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2 results on '"Sutton TD"'

1. VIGA: a sensitive, precise and automatic de novo VIral Genome Annotator

Author

Sean Sutton Td, Velayudhan, Colin Hill, Lorraine A. Draper, Andrey N. Shkoporov, R.P. Ross, Enrique González-Tortuero, and Stockdale

Subjects
Viral metagenomics, ComputingMethodologies_PATTERNRECOGNITION, Viral genomes, viruses, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Genomics, Genome project, Computational biology, Biology, Genome
Abstract

Viral (meta)genomics is a rapidly growing field of study that is hampered by an inability to annotate the majority of viral sequences; therefore, the development of new bioinformatic approaches is very important. Here, we present a new automatic de novo genome annotation pipeline, called VIGA, to annotate prokaryotic and eukaryotic viral sequences from (meta)genomic studies. VIGA was benchmarked on a database of known viral genomes and a viral metagenomics case study. VIGA generated the most accurate outputs according to the number of coding sequences and their coordinates, outputs also had a lower number of non-informative annotations compared to other programs.

Published
2018
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2. Use of immunostains to ABH blood group antigens to resolve problems in identity of tissue specimens.

Author

Ritter JH, Sutton TD, and Wick MR

Subjects
Humans, Specimen Handling, ABO Blood-Group System immunology, Artifacts, Immunohistochemistry
Abstract

Identification of contaminating tissue fragments as "floaters" is a common problem in surgical pathology. They may be introduced at several steps in the processing of specimens, and they are capable of causing interpretative consternation. Using immunohistochemistry with monoclonal antibodies to blood group isoantigens A, B, and H, we studied nine cases in which floaters were present. In five of the study cases, discordant blood group immunostains allowed identification of the artifactual tissue fragments. By chance, the other four specimens contained probable floaters from patients whose blood groups were concordant with those from whom the "native" tissue had been obtained. These results indicate that in some instances, blood group immunostains may resolve interpretative difficulties surrounding floaters. It is likely that application of immunostains, directed at additional blood group antigens, will extend the utility of this procedure.

Published
1994

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