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1,283 results on '"Song, Zhen"'

1. Forecasting the Future with Future Technologies: Advancements in Large Meteorological Models

Author

Shu, Hailong, Wang, Yue, Song, Weiwei, Guo, Huichuang, and Song, Zhen

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Physics - Atmospheric and Oceanic Physics
Abstract

The field of meteorological forecasting has undergone a significant transformation with the integration of large models, especially those employing deep learning techniques. This paper reviews the advancements and applications of these models in weather prediction, emphasizing their role in transforming traditional forecasting methods. Models like FourCastNet, Pangu-Weather, GraphCast, ClimaX, and FengWu have made notable contributions by providing accurate, high-resolution forecasts, surpassing the capabilities of traditional Numerical Weather Prediction (NWP) models. These models utilize advanced neural network architectures, such as Convolutional Neural Networks (CNNs), Graph Neural Networks (GNNs), and Transformers, to process diverse meteorological data, enhancing predictive accuracy across various time scales and spatial resolutions. The paper addresses challenges in this domain, including data acquisition and computational demands, and explores future opportunities for model optimization and hardware advancements. It underscores the integration of artificial intelligence with conventional meteorological techniques, promising improved weather prediction accuracy and a significant contribution to addressing climate-related challenges. This synergy positions large models as pivotal in the evolving landscape of meteorological forecasting., Comment: 5 pages

Published
2024

2. LightSword: A Customized Virtual Reality Exergame for Long-Term Cognitive Inhibition Training in Older Adults

Author

Du, Qiuxin, Song, Zhen, Jiang, Haiyan, Wei, Xiaoying, Weng, Dongdong, and Fan, Mingming

Subjects
Computer Science - Human-Computer Interaction
Abstract

The decline of cognitive inhibition significantly impacts older adults' quality of life and well-being, making it a vital public health problem in today's aging society. Previous research has demonstrated that Virtual reality (VR) exergames have great potential to enhance cognitive inhibition among older adults. However, existing commercial VR exergames were unsuitable for older adults' long-term cognitive training due to the inappropriate cognitive activation paradigm, unnecessary complexity, and unbefitting difficulty levels. To bridge these gaps, we developed a customized VR cognitive training exergame (LightSword) based on Dual-task and Stroop paradigms for long-term cognitive inhibition training among healthy older adults. Subsequently, we conducted an eight-month longitudinal user study with 12 older adults aged 60 years and above to demonstrate the effectiveness of LightSword in improving cognitive inhibition. After the training, the cognitive inhibition abilities of older adults were significantly enhanced, with benefits persisting for 6 months. This result indicated that LightSword has both short-term and long-term effects in enhancing cognitive inhibition. Furthermore, qualitative feedback revealed that older adults exhibited a positive attitude toward long-term training with LightSword, which enhanced their motivation and compliance., Comment: 23 pages

Published
2024
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3. High-order BDF convolution quadrature for stochastic fractional evolution equations driven by integrated additive noise

Author

Chen, Minghua, Shi, Jiankang, Song, Zhen, Yan, Yubin, and Zhou, Zhi

Subjects
Mathematics - Numerical Analysis
Abstract

The numerical analysis of stochastic time fractional evolution equations presents considerable challenges due to the limited regularity of the model caused by the nonlocal operator and the presence of noise. The existing time-stepping methods exhibit a significantly low order convergence rate. In this work, we introduce a smoothing technique and develop the novel high-order schemes for solving the linear stochastic fractional evolution equations driven by integrated additive noise. Our approach involves regularizing the additive noise through an $m$-fold integral-differential calculus, and discretizing the equation using the $k$-step BDF convolution quadrature. This novel method, which we refer to as the ID$m$-BDF$k$ method, is able to achieve higher-order convergence in solving the stochastic models. Our theoretical analysis reveals that the convergence rate of the ID$2$-BDF2 method is $O(\tau^{\alpha + \gamma -1/2})$ for $1< \alpha + \gamma \leq 5/2$, and $O(\tau^{2})$ for $5/2< \alpha + \gamma <3$, where $\alpha \in (1, 2)$ and $\gamma \in (0, 1)$ denote the time fractional order and the order of the integrated noise, respectively. Furthermore, this convergence rate could be improved to $O(\tau^{\alpha + \gamma -1/2})$ for any $\alpha \in (1, 2)$ and $\gamma \in (0, 1)$, if we employ the ID$3$-BDF3 method. The argument could be easily extended to the subdiffusion model with $\alpha \in (0, 1)$. Numerical examples are provided to support and complement the theoretical findings., Comment: 22pages

Published
2024

4. Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis.

Author

Wang, Yijie, Li, Qihao, Tao, Bo, Angelini, Marina, Ramadoss, Sivakumar, Sun, Baiming, Wang, Ping, Krokhaleva, Yuliya, Ma, Feiyang, Gu, Yiqian, Espinoza, Alejandro, Yamauchi, Ken, Pellegrini, Matteo, Novitch, Bennett, Olcese, Riccardo, Qu, Zhilin, Song, Zhen, and Deb, Arjun

Subjects
Animals, Mice, Arrhythmias, Cardiac, Cicatrix, Fibroblasts, Myocytes, Cardiac, Channelrhodopsins, Optogenetics, Connexin 43, Gene Knockout Techniques
Abstract

After heart injury, dead heart muscle is replaced by scar tissue. Fibroblasts can electrically couple with myocytes, and changes in fibroblast membrane potential can lead to myocyte excitability, which suggests that fibroblast-myocyte coupling in scar tissue may be responsible for arrhythmogenesis. However, the physiologic relevance of electrical coupling of myocytes and fibroblasts and its impact on cardiac excitability in vivo have never been demonstrated. We genetically engineered a mouse that expresses the optogenetic cationic channel ChR2 (H134R) exclusively in cardiac fibroblasts. After myocardial infarction, optical stimulation of scar tissue elicited organ-wide cardiac excitation and induced arrhythmias in these animals. Complementing computational modeling with experimental approaches, we showed that gap junctional and ephaptic coupling, in a synergistic yet functionally redundant manner, excited myocytes coupled to fibroblasts.

Published
2023

6. Comparative efficacy of Bacillus Calmette–Guérin instillation and radical cystectomy treatments for high-risk non-muscle-invasive urothelial cancer classified as high-grade T1 in initial and repeat transurethral resection of bladder tumor

Author

Song Zhen, Chen Hao, Yu Yanhang, Lin Yuxin, Ouyang Jun, and Zhang Zhiyu

Subjects
high-risk non-muscle-invasive urothelial cancer, Bacillus Calmette-Guérin instillation, radical cystectomy, overall survival, progression-free survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

ObjectiveTo compare the differential therapeutic effects of Bacillus Calmette-Guérin (BCG) instillation and radical cystectomy (RC) for high-risk non-muscle–invasive urothelial cancer (NMIBC) classified as high-grade T1 in initial and repeat transurethral resection of bladder tumors (TURBT) and to construct a prediction model.MethodsWe retrospectively analyzed the clinical data of patients with malignant bladder tumors treated at the First Affiliated Hospital of Soochow University from January 2016 to December 2017 and compared the differences in 1-year, 2-year, 3-year, 5-year, and comprehensive overall survival (OS) and progression-free survival (PFS) between BCG instillation treatment and RC treatment. Survival curves were drawn to show differences in OS and PFS between the two groups. Concurrently, univariate and multivariate COX analyses were performed to identify risk factors affecting OS and PFS, and a nomogram was created.ResultsIn total, 146 patients were included in the study, of whom 97 and 49 were in the BCG and RC groups, respectively. No statistical differences were observed in the 1- and 2-year OS and PFS between the two groups, whereas significant statistical differences were found in the 3-year, 5-year, and comprehensive OS and PFS. Survival curves also confirmed the statistical differences in OS and PFS between the BCG and RC groups. Multivariate COX analysis revealed that the treatment method, concomitant satellite lesions, and albumin-to-alkaline phosphatase ratio (AAPR) were independent risk factors affecting OS and PFS. The nomogram that was further plotted showed good predictive ability for OS and PFS.ConclusionFor patients who exhibit high-level T1 pathology after both initial and repeat TURBT, especially those with low AAPR, and concomitant satellite lesions, choosing RC as a treatment method offers a better prognosis.

Published
2024
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23. Qualitative and Quantitative Analysis of Five Indoles or Indazole Amide Synthetic Cannabinoids in Suspected E-Cigarette Oil by GC-MS

Author

Cui-mei LIU, Wei JIA, Chun-hui SONG, Zhen-hua QIAN, Zhen-dong HUA, Yue-meng CHEN

Subjects
forensic toxicology, e-cigarette oil, synthetic cannabinoids, gas chromatography-mass spectrometry （gc-ms）, indole, indazole amide, Medicine
Abstract

Objective To establish the GC-MS qualitative and quantitative analysis methods for the synthetic cannabinoids, its main matrix and additives in suspicious electronic cigarette （e-cigarette） oil samples. Methods The e-cigarette oil samples were analyzed by GC-MS after diluted with methanol. Synthetic cannabinoids, its main matrix and additives in e-cigarette oil samples were qualitatively analyzed by the characteristic fragment ions and retention time. The synthetic cannabinoids were quantitatively analyzed by using the selective ion monitoring mode. Results The linear range of each compound in GC-MS quantitative method was 0.025-1 mg/mL, the matrix recovery rate was 94%-103%, the intra-day precision relative standard deviations （RSD） was less than 2.5%, and inter-day precision RSD was less than 4.0%. Five indoles or indazole amide synthetic cannabinoids were detected in 25 e-cigarette samples. The main matrixes of e-cigarette samples were propylene glycol and glycerol. Additives such as N,2,3-trimethyl-2-isopropyl butanamide （WS-23）, glycerol triacetate and nicotine were detected in some samples. The content range of synthetic cannabinoids in 25 e-cigarette samples was 0.05%-2.74%. Conclusion The GC-MS method for synthesizing cannabinoid, matrix and additive in e-cigarette oil samples has good selectivity, high resolution, low detection limit, and can be used for simultaneous qualitative and quantitative analysis of multiple components; The explored fragment ion fragmentation mechanism of the electron bombardment ion source of indole or indoxamide compounds helps to identify such substances or other compounds with similar structures in cases.

Published
2023
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30. Progression of an emission inventory of China integrating CO2 with air pollutants: A chance to learn the influence of development on emissions

Author

Zhi, Guorui, Du, Jinhong, Chen, Aizhong, Jin, Wenjing, Ying, Na, Huang, Zhihui, Xu, Peng, Wang, Di, Ma, Jinghua, Zhang, Yuzhe, Qu, Jiabao, Zhang, Hao, Yang, Li, Ma, Zhanyun, Ren, Yanjun, Dang, Hongyan, Cui, Jianglong, Lin, Pengchuan, He, Zhuoshi, Zhao, Jinmin, Qi, Shuo, Zhang, Weiqi, Zhao, Wenjuan, Li, Yingxin, Liu, Qian, Zhao, Chen, Tang, Yi, Wei, Peng, Wang, Jingxu, Song, Zhen, Kong, Yao, Zhu, Xiangzhe, Shen, Yi, Zhang, Tianning, Chu, Yangxi, Zhang, Xinmin, Fu, Jiafeng, Gao, Qingxian, Hu, Jingnan, and Xue, Zhigang

Published
2024
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32. Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries.

Author

Oh, Yong, Kim, Jae-Hwan, Xie, Zhaoqian, Cho, Seokjoo, Han, Hyeonseok, Jeon, Sung, Park, Minsu, Namkoong, Myeong, Avila, Raudel, Song, Zhen, Lee, Sung-Uk, Ko, Kabseok, Lee, Jungyup, Lee, Je-Sang, Min, Weon, Lee, Byeong-Ju, Choi, Myungwoo, Chung, Ha, Kim, Jongwon, Han, Mengdi, Koo, Jahyun, Choi, Yeon, Kwak, Sung, Kim, Sung, Kim, Jeonghyun, Choi, Jungil, Kang, Chang-Mo, Kim, Jong, Kwon, Kyeongha, Won, Sang, Baek, Janice, Lee, Yujin, Kim, So, Lu, Wei, Vazquez-Guardado, Abraham, Jeong, Hyoyoung, Ryu, Hanjun, Lee, Geumbee, Kim, Kyuyoung, Kim, Seunghwan, Kim, Min, Choi, Jungrak, Choi, Dong, Yang, Quansan, Zhao, Hangbo, Bai, Wubin, Jang, Hokyung, Yu, Yongjoon, Lim, Jaeman, Guo, Xu, Kim, Bong, Jeon, Seokwoo, Davies, Charles, Banks, Anthony, Sung, Hyung, Huang, Yonggang, Park, Inkyu, and Rogers, John

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Biosensing Techniques, Electric Power Supplies, Equipment Design, Monitoring, Physiologic, Pressure, Skin, Temperature, Thermography, Wireless Technology, Pressure Ulcer
Abstract

Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential for pressure injuries in hospitalized patients or in individuals confined to the bed. This paper introduces a soft, skin-mountable class of sensor system for this purpose. The design includes a pressure-responsive element based on membrane deflection and a battery-free, wireless mode of operation capable of multi-site measurements at strategic locations across the body. Such devices yield continuous, simultaneous readings of pressure and temperature in a sequential readout scheme from a pair of primary antennas mounted under the bedding and connected to a wireless reader and a multiplexer located at the bedside. Experimental evaluation of the sensor and the complete system includes benchtop measurements and numerical simulations of the key features. Clinical trials involving two hemiplegic patients and a tetraplegic patient demonstrate the feasibility, functionality and long-term stability of this technology in operating hospital settings.

Published
2021

33. Strain Tunable Berry Curvature Dipole, Orbital Magnetization and Nonlinear Hall Effect in WSe2 Monolayer

Author

Qin, Mao-Sen, Zhu, Peng-Fei, Ye, Xing-Guo, Xu, Wen-Zheng, Song, Zhen-Hao, Liang, Jing, Liu, Kaihui, and Liao, Zhi-Min

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

The electronic topology is generally related to the Berry curvature, which can induce the anomalous Hall effect in time-reversal symmetry breaking systems. Intrinsic monolayer transition metal dichalcogenides possesses two nonequivalent K and K' valleys, having Berry curvatures with opposite signs, and thus vanishing anomalous Hall effect in this system. Here we report the experimental realization of asymmetrical distribution of Berry curvature in a single valley in monolayer WSe2 through applying uniaxial strain to break C3v symmetry. As a result, although the Berry curvature itself is still opposite in K and K' valleys, the two valleys would contribute equally to nonzero Berry curvature dipole. Upon applying electric field, the emergent Berry curvature dipole would lead to an out-of-plane orbital magnetization, which further induces an anomalous Hall effect with a linear response to E^2, known as nonlinear Hall effect. We show the strain modulated transport properties of nonlinear Hall effect in monolayer WSe2 with moderate hole-doping by gating. The second-harmonic Hall signals show quadratic dependence on electric field, and the corresponding orbital magnetization per current density can reach as large as 60. In contrast to the conventional Rashba-Edelstein effect with in-plane spin polarization, such current-induced orbital magnetization is along the out-of-plane direction, thus promising for high-efficient electrical switching of perpendicular magnetization.

Published
2020
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41. Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

Author

Chen, Yunfei, Xu, Yanmei, Chi, Ying, Sun, Ting, Gao, Yuchen, Dou, Xueqing, Han, Zhibo, Xue, Feng, Li, Huiyuan, Liu, Wei, Liu, Xiaofan, Dong, Huan, Fu, Rongfeng, Ju, Mankai, Dai, Xinyue, Wang, Wentian, Ma, Yueshen, Song, Zhen, Gu, Jundong, Gong, Wei, Yang, Renchi, and Zhang, Lei

Published
2024
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