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274 results on '"Singh, Sheldon M"'

7. MRI Accurately Visualizes RF Ablation Delivery Targeted to MRI-Defined Arrhythmia Substrates in the Left Ventricle

Author

Krahn, Philippa R. P., Escartin, Terenz, Singh, Sheldon M., Barry, Jennifer, Larsen, Melissa, Guo, Fumin, Pop, Mihaela, and Wright, Graham A.

Abstract

Objective: Investigate the capacity of MRI to evaluate efficacy of radiofrequency (RF) ablations delivered to MRI-defined arrhythmogenic substrates. Methods: Baseline MRI was performed at 3 T including 3D LGE in a swine model of chronic myocardial infarct (N = 8). MRI-derived maps of scar and heterogeneous tissue channels (HTCs) were generated using ADAS 3D. Animals underwent electroanatomic mapping and ablation of the left ventricle in CARTO3, guided by MRI-derived scar maps. Post-ablation MRI (in vivo at 3 T in 5/8 animals; ex vivo at 1.5 T in 3/8) included 3D native T1-weighted IR-SPGR (TI = 700–800 ms) to visualize RF lesions. T1-derived RF lesions were compared against excised tissue. The locations of T1-derived RF lesions were compared against CARTO ablation tags, and segment-wise sensitivity and specificity of lesion detection were calculated within the AHA 17-segment model. Results: RF lesions were clearly visualized in HTCs, scar, and myocardium. Ablation patterns delivered in CARTO matched T1-derived RF lesion patterns with high sensitivity (88.9%) and specificity (94.7%), and were closely matched in registered MR-EP data sets, with a displacement of 5.4$\pm$3.8 mm (N = 152 ablation tags). Conclusion: Integrating MRI into ablative procedures for RF lesion assessment is feasible. Patterns of RF lesions created using a standard 3D EAM system are accurately reflected by MRI visualization in healthy myocardium, scar, and HTCs comprising the MRI-defined arrhythmia substrate. Significance: MRI visualization of RF lesions can provide near-immediate ($< $24 h) assessment of ablation, potentially indicating whether critical MRI-defined ventricular tachycardia substrates have been adequately ablated.

Published
2024
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10. Stroke risk in women with atrial fibrillation

Author

Buhari, Hifza, primary, Fang, Jiming, additional, Han, Lu, additional, Austin, Peter C, additional, Dorian, Paul, additional, Jackevicius, Cynthia A, additional, Yu, Amy Y X, additional, Kapral, Moira K, additional, Singh, Sheldon M, additional, Tu, Karen, additional, Ko, Dennis T, additional, Atzema, Clare L, additional, Benjamin, Emelia J, additional, Lee, Douglas S, additional, and Abdel-Qadir, Husam, additional

Published
2023
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11. Prognostic Value of Different Thresholds for Myocardial Scar Quantification on Cardiac MRI Late Gadolinium Enhancement Images in Patients Receiving Implantable Cardioverter Defibrillators

Author

Shalmon, Tamar, primary, Hamad, Faisal Mhd. Dib, additional, Jimenez-Juan, Laura, additional, Kirpalani, Anish, additional, Urzua Fresno, Camila M., additional, Folador, Luciano, additional, Tan, Nigel S., additional, Singh, Sheldon M., additional, Ge, Yin, additional, Dorian, Paul, additional, Lima, João A. C., additional, Wong, Kathy C. K., additional, Deva, Djeven P., additional, and Yan, Andrew T., additional

Published
2023
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15. Metabolic cardiomyopathy from propionic acidemia precipitating cardiac arrest in a 25-year-old man

Author

Tan, Nigel S., Bajaj, Ravi R., Morel, Chantal, and Singh, Sheldon M.

Subjects
Cardiac arrest -- Causes of -- Diagnosis -- Care and treatment, Echocardiography -- Usage, Youth -- Health aspects -- Genetic aspects, Propionic acidemia -- Complications and side effects -- Care and treatment, Dietary supplements -- Research, Health
Abstract

A 25-year-old man with a medical history of propionic acidemia was brought to hospital after he collapsed while jogging. He was unresponsive, received immediate bystander cardiopulmonary resuscitation and was defibrillated [...]

Published
2018
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26. Association of Diabetes Duration and Glycemic Control With Stroke Rate in Patients With Atrial Fibrillation and Diabetes: A Population‐Based Cohort Study

Author

Abdel‐Qadir, Husam, primary, Gunn, Madison, additional, Lega, Iliana C., additional, Pang, Andrea, additional, Austin, Peter C., additional, Singh, Sheldon M., additional, Jackevicius, Cynthia A., additional, Tu, Karen, additional, Dorian, Paul, additional, Lee, Douglas S., additional, and Ko, Dennis T., additional

Published
2022
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32. Right Ventricular Function at Cardiac MRI Predicts Cardiovascular Events in Patients with an Implantable Cardioverter-Defibrillator

Author

Jimenez-Juan, Laura, primary, Ben-Dov, Nissan, additional, Goncalves Frazao, Caio V., additional, Tan, Nigel S., additional, Singh, Sheldon M., additional, Dorian, Paul, additional, Angaran, Paul, additional, Oikonomou, Anastasia, additional, Kha, Lan-Chau T., additional, Roifman, Idan, additional, Chacko, Binita, additional, Connelly, Kim A., additional, Kirpalani, Anish, additional, Deva, Djeven, additional, and Yan, Andrew T., additional

Published
2021
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38. Surgical Repair of Atrial-Esophageal Fistula Following Catheter Ablation.

Author

Shimamura, Junichi, Moussa, Fuad, Tarola, Christopher, Christakis, George, Cohen, Gideon, Fremes, Stephen, Rezaei, Reza M., Simone, Carmine, and Singh, Sheldon M.

Abstract

Left atrial-esophageal fistula after radiofrequency ablation for atrial fibrillation is a rare and potentially lethal complication. Although surgical management is associated with improved outcomes, the optimal approach remains to be elucidated. We describe a case of atrial-esophageal fistula treated with a simultaneous repair of the atrium and esophagus via a right thoracotomy with an extrapericardial off-pump approach. [ABSTRACT FROM AUTHOR]

Published
2022
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