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9 results on '"Sugawara, Takeyuki"'

7. Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions

Author

Saegusa, Shintaro, primary, Fukaya, Masahiro, additional, Kakegawa, Wataru, additional, Tanaka, Manabu, additional, Katsumata, Osamu, additional, Sugawara, Takeyuki, additional, Hara, Yoshinobu, additional, Itakura, Makoto, additional, Okubo, Tadashi, additional, Sato, Toshiya, additional, Yuzaki, Michisuke, additional, and Sakagami, Hiroyuki, additional

Published
2019
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8. IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice

Author

Hisatsune, Chihiro, primary, Miyamoto, Hiroyuki, additional, Hirono, Moritoshi, additional, Yamaguchi, Naohide, additional, Sugawara, Takeyuki, additional, Ogawa, Naoko, additional, Ebisui, Etsuko, additional, Ohshima, Toshio, additional, Yamada, Masahisa, additional, Hensch, Takao K., additional, Hattori, Mitsuharu, additional, and Mikoshiba, Katsuhiko, additional

Published
2013
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9. Type 1 Inositol Trisphosphate Receptor Regulates Cerebellar Circuits by Maintaining the Spine Morphology of Purkinje Cells in Adult Mice.

Author

Sugawara, Takeyuki, Hisatsune, Chihiro, Tung Dinh Le, Hashikawa, Tsutomu, Hirono, Moritoshi, Hattori, Mitsuharu, Nagao, Soichi, and Mikoshiba, Katsuhiko

Subjects
*NEURAL circuitry, *INOSITOL trisphosphate receptors, *BRAIN function localization, *PURKINJE cells, *CEREBELLUM, *ATAXIA, *NEURAL physiology, *LABORATORY mice
Abstract

The structural maintenance of neural circuits is critical for higher brain functions in adulthood. Although several molecules have been identified as regulators for spine maintenance in hippocampal and cortical neurons, it is poorly understood how Purkinje cell (PC) spines are maintained in the mature cerebellum. Here we show that the calcium channel type 1 inositol trisphosphate receptor (IP3R1) in PCs plays a crucial role in controlling the maintenance of parallel fiber (PF)-PC synaptic circuits in the mature cerebellum in vivo. Significantly, adult mice lacking IP3R1 specifically in PCs (L7-Cre;Itpr1flox/flox) showed dramatic increase in spine density and spine length of PCs, despite having normal spines during development. In addition, the abnormally rearranged PF-PC synaptic circuits in mature cerebellum caused unexpectedly severe ataxia in adult L7-Cre;Itprlflox/flox mice. Our findings reveal a specific role for IP3R1 in PCs not only as an intracellular mediator of cerebellar synaptic plasticity induction, but also as a critical regulator of PF-PC synaptic circuit maintenance in the mature cerebellum in vivo; this mechanism may underlie motor coordination and learning in adults. [ABSTRACT FROM AUTHOR]

Published
2013
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