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1. A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Djuka Fokou, Carine, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Lorenz, Hanns-Martin, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Kräusslich, Hans-Georg, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Published
2020
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2. 1142. Plasma with high titers of anti-SARS-Cov2 antibodies improves outcome of COVID-19 in patients with hematological malignancy and cancer in a randomized controlled trial

Author

Denkinger, Claudia M, primary, Janssen, Maike, additional, Schäkel, Ulrike, additional, Gall, Julia, additional, Leo, Albrecht, additional, Stelmach, Patrick, additional, Weber, Stefan F, additional, Krisam, Johannes, additional, Baumann, Lukas, additional, Stermann, Jacek, additional, Merle, Uta, additional, Weigand, Markus, additional, Bullinger, Lars, additional, Schrezenmeier, Jens-Florian, additional, Bornhäuser, Martin, additional, Alakel, Nael, additional, Witzke, Oliver, additional, Wolf, Timo, additional, Vehreschild, Maria, additional, Schmiedel, Stefan, additional, Addo, Marylyn, additional, Herth, Felix, additional, Kreuter, Michael, additional, Tepasse, Phil-Robin, additional, Hertenstein, Bernd, additional, Hänel, Mathias, additional, Morgner, Anke, additional, Kiehl, Michael, additional, Hopfer, Olaf, additional, Wattad, Mohammad-Amen, additional, Schimanski, Carl, additional, Celik, Cihan, additional, Pohle, Thorsten, additional, Ruhe, Matthias, additional, Kern, Winfried, additional, Schmitt, Anita, additional, Schmitt, Michael, additional, Lorenz, Hanns-Martin, additional, Souto-Carneiro, Margarida, additional, Halama, Niels, additional, Meurer, Stefan, additional, Kräusslich, Hans-Georg, additional, Müller, Barbara, additional, Bartenschlager, Ralf, additional, Gronkowski, Martina, additional, Klemmer, Jennifer, additional, Kriegsmann, Katharina, additional, Schlenk, Richard, additional, and Müller-Tidow, Carsten, additional

Published
2022
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3. Additional file 1 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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4. Additional file 2 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2020
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5. Additional file 3 of A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial

Author

Janssen, Maike, Schäkel, Ulrike, Fokou, Carine Djuka, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Hanns-Martin Lorenz, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Hans-Georg Kräusslich, Halama, Niels, Jäger, Dirk, Schlenk, Richard F., Leo, Albrecht, Meuer, Stefan, Weigand, Markus A., Motsch, Johann, Merle, Uta, Denkinger, Claudia M., and Müller-Tidow, Carsten

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2020
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6. Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function

Author

Probst, Kristina, Stermann, Jacek, von Bomhard, Inga, Etich, Julia, Pitzler, Lena, Niehoff, Anja, Bluhm, Bjoern, Xu, Haifeng C., Lang, Philipp A., Chmielewski, Markus, Abken, Hinrich, Blissenbach, Birgit, Machova, Alzbeta, Papadopoulou, Nikoletta, Brachvogel, Bent, Probst, Kristina, Stermann, Jacek, von Bomhard, Inga, Etich, Julia, Pitzler, Lena, Niehoff, Anja, Bluhm, Bjoern, Xu, Haifeng C., Lang, Philipp A., Chmielewski, Markus, Abken, Hinrich, Blissenbach, Birgit, Machova, Alzbeta, Papadopoulou, Nikoletta, and Brachvogel, Bent

Abstract

The trabecular extracellular matrix (ECM) forms a three-dimensional scaffold to stabilize the bone marrow, provide substrates for cell-matrix interactions and retain, present or release signals to modulate hematopoietic stem and progenitor cell development. However, the impact of trabecular ECM components on hematopoiesis has been poorly studied. Using collagen IX alpha1 - deficient (Col9a1((-/-))) mice, we revealed that a lack of collagen IX alpha1 results in a disorganized trabecular network enriched in fibronectin, and in a reduction in myeloid cells, which was accompanied by a decrease in colony-stimulating factor 1 receptor expression on monocytes from the bone marrow. In contrast, B-cell numbers in the bone marrow and T-cell numbers in the thymus remained unchanged. Alterations in the bone marrow microenvironment may not only reduce myeloid cell numbers, but also have long-term implications for myeloid cell function. Mice were infected with Listeria moncytogenes to analyze the function of myeloid cells. In this case, an inadequate macrophage-dependent clearance of bacterial infections was observed in Col9a1((-/-)) mice in vivo. This was mainly caused by an impaired interferon-gamma/tumor necrosis factor-alpha-mediated activation of macrophages. The loss of collagen IX alpha1 therefore destabilizes the trabecular bone network, impairs myeloid cell differentiation, and affects the innate immune response against Listeria. Stem Cells 2018;36:1752-1763

Published
2018

7. Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function

Author

Probst, Kristina, primary, Stermann, Jacek, additional, Bomhard, Inga, additional, Etich, Julia, additional, Pitzler, Lena, additional, Niehoff, Anja, additional, Bluhm, Björn, additional, Xu, Haifeng C., additional, Lang, Philipp A., additional, Chmielewski, Markus, additional, Abken, Hinrich, additional, Blissenbach, Birgit, additional, Machova, Alzbeta, additional, Papadopoulou, Nikoletta, additional, and Brachvogel, Bent, additional

Published
2018
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8. Depletion of Annexin A5, Annexin A6, and Collagen X Causes No Gross Changes in Matrix Vesicle-Mediated Mineralization, but Lack of Collagen X Affects Hematopoiesis and the Th1/Th2 Response

Author

Grskovic, Ivan, Kutsch, Anna, Frie, Christian, Groma, Gergely, Stermann, Jacek, Schloetzer-Schrehardt, Ursula, Niehoff, Anja, Moss, Stephen E., Rosenbaum, Sabrina, Poeschl, Ernst, Chmielewski, Markus, Rappl, Gunter, Abken, Hinrich, Bateman, John F., Cheah, Kathryn S. E., Paulsson, Mats, Brachvogel, Bent, Grskovic, Ivan, Kutsch, Anna, Frie, Christian, Groma, Gergely, Stermann, Jacek, Schloetzer-Schrehardt, Ursula, Niehoff, Anja, Moss, Stephen E., Rosenbaum, Sabrina, Poeschl, Ernst, Chmielewski, Markus, Rappl, Gunter, Abken, Hinrich, Bateman, John F., Cheah, Kathryn S. E., Paulsson, Mats, and Brachvogel, Bent

Abstract

Numerous biochemical studies have pointed to an essential role of annexin A5 (AnxA5), annexin A6 (AnxA6), and collagen X in matrix vesicle-mediated biomineralization during endochondral ossification and in osteoarthritis. By binding to the extracellular matrix protein collagen X and matrix vesicles, annexins were proposed to anchor matrix vesicles in the extracellular space of hypertrophic chondrocytes to initiate the calcification of cartilage. However, mineralization appears to be normal in mice lacking AnxA5 and AnxA6, whereas collagen X-deficient mice show only subtle alterations in the growth plate organization. We hypothesized that the simultaneous lack of AnxA5, AnxA6, and collagen X in vivo induces more pronounced changes in the growth plate development and the initiation of mineralization. In this study, we generated and analyzed mice deficient for AnxA5, AnxA6, and collagen X. Surprisingly, mice were viable, fertile, and showed no obvious abnormalities. Assessment of growth plate development indicated that the hypertrophic zone was expanded in Col10a1(-/-) and AnxA5(-/-) AnxA6(-/-) Col10a1(-/-) newborns, whereas endochondral ossification and mineralization were not affected in 13-day- and 1-month-old mutants. In peripheral quantitative computed tomography, no changes in the degree of biomineralization were found in femora of 1-month- and 1-year-old mutants even though the diaphyseal circumference was reduced in Col10a1(-/-) and AnxA5(-/-) AnxA6(-/-) Col10a1(-/-) mice. The percentage of naive immature IgM(+)/IgM(+) B cells and peripheral T-helper cells were increased in Col10a1(-/)- and AnxA5(-/-) AnxA6(-/-) Col10a1(-/-) mutants, and activated splenic T cells isolated from Col10a1(-/-) mice secreted elevated levels of IL-4 and GM-CSF. Hence, collagen X is needed for hematopoiesis during endochondral ossification and for the immune response, but the interaction of annexin A5, annexin A6, and collagen X is not essential for physiological calcification of grow

Published
2012

9. Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome

Author

Brachvogel, Bent, primary, Zaucke, Frank, additional, Dave, Keyur, additional, Norris, Emma L., additional, Stermann, Jacek, additional, Dayakli, Münire, additional, Koch, Manuel, additional, Gorman, Jeffrey J., additional, Bateman, John F., additional, and Wilson, Richard, additional

Published
2013
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10. Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response

Author

Grskovic, Ivan, primary, Kutsch, Anna, additional, Frie, Christian, additional, Groma, Gergely, additional, Stermann, Jacek, additional, Schlötzer‐Schrehardt, Ursula, additional, Niehoff, Anja, additional, Moss, Stephen E, additional, Rosenbaum, Sabrina, additional, Pöschl, Ernst, additional, Chmielewski, Markus, additional, Rappl, Gunter, additional, Abken, Hinrich, additional, Bateman, John F, additional, Cheah, Kathryn SE, additional, Paulsson, Mats, additional, and Brachvogel, Bent, additional

Published
2012
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11. Changes in the Chondrocyte and Extracellular Matrix Proteome during Post-natal Mouse Cartilage Development

Author

Wilson, Richard, primary, Norris, Emma L., additional, Brachvogel, Bent, additional, Angelucci, Constanza, additional, Zivkovic, Snezana, additional, Gordon, Lavinia, additional, Bernardo, Bianca C., additional, Stermann, Jacek, additional, Sekiguchi, Kiyotoshi, additional, Gorman, Jeffrey J., additional, and Bateman, John F., additional

Published
2012
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12. Identification of Novel Binding Partners (Annexins) for the Cell Death Signal Phosphatidylserine and Definition of Their Recognition Motif

Author

Rosenbaum, Sabrina, primary, Kreft, Sandra, additional, Etich, Julia, additional, Frie, Christian, additional, Stermann, Jacek, additional, Grskovic, Ivan, additional, Frey, Benjamin, additional, Mielenz, Dirk, additional, Pöschl, Ernst, additional, Gaipl, Udo, additional, Paulsson, Mats, additional, and Brachvogel, Bent, additional

Published
2011
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13. Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status

Author

Belluoccio, Daniele, primary, Etich, Julia, additional, Rosenbaum, Sabrina, additional, Frie, Christian, additional, Grskovic, Ivan, additional, Stermann, Jacek, additional, Ehlen, Harald, additional, Vogel, Simon, additional, Zaucke, Frank, additional, Mark, Klaus von der, additional, Bateman, John F, additional, and Brachvogel, Bent, additional

Published
2010
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