Search

Your search keyword '"Surovaia AN"' showing total 3 results
Start Over Author "Surovaia AN" Search Limiters Full Text
3 results on '"Surovaia AN"'

1. [Estimation of activity of bis-netropsin derivatives based on a model of an experimental cutaneous herpes simplex virus disease of guinea pigs]

Author

Vl, Andronova, Sl, Grokhovskiĭ, An, Surovaia, Gv, Gurskiĭ, Pg, Deriabin, Vov Dk, L., and Georgy Galegov

Subjects
Male, Ointments, Disease Models, Animal, Administration, Topical, Guinea Pigs, Acyclovir, Animals, Herpes Simplex, Netropsin, Herpesvirus 1, Human, Antiviral Agents
Abstract

Using the model of an experimental cutaneous infection of guinea pig males caused by herpes simple virus type 1, it is shown that application of dimerico derivatives of netropsin Lys-bis Nt and 15Lys-bis Nt in the form of polietilenglicol-based ointment suppresses viral infection more effectively than acyclovir.

2. [Research of suppression of the herpes simplex virus reproduction with drug resistance using a combination 15-Lys-bis-Nt with some antiherpetic drugs]

Author

Valeriya Andronova, Sl, Grokhovskiĭ, An, Surovaia, Pg, Deriabin, Gv, Gurskiĭ, and Ga, Galegov

Subjects
Dose-Response Relationship, Drug, Chlorocebus aethiops, Animals, Humans, Herpes Simplex, Herpesvirus 1, Human, Virus Replication, Antiviral Agents, Vero Cells
Abstract

The antiviral effect of combinations of netropsin derivative 15-Lys-bis-Nt with the known antiherpetic compounds, whose activity does not depend on viral TK and which are able to inhibit replication of HSV in most cases, including strains resistant to acyclovir and pencyclovir, was studied. The combinations evoking additive, synergistic and significant synergistic effects of interaction of tested compounds were observed. The results obtained in this work indicated the possibility of significant reduction of concentrations of high toxic compounds in case of the combined use.

3. [The suppression of a herpes simplex virus reproduction with drug resistance by combination 15lys-bis-nt and phosphate of acycloguanosine with some antiherpetic drugs]

Author

Vl, Andronova, Sl, Grokhovskiĭ, Pg, Deriabin, Gv, Gurskiĭ, An, Surovaia, Mv, Jas Ko, Mk, Kukhanova, Sn, Kochetkov, Skoblov IuS, and Georgy Galegov

Subjects
Chlorocebus aethiops, Drug Resistance, Viral, Acyclovir, Animals, Simplexvirus, Drug Synergism, Herpes Simplex, Virus Replication, Antiviral Agents, Vero Cells
Abstract

Antiherpetic activity of the double and triple combinations, including original connections 15Lys-bis-Nt and phosphate of acycloguanosine (P-ACG), was studied in vitro. For the first time, it was demonstrated that in case of their combined use with known antiherpetic agents, whose activity does not depend on TK of HSV (PFA, AraA, CDV, Rib, GLN, αa-IFN), synergistic or additive effects of interaction was observed. The antiviral effect of the tested combinations was studied on the model of ACG-resistant viral strain. The tested combinations could be of interest for practical medicine.

Catalog

Books, media, physical & digital resources
See catalog results