fogel, Brent L., additional, Forghani, Irman, additional, Fu, Jiayu, additional, Gahl, William A., additional, Glass, Ian, additional, Goddard, Page C., additional, Godfrey, Rena A., additional, Grajewski, Alana, additional, Gropman, Andrea, additional, Halley, Meghan C., additional, Hamid, Rizwan, additional, Hanchard, Neal, additional, Hassey, Kelly, additional, Hayes, Nichole, additional, High, Frances, additional, Hing, Anne, additional, Hisama, Fuki M., additional, Holm, Ingrid A., additional, Hom, Jason, additional, Horike-Pyne, Martha, additional, Huang, Alden, additional, Huang, Yan, additional, Hutchison, Sarah, additional, Introne, Wendy, additional, Isasi, Rosario, additional, Izumi, Kosuke, additional, Jarvik, Gail P., additional, Jarvik, Jeffrey, additional, Jayadev, Suman, additional, Jean-Marie, Orpa, additional, Jobanputra, Vaidehi, additional, Kaitryn, Emerald, additional, Ketkar, Shamika, additional, Kiley, Dana, additional, Kilich, Gonench, additional, Kobren, Shilpa N., additional, Kohane, Isaac S., additional, Kohler, Jennefer N., additional, Korrick, Susan, additional, Krakow, Deborah, additional, Krasnewich, Donna M., additional, Kravets, Elijah, additional, Lalani, Seema R., additional, Lam, Byron, additional, Lam, Christina, additional, Lanpher, Brendan C., additional, Lanza, Ian R., additional, LeBlanc, Kimberly, additional, Lee, Brendan H., additional, Levitt, Roy, additional, Lewis, Richard A., additional, Liu, Pengfei, additional, Liu, Xue Zhong, additional, Longo, Nicola, additional, Loo, Sandra K., additional, Loscalzo, Joseph, additional, Maas, Richard L., additional, Macnamara, Ellen F., additional, MacRae, Calum A., additional, Maduro, Valerie V., additional, Maghiro, AudreyStephannie, additional, Mahoney, Rachel, additional, Malicdan, May Christine V., additional, Mamounas, Laura A., additional, Manolio, Teri A., additional, Mao, Rong, additional, Marom, Ronit, additional, Marth, Gabor, additional, Martin, Beth A., additional, Martin, Martin G., additional, Martínez-Agosto, Julian A., additional, Marwaha, Shruti, additional, McCauley, Jacob, additional, McConkie-Rosell, Allyn, additional, McCray, Alexa T., additional, McGee, Elisabeth, additional, Might, Matthew, additional, Miller, Danny, additional, Mirzaa, Ghayda, additional, Morava, Eva, additional, Moretti, Paolo, additional, Morimoto, Marie, additional, Mulvihill, John J., additional, Nakano-Okuno, Mariko, additional, Nelson, Stanley F., additional, Nieves-Rodriguez, Shirley, additional, Novacic, Donna, additional, Oglesbee, Devin, additional, Orengo, James P., additional, Pace, Laura, additional, Pak, Stephen, additional, Pallais, J. Carl, additional, Papp, Jeanette C., additional, Parker, Neil H., additional, Petcharet, Leoyklang, additional, Posey, Jennifer E., additional, Potocki, Lorraine, additional, Swerdzewski, Barbara N. Pusey, additional, Quinlan, Aaron, additional, Rao, Deepak A., additional, Raper, Anna, additional, Raskind, Wendy, additional, Renteria, Genecee, additional, Reuter, Chloe M., additional, Rives, Lynette, additional, Robertson, Amy K., additional, Rodan, Lance H., additional, Rosenthal, Elizabeth, additional, Rossignol, Francis, additional, Ruzhnikov, Maura, additional, Sabaii, Marla, additional, Sacco, Ralph, additional, Sampson, Jacinda B., additional, Saporta, Mario, additional, Schaechter, Judy, additional, Schedl, Timothy, additional, Schoch, Kelly, additional, Scott, Daryl A., additional, Seto, Elaine, additional, Sharma, Prashant, additional, Shashi, Vandana, additional, Shelkowitz, Emily, additional, Sheppeard, Sam, additional, Shin, Jimann, additional, Silverman, Edwin K., additional, Sinsheimer, Janet S., additional, Sisco, Kathy, additional, Smith, Edward C., additional, Smith, Kevin S., additional, Solnica-Krezel, Lilianna, additional, Solomon, Ben, additional, Spillmann, Rebecca C., additional, Stergachis, Andrew, additional, Stoler, Joan M., additional, Sullivan, Kathleen, additional, Sullivan, Jennifer A., additional, Sutton, Shirley, additional, Sweetser, David A., additional, Sybert, Virginia, additional, Tabor, Holly K., additional, Tan, Queenie K.-G., additional, Tan, Amelia L.M., additional, Tarakad, Arjun, additional, Taylor, Herman, additional, Tekin, Mustafa, additional, Telischi, Fred, additional, Thorson, Willa, additional, Tifft, Cynthia J., additional, Toro, Camilo, additional, Tran, Alyssa A., additional, Ungar, Rachel A., additional, Urv, Tiina K., additional, Vanderver, Adeline, additional, Velinder, Matt, additional, Viskochil, Dave, additional, Vogel, Tiphanie P., additional, Wahl, Colleen E., additional, Walker, Melissa, additional, Walley, Nicole M., additional, Wambach, Jennifer, additional, Wan, Jijun, additional, Wang, Lee-kai, additional, Wangler, Michael F., additional, Ward, Patricia A., additional, Wegner, Daniel, additional, Weisz Hubshman, Monika, additional, Wener, Mark, additional, Wenger, Tara, additional, Westerfield, Monte, additional, Wheeler, Matthew T., additional, Whitlock, Jordan, additional, Wolfe, Lynne A., additional, Worley, Kim, additional, Yamamoto, Shinya, additional, Zhang, Zhe, additional, and Zuchner, Stephan, additional

Published
2024
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44. Kilquist syndrome: A novel syndromic hearing loss disorder caused by homozygous deletion of SLC12A2.

Author

Macnamara, Ellen F, Koehler, Alanna E, D'Souza, Precilla, Estwick, Tyra, Lee, Paul, Vezina, Gilbert, Undiagnosed Diseases Network, Fauni, Harper, Braddock, Stephen R, Torti, Erin, Holt, James Matthew, Sharma, Prashant, Malicdan, May Christine V, and Tifft, Cynthia J

Subjects
Undiagnosed Diseases Network, Humans, Hearing Loss, Sensorineural, Syndrome, Genetic Predisposition to Disease, Facies, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Sequence Deletion, Homozygote, Phenotype, Child, Preschool, Male, Genetic Loci, Genetic Association Studies, Solute Carrier Family 12, Member 2, NKCC1, absent salivation, cystic fibrosis, gut malrotation, uniparental isodisomy, Brain Disorders, Clinical Research, Neurosciences, Digestive Diseases, Intellectual and Developmental Disabilities (IDD), Pediatric, Genetics, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Ear, Congenital, Clinical Sciences, Genetics & Heredity
Abstract

Syndromic sensorineural hearing loss is multigenic and associated with malformations of the ear and other organ systems. Herein we describe a child admitted to the NIH Undiagnosed Diseases Program with global developmental delay, sensorineural hearing loss, gastrointestinal abnormalities, and absent salivation. Next-generation sequencing revealed a uniparental isodisomy in chromosome 5, and a 22 kb homozygous deletion in SLC12A2, which encodes for sodium, potassium, and chloride transporter in the basolateral membrane of secretory epithelia. Functional studies using patient-derived fibroblasts showed truncated SLC12A2 transcripts and markedly reduced protein abundance when compared with control. Loss of Slc12a2 in mice has been shown to lead to deafness, abnormal neuronal growth and migration, severe gastrointestinal abnormalities, and absent salivation. Together with the described phenotype of the Slc12a2-knockout mouse model, our results suggest that the absence of functional SLC12A2 causes a new genetic syndrome and is crucial for the development of auditory, neurologic, and gastrointestinal tissues.

Published
2019

45. A dated molecular phylogeny of mite harvestmen (Arachnida: Opiliones: Cyphophthalmi) elucidates ancient diversification dynamics in the Australian Wet Tropics

Author

Oberski, Jill T, Sharma, Prashant P, Jay, Katya R, Coblens, Michelle J, Lemon, Kaelyn A, Johnson, Joanne E, and Boyer, Sarah L

Subjects
Biological Sciences, Ecology, Evolutionary Biology, Genetics, Animals, Bayes Theorem, Biodiversity, DNA, Mitochondrial, Geography, Humidity, Likelihood Functions, Mites, Phylogeny, Queensland, Rainforest, Time Factors, Tropical Climate, Australian Wet Tropics, Historical refugia, Pleistocene refugia, Quaternary climate fluctuations, Miocene aridification, Zoology, Evolutionary biology
Abstract

Austropurcellia, a genus of dispersal-limited arachnids endemic to isolated patches of coastal rainforest in Queensland, Australia, has a remarkable biogeographic history. The genus is a member of the family Pettalidae, which has a classical temperate Gondwanan distribution; previous work has suggested that Austropurcellia is an ancient lineage, with an origin that predates Gondwanan rifting. Subsequently, this lineage has persisted through major climatic fluctuations, such as major aridification during the Miocene and contraction and fragmentation of forest habitats during the Last Glacial Maximum (LGM). In order to understand Austropurcellia's evolutionary and biogeographic history, we generated DNA sequences from both mitochondrial and nuclear loci and combined this information with previously published datasets for the globally-distributed suborder Cyphophthalmi (i.e., all mite harvestmen). We generated phylogenetic trees using maximum likelihood and Bayesian approaches to date divergences using a relaxed molecular clock. According to our estimates, the family Pettalidae diversified in the late Jurassic, in accordance with Gondwanan vicariance. Within Pettalidae, Austropurcellia split from its sister group in the early Cretaceous and began to diversify some 15 Ma later. Therefore, its presence in Australia predates continental rifting-making it one of very few hypothesized examples of Gondwanan vicariance that have withstood rigorous testing. We found a steady rate of diversification within the genus, with no evidence for a shift in rate associated with Miocene aridification. Ages of splits between species predate the Pleistocene, consistent with a "museum" model in which forest refugia acted to preserve existing lineages rather than drive speciation within the group.

Published
2018

49. The house spider genome reveals an ancient whole-genome duplication during arachnid evolution

Author

Schwager, Evelyn E, Sharma, Prashant P, Clarke, Thomas, Leite, Daniel J, Wierschin, Torsten, Pechmann, Matthias, Akiyama-Oda, Yasuko, Esposito, Lauren, Bechsgaard, Jesper, Bilde, Trine, Buffry, Alexandra D, Chao, Hsu, Dinh, Huyen, Doddapaneni, HarshaVardhan, Dugan, Shannon, Eibner, Cornelius, Extavour, Cassandra G, Funch, Peter, Garb, Jessica, Gonzalez, Luis B, Gonzalez, Vanessa L, Griffiths-Jones, Sam, Han, Yi, Hayashi, Cheryl, Hilbrant, Maarten, Hughes, Daniel ST, Janssen, Ralf, Lee, Sandra L, Maeso, Ignacio, Murali, Shwetha C, Muzny, Donna M, Nunes da Fonseca, Rodrigo, Paese, Christian LB, Qu, Jiaxin, Ronshaugen, Matthew, Schomburg, Christoph, Schönauer, Anna, Stollewerk, Angelika, Torres-Oliva, Montserrat, Turetzek, Natascha, Vanthournout, Bram, Werren, John H, Wolff, Carsten, Worley, Kim C, Bucher, Gregor, Gibbs, Richard A, Coddington, Jonathan, Oda, Hiroki, Stanke, Mario, Ayoub, Nadia A, Prpic, Nikola-Michael, Flot, Jean-François, Posnien, Nico, Richards, Stephen, and McGregor, Alistair P

Subjects
Human Genome, Genetics, Generic health relevance, Animals, Evolution, Molecular, Female, Gene Duplication, Genome, Male, Spiders, Synteny, Parasteatoda tepidariorum, Centruroides sculpturatus, Gene duplication, Evolution, Hox genes, Developmental Biology
Abstract

BackgroundThe duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum.ResultsWe found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication.ConclusionsOur results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.

Published
2017

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