312 results on '"Shears, Stephen B."'
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2. Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
3. PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.
4. A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop
5. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line
6. InsP₇ is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics
7. Control of XPR1-dependent cellular phosphate efflux by InsP₈ is an exemplar for functionally-exclusive inositol pyrophosphate signaling
8. Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors
9. Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling
10. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress
11. KO of 5-InsP₇ kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype
12. Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
13. Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7
14. Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
15. A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging
16. Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs
17. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery
18. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut
19. Dephosphorylation of 2,3-Bisphosphoglycerate by MIPP Expands the Regulatory Capacity of the Rapoport-Luebering Glycolytic Shunt
20. Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7† †Electronic supplementary information (ESI) available: Data deposition: atomic coordinates and structure factors have been deposited in the Protein Data Bank (PDB ID code 6N5C). See DOI: 10.1039/c9md00163h
21. The Effects of Mastoparan on the Carrot Cell Plasma Membrane Polyphosphoinositide Phospholipase C
22. Changes in Phosphatidylinositol Metabolism in Response to Hyperosmotic Stress in Daucus carota L. Cells Grown in Suspension Culture
23. The Nucleolus Exhibits an Osmotically Regulated Gatekeeping Activity That Controls the Spatial Dynamics and Functions of Nucleolin
24. Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues
25. Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”
26. InsP 7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics
27. Control of XPR1-dependent cellular phosphate efflux by InsP 8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling
28. Flavored e-liquids increase cytoplasmic Ca2+levels in airway epithelia
29. Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode
30. Telomere Maintenance by Intracellular Signals: New Kid on the Block?
31. Essential role of phosphinositide metabolism in synaptic vesicle recycling
32. D-myo-inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways
33. Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4
34. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization
35. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.
36. Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine
37. Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress
38. The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?
39. Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode.
40. Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae
41. Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling.
42. Flavored e-liquids increase cytoplasmic Ca2+ levels in airway epithelia.
43. Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates
44. Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse
45. Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
46. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities
47. KO of 5-InsP 7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype
48. Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
49. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis
50. Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels
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