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22 results on '"Shimokawa, Chikako"'

2. Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications

Author

Nagata, Naoyoshi, Takeuchi, Tadashi, Masuoka, Hiroaki, Aoki, Ryo, Ishikane, Masahiro, Iwamoto, Noriko, Sugiyama, Masaya, Suda, Wataru, Nakanishi, Yumiko, Terada-Hirashima, Junko, Kimura, Moto, Nishijima, Tomohiko, Inooka, Hiroshi, Miyoshi-Akiyama, Tohru, Kojima, Yasushi, Shimokawa, Chikako, Hisaeda, Hajime, Zhang, Fen, Yeoh, Yun Kit, Ng, Siew C., Uemura, Naomi, Itoi, Takao, Mizokami, Masashi, Kawai, Takashi, Sugiyama, Haruhito, Ohmagari, Norio, and Ohno, Hiroshi

Published
2023
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6. Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator

Author

Nagaraja, Shruti, primary, Cai, Maggi W., additional, Sun, Jingjing, additional, Varet, Hugo, additional, Sarid, Lotem, additional, Trebicz-Geffen, Meirav, additional, Shaulov, Yana, additional, Mazumdar, Mohit, additional, Legendre, Rachel, additional, Coppée, Jean-Yves, additional, Begley, Thomas J., additional, Dedon, Peter C., additional, Gourinath, Samudrala, additional, Guillen, Nancy, additional, Saito-Nakano, Yumiko, additional, Shimokawa, Chikako, additional, Hisaeda, Hajime, additional, and Ankri, Serge, additional

Published
2021
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9. Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii

Author

Imai, Takashi, primary, Suzue, Kazutomo, additional, Ngo-Thanh, Ha, additional, Ono, Suguri, additional, Orita, Wakako, additional, Suzuki, Haruka, additional, Shimokawa, Chikako, additional, Olia, Alex, additional, Obi, Seiji, additional, Taniguchi, Tomoyo, additional, Ishida, Hidekazu, additional, Van Kaer, Luc, additional, Murata, Shigeo, additional, Tanaka, Keiji, additional, and Hisaeda, Hajime, additional

Published
2019
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12. Corrigendum: Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis

Author

Taniguchi, Tomoyo, Miyauchi, Eiji, Nakamura, Shota, Hirai, Makoto, Suzue, Kazutomo, Imai, Takashi, Nomura, Takahiro, Handa, Tadashi, Okada, Hiroko, Shimokawa, Chikako, Onishi, Risa, Olia, Alex, Hirata, Jun, Tomita, Haruyoshi, Ohno, Hiroshi, Horii, Toshihiro, and Hisaeda, Hajime

Subjects
DNA, Bacterial, Male, Mice, Inbred BALB C, Plasmodium berghei, Microbiota, Firmicutes, Corrigenda, Malaria, Intestines, Mice, Inbred C57BL, Feces, Mice, Blood-Brain Barrier, RNA, Ribosomal, 16S, Databases, Genetic, Proteobacteria, Animals, Dysbiosis
Abstract

Gastrointestinal symptoms, such as abdominal pain and diarrhea, are frequently observed in patients with Plasmodium falciparum malaria. However, the correlation between malaria intestinal pathology and intestinal microbiota has not been investigated. In the present study, infection of C57BL/6 mice with P. berghei ANKA (PbA) caused intestinal pathological changes, such as detachment of epithelia in the small intestines and increased intestinal permeability, which correlated with development with experimental cerebral malaria (ECM). Notably, an apparent dysbiosis occurred, characterized by a reduction of Firmicutes and an increase in Proteobacteria. Furthermore, some genera of microbiota correlated with parasite growth and/or ECM development. By contrast, BALB/c mice are resistant to ECM and exhibit milder intestinal pathology and dysbiosis. These results indicate that the severity of cerebral and intestinal pathology coincides with the degree of alteration in microbiota. This is the first report demonstrating that malaria affects intestinal microbiota and causes dysbiosis.

Published
2016

14. Correction: Corrigendum: Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis

Author

Taniguchi, Tomoyo, primary, Miyauchi, Eiji, additional, Nakamura, Shota, additional, Hirai, Makoto, additional, Suzue, Kazutomo, additional, Imai, Takashi, additional, Nomura, Takahiro, additional, Handa, Tadashi, additional, Okada, Hiroko, additional, Shimokawa, Chikako, additional, Onishi, Risa, additional, Olia, Alex, additional, Hirata, Jun, additional, Tomita, Haruyoshi, additional, Ohno, Hiroshi, additional, Horii, Toshihiro, additional, and Hisaeda, Hajime, additional

Published
2016
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15. Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis

Author

Taniguchi, Tomoyo, primary, Miyauchi, Eiji, additional, Nakamura, Shota, additional, Hirai, Makoto, additional, Suzue, Kazutomo, additional, Imai, Takashi, additional, Nomura, Takahiro, additional, Handa, Tadashi, additional, Okada, Hiroko, additional, Shimokawa, Chikako, additional, Onishi, Risa, additional, Olia, Alex, additional, Hirata, Jun, additional, Tomita, Haruyoshi, additional, Ohno, Hiroshi, additional, Horii, Toshihiro, additional, and Hisaeda, Hajime, additional

Published
2015
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21. Queuine Is a Nutritional Regulator of Entamoeba histolyticaResponse to Oxidative Stress and a Virulence Attenuator

Author

Nagaraja, Shruti, Cai, Maggi W., Sun, Jingjing, Varet, Hugo, Sarid, Lotem, Trebicz-Geffen, Meirav, Shaulov, Yana, Mazumdar, Mohit, Legendre, Rachel, Coppée, Jean-Yves, Begley, Thomas J., Dedon, Peter C., Gourinath, Samudrala, Guillen, Nancy, Saito-Nakano, Yumiko, Shimokawa, Chikako, Hisaeda, Hajime, and Ankri, Serge

Abstract

Entamoeba histolyticais a unicellular parasite that causes amebiasis. The parasite resides in the colon and feeds on the colonic microbiota.

Published
2021
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22. Species-Specific Immunity Induced by Infection with Entamoeba histolytica and Entamoeba moshkovskii in Mice.

Author

Shimokawa, Chikako, Culleton, Richard, Imai, Takashi, Suzue, Kazutomo, Hirai, Makoto, Taniguchi, Tomoyo, Kobayashi, Seiki, Hisaeda, Hajime, and Hamano, Shinjiro

Subjects
*ENTAMOEBA histolytica, *AMEBIASIS, *PARASITIC diseases, *DEATH rate, *TROPHOZOITES, *METRONIDAZOLE, *IMMUNE response, *LABORATORY mice
Abstract

Entamoeba histolytica, the parasitic amoeba responsible for amoebiasis, causes approximately 100,000 deaths every year. There is currently no vaccine against this parasite. We have previously shown that intracecal inoculation of E. histolytica trophozoites leads to chronic and non-healing cecitis in mice. Entamoeba moshkovskii, a closely related amoeba, also causes diarrhea and other intestinal disorders in this model. Here, we investigated the effect of infection followed by drug-cure of these species on the induction of immunity against homologous or heterologous species challenge. Mice were infected with E. histolytica or E. moshkovskii and treated with metronidazole 14 days later. Re-challenge with E. histolytica or E. moshkovskii was conducted seven or 28 days following confirmation of the clearance of amoebae, and the degree of protection compared to non-exposed control mice was evaluated. We show that primary infection with these amoebae induces a species-specific immune response which protects against challenge with the homologous, but not a heterologous species. These findings pave the way, therefore, for the identification of novel amoebae antigens that may become the targets of vaccines and provide a useful platform to investigate host protective immunity to Entamoeba infections. [ABSTRACT FROM AUTHOR]

Published
2013
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