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Probabilistic projections from the UK Climate Projections 2018 are presented for four global warming levels (GWLs) at 1.5, 2, 3, and 4°C above the 1850–1900 baseline. Our results show how uncertainties associated with climate models and four representative concentration pathways (RCP) emission scenarios translate to UK regional scale changes in maximum temperature and precipitation, with data also available for minimum and mean temperatures, humidity and surface net downward shortwave radiation flux. We compare weighting the likelihood of RCPs based on (hypothetical) policy decisions, against our baseline assumption that each RCP is equally likely. Differences between weighted and unweighted GWL distributions are small, particularly in relation to the full breadth of uncertainties that are incorporated into the probabilistic projections. Finally we quantify the relative importance of scenario, model and internal variability on regional projected GWLs and show that uncertainty associated with an uncertain climate response to forcings dominates at all GWLs. Plain Language Summary: Global warming levels define the global averaged increase in temperature since the pre‐industrial period. This study looks at what the regional climate in the UK could be like in the future. We estimate how temperature and precipitation in the UK might change under four different global warming levels (GWLs) (1.5, 2, 3, and 4°C above pre‐industrial times). We account for a wide range of outcomes from both climate models and future emissions scenarios. Assuming that the range of future emissions scenarios are equally likely, the center of the ranges of years that we could reach GWLs of 1.5, 2, 3, and 4°C are 2032, 2050, 2072, and 2078 respectively. The largest influence of future climate on these range estimates comes from our understanding of how the Earth actually responds to changes in greenhouse gases. Even if we knew the exact quantity of greenhouse gas emissions we would emit in the future, we still wouldn't be able to predict the exact changes in UK climate with perfect accuracy because our understanding of the regional climate response to these emissions requires further investigation. Key Points: Probabilistic climate projections from the UK are presented for four global warming levels (GWLs) across four representative concentration pathways (RCP)We show how uncertainty associated with climate models and future emission scenarios translate to UK regional scale changesUncertainty associated with an uncertain climate response to forcings dominates at all GWLs [ABSTRACT FROM AUTHOR]