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6 results on '"Soliman, Moaaz"'

1. Landmark‐based auto‐contouring of clinical target volumes for radiotherapy of nasopharyngeal cancer.

Author

Sjogreen, Carlos, Netherton, Tucker J., Lee, Anna, Soliman, Moaaz, Gay, Skylar S., Nguyen, Callistus, Mumme, Raymond, Vazquez, Ivan, Rhee, Dong Joo, Cardenas, Carlos E., Martel, Mary K., Beadle, Beth M., and Court, Laurence Edward

Subjects
NASOPHARYNX cancer, PHYSICIANS, CANCER radiotherapy, ONCOLOGISTS, CANCER patients
Abstract

Background: The delineation of clinical target volumes (CTVs) for radiotherapy for nasopharyngeal cancer is complex and varies based on the location and extent of disease. Purpose: The current study aimed to develop an auto‐contouring solution following one protocol guidelines (NRG‐HN001) that can be adjusted to meet other guidelines, such as RTOG‐0225 and the 2018 International guidelines. Methods: The study used 2‐channel 3‐dimensional U‐Net and nnU‐Net framework to auto‐contour 27 normal structures in the head and neck (H&N) region that are used to define CTVs in the protocol. To define the CTV‐Expansion (CTV1 and CTV2) and CTV‐Overall (the outer envelope of all the CTV contours), we used adjustable morphological geometric landmarks and mimicked physician interpretation of the protocol rules by partially or fully including select anatomic structures. The results were evaluated quantitatively using the dice similarity coefficient (DSC) and mean surface distance (MSD) and qualitatively by independent reviews by two H&N radiation oncologists. Results: The auto‐contouring tool showed high accuracy for nasopharyngeal CTVs. Comparison between auto‐contours and clinical contours for 19 patients with cancers of various stages showed a DSC of 0.94 ± 0.02 and MSD of 0.4 ± 0.4 mm for CTV‐Expansion and a DSC of 0.83 ± 0.02 and MSD of 2.4 ± 0.5 mm for CTV‐Overall. Upon independent review, two H&N physicians found the auto‐contours to be usable without edits in 85% and 75% of cases. In 15% of cases, minor edits were required by both physicians. Thus, one physician rated 100% of the auto‐contours as usable (use as is, or after minor edits), while the other physician rated 90% as usable. The second physician required major edits in 10% of cases. Conclusions: The study demonstrates the ability of an auto‐contouring tool to reliably delineate nasopharyngeal CTVs based on protocol guidelines. The tool was found to be clinically acceptable by two H&N radiation oncology physicians in at least 90% of the cases. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Cross-Modality Brain Structures Image Segmentation for the Radiotherapy Target Definition and Plan Optimization

Author

Shusharina, Nadya, Bortfeld, Thomas, Cardenas, Carlos, De, Brian, Diao, Kevin, Hernandez, Soleil, Liu, Yufei, Maroongroge, Sean, Söderberg, Jonas, and Soliman, Moaaz

Subjects
Radiotherapy target, Segmentation, Cross-modality, Deep learning, Article
Abstract

This paper summarizes results of the International Challenge “Anatomical Brain Barriers to Cancer Spread: Segmentation from CT and MR Images”, ABCs, organized in conjunction with the MICCAI 2020 conference. Eighteen segmentation algorithms were trained on a set of 45 CT, T\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_1$$\end{document}1-weighted MR, and T\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_2$$\end{document}2-weighted FLAIR MR post-operative images of glioblastoma and low-grade glioma patients. Manual delineations were provided for the brain structures: falx cerebri, tentorium cerebelli, transverse and sagittal brain sinuses, ventricles, cerebellum (Task 1) and for the brainstem, structures of visual pathway, optic chiasm, optic nerves, and eyes, structures of auditory pathway, cochlea, and lacrimal glands (Task 2). The algorithms were tested on a set of 15 cases and received the final score for predicting segmentation on a separate 15 case image set. Multi-rater delineations with seven raters were obtained for the three cases. The results suggest that neural network based algorithms have become a successful technique of brain structure segmentation, and closely approach human performance in segmenting specific brain structures.

Published
2021

6. Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88and chromatin modifiers: new routes to targeted therapies

Author

Cani, Andi K, Soliman, Moaaz, Hovelson, Daniel H, Liu, Chia-Jen, McDaniel, Andrew S, Haller, Michaela J, Bratley, Jarred V, Rahrig, Samantha E, Li, Qiang, Briceño, César A, Tomlins, Scott A, and Rao, Rajesh C

Abstract

Non-Hodgkin lymphoma of the orbit and ocular adnexa is the most common primary orbital malignancy. Treatments for low- (extra-nodal marginal zone and follicular lymphomas) and high-grade (diffuse large B-cell lymphoma) are associated with local and vision-threatening toxicities. High-grade lymphomas relapse frequently and exhibit poor survival rates. Despite advances in genomic profiling and precision medicine, orbital and ocular adnexal lymphomas remain poorly characterized molecularly. We performed targeted next-generation sequencing (NGS) profiling of 38 formalin-fixed, paraffin-embedded orbital and ocular adnexal lymphomas obtained from a single-center using a panel targeting near-term, clinically relevant genes. Potentially actionable mutations and copy number alterations were prioritized based on gain- and loss-of-function analyses, and catalogued, approved, and investigational therapies. Of 36 informative samples, including marginal zone lymphomas (n=20), follicular lymphomas (n=9), and diffuse large B-cell lymphomas (n=7), 53% harbored a prioritized alteration (median=1, range 0–5/sample). MYD88was the most frequently altered gene in our cohort, with potentially clinically relevant hotspot gain-of-function mutations identified in 71% of diffuse large B-cell lymphomas and 25% of marginal zone lymphomas. Prioritized alterations in epigenetic modulators were common and included gain-of-function EZH2and loss-of-function ARID1Amutations (14% of diffuse large B-cell lymphomas and 22% of follicular lymphomas contained alterations in each of these two genes). Single prioritized alterations were also identified in the histone methyltransferases KMT2B(follicular lymphoma) and KMT3B(diffuse large B-cell lymphoma). Loss-of-function mutations and copy number alterations in the tumor suppressors TP53(diffuse large B-cell and follicular lymphoma), CDKN2A(diffuse large B-cell and marginal zone lymphoma), PTEN(diffuse large B-cell lymphoma), ATM(diffuse large B-cell lymphoma), and NF1(diffuse large B-cell lymphoma), and gain-of-function mutations in the oncogenes HRAS(follicular lymphoma) and NRAS(diffuse large B-cell lymphoma) were also observed. Together, our study demonstrates that NGS can be used to profile routine formalin-fixed, paraffin-embedded orbital and ocular adnexal lymphomas for identification of somatic-driving alterations and nomination of potential therapeutic strategies.

Published
2016
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