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1. Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases

Author: Hasseli-Fräbel, R, Richter, JG, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, AC, Schmeiser, T, Strangfeld, A, Voll, RE, Krause, A, Reckert, S, Gräßler, A, Saar, P, Kapelle, A, Backhaus, M, Blank, N, Henes, J, Osiek, S, Knothe, A, Hoese, G, Brandt-Jürgens, J, Maltzahn, A, Specker, C, Müller-Ladner, U, Schulze-Koops, H, Hasseli-Fräbel, R, Richter, JG, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, AC, Schmeiser, T, Strangfeld, A, Voll, RE, Krause, A, Reckert, S, Gräßler, A, Saar, P, Kapelle, A, Backhaus, M, Blank, N, Henes, J, Osiek, S, Knothe, A, Hoese, G, Brandt-Jürgens, J, Maltzahn, A, Specker, C, Müller-Ladner, U, and Schulze-Koops, H
Published: 2024

2. Impact of Risk Factors on COVID-19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID-19 Global Rheumatology Alliance Registry

Author: Yazdany, J, Ware, A, Wallace, Z, Bhana, S, Grainger, R, Hachulla, E, Richez, C, Cacoub, P, Hausmann, J, Liew, J, Sirotich, E, Jacobsohn, L, Strangfeld, A, Mateus, E, Hyrich, K, Gossec, L, Carmona, L, Lawson-Tovey, S, Kearsley-Fleet, L, Schaefer, M, Ribeiro, S, Al-Emadi, S, Hasseli, R, Müller-Ladner, U, Specker, C, Schulze-Koops, H, Bernardes, M, Fraga, V, Rodrigues, A, Sparks, J, Ljung, L, Di Giuseppe, D, Tidblad, L, Wise, L, Duarte-García, A, Ugarte-Gil, M, Colunga-Pedraza, I, Martínez-Martínez, M, Alpizar-Rodriguez, D, Xavier, R, Isnardi, C, Pera, M, Pons-Estel, G, Izadi, Z, Gianfrancesco, M, Carrara, G, Scirè, C, Zanetti, A, Machado, P, Wallace, ZS, Hausmann, JS, Liew, JW, Mateus, EF, Hyrich, KL, Ribeiro, SLE, Fraga, VM, Rodrigues, AM, Sparks, JA, Ugarte-Gil, MF, Colunga-Pedraza, IJ, Martínez-Martínez, MU, Xavier, RM, Isnardi, CA, Gianfrancesco, MA, Scirè, CA, Machado, PM, Yazdany, J, Ware, A, Wallace, Z, Bhana, S, Grainger, R, Hachulla, E, Richez, C, Cacoub, P, Hausmann, J, Liew, J, Sirotich, E, Jacobsohn, L, Strangfeld, A, Mateus, E, Hyrich, K, Gossec, L, Carmona, L, Lawson-Tovey, S, Kearsley-Fleet, L, Schaefer, M, Ribeiro, S, Al-Emadi, S, Hasseli, R, Müller-Ladner, U, Specker, C, Schulze-Koops, H, Bernardes, M, Fraga, V, Rodrigues, A, Sparks, J, Ljung, L, Di Giuseppe, D, Tidblad, L, Wise, L, Duarte-García, A, Ugarte-Gil, M, Colunga-Pedraza, I, Martínez-Martínez, M, Alpizar-Rodriguez, D, Xavier, R, Isnardi, C, Pera, M, Pons-Estel, G, Izadi, Z, Gianfrancesco, M, Carrara, G, Scirè, C, Zanetti, A, Machado, P, Wallace, ZS, Hausmann, JS, Liew, JW, Mateus, EF, Hyrich, KL, Ribeiro, SLE, Fraga, VM, Rodrigues, AM, Sparks, JA, Ugarte-Gil, MF, Colunga-Pedraza, IJ, Martínez-Martínez, MU, Xavier, RM, Isnardi, CA, Gianfrancesco, MA, Scirè, CA, and Machado, PM
Abstract: Objective: Approximately one third of individuals worldwide have not received a COVID-19 vaccine. Although studies have investigated risk factors linked to severe COVID-19 among unvaccinated people with rheumatic diseases (RDs), we know less about whether these factors changed as the pandemic progressed. We aimed to identify risk factors associated with severe COVID-19 in unvaccinated individuals in different pandemic epochs corresponding to major variants of concern. Methods: Patients with RDs and COVID-19 were entered into the COVID-19 Global Rheumatology Alliance Registry between March 2020 and June 2022. An ordinal logistic regression model (not hospitalized, hospitalized, and death) was used with date of COVID-19 diagnosis, age, sex, race and/or ethnicity, comorbidities, RD activity, medications, and the human development index (HDI) as covariates. The main analysis included all unvaccinated patients across COVID-19 pandemic epochs; subanalyses stratified patients according to RD types. Results: Among 19,256 unvaccinated people with RDs and COVID-19, those who were older, male, had more comorbidities, used glucocorticoids, had higher disease activity, or lived in lower HDI regions had worse outcomes across epochs. For those with rheumatoid arthritis, sulfasalazine and B-cell–depleting therapy were associated with worse outcomes, and tumor necrosis factor inhibitors were associated with improved outcomes. In those with connective tissue disease or vasculitis, B-cell–depleting therapy was associated with worse outcomes. Conclusion: Risk factors for severe COVID-19 outcomes were similar throughout pandemic epochs in unvaccinated people with RDs. Ongoing efforts, including vaccination, are needed to reduce COVID-19 severity in this population, particularly in those with medical and social vulnerabilities identified in this study.
Published: 2024

3. Analysis of fertility data in A.I. populations

Author: Specker C and Gasteiger F
Subjects: Animal culture, SF1-1100, Genetics, QH426-470
Published: 1980
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4. Analysis of fertility data in A.I. populations

Author: Gasteiger F and Specker C
Subjects: Animal culture, SF1-1100, Genetics, QH426-470
Published: 1980

5. Faktoren, die mit medikamentenbedingten Sorgen bei Frauen mit entzündlich-rheumatischen Erkrankungen zusammenhängen - eine Analyse des Rhekiss-Registers

Author: Meissner, Y, Glaser, C, Strangfeld, A, Richter, J, Späthling-Mestekemper, S, Henes, J, Eickhoff, B, Specker, C, Fischer-Betz, R, Meissner, Y, Glaser, C, Strangfeld, A, Richter, J, Späthling-Mestekemper, S, Henes, J, Eickhoff, B, Specker, C, and Fischer-Betz, R
Published: 2023

6. Einfluss des adulten Morbus Still (AOSD) auf die Lebensqualität und die Erwerbssituation von diagnostizierten Patienten in Deutschland - Daten aus der PRO-AOSD Erhebung

Author: Blank, N, Andreica, I, Pankow, A, Schmalzing, M, Rech, J, Prothmann, U, Bidilean, C, Tatsis, S, Strunk, J, Kästner, P, Specker, C, Sensse, J, Bestler, D, Eisterhues, C, Henes, J, Bühring, B, Häckel, B, Krusche, M, Sözen, Z, Feist, E, Blank, N, Andreica, I, Pankow, A, Schmalzing, M, Rech, J, Prothmann, U, Bidilean, C, Tatsis, S, Strunk, J, Kästner, P, Specker, C, Sensse, J, Bestler, D, Eisterhues, C, Henes, J, Bühring, B, Häckel, B, Krusche, M, Sözen, Z, and Feist, E
Published: 2023

7. Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry

Author: Sparks, J, Wallace, Z, Seet, A, Gianfrancesco, M, Izadi, Z, Hyrich, K, Strangfeld, A, Gossec, L, Carmona, L, Mateus, E, Lawson-Tovey, S, Trupin, L, Rush, S, Katz, P, Schmajuk, G, Jacobsohn, L, Wise, L, Gilbert, E, Duarte-Garcia, A, Valenzuela-Almada, M, Pons-Estel, G, Isnardi, C, Berbotto, G, Hsu, T, D'Silva, K, Patel, N, Kearsley-Fleet, L, Schafer, M, Ribeiro, S, Al Emadi, S, Tidblad, L, Scire, C, Raffeiner, B, Thomas, T, Flipo, R, Avouac, J, Seror, R, Bernardes, M, Cunha, M, Hasseli, R, Schulze-Koops, H, Muller-Ladner, U, Specker, C, De Souza, V, Da Mota, L, Gomides, A, Dieude, P, Nikiphorou, E, Kronzer, V, Singh, N, Ugarte-Gil, M, Wallace, B, Akpabio, A, Thomas, R, Bhana, S, Costello, W, Grainger, R, Hausmann, J, Liew, J, Sirotich, E, Sufka, P, Robinson, P, Machado, P, Yazdany, J, Sparks J. A., Wallace Z. S., Seet A. M., Gianfrancesco M. A., Izadi Z., Hyrich K. L., Strangfeld A., Gossec L., Carmona L., Mateus E. F., Lawson-Tovey S., Trupin L., Rush S., Katz P., Schmajuk G., Jacobsohn L., Wise L., Gilbert E. L., Duarte-Garcia A., Valenzuela-Almada M. O., Pons-Estel G. J., Isnardi C. A., Berbotto G. A., Hsu T. Y. -T., D'Silva K. M., Patel N. J., Kearsley-Fleet L., Schafer M., Ribeiro S. L. E., Al Emadi S., Tidblad L., Scire C. A., Raffeiner B., Thomas T., Flipo R. -M., Avouac J., Seror R., Bernardes M., Cunha M. M., Hasseli R., Schulze-Koops H., Muller-Ladner U., Specker C., De Souza V. A., Da Mota L. M. H., Gomides A. P. M., Dieude P., Nikiphorou E., Kronzer V. L., Singh N., Ugarte-Gil M. F., Wallace B., Akpabio A., Thomas R., Bhana S., Costello W., Grainger R., Hausmann J. S., Liew J. W., Sirotich E., Sufka P., Robinson P. C., MacHado P. M., Yazdany J., Sparks, J, Wallace, Z, Seet, A, Gianfrancesco, M, Izadi, Z, Hyrich, K, Strangfeld, A, Gossec, L, Carmona, L, Mateus, E, Lawson-Tovey, S, Trupin, L, Rush, S, Katz, P, Schmajuk, G, Jacobsohn, L, Wise, L, Gilbert, E, Duarte-Garcia, A, Valenzuela-Almada, M, Pons-Estel, G, Isnardi, C, Berbotto, G, Hsu, T, D'Silva, K, Patel, N, Kearsley-Fleet, L, Schafer, M, Ribeiro, S, Al Emadi, S, Tidblad, L, Scire, C, Raffeiner, B, Thomas, T, Flipo, R, Avouac, J, Seror, R, Bernardes, M, Cunha, M, Hasseli, R, Schulze-Koops, H, Muller-Ladner, U, Specker, C, De Souza, V, Da Mota, L, Gomides, A, Dieude, P, Nikiphorou, E, Kronzer, V, Singh, N, Ugarte-Gil, M, Wallace, B, Akpabio, A, Thomas, R, Bhana, S, Costello, W, Grainger, R, Hausmann, J, Liew, J, Sirotich, E, Sufka, P, Robinson, P, Machado, P, Yazdany, J, Sparks J. A., Wallace Z. S., Seet A. M., Gianfrancesco M. A., Izadi Z., Hyrich K. L., Strangfeld A., Gossec L., Carmona L., Mateus E. F., Lawson-Tovey S., Trupin L., Rush S., Katz P., Schmajuk G., Jacobsohn L., Wise L., Gilbert E. L., Duarte-Garcia A., Valenzuela-Almada M. O., Pons-Estel G. J., Isnardi C. A., Berbotto G. A., Hsu T. Y. -T., D'Silva K. M., Patel N. J., Kearsley-Fleet L., Schafer M., Ribeiro S. L. E., Al Emadi S., Tidblad L., Scire C. A., Raffeiner B., Thomas T., Flipo R. -M., Avouac J., Seror R., Bernardes M., Cunha M. M., Hasseli R., Schulze-Koops H., Muller-Ladner U., Specker C., De Souza V. A., Da Mota L. M. H., Gomides A. P. M., Dieude P., Nikiphorou E., Kronzer V. L., Singh N., Ugarte-Gil M. F., Wallace B., Akpabio A., Thomas R., Bhana S., Costello W., Grainger R., Hausmann J. S., Liew J. W., Sirotich E., Sufka P., Robinson P. C., MacHado P. M., and Yazdany J.
Abstract: Objective To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA). Methods We analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders. Results Of 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity. Conclusions People with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.
Published: 2021

8. Regionale kooperative Rheumazentren

Author: Gundelach, B. and Specker, C.
Subjects: Versorgungsforschung, Patient Care Team, Registerstudien, Interdisciplinary cooperation, Interprofessional Relations, Kerndokumentation, Rheumatological care, Register studies, Core documentation, Interdisziplinäre Zusammenarbeit, Rheumatology, Germany, Rheumatic Diseases, Leitthema, Health services research, Humans, Rheumatologische Versorgung, Forecasting
Abstract: Die regionalen kooperativen Rheumazentren haben sich in den letzten 25 Jahren deutschlandweit als „Katalysatoren“ zur Verbesserung der rheumatologischen Versorgung auf vielfältigen Ebenen etabliert. Sie haben mit Kampagnen und vielen Aktivitäten die Sichtbarkeit des Fachgebietes gemeinsam mit rheumatologischen Bündnispartnern gefördert und auf wissenschaftlicher Seite gemeinsam mit dem Deutschen Rheumaforschungszentrum zur Verbesserung der rheumatologischen Versorgungsforschung in Deutschland beigetragen. Die regionalen kooperativen Rheumazentren sind in ihrem Zusammenschluss als Arbeitsgemeinschaft der Deutschen Gesellschaft für Rheumatologie inzwischen zu einem wichtigen Partner im „Netzwerk Rheumatologie“ geworden, und sie stellen sich auch in Zukunft neuen Aufgaben zur weiteren Verbesserung der rheumatologischen Versorgung in Deutschland.
Published: 2020

9. Zeitliche Trends im Verlauf von SARS-CoV-2-Infektionen seit Beginn des COVID19-Rheuma.de-Registers

Author: Hasseli, R, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Voll, R, Krause, A, Schulze-Koops, H, Müller-Ladner, U, Specker, C, Hasseli, R, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Voll, R, Krause, A, Schulze-Koops, H, Müller-Ladner, U, and Specker, C
Published: 2022

10. Durchbruchinfektionen bei vollständig geimpften Patienten mit entzündlich-rheumatischen Erkrankungen - Daten aus dem COVID19-Rheuma.de-Register

Author: Hasseli, R, Hoyer, BF, Huppke, L, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Voll, R, Krause, A, Schulze-Koops, H, Specker, C, Müller-Ladner, U, Hasseli, R, Hoyer, BF, Huppke, L, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Voll, R, Krause, A, Schulze-Koops, H, Specker, C, and Müller-Ladner, U
Published: 2022

11. Verträglichkeit und Sicherheit von COVID-19-Impfstoffen nach Erstimpfung bei Patienten mit rheumatischen Erkrankungen

Author: Hasseli, R, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, A, Richter, JG, Schmeiser, T, Strangfeld, A, Voll, R, Krause, A, Specker, C, Müller-Ladner, U, Schulze-Koops, H, Hasseli, R, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, A, Richter, JG, Schmeiser, T, Strangfeld, A, Voll, R, Krause, A, Specker, C, Müller-Ladner, U, and Schulze-Koops, H
Published: 2022

12. Evaluation des Einsatzes von Videosprechstunden in der rheumatologischen Versorgung - präpandemisch und während der COVID-19-Pandemie

Author: Richter, J, Reiter, JR, Chehab, G, Aries, PM, Mühlensiepen, F, Welcker, M, Voormann, A, Schneider, M, Specker, C, Richter, J, Reiter, JR, Chehab, G, Aries, PM, Mühlensiepen, F, Welcker, M, Voormann, A, Schneider, M, and Specker, C
Published: 2022

13. Ein Jahr digitale Gesundheitsanwendungen (DiGA) in Deutschland - Perspektiven der Rheumatologen

Author: Richter, J, Chehab, G, Stachwitz, P, Hagen, J, Larsen, D, Knitza, J, Schneider, M, Voormann, A, Specker, C, Richter, J, Chehab, G, Stachwitz, P, Hagen, J, Larsen, D, Knitza, J, Schneider, M, Voormann, A, and Specker, C
Published: 2022

14. Ein Jahr digitale Gesundheitsanwendungen (DiGA) in Deutschland - rheumatologische Perspektiven

Author: Richter, JG, Chehab, G, Stachwitz, P, Hagen, J, Larsen, D, Knitza, J, Schneider, M, Voormann, A, Specker, C, Richter, JG, Chehab, G, Stachwitz, P, Hagen, J, Larsen, D, Knitza, J, Schneider, M, Voormann, A, and Specker, C
Published: 2022

15. Videosprechstunden in der rheumatologischen Versorgung - vor und während der COVID-19-Pandemie

Author: Reiter, J, Chehab, G, Aries, P, Muehlensiepen, F, Welcker, M, Voormann, A, Schneider, M, Specker, C, Richter, JG, Reiter, J, Chehab, G, Aries, P, Muehlensiepen, F, Welcker, M, Voormann, A, Schneider, M, Specker, C, and Richter, JG
Published: 2022

16. Krankheitsbezogener Wissenserwerb durch strukturierte Patienteninformation bei Rheumatoider Arthritis (StruPI-RA)

Author: Schwarze, M., Fieguth, V., Schuch, F., Sandner, P., Edelmann, E., Händel, A., Kettler, M., Hanke, A., Kück, M., Stein, L., Stille, C., Fellner, M., De Angelis, V., Touissant, S., and Specker, C.
Subjects: Patientenschulung, Ambulante Versorgung, Patient education, Originalien, Early rheumatoid arthritis, Health Literacy, Arthritis, Rheumatoid, Patient Knowledge Questionnaire, Outpatient care, Frühe Rheumatoide Arthritis, Germany, Rheumatic Diseases, Surveys and Questionnaires, Quality of Life, Humans, Gesundheitskompetenz
Abstract: The structured patient information for rheumatoid arthritis (StruPi-RA) program was the first standardized outpatient education program in rheumatoid arthritis (RA) in Germany. The main objective of the study was to determine the efficacy of the StruPi-RA program concerning disease-specific knowledge acquisition in patients with early stage RA or after changing the treatment regimen.A total of 61 patients were included in a control group design, 32 in the intervention group (IG) and 29 in the control group (CG). Patients of the IG attended 3 modules of 90 min in a structured patient information program (StruPI-RA) including the topics of diagnostics, treatment and living with RA. Patients in the CG only received information material from the German Rheumatism League. The primary target criterion was the disease-related acquisition of knowledge, measured with the patient knowledge questionnaire (PKQ). Data were collected before and after participation in StruPI-RA.The improvement in knowledge in the IG attending the StruPI-RA compared to the CG was significant in time and group comparisons. No influence of disease duration or educational level was observed. The subscale treatment alone showed a significant difference in the group and time comparison.Participation in the StruPI-RA program in early RA was associated with a significant increase in disease-specific knowledge compared to the control group of patients. This leads to better decision-making in terms of treatment, a more beneficial doctor-patient communication and better self-management. In the long term an improvement in treatment adherence and quality of life is expected.HINTERGRUND/ZIEL: Mit der strukturierten Patienteninformation für Rheumatoide Arthritis (StruPi-RA) liegt das erste standardisierte ambulante Patientenschulungsprogramm für Rheumatoide Arthritis (RA) in Deutschland vor. Das Hauptziel der vorliegenden Studie ist die Erfassung der Wirksamkeit von StruPI-RA in Bezug auf den krankheitsspezifischen Wissenserwerb bei Patienten mit früher RA oder nach Therapiewechsel.Insgesamt wurden 61 Patienten eingeschlossen: n = 32 in die Interventionsgruppe (IG) und n = 29 in die Kontrollgruppe (KG). Die Intervention umfasste ein strukturiertes Patienteninformationsprogramm (StruPi-RA) zu den Themen Diagnostik, Therapie und Leben mit RA, welches drei 90-minütige Module beinhaltet. Die KG erhielt nur einen Patientenratgeber der Deutschen Rheumaliga zur Information über die Erkrankung. Primäres Zielkriterium war der krankheitsbezogene Wissenserwerb, der anhand des Patient Knowledge Questionnaire (PKQ) sowie Erweiterungsfragen zu 2 Messzeitpunkten, einmal unmittelbar vor und dann nach Durchführung von StruPI-RA, erhoben wurde.Die Teilnahme an StruPI-RA führte zu einer signifikanten Verbesserung des krankheitsspezifischen Wissens im Gruppen- und Zeitvergleich zur ungeschulten Gruppe im Original-PKQ sowie in der Fragebogenerweiterung. Ein Einfluss der Krankheitsdauer oder des Bildungsstands wurde nicht beobachtet. Allein in der Subskala Therapie zeigte sich ein signifikanter Unterscheid im Gruppen- und Zeitvergleich.Die Teilnehmer am StruPI-RA-Programm hatten im Vergleich zu ungeschulten Patienten einen nachweisbaren krankheitsspezifischen Wissenszuwachs. Dadurch kann sich die Arzt-Patienten-Kommunikation verbessern und eine fundierte Entscheidungsfindung hinsichtlich der Therapie befördert werden. Mittelfristig können sich darüber hinaus eine erhöhte Selbstmanagementkompetenz der Patienten und langfristig auch eine Verbesserung der Lebensqualität sowie der Therapieadhärenz ergeben.
Published: 2020

17. Wieviele rheumatologische Gesundheits-Apps ließen sich 2020 mit der 'Semiautomatischen retrospektiven App Store Analyse'-Methode identifizieren?

Author: Richter, J, Chehab, G, Kiltz, U, Schneider, M, and Specker, C
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Die App-Stores von Apple und Google bieten eine Vielzahl gesundheitsbezogener Apps an. Verschiedene Gütesiegel sollen dem User helfen, die Qualität der App Angebote einzuschätzen. Allerdings ist es immer noch eine Herausforderung, wertvolle und qualifizierte Apps zu finden.[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2021
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18. Krankheitsaktivität und Schmerzen von Patienten mit rheumatologischen Erkrankungen wurden durch die COVID-19-Pandemie nicht beeinflusst – Interims-Analyse aus der Deutschen Rheuma-COVID19-Patienten-Befragung

Author: Hoyer, BF, Hasseli, R, Müller-Ladner, U, Schmeiser, T, Krause, A, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schulze-Koops, H, Strangfeld, A, Voll, R, and Specker, C
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Die derzeitige Pandemie ist insbesondere für Patienten mit chronisch-entzündlichen Erkrankungen und ihre Ärzte eine schwierige Phase: Lockdowns, steigende Infektionsraten und neue Mutationen sorgen für eine große Verunsicherung. Die psychosoziale Belastung und Versorgungsprobleme[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2021
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19. Does TNF-inhibition decrease the risk of severe COVID-19 in RMD-patients?

Author: Hasseli, R, Hoyer, BF, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Voll, R, Specker, C, Schulze-Koops, H, Müller-Ladner, U, and Krause, A
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Introduction: Patients with rheumatic and musculoskeletal diseases (RMD) might have an increased risk for infection due to their immunomodulatory treatment. The aim of this study was to assess courses of RMD-patients treated with TNF-inhibitors (TNF-I) included in the German COVID-19 registry. Methods:[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2021
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20. Immunosuppressive profile of deadly courses of COVID-19 in a large-scale real-life rheumatic cohort

Author: Hasseli, R, Hoyer, BF, Krause, A, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Voll, R, Müller-Ladner, U, Schulze-Koops, H, and Specker, C
Subjects: musculoskeletal diseases, ddc: 610, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract: Introduction: Patients with inflammatory rheumatic diseases (IRD) are routinely treated with disease-modifying anti-rheumatic drugs (DMARDs). After more than a year of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, still few data are available on the association of DMARDs with[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2021
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21. Nailfold capillaroscopy characteristics of antisynthetase syndrome and possible clinical associations: Results of a multicenter international study

Author: Sebastiani, M, Triantafyllias, K, Manfredi, A, Gonzalez-Gay, M, Palmou-Fontana, N, Cassone, G, Drott, U, Delbruck, C, Rojas-Serrano, J, Bertolazzi, C, Nuno, L, Giannini, M, Iannone, F, Vicente, E, Castaneda, S, Selva-O'Callaghan, A, Araguas, E, Emmi, G, Iuliano, A, Bauhammer, J, Miehle, N, Parisi, S, Cavagna, L, Codullo, V, Montecucco, C, Lopez-Longo, F, Martinez-Barrio, J, Nieto-Gonzalez, J, Vichi, S, Confalonieri, M, Tomietto, P, Bergner, R, Sulli, A, Bonella, F, Furini, F, Scire, C, Bortoluzzi, A, Specker, C, Barsotti, S, Neri, R, Mosca, M, Caproni, M, Weinmann-Menke, J, Schwarting, A, Smith, V, Cutolo, M, Sebastiani M., Triantafyllias K., Manfredi A., Gonzalez-Gay M. A., Palmou-Fontana N., Cassone G., Drott U., Delbruck C., Rojas-Serrano J., Bertolazzi C., Nuno L., Giannini M., Iannone F., Vicente E. F., Castaneda S., Selva-O'Callaghan A., Araguas E. T., Emmi G., Iuliano A., Bauhammer J., Miehle N., Parisi S., Cavagna L., Codullo V., Montecucco C., Lopez-Longo F. J., Martinez-Barrio J., Nieto-Gonzalez J. C., Vichi S., Confalonieri M., Tomietto P., Bergner R., Sulli A., Bonella F., Furini F., Scire C. A., Bortoluzzi A., Specker C., Barsotti S., Neri R., Mosca M., Caproni M., Weinmann-Menke J., Schwarting A., Smith V., Cutolo M., Sebastiani, M, Triantafyllias, K, Manfredi, A, Gonzalez-Gay, M, Palmou-Fontana, N, Cassone, G, Drott, U, Delbruck, C, Rojas-Serrano, J, Bertolazzi, C, Nuno, L, Giannini, M, Iannone, F, Vicente, E, Castaneda, S, Selva-O'Callaghan, A, Araguas, E, Emmi, G, Iuliano, A, Bauhammer, J, Miehle, N, Parisi, S, Cavagna, L, Codullo, V, Montecucco, C, Lopez-Longo, F, Martinez-Barrio, J, Nieto-Gonzalez, J, Vichi, S, Confalonieri, M, Tomietto, P, Bergner, R, Sulli, A, Bonella, F, Furini, F, Scire, C, Bortoluzzi, A, Specker, C, Barsotti, S, Neri, R, Mosca, M, Caproni, M, Weinmann-Menke, J, Schwarting, A, Smith, V, Cutolo, M, Sebastiani M., Triantafyllias K., Manfredi A., Gonzalez-Gay M. A., Palmou-Fontana N., Cassone G., Drott U., Delbruck C., Rojas-Serrano J., Bertolazzi C., Nuno L., Giannini M., Iannone F., Vicente E. F., Castaneda S., Selva-O'Callaghan A., Araguas E. T., Emmi G., Iuliano A., Bauhammer J., Miehle N., Parisi S., Cavagna L., Codullo V., Montecucco C., Lopez-Longo F. J., Martinez-Barrio J., Nieto-Gonzalez J. C., Vichi S., Confalonieri M., Tomietto P., Bergner R., Sulli A., Bonella F., Furini F., Scire C. A., Bortoluzzi A., Specker C., Barsotti S., Neri R., Mosca M., Caproni M., Weinmann-Menke J., Schwarting A., Smith V., and Cutolo M.
Abstract: Objective. To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease. Methods. We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures. Results. NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP. Conclusion. NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.
Published: 2019

22. Outcome of SARS-CoV-2 infection in patients with rheumatoid arthritis under treatment with Janus kinase inhibitors compared to etanercept

Author: Hasseli, R, Hoyer, BF, Krause, A, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Schulze-Koops, H, Voll, R, Specker, C, Müller-Ladner, U, Hasseli, R, Hoyer, BF, Krause, A, Lorenz, HM, Pfeil, A, Regierer, A, Richter, J, Schmeiser, T, Strangfeld, A, Schulze-Koops, H, Voll, R, Specker, C, and Müller-Ladner, U
Published: 2021

23. Anwendung der 'Semiautomatischen retrospektiven App Store Analyse' Methode - wieviele und welche Art rheumatologischer Gesundheits-Apps ließen sich im Jahr 2020 identifizieren?

Author: Richter, JG, Chehab, G, Kiltz, U, Schneider, M, Specker, C, Richter, JG, Chehab, G, Kiltz, U, Schneider, M, and Specker, C
Published: 2021

24. The influence of the SARS-CoV-2 lockdown on patients with inflammatory rheumatic diseases on their adherence to immunomodulatory medication: a cross sectional study over 3 months in Germany

Author: Hasseli, R, primary, Müller-Ladner, U, additional, Keil, F, additional, Broll, M, additional, Dormann, A, additional, Fräbel, C, additional, Hermann, W, additional, Heinmüller, C -J, additional, Hoyer, B F, additional, Löffler, F, additional, Özden, F, additional, Pfeiffer, U, additional, Saech, J, additional, Schneidereit, T, additional, Schlesinger, A, additional, Schwarting, A, additional, Specker, C, additional, Stapfer, G, additional, Steinmüller, M, additional, Storck-Müller, K, additional, Strunk, J, additional, Thiele, A, additional, Triantafyllias, K, additional, Vagedes, D, additional, Wassenberg, S, additional, Wilden, E, additional, Zeglam, S, additional, and Schmeiser, T, additional
Published: 2021
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25. Deutsches COVID-19 Register für Patienten mit entzündlich-rheumatischen Erkrankungen

Author: Hasseli, R, Müller-Ladner, U, Richter, J, Regierer, A, Hoyer, BF, Voll, R, Schmeiser, T, Lorenz, HM, Strangfeld, A, Krause, A, Pfeil, A, Schulze-Koops, H, and Specker, C
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Patienten mit entzündlich-rheumatischen Erkrankungen weisen eine Fehlregulation des Immunsystems auf. Zudem können immunmodulierende und immunsuppressive Therapien den Infektionsverlauf beeinflussen. Die aktuelle SARS-CoV-2 Pandemie stellt für die Rheumatologie daher eine [zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Published: 2020
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26. SARS-CoV-2 & Rheuma

Author: Leipe, J., Hoyer, B. F., Iking-Konert, C., Schulze-Koops, H., Specker, C., and Krüger, K.
Subjects: Inflammatory rheumatic diseases, Inflammation, SARS-CoV-2, Pneumonia, Viral, Hot Topics, COVID-19, Recommendations, Risk Assessment, United States, Management, Europe, DMARD, Betacoronavirus, Rheumatology, Entzündlich rheumatische Erkrankungen, Antirheumatic Agents, Germany, Rheumatic Diseases, Practice Guidelines as Topic, Humans, Coronavirus Infections, Empfehlungen, Pandemics, Societies, Medical
Abstract: Die Empfehlungen des Deutschen Gesellschaft für Rheumatologie(DGRh)-Updates – welches die zu Beginn der COVID-19-Pandemie erstellte Hilfestellung zum Management von Patienten mit entzündlich rheumatischen Erkrankungen angesichts der Bedrohung durch SARS-CoV‑2 aktualisiert und erweitert – stimmen in vielen Punkten mit den Handlungsempfehlungen der amerikanischen (ACR) und europäischen Fachgesellschaften (EULAR) überein, unterscheiden sich aber auch in einigen Punkten. In diesem Artikel sollen daher Kernempfehlungen des DGRh-Updates zu den Themen Prävention von SARS-CoV-2/COVID-19, Risikoeinschätzung bei ERE sowie der Umgang mit antirheumatischen Therapien im Kontext bzw. im Vergleich zu den ACR- und EULAR-Empfehlungen diskutiert und eine Übersicht zur Risikobeurteilung einzelner antirheumatischer Medikamente gegeben werden.
Published: 2020
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27. Häufigkeiten muskuloskelettaler Symptome und Erkrankungen in der bevölkerungsbezogenen NAKO Gesundheitsstudie [Frequencies of musculoskeletal symptoms and disorders in the population-based German National Cohort (GNC)]

Author: Schmidt, C.O., Günther, K.P., Goronzy, J., Albrecht, K., Chenot, J.F., Callhoff, J., Richter, A., Kasch, R., Ahrens, W., Becher, H., Berger, K., Brenner, H., Fischer, B., Franzke, C.W., Hoffmann, W., Holleczek, B., Jaeschke, L., Jenning, C., Jöckel, K.H., Kaaks, R., Keil, T., Kluttig, A., Krause, G., Kuß, O., Leitzmann, M., Lieb, W., Linseisen, J., Löffler, M., Meinke-Franze, C., Meisinger, C., Michels, K.B., Mikolajczyk, R., Obi, N., Peters, A., Pischon, T., Schikowski, T., Schipf, S., Specker, C., Völzke, H., Wirkner, K., Zink, A., and Sander, O.
Subjects: Cardiovascular and Metabolic Diseases
Abstract: BACKGROUND: Musculoskeletal diseases and symptoms are very common in the general population. They lead to high healthcare costs and pose a significant burden to the national economy. OBJECTIVES: Based on data from the population-based German National Cohort (GNC), frequencies of musculoskeletal symptoms and diseases are reported, including back pain, osteoporosis, osteoarthritis, and arthritis. MATERIALS AND METHODS: Data were collected from March 2014 to March 2017 in adults aged 20-75 years during the first half of the baseline survey of the GNC. The sample comprised 101,779 interviewed subjects, including 9370 subjects who underwent clinical musculoskeletal examinations. The interview included questions about specific musculoskeletal disorders. A clinical examination of the hand provided information about palpable swollen joints and pressure-sensitive joints. Resting pain of the knees and hips was also assessed by a clinical examination. Frequencies were standardized to the German standard population of the year 2011. RESULTS: Having ever been diagnosed with recurrent back pain (22.5%) or osteoarthritis (20.6%) were the most common complaints reported in the interview; osteoporosis (2.9%) and rheumatoid arthritis (1.9%) were stated more seldom. According to the hand examination, 6.0% of all participants experienced pain in at least one finger joint. Resting pain was present in at least one knee among 8.2% and in at least one hip among 5.1% of the participants as assessed during the clinical examination. Women were more likely to report musculoskeletal disorders and symptoms than men. The proportion of adults affected by musculoskeletal diseases increased strongly with age. CONCLUSION: Musculoskeletal disorders and symptoms occur frequently. The burden of complaints and diagnoses is comparable to previous population-based surveys.
Published: 2020

28. Evaluation von Patienten mit entzündlich-rheumatischen Erkrankungen unter Immunsuppressiva und ihrer Haltung zur Medikation im zeitlichen Verlauf der Covid-19 Pandemie

Author: Schmeiser, T, Broll, M, Dormann, A, Fräbel, C, Heinmüller, CJ, Hermann, W, Hoyer, BF, Keil, F, Müller-Ladner, U, Özden, F, Pfeiffer, U, Saech, J, Schwarting, A, Sluszniak, M, Specker, C, Stapfer, G, Steinchen, N, Steinmüller, M, Storck-Mueller, K, Strunk, J, Thiele, A, Triantafyllias, K, Vagedes, D, Wassenberg, S, Wilden, E, Hasseli, R, Schmeiser, T, Broll, M, Dormann, A, Fräbel, C, Heinmüller, CJ, Hermann, W, Hoyer, BF, Keil, F, Müller-Ladner, U, Özden, F, Pfeiffer, U, Saech, J, Schwarting, A, Sluszniak, M, Specker, C, Stapfer, G, Steinchen, N, Steinmüller, M, Storck-Mueller, K, Strunk, J, Thiele, A, Triantafyllias, K, Vagedes, D, Wassenberg, S, Wilden, E, and Hasseli, R
Published: 2020

29. Alter, Komorbiditäten und Therapie mit Glukokortikoiden sind Risikofaktoren für eine COVID-19-bedingte Hospitalisierung: erste Ergebnisse aus dem deutschen COVID-19-Rheuma-Register

Author: Regierer, A, Hasseli, R, Müller-Ladner, U, Hoyer, BF, Krause, A, Lorenz, HM, Pfeil, A, Richter, J, Schmeiser, T, Schulze-Koops, H, Strangfeld, A, Voll, R, Specker, C, Regierer, A, Hasseli, R, Müller-Ladner, U, Hoyer, BF, Krause, A, Lorenz, HM, Pfeil, A, Richter, J, Schmeiser, T, Schulze-Koops, H, Strangfeld, A, Voll, R, and Specker, C
Published: 2020

30. Identifikation rheumatologisch relevanter gesundheitsbezogener Apps mit der 'Semiautomatischen retrospektiven App Store Analyse' Methode

Author: Richter, J, Kiltz, U, Chehab, G, Schneider, M, Specker, C, Richter, J, Kiltz, U, Chehab, G, Schneider, M, and Specker, C
Published: 2020

31. Untersuchung des psychosozialen Einflusses der Corona-Pandemie auf rheumatologische Patienten in einer prospektiven, longitudinalen Befragung

Author: Hasseli, R, Schmeiser, T, Hermann, C, Kappesser, J, Pfeiffer, S, Müller-Ladner, U, Richter, J, Regierer, A, Voll, R, Lorenz, HM, Strangfeld, A, Krause, A, Pfeil, A, Schulze-Koops, H, Specker, C, Hoyer, BF, Hasseli, R, Schmeiser, T, Hermann, C, Kappesser, J, Pfeiffer, S, Müller-Ladner, U, Richter, J, Regierer, A, Voll, R, Lorenz, HM, Strangfeld, A, Krause, A, Pfeil, A, Schulze-Koops, H, Specker, C, and Hoyer, BF
Published: 2020

32. Canakinumab zur Behandlung von adultem Still Syndrom (AOSD): eine Prüfer-initiierte, multizentrische, plazebokontrollierte Studie (CONSIDER)

Author: Kedor, C, Listing, J, Zernicke, J, Weiß, A, Behrens, F, Blank, N, Henes, J, Kekow, J, Rubbert-Roth, A, Schulze-Koops, H, Seipelt, E, Specker, C, Feist, E, Kedor, C, Listing, J, Zernicke, J, Weiß, A, Behrens, F, Blank, N, Henes, J, Kekow, J, Rubbert-Roth, A, Schulze-Koops, H, Seipelt, E, Specker, C, and Feist, E
Published: 2020

33. Serum Jo-1 Autoantibody and Isolated Arthritis in the Antisynthetase Syndrome: Review of the Literature and Report of the Experience of AENEAS Collaborative Group

Author: Cavagna, L, Nuno, L, Scire, C, Govoni, M, Longo, F, Franceschini, F, Neri, R, Castaneda, S, Sifuentes Giraldo, W, Caporali, R, Iannone, F, Fusaro, E, Paolazzi, G, Pellerito, R, Schwarting, A, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Bartoloni, E, Specker, C, Pina Murcia, T, La Corte, R, Furini, F, Foschi, V, Bachiller Corral, J, Airo, P, Cavazzana, I, Martinez-Barrio, J, Hinojosa, M, Giannini, M, Barsotti, S, Menke, J, Triantafyllias, K, Vitetta, R, Russo, A, Bogliolo, L, Bajocchi, G, Bravi, E, Barausse, G, Bortolotti, R, Selmi, C, Parisi, S, Salaffi, F, Montecucco, C, Gonzalez-Gay, M, Cavagna L., Nuno L., Scire C. A., Govoni M., Longo F. J. L., Franceschini F., Neri R., Castaneda S., Sifuentes Giraldo W. A., Caporali R., Iannone F., Fusaro E., Paolazzi G., Pellerito R., Schwarting A., Saketkoo L. A., Ortego-Centeno N., Quartuccio L., Bartoloni E., Specker C., Pina Murcia T., La Corte R., Furini F., Foschi V., Bachiller Corral J., Airo P., Cavazzana I., Martinez-Barrio J., Hinojosa M., Giannini M., Barsotti S., Menke J., Triantafyllias K., Vitetta R., Russo A., Bogliolo L., Bajocchi G., Bravi E., Barausse G., Bortolotti R., Selmi C., Parisi S., Salaffi F., Montecucco C., Gonzalez-Gay M. A., Cavagna, L, Nuno, L, Scire, C, Govoni, M, Longo, F, Franceschini, F, Neri, R, Castaneda, S, Sifuentes Giraldo, W, Caporali, R, Iannone, F, Fusaro, E, Paolazzi, G, Pellerito, R, Schwarting, A, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Bartoloni, E, Specker, C, Pina Murcia, T, La Corte, R, Furini, F, Foschi, V, Bachiller Corral, J, Airo, P, Cavazzana, I, Martinez-Barrio, J, Hinojosa, M, Giannini, M, Barsotti, S, Menke, J, Triantafyllias, K, Vitetta, R, Russo, A, Bogliolo, L, Bajocchi, G, Bravi, E, Barausse, G, Bortolotti, R, Selmi, C, Parisi, S, Salaffi, F, Montecucco, C, Gonzalez-Gay, M, Cavagna L., Nuno L., Scire C. A., Govoni M., Longo F. J. L., Franceschini F., Neri R., Castaneda S., Sifuentes Giraldo W. A., Caporali R., Iannone F., Fusaro E., Paolazzi G., Pellerito R., Schwarting A., Saketkoo L. A., Ortego-Centeno N., Quartuccio L., Bartoloni E., Specker C., Pina Murcia T., La Corte R., Furini F., Foschi V., Bachiller Corral J., Airo P., Cavazzana I., Martinez-Barrio J., Hinojosa M., Giannini M., Barsotti S., Menke J., Triantafyllias K., Vitetta R., Russo A., Bogliolo L., Bajocchi G., Bravi E., Barausse G., Bortolotti R., Selmi C., Parisi S., Salaffi F., Montecucco C., and Gonzalez-Gay M. A.
Abstract: Anti-Jo-1 is the most frequently detectable antibody in the antisynthetase syndrome (ASSD), an autoimmune disease characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). Recently, we organized an international collaborative group called American and European NEtwork of Antisynthetase Syndrome (AENEAS) for the study of this rare and fascinating disease. The group collected and published one of the largest series of ASSD patients ever described and with one of the longer follow-up ever reported. The number of participating centers is steadily increasing, as well as the available cohort. In the first paper, we showed that arthritis, myositis, and ILD may be frequently the only feature at disease onset, raising problems to reach a correct diagnosis of this syndrome. Nevertheless, we first observed that the ex novo appearance of further manifestations is common during the follow-up, strengthening the importance of a correct diagnosis. In our cohort, the 24 % of the 243 patients up to now collected had isolated arthritis as a presenting feature. These patients represent the most intriguing group in terms of differential diagnosis and clinical time course. Furthermore, data on this aspect are scanty, the reason that lead us to evaluate these aspects in our cohort of patients, reviewing also available literature. In fact, the most relevant aspect is that ASSD is rarely suspected in this setting of patients, in particular in case of poliarticular involvement, positive rheumatoid factor (RF), or anti-cyclic citrullinated peptide antibodies (ACPA) or evidence of joint erosions at plain radiographs. These findings were not rare in our cohort, and they have been also described in other series. Furthermore, manifestations such as Raynaud’s phenomenon, mechanic’s hands, and fever that may lead to the suspect of ASSD are observed only in a third of cases. If we consider the high rate of clinical picture progression in these patients, we fee
Published: 2017

34. Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

Author: Bartoloni, E, Gonzalez-Gay, M, Scire, C, Castaneda, S, Gerli, R, Lopez-Longo, F, Martinez-Barrio, J, Govoni, M, Furini, F, Pina, T, Iannone, F, Giannini, M, Nuno, L, Quartuccio, L, Ortego-Centeno, N, Alunno, A, Specker, C, Montecucco, C, Triantafyllias, K, Balduzzi, S, Sifuentes-Giraldo, W, Paolazzi, G, Bravi, E, Schwarting, A, Pellerito, R, Russo, A, Selmi, C, Saketkoo, L, Fusaro, E, Parisi, S, Pipitone, N, Franceschini, F, Cavazzana, I, Neri, R, Barsotti, S, Codullo, V, Cavagna, L, Bartoloni E., Gonzalez-Gay M. A., Scire CA., Castaneda S., Gerli R., Lopez-Longo F. J., Martinez-Barrio J., Govoni M., Furini F., Pina T., Iannone F., Giannini M., Nuno L., Quartuccio L., Ortego-Centeno N., Alunno A., Specker C., Montecucco C., Triantafyllias K., Balduzzi S., Sifuentes-Giraldo W. A., Paolazzi G., Bravi E., Schwarting A., Pellerito R., Russo A., Selmi C., Saketkoo L. -A., Fusaro E., Parisi S., Pipitone N., Franceschini F., Cavazzana I., Neri R., Barsotti S., Codullo V., Cavagna L., Bartoloni, E, Gonzalez-Gay, M, Scire, C, Castaneda, S, Gerli, R, Lopez-Longo, F, Martinez-Barrio, J, Govoni, M, Furini, F, Pina, T, Iannone, F, Giannini, M, Nuno, L, Quartuccio, L, Ortego-Centeno, N, Alunno, A, Specker, C, Montecucco, C, Triantafyllias, K, Balduzzi, S, Sifuentes-Giraldo, W, Paolazzi, G, Bravi, E, Schwarting, A, Pellerito, R, Russo, A, Selmi, C, Saketkoo, L, Fusaro, E, Parisi, S, Pipitone, N, Franceschini, F, Cavazzana, I, Neri, R, Barsotti, S, Codullo, V, Cavagna, L, Bartoloni E., Gonzalez-Gay M. A., Scire CA., Castaneda S., Gerli R., Lopez-Longo F. J., Martinez-Barrio J., Govoni M., Furini F., Pina T., Iannone F., Giannini M., Nuno L., Quartuccio L., Ortego-Centeno N., Alunno A., Specker C., Montecucco C., Triantafyllias K., Balduzzi S., Sifuentes-Giraldo W. A., Paolazzi G., Bravi E., Schwarting A., Pellerito R., Russo A., Selmi C., Saketkoo L. -A., Fusaro E., Parisi S., Pipitone N., Franceschini F., Cavazzana I., Neri R., Barsotti S., Codullo V., and Cavagna L.
Abstract: Objective Arthritis, myositis and interstitial lung disease (ILD) constitute the classic clinical triad of anti-synthetase syndrome (ASSD). These patients experience other accompanying features, such as Raynaud's phenomenon, fever or mechanic's hands. Most ASSD patients develop the complete triad during the follow-up. In the present study we aimed to determine whether the subsequent appearance of accompanying features may suggest the development of triad findings lacking at the onset in anti-Jo1 positive ASSD patients. Methods Anti-Jo1 positive patients presenting with incomplete ASSD (no > 2 classic triad features) were assessed. Clinical characteristics and clusters of disease manifestations were retrospectively collected and analyzed in a large international multicenter cohort of ASSD patients. Results 165 patients (123 women) with incomplete ASSD were identified. Ninety-five patients (57.5%) developed new classic triad manifestations after 15 months median (IQR 9–51) and 40 (24%) developed new accompanying features after 19 months median (IQR 6–56) from disease onset. During the follow-up, the ex-novo occurrence of triad features was observed in 32 out of 40 patients (80%) with new accompanying findings and in 63 out of 125 patients (50.5%) without new accompanying findings (p = 0.002). In patients with at least one new accompanying feature the odds ratio for the occurrence of new triad manifestations was 3.94 with respect to patients not developing ex-novo accompanying findings (95% CI 1.68–9.21, p = 0.002). Conclusion Anti-Jo1 ASSD patients with incomplete forms at disease onset are at high risk for the subsequent occurrence of lacking classic triad findings. Although all ASSD patients should be carefully assessed for the occurrence of new triad features, a closer follow-up should be considered in the subgroup of patients developing ex novo accompanying findings. These patients, indeed, have near four-fold increased risk f
Published: 2017

35. Sicherheitsmanagement der Therapie mit Antimalariamitteln in der Rheumatologie – Systematische Literaturrecherche als Basis für aktualisierte Empfehlungen

Author: Christoph, F, Neß, T, Weseloh, C, Specker, C, Hadjiski, D, Detert, J, and Krüger, K
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Antimalariamittel (AM) spielen eine wichtige Rolle in der Behandlung des SLE und weiterer rheumatologischer Erkrankungen. Ziel dieser Arbeit war es, die Grundlage für aktualisierte Empfehlungen zum Sicherheitsmanagement der rheumatologischen Therapie mit AM zu erarbeiten. Methoden:[zum vollständigen Text gelangen Sie über die oben angegebene URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2019
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36. CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus

Author: Patschan, S., Dolff, S., Kribben, A., Dürig, J., Patschan, D., Wilde, B., Specker, C., Philipp, T., and Witzke, O.
Published: 2006

37. Strukturierte Patienteninformation bei rheumatoider Arthritis (StruPI-RA) - Verfügen Patient*innen nach Teilnahme an StruPI-RA über eine Verbesserung ihres krankheitsbezogenen Wissens?

Author: Fieguth, V, Kettler, M, Kück, M, Stein, L, Schuch, F, Specker, C, Schwarze, M, Fieguth, V, Kettler, M, Kück, M, Stein, L, Schuch, F, Specker, C, and Schwarze, M
Published: 2019

38. Einfluss einer strukturierten Patientenschulung (StruPI-RA) auf den Wissenserwerb von Patienten mit Rheumatoider Arthritis

Author: Fieguth, V, Specker, C, Kück, M, Tegtbur, U, Schwarze, M, Fieguth, V, Specker, C, Kück, M, Tegtbur, U, and Schwarze, M
Published: 2019

39. Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

Author: Cavagna, L, Trallero-Araguás, E, Meloni, F, Cavazzana, I, Rojas-Serrano, J, Feist, E, Zanframundo, G, Morandi, V, Meyer, A, Pereira da Silva, J, Matos Costa, C, Molberg, O, Andersson, H, Codullo, V, Mosca, M, Barsotti, S, Neri, R, Scirè, C, Govoni, M, Furini, F, Lopez-Longo, F, Martinez-Barrio, J, Schneider, U, Lorenz, H, Doria, A, Ghirardello, A, Ortego-Centeno, N, Confalonieri, M, Tomietto, P, Pipitone, N, Rodriguez Cambron, A, Blázquez Cañamero, M, Voll, R, Wendel, S, Scarpato, S, Maurier, F, Limonta, M, Colombelli, P, Giannini, M, Geny, B, Arrigoni, E, Bravi, E, Migliorini, P, Mathieu, A, Piga, M, Drott, U, Delbrueck, C, Bauhammer, J, Cagnotto, G, Vancheri, C, Sambataro, G, De Langhe, E, Sainaghi, P, Monti, C, Gigli Berzolari, F, Romano, M, Bonella, F, Specker, C, Schwarting, A, Villa Blanco, I, Selmi, C, Ceribelli, A, Nuno, L, Mera-Varela, A, Perez Gomez, N, Fusaro, E, Parisi, S, Sinigaglia, L, Del Papa, N, Benucci, M, Cimmino, M, Riccieri, V, Conti, F, Sebastiani, G, Iuliano, A, Emmi, G, Cammelli, D, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Paolazzi, G, Saketkoo, L, Giorgi, R, Salaffi, F, Cifrian, J, Caporali, R, Locatelli, F, Marchioni, E, Pesci, A, Dei, G, Pozzi, M, Claudia, L, Distler, J, Knitza, J, Schett, G, Iannone, F, Fornaro, M, Franceschini, F, Quartuccio, L, Gerli, R, Bartoloni, E, Bellando Randone, S, Zampogna, G, Gonzalez Perez, M, Mejia, M, Vicente, E, Triantafyllias, K, Lopez-Mejias, R, Matucci-Cerinic, M, Selva-O'Callaghan, A, Castañeda, S, Montecucco, C, Gonzalez-Gay, M, Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Scirè, Carlo, Govoni, Marcello, Furini, Federica, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Schneider, Udo, Lorenz, Hanns-Martin, Doria, Andrea, Ghirardello, Anna, Ortego-Centeno, Norberto, Confalonieri, Marco, Tomietto, Paola, Pipitone, Nicolò, Rodriguez Cambron, Ana Belen, Blázquez Cañamero, María Ángeles, Voll, Reinhard Edmund, Wendel, Sarah, Scarpato, Salvatore, Maurier, Francois, Limonta, Massimiliano, Colombelli, Paolo, Giannini, Margherita, Geny, Bernard, Arrigoni, Eugenio, Bravi, Elena, Migliorini, Paola, Mathieu, Alessandro, Piga, Matteo, Drott, Ulrich, Delbrueck, Christiane, Bauhammer, Jutta, Cagnotto, Giovanni, Vancheri, Carlo, Sambataro, Gianluca, De Langhe, Ellen, Sainaghi, Pier Paolo, Monti, Cristina, Gigli Berzolari, Francesca, Romano, Mariaeva, Bonella, Francesco, Specker, Christof, Schwarting, Andreas, Villa Blanco, Ignacio, Selmi, Carlo, Ceribelli, Angela, Nuno, Laura, Mera-Varela, Antonio, Perez Gomez, Nair, Fusaro, Enrico, Parisi, Simone, Sinigaglia, Luigi, Del Papa, Nicoletta, Benucci, Maurizio, Cimmino, Marco Amedeo, Riccieri, Valeria, Conti, Fabrizio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Emmi, Giacomo, Cammelli, Daniele, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Paolazzi, Giuseppe, Saketkoo, Lesley Ann, Giorgi, Roberto, Salaffi, Fausto, Cifrian, Jose, Caporali, Roberto, Locatelli, Francesco, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Pozzi, Maria Rosa, Claudia, Lomater, Distler, Jorg, Knitza, Johannes, Schett, George, Iannone, Florenzo, Fornaro, Marco, Franceschini, Franco, Quartuccio, Luca, Gerli, Roberto, Bartoloni, Elena, Bellando Randone, Silvia, Zampogna, Giuseppe, Gonzalez Perez, Montserrat I, Mejia, Mayra, Vicente, Esther, Triantafyllias, Konstantinos, Lopez-Mejias, Raquel, Matucci-Cerinic, Marco, Selva-O'Callaghan, Albert, Castañeda, Santos, Montecucco, Carlomaurizio, Gonzalez-Gay, Miguel Angel, Cavagna, L, Trallero-Araguás, E, Meloni, F, Cavazzana, I, Rojas-Serrano, J, Feist, E, Zanframundo, G, Morandi, V, Meyer, A, Pereira da Silva, J, Matos Costa, C, Molberg, O, Andersson, H, Codullo, V, Mosca, M, Barsotti, S, Neri, R, Scirè, C, Govoni, M, Furini, F, Lopez-Longo, F, Martinez-Barrio, J, Schneider, U, Lorenz, H, Doria, A, Ghirardello, A, Ortego-Centeno, N, Confalonieri, M, Tomietto, P, Pipitone, N, Rodriguez Cambron, A, Blázquez Cañamero, M, Voll, R, Wendel, S, Scarpato, S, Maurier, F, Limonta, M, Colombelli, P, Giannini, M, Geny, B, Arrigoni, E, Bravi, E, Migliorini, P, Mathieu, A, Piga, M, Drott, U, Delbrueck, C, Bauhammer, J, Cagnotto, G, Vancheri, C, Sambataro, G, De Langhe, E, Sainaghi, P, Monti, C, Gigli Berzolari, F, Romano, M, Bonella, F, Specker, C, Schwarting, A, Villa Blanco, I, Selmi, C, Ceribelli, A, Nuno, L, Mera-Varela, A, Perez Gomez, N, Fusaro, E, Parisi, S, Sinigaglia, L, Del Papa, N, Benucci, M, Cimmino, M, Riccieri, V, Conti, F, Sebastiani, G, Iuliano, A, Emmi, G, Cammelli, D, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Paolazzi, G, Saketkoo, L, Giorgi, R, Salaffi, F, Cifrian, J, Caporali, R, Locatelli, F, Marchioni, E, Pesci, A, Dei, G, Pozzi, M, Claudia, L, Distler, J, Knitza, J, Schett, G, Iannone, F, Fornaro, M, Franceschini, F, Quartuccio, L, Gerli, R, Bartoloni, E, Bellando Randone, S, Zampogna, G, Gonzalez Perez, M, Mejia, M, Vicente, E, Triantafyllias, K, Lopez-Mejias, R, Matucci-Cerinic, M, Selva-O'Callaghan, A, Castañeda, S, Montecucco, C, Gonzalez-Gay, M, Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Scirè, Carlo, Govoni, Marcello, Furini, Federica, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Schneider, Udo, Lorenz, Hanns-Martin, Doria, Andrea, Ghirardello, Anna, Ortego-Centeno, Norberto, Confalonieri, Marco, Tomietto, Paola, Pipitone, Nicolò, Rodriguez Cambron, Ana Belen, Blázquez Cañamero, María Ángeles, Voll, Reinhard Edmund, Wendel, Sarah, Scarpato, Salvatore, Maurier, Francois, Limonta, Massimiliano, Colombelli, Paolo, Giannini, Margherita, Geny, Bernard, Arrigoni, Eugenio, Bravi, Elena, Migliorini, Paola, Mathieu, Alessandro, Piga, Matteo, Drott, Ulrich, Delbrueck, Christiane, Bauhammer, Jutta, Cagnotto, Giovanni, Vancheri, Carlo, Sambataro, Gianluca, De Langhe, Ellen, Sainaghi, Pier Paolo, Monti, Cristina, Gigli Berzolari, Francesca, Romano, Mariaeva, Bonella, Francesco, Specker, Christof, Schwarting, Andreas, Villa Blanco, Ignacio, Selmi, Carlo, Ceribelli, Angela, Nuno, Laura, Mera-Varela, Antonio, Perez Gomez, Nair, Fusaro, Enrico, Parisi, Simone, Sinigaglia, Luigi, Del Papa, Nicoletta, Benucci, Maurizio, Cimmino, Marco Amedeo, Riccieri, Valeria, Conti, Fabrizio, Sebastiani, Gian Domenico, Iuliano, Annamaria, Emmi, Giacomo, Cammelli, Daniele, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Paolazzi, Giuseppe, Saketkoo, Lesley Ann, Giorgi, Roberto, Salaffi, Fausto, Cifrian, Jose, Caporali, Roberto, Locatelli, Francesco, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Pozzi, Maria Rosa, Claudia, Lomater, Distler, Jorg, Knitza, Johannes, Schett, George, Iannone, Florenzo, Fornaro, Marco, Franceschini, Franco, Quartuccio, Luca, Gerli, Roberto, Bartoloni, Elena, Bellando Randone, Silvia, Zampogna, Giuseppe, Gonzalez Perez, Montserrat I, Mejia, Mayra, Vicente, Esther, Triantafyllias, Konstantinos, Lopez-Mejias, Raquel, Matucci-Cerinic, Marco, Selva-O'Callaghan, Albert, Castañeda, Santos, Montecucco, Carlomaurizio, and Gonzalez-Gay, Miguel Angel
Abstract: Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.
Published: 2019

40. Verbesserung des HbA1c bei RA Patienten mit Diabetes unter Tocilizumab

Author: Specker, C, Alberding, A, Aringer, M, Burmester, GR, Flacke, JP, Hofmann, MW, Kästner, P, Kellner, H, Moosig, F, Sieburg, M, Tony, HP, Fliedner, G, Specker, C, Alberding, A, Aringer, M, Burmester, GR, Flacke, JP, Hofmann, MW, Kästner, P, Kellner, H, Moosig, F, Sieburg, M, Tony, HP, and Fliedner, G
Published: 2019

41. Video-kapillarmikroskopische Veränderungen bei Patienten mit Antisynthetase-Syndrom. Ergebnisse einer internationalen, multizentrischen Studie des American and European Network of Antisynthetase Syndrome (AENEAS)

Author: Triantafyllias, K, Sebastiani, M, Manfredi, A, Codullo, V, Schwarting, A, Drott, U, Delbrück, C, Weinmann-Menke, J, Bauhammer, J, Miehle, N, Bonella, F, Bergner, R, Specker, C, Lütgendorf, F, Cavagna, L, Triantafyllias, K, Sebastiani, M, Manfredi, A, Codullo, V, Schwarting, A, Drott, U, Delbrück, C, Weinmann-Menke, J, Bauhammer, J, Miehle, N, Bonella, F, Bergner, R, Specker, C, Lütgendorf, F, and Cavagna, L
Published: 2019

42. influence of the SARS-CoV-2 lockdown on patients with inflammatory rheumatic diseases on their adherence to immunomodulatory medication: a cross sectional study over 3 months in Germany.

Author: Hasseli, R, Müller-Ladner, U, Keil, F, Broll, M, Dormann, A, Fräbel, C, Hermann, W, Heinmüller, C -J, Hoyer, B F, Löffler, F, Özden, F, Pfeiffer, U, Saech, J, Schneidereit, T, Schlesinger, A, Schwarting, A, Specker, C, Stapfer, G, Steinmüller, M, and Storck-Müller, K
Subjects: DRUG therapy for rheumatism, PATIENT compliance, CROSS-sectional method, ACADEMIC medical centers, QUESTIONNAIRES, PRIMARY health care, TERMINATION of treatment, DESCRIPTIVE statistics, STAY-at-home orders, DEPARTMENTS, HEALTH behavior, HEALTH facilities, COVID-19 pandemic, IMMUNOMODULATORS, MEDICAL practice, RHEUMATISM
Abstract: Objectives To evaluate the influence of the SARS-CoV-2 pandemic on the adherence of patients with inflammatory rheumatic diseases (IRD) to their immunomodulatory medication during the three-month lockdown in Germany. Methods From 16th March until 15th June 2020, IRD patients from private practices and rheumatology departments were asked to answer a questionnaire addressing their behaviour with respect to their immunomodulating therapy. Eight private practices and nine rheumatology departments that included rheumatology primary care centres and university hospitals participated. A total of 4252 questionnaires were collected and evaluated. Results The majority of patients (54%) were diagnosed with RA, followed by psoriatic arthritis (14%), ankylosing spondylitis (10%), connective tissue diseases (12%) and vasculitides (6%). Most of the patients (84%) reported to continue their immunomodulatory therapy. Termination of therapy was reported by only 3% of the patients. The results were independent from the type of IRD, the respective immunomodulatory therapy and by whom the patients were treated (private practices vs rheumatology departments). Younger patients (<60 years) reported just as often as older patients to discontinue their therapy. Conclusion The data show that most of the patients continued their therapy in spite of the pandemic. A significant change in behaviour with regard to their immunomodulatory therapy was not observed during the three months of observation. The results support the idea that the immediate release of recommendations of the German Society of Rheumatology were well received, supporting the well-established physician–patient relationship in times of a crisis. [ABSTRACT FROM AUTHOR]
Published: 2021
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43. Clinical spectrum time course in anti jo-1 positive antisynthetase syndrome: Results from an international retrospective multicenter study

Author: Cavagna L., Nuno L., Scire C. A., Govoni M., Longo F. J. L., Franceschini F., Neri R., Castaneda S., Giraldo W. A. S., Caporali R., Iannone F., Fusaro E., Paolazzi G., Pellerito R., Schwarting A., Saketkoo L. A., Ortego-Centeno N., Quartuccio L., Bartoloni E., Specker C., Murcia T. P., La Corte R., Furini F., Foschi V., Corral J. B., Airo P., Cavazzana I., Martinez-Barrio J., Hinojosa M., Giannini M., Barsotti S., Menke J., Triantafyllias K., Vitetta R., Russo A., Bajocchi G., Bravi E., Barausse G., Bortolotti R., Selmi C., Parisi S., Montecucco C., Gonzalez-Gay M. A., Rosenthal K., Cavagna, L, Nuno, L, Scire, C, Govoni, M, Longo, F, Franceschini, F, Neri, R, Castaneda, S, Giraldo, W, Caporali, R, Iannone, F, Fusaro, E, Paolazzi, G, Pellerito, R, Schwarting, A, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Bartoloni, E, Specker, C, Murcia, T, La Corte, R, Furini, F, Foschi, V, Corral, J, Airo, P, Cavazzana, I, Martinez-Barrio, J, Hinojosa, M, Giannini, M, Barsotti, S, Menke, J, Triantafyllias, K, Vitetta, R, Russo, A, Bajocchi, G, Bravi, E, Barausse, G, Bortolotti, R, Selmi, C, Parisi, S, Montecucco, C, Gonzalez-Gay, M, Rosenthal, K, AENEAS (American, European NEtwork of Antisynthetase Syndrome) collaborative group, [Cavagna,L, Caporali,L, Montecucco,C] Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy. [Nuño,L] Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain. [Scire,CA] Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy. [Govoni ,M, Furini,F, La Corte,R, Foschi,V] UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy. [Lopez Longo.FJ, Martínez-Barrio,J, Hinojosa,M] Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Franceschini,F, Airó,P, Cavazzana,I] Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy. [Neri,R, Barsotti,S] Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. [Castañeda,S] Department of Rheumatology, Hospital Universitario de la Princesa, IIS Princesa, Madrid, Spain.[Sifuentes Giraldo,WA, Bachiller Corral,AJ] Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain. [Iannone,F] Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy. [Fusaro,E, Parisi,S] Department of Rheumatology, Città Della Salute e della Scienza, Torino, Italy. [Paolazzi,G, Barausse,G, Bortolotti,R] Rheumatology Unit, Santa Chiara Hospital, Trento, Italy. [Pellerito,R, Vitetta,R, Russo,A] Division of Rheumatology, Mauriziano Hospital, Turin, Italy. [Schwarting,A, Menke,J] Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany. [Saketkoo,LA] Tulane University Lung Center Tulane/UMC Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, USA. [Ortego-Centeno,N] Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain. [Quartuccio,L] Santa Maria della Misericordia Hospital, Udine, Italy. [Bartoloni,E] Clinic of Rheumatology, Department of Medical and Biological Sciences. Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy. [Specker,C] Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany. [Pina Murcia,T, and González-Gay,MA] Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain. [Triantafyllias,K] ACURA Rheumatology Center, Bad Kreuznach, Germany. [Bajocchi,G] Rheumatology Unit, Department of Internal Medicine, S. Maria Hospital—IRCCS, Reggio Emilia, Italy. [Bravi,E] Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy. [Selmi,C] Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milano, Italy.
Subjects: Male, Pathology, Neurology, Anti Jo-1, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Medizin, Arthritis, Antisynthetase syndrome, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Antinuclear, Masculino, Myositis, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Medicine (all), Interstitial lung disease, Femenino, General Medicine, Middle Aged, Diseases::Musculoskeletal Diseases::Muscular Diseases::Myositis [Medical Subject Headings], Humanos, Anticuerpos antinucleares, Antibodies, Antinuclear, Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis [Medical Subject Headings], Female, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Antibodies, Antinuclear [Medical Subject Headings], Adult, medicine.medical_specialty, Check Tags::Male [Medical Subject Headings], Antibodies, NO, Estudios retrospectivos, Internal medicine, medicine, Humans, Risk factor, Aged, Retrospective Studies, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Artritis, business.industry, Retrospective cohort study, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Anti Jo-1, Antisynthetase Syndrome, medicine.disease, Dermatology, Rheumatology, Check Tags::Female [Medical Subject Headings], Miositis, antisynthetase syndrome, business
Abstract: Anti Jo-1 antibodies are the main markers of the antisynthetase syndrome (ASSD), an autoimmune disease clinically characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). These manifestations usually co-occur (for practical purpose complete forms) in the same patient, but cases with only 1 or 2 of these findings (for practical purpose incomplete forms) have been described. In incomplete forms, the ex novo occurrence of further manifestations is possible, although with frequencies and timing not still defined. The aim of this international, multicenter, retrospective study was to characterize the clinical time course of anti Jo-1 positive ASSD in a large cohort of patients. Included patients should be anti Jo-1 positive and with at least 1 feature between arthritis, myositis, and ILD. We evaluated the differences between complete and incomplete forms, timing of clinical picture appearance and analyzed factors predicting the appearance of further manifestations in incomplete ASSD. Finally, we collected 225 patients (58 males and 167 females) with a median follow-up of 80 months. At the onset, complete ASSD were 44 and incomplete 181. Patients with incomplete ASSD had frequently only 1 of the classic triad findings (110 cases), in particular, isolated arthritis in 54 cases, isolated myositis in 28 cases, and isolated ILD in 28 cases. At the end of follow-up, complete ASSD were 113, incomplete 112. Only 5 patients had an isolated arthritis, only 5 an isolated myositis, and 15 an isolated ILD. During the follow-up, 108 patients with incomplete forms developed further manifestations. Single main feature onset was the main risk factor for the ex novo appearance of further manifestation. ILD was the prevalent ex novo manifestation (74 cases). In conclusion, ASSD is a condition that should be carefully considered in all patients presenting with arthritis, myositis, and ILD, even when isolated. The ex novo appearance of further manifestations in patients with incomplete forms is common, thus indicating the need for an adequate clinical and instrumental follow-up. Furthermore, the study clearly suggested that in ASSD multidisciplinary approach involving Rheumatology, Neurology, Pneumology, and Internal Medicine specialists is mandatory. CA extern
Published: 2015

44. Novel 68 kDa autoantigen detected by rheumatoid arthritis specific antibodies

Author: BlaB, S., Specker, C., Lakomek, H.-J., Schneider, E. M., and Schwochau, M.
Published: 1995

45. Timing of onset affects arthritis presentation pattern in antisyntethase syndrome

Author: González-Gay, M, Montecucco, C, Selva-O'Callaghan, A, Trallero-Araguas, E, Molberg, O, Andersson, H, Rojas-Serrano, J, Perez-Roman, D, Bauhammer, J, Fiehn, C, Neri, R, Barsotti, S, Lorenz, H, Doria, A, Ghirardello, A, Iannone, F, Giannini, M, Franceschini, F, Cavazzana, I, Triantafyllias, K, Benucci, M, Infantino, M, Manfredi, M, Conti, F, Schwarting, A, Sebastiani, G, Iuliano, A, Emmi, G, Silvestri, E, Govoni, M, Scirè, C, Furini, F, Lopez-Longo, F, Martínez-Barrio, J, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Cimmino, M, Cosso, C, Belotti Masserini, A, Cagnotto, G, Codullo, V, Romano, M, Paolazzi, G, Pellerito, R, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Batticciotto, A, Bartoloni Bocci, E, Gerli, R, Specker, C, Bravi, E, Selmi, C, Parisi, S, Salaffi, F, Meloni, F, Marchioni, E, Pesci, A, Dei, G, Confalonieri, M, Tomietto, P, Nuno, L, Bonella, F, Pipitone, N, Mera-Valera, A, Perez-Gomez, N, Gerzeli, S, Lopez-Mejias, R, Matos-Costa, C, Pereira da Silva, J, Cifrian, J, Alpini, C, Olivieri, I, Blázquez Cañamero, M, Rodriguez Cambrón, A, Castañeda, S, Cavagna, L, González-Gay, Miguel A, Montecucco, Carlomaurizio, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Molberg, Ovynd, Andersson, Helena, Rojas-Serrano, Jorge, Perez-Roman, Diana Isabel, Bauhammer, Jutta, Fiehn, Christoph, Neri, Rossella, Barsotti, Simone, Lorenz, Hannes M, Doria, Andrea, Ghirardello, Anna, Iannone, Florenzo, Giannini, Margherita, Franceschini, Franco, Cavazzana, Ilaria, Triantafyllias, Konstantinos, Benucci, Maurizio, Infantino, Maria, Manfredi, Mariangela, Conti, Fabrizio, Schwarting, Andreas, Sebastiani, Giandomenico, Iuliano, Annamaria, Emmi, Giacomo, Silvestri, Elena, Govoni, Marcello, Scirè, Carlo Alberto, Furini, Federica, Lopez-Longo, Francisco Javier, Martínez-Barrio, Julia, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Cimmino, Marco A, Cosso, Claudio, Belotti Masserini, Alessandro, Cagnotto, Giovanni, Codullo, Veronica, Romano, Mariaeva, Paolazzi, Giuseppe, Pellerito, Raffaele, Saketkoo, Lesley Ann, Ortego-Centeno, Norberto, Quartuccio, Luca, Batticciotto, Alberto, Bartoloni Bocci, Elena, Gerli, Roberto, Specker, Christof, Bravi, Elena, Selmi, Carlo, Parisi, Simone, Salaffi, Fausto, Meloni, Federica, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Confalonieri, Marco, Tomietto, Paola, Nuno, Laura, Bonella, Francesco, Pipitone, Nicolò, Mera-Valera, Antonio, Perez-Gomez, Nair, Gerzeli, Simone, Lopez-Mejias, Raquel, Matos-Costa, Carlo Jorge, Pereira da Silva, Jose Antonio, Cifrian, José, Alpini, Claudia, Olivieri, Ignazio, Blázquez Cañamero, María Ángeles, Rodriguez Cambrón, Ana Belén, Castañeda, Santos, Cavagna, Lorenzo, González-Gay, M, Montecucco, C, Selva-O'Callaghan, A, Trallero-Araguas, E, Molberg, O, Andersson, H, Rojas-Serrano, J, Perez-Roman, D, Bauhammer, J, Fiehn, C, Neri, R, Barsotti, S, Lorenz, H, Doria, A, Ghirardello, A, Iannone, F, Giannini, M, Franceschini, F, Cavazzana, I, Triantafyllias, K, Benucci, M, Infantino, M, Manfredi, M, Conti, F, Schwarting, A, Sebastiani, G, Iuliano, A, Emmi, G, Silvestri, E, Govoni, M, Scirè, C, Furini, F, Lopez-Longo, F, Martínez-Barrio, J, Sebastiani, M, Manfredi, A, Bachiller-Corral, J, Sifuentes Giraldo, W, Cimmino, M, Cosso, C, Belotti Masserini, A, Cagnotto, G, Codullo, V, Romano, M, Paolazzi, G, Pellerito, R, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Batticciotto, A, Bartoloni Bocci, E, Gerli, R, Specker, C, Bravi, E, Selmi, C, Parisi, S, Salaffi, F, Meloni, F, Marchioni, E, Pesci, A, Dei, G, Confalonieri, M, Tomietto, P, Nuno, L, Bonella, F, Pipitone, N, Mera-Valera, A, Perez-Gomez, N, Gerzeli, S, Lopez-Mejias, R, Matos-Costa, C, Pereira da Silva, J, Cifrian, J, Alpini, C, Olivieri, I, Blázquez Cañamero, M, Rodriguez Cambrón, A, Castañeda, S, Cavagna, L, González-Gay, Miguel A, Montecucco, Carlomaurizio, Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Molberg, Ovynd, Andersson, Helena, Rojas-Serrano, Jorge, Perez-Roman, Diana Isabel, Bauhammer, Jutta, Fiehn, Christoph, Neri, Rossella, Barsotti, Simone, Lorenz, Hannes M, Doria, Andrea, Ghirardello, Anna, Iannone, Florenzo, Giannini, Margherita, Franceschini, Franco, Cavazzana, Ilaria, Triantafyllias, Konstantinos, Benucci, Maurizio, Infantino, Maria, Manfredi, Mariangela, Conti, Fabrizio, Schwarting, Andreas, Sebastiani, Giandomenico, Iuliano, Annamaria, Emmi, Giacomo, Silvestri, Elena, Govoni, Marcello, Scirè, Carlo Alberto, Furini, Federica, Lopez-Longo, Francisco Javier, Martínez-Barrio, Julia, Sebastiani, Marco, Manfredi, Andreina, Bachiller-Corral, Javier, Sifuentes Giraldo, Walter Alberto, Cimmino, Marco A, Cosso, Claudio, Belotti Masserini, Alessandro, Cagnotto, Giovanni, Codullo, Veronica, Romano, Mariaeva, Paolazzi, Giuseppe, Pellerito, Raffaele, Saketkoo, Lesley Ann, Ortego-Centeno, Norberto, Quartuccio, Luca, Batticciotto, Alberto, Bartoloni Bocci, Elena, Gerli, Roberto, Specker, Christof, Bravi, Elena, Selmi, Carlo, Parisi, Simone, Salaffi, Fausto, Meloni, Federica, Marchioni, Enrico, Pesci, Alberto, Dei, Giulia, Confalonieri, Marco, Tomietto, Paola, Nuno, Laura, Bonella, Francesco, Pipitone, Nicolò, Mera-Valera, Antonio, Perez-Gomez, Nair, Gerzeli, Simone, Lopez-Mejias, Raquel, Matos-Costa, Carlo Jorge, Pereira da Silva, Jose Antonio, Cifrian, José, Alpini, Claudia, Olivieri, Ignazio, Blázquez Cañamero, María Ángeles, Rodriguez Cambrón, Ana Belén, Castañeda, Santos, and Cavagna, Lorenzo
Abstract: Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). Conclusion In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility
Published: 2018

46. Clinical spectrum time course in anti jo-1 positive antisynthetase syndrome: Results from an international retrospective multicenter study

Author: Cavagna, L, Nuno, L, Scire, C, Govoni, M, Longo, F, Franceschini, F, Neri, R, Castaneda, S, Giraldo, W, Caporali, R, Iannone, F, Fusaro, E, Paolazzi, G, Pellerito, R, Schwarting, A, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Bartoloni, E, Specker, C, Murcia, T, La Corte, R, Furini, F, Foschi, V, Corral, J, Airo, P, Cavazzana, I, Martinez-Barrio, J, Hinojosa, M, Giannini, M, Barsotti, S, Menke, J, Triantafyllias, K, Vitetta, R, Russo, A, Bajocchi, G, Bravi, E, Barausse, G, Bortolotti, R, Selmi, C, Parisi, S, Montecucco, C, Gonzalez-Gay, M, Rosenthal, K, Cavagna L., Nuno L., Scire C. A., Govoni M., Longo F. J. L., Franceschini F., Neri R., Castaneda S., Giraldo W. A. S., Caporali R., Iannone F., Fusaro E., Paolazzi G., Pellerito R., Schwarting A., Saketkoo L. A., Ortego-Centeno N., Quartuccio L., Bartoloni E., Specker C., Murcia T. P., La Corte R., Furini F., Foschi V., Corral J. B., Airo P., Cavazzana I., Martinez-Barrio J., Hinojosa M., Giannini M., Barsotti S., Menke J., Triantafyllias K., Vitetta R., Russo A., Bajocchi G., Bravi E., Barausse G., Bortolotti R., Selmi C., Parisi S., Montecucco C., Gonzalez-Gay M. A., Rosenthal K., Cavagna, L, Nuno, L, Scire, C, Govoni, M, Longo, F, Franceschini, F, Neri, R, Castaneda, S, Giraldo, W, Caporali, R, Iannone, F, Fusaro, E, Paolazzi, G, Pellerito, R, Schwarting, A, Saketkoo, L, Ortego-Centeno, N, Quartuccio, L, Bartoloni, E, Specker, C, Murcia, T, La Corte, R, Furini, F, Foschi, V, Corral, J, Airo, P, Cavazzana, I, Martinez-Barrio, J, Hinojosa, M, Giannini, M, Barsotti, S, Menke, J, Triantafyllias, K, Vitetta, R, Russo, A, Bajocchi, G, Bravi, E, Barausse, G, Bortolotti, R, Selmi, C, Parisi, S, Montecucco, C, Gonzalez-Gay, M, Rosenthal, K, Cavagna L., Nuno L., Scire C. A., Govoni M., Longo F. J. L., Franceschini F., Neri R., Castaneda S., Giraldo W. A. S., Caporali R., Iannone F., Fusaro E., Paolazzi G., Pellerito R., Schwarting A., Saketkoo L. A., Ortego-Centeno N., Quartuccio L., Bartoloni E., Specker C., Murcia T. P., La Corte R., Furini F., Foschi V., Corral J. B., Airo P., Cavazzana I., Martinez-Barrio J., Hinojosa M., Giannini M., Barsotti S., Menke J., Triantafyllias K., Vitetta R., Russo A., Bajocchi G., Bravi E., Barausse G., Bortolotti R., Selmi C., Parisi S., Montecucco C., Gonzalez-Gay M. A., and Rosenthal K.
Abstract: Anti Jo-1 antibodies are the main markers of the anti-synthetase syndrome (ASSD), an autoimmune disease clinically characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). These manifestations usually co-occur (for practical purpose complete forms) in the same patient, but cases with only 1 or 2 of these findings (for practical purpose incomplete forms) have been described. In incomplete forms, the ex novo occurrence of further manifestations is possible, although with frequencies and timing not still defined. The aim of this international, multicenter, retrospective study was to characterize the clinical time course of anti Jo-1 positive ASSD in a large cohort of patients. Included patients should be anti Jo-1 positive and with at least 1 feature between arthritis, myositis, and ILD. We evaluated the differences between complete and incomplete forms, timing of clinical picture appearance and analyzed factors predicting the appearance of further manifestations in incomplete ASSD. Finally, we collected 225 patients (58 males and 167 females) with a median follow-up of 80 months. At the onset, complete ASSD were 44 and incomplete 181. Patients with incomplete ASSD had frequently only 1 of the classic triad findings (110 cases), in particular, isolated arthritis in 54 cases, isolated myositis in 28 cases, and isolated ILD in 28 cases. At the end of follow-up, complete ASSD were 113, incomplete 112. Only 5 patients had an isolated arthritis, only 5 an isolated myositis, and 15 an isolated ILD. During the follow-up, 108 patients with incomplete forms developed further manifestations. Single main feature onset was the main risk factor for the ex novo appearance of further manifestation. ILD was the prevalent ex novo manifestation (74 cases). In conclusion, ASSD is a condition that should be carefully considered in all patients presenting with arthritis, myositis, and ILD, even when isolated. The ex novo appearance of further manifestati
Published: 2015

47. Novel 68 kDa autoantigen detected by rheumatoid arthritis specific antibodies

Author: Blass, S., Specker, C., Lakomek, H.-J., Schneider, E.M., and Schwochau, M.
Subjects: Rheumatoid arthritis -- Development and progression, Autoantibodies -- Analysis, Autoantigens -- Analysis, Health
Abstract: A new test to identify rheumatoid arthritis (RA) may enable diagnosis to be made earlier and more accurately. The 68 kDa antigen, which may be present in all human tissues, was recognized as an autoantigen by blood from 64% of 167 RA patients. The 68 kDa antigen was identified in RA patients negative for the rheumatoid factor, but in only 1% of patients with other rheumatic diseases. The discovery that this antigen may be a specific indicator of RA fits with the current theory that major proteins involved in cell metabolism are attacked by autoimmune diseases. The disease process of RA may involve autoimmunity against the 68 kDa antigen.
Published: 1995

48. Wechsel von Tocilizumab i.v. auf s.c. ohne Wirkverlust möglich

Author: Specker, C, Kaufmann, J, Kellner, H, Kästner, P, Volberg, C, Schwarze, I, Aringer, M, Sieburg, M, Meier, L, Hofmann, MW, Flacke, JP, Tony, HP, and Fliedner, G
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Die Wirksamkeit und Sicherheit der intravenösen (i.v.) und subkutanen (s.c.) Tocilizumab (TCZ)-Darreichungsform waren in klinischen Studien vergleichbar (Burmester et al. Ann Rheum Dis. 2014;73:69-74; Ogata et al. Arthritis Care Res 2014;66:344-354). In dieser Interimsanalyse der nicht-interventionellen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2017
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49. Effektivität von Tocilizumab: Stärkeres Ansprechen bei anti-CCP-positiven Patienten

Author: Specker, C, Kaufmann, J, Kellner, H, Kästner, P, Volberg, C, Schwarze, I, Aringer, M, Sieburg, M, Meier, LG, Hofmann, MW, Flacke, JP, Tony, HP, and Fliedner, G
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Das Auftreten von Antikörpern gegen cyclische citrullinierte Peptide (Anti-CCP) bei Patienten mit rheumatoider Arthritis (RA) ist prädiktiv für eine höhere Krankheitsaktivität und eine stärkere radiographische Progression (Rönnelid et al., Ann Rheum Dis.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2017
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50. Zeitlicher Verlauf klinischer Manifestationen im Vergleich zwischen PL-7-, PL-12- und EJ-positiven Patienten mit Antisynthetase Syndrom

Author: Triantafyllias, K, Cavagna, L, Bauhammer, J, Delbrück, C, Drott, U, Specker, C, Weinmann-Menke, J, Wendel, S, Voll, R, Bonella, F, Lorenz, HM, Lütgendorf, F, Castaneda, S, Gonzalez-Gay, MA, Selva-O' Callaghan, A, and Schwarting, A
Subjects: ddc: 610, 610 Medical sciences, Medicine
Abstract: Einleitung: Arthritis, Myositis und interstitielle Lungenerkrankung (ILD) bilden die klassische klinische Trias des Antisynthetase-Syndroms (ASSD). Bei Jo-1-positiven Patienten können diese Charakteristika auch während der Follow-Up-Periode auftreten. Auch wenn eine ähnliche Tendenz bei[zum vollständigen Text gelangen Sie über die oben angegebene URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Published: 2017
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