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26 results on '"Tárnoki, Dávid László"'

10. Clinical Predictors of Lung-Function Decline in Systemic-Sclerosis-Associated Interstitial Lung Disease Patients with Normal Spirometry

Author

Nagy, Tamas, primary, Toth, Nora Melinda, additional, Palmer, Erik, additional, Polivka, Lorinc, additional, Csoma, Balazs, additional, Nagy, Alexandra, additional, Eszes, Noémi, additional, Vincze, Krisztina, additional, Bárczi, Enikő, additional, Bohács, Anikó, additional, Tárnoki, Ádám Domonkos, additional, Tárnoki, Dávid László, additional, Nagy, György, additional, Kiss, Emese, additional, Maurovich-Horvát, Pál, additional, and Müller, Veronika, additional

Published
2022
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11. Genetic and environmental factors on the relation of lung function and arterial stiffness

Author

Tarnoki, David Laszlo, Tarnoki, Adam Domonkos, Lazar, Zsofia, Medda, Emanuela, Littvay, Levente, Cotichini, Rodolfo, Fagnani, Corrado, Stazi, Maria Antonietta, Nisticó, Lorenza, Lucatelli, Pierleone, Boatta, Emanuele, Zini, Chiara, Fanelli, Fabrizio, Baracchini, Claudio, Meneghetti, Giorgio, Jermendy, Gyorgy, Préda, István, Kiss, Róbert Gábor, Karlinger, Kinga, Lannert, Agnes, Schillaci, Giuseppe, Molnar, Andrea Agnes, Garami, Zsolt, Berczi, Viktor, and Horvath, Ildiko

Published
2013
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15. Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study

Author

Molnár, Andrea Ágnes, primary, Kolossváry, Márton, additional, Lakatos, Bálint, additional, Tokodi, Márton, additional, Tárnoki, Ádám Domonkos, additional, Tárnoki, Dávid László, additional, Kovács, Attila, additional, Szilveszter, Bálint, additional, Voros, Szilard, additional, Jermendy, György, additional, Maurovich-Horvat, Pál, additional, and Merkely, Béla, additional

Published
2021
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16. The role of imaging in the diagnosis and management of idiopathic pulmonary fibrosis.

Author

NARDOCCI, CHIARA, SIMON, JUDIT, KISS, FANNI, GYÖRKE, TAMÁS, SZÁNTÓ, PÉTER, TÁRNOKI, ÁDÁM DOMONKOS, TÁRNOKI, DÁVID LÁSZLÓ, MÜLLER, VERONIKA, and MAUROVICH-HORVAT, PÁL

Subjects
IDIOPATHIC pulmonary fibrosis, DIAGNOSTIC imaging, SYMPTOMS, COMPUTED tomography, MAGNETIC resonance imaging
Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease lacking a definite etiology, characterized by the nonspecific symptoms of dyspnea and dry cough. Due to its poor prognosis, imaging techniques play an essential role in diagnosing and managing IPF. High resolution computed tomography (HRCT) has been shown to be the most sensitive modality for the diagnosis of pulmonary fibrosis. It is the primary imaging modality used for the assessment and follow-up of patients with IPF. Other not commonly used imaging methods are under research, such as ultrasound, magnetic resonance imaging and positron emission tomography-computed tomography are alternative imaging techniques. This literature review aims to provide a brief overview of the imaging of IPF-related alterations. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Positive association and future perspectives of mitochondrial DNA copy number and telomere length - a pilot twin study.

Author

Melicher, Dóra, Illés, Anett, Littvay, Levente, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Bikov, András, Kunos, László, Csabán, Dóra, Buzás, Edit Irén, Molnár, Mária Judit, and Falus, András

Subjects
MITOCHONDRIAL DNA, MITOCHONDRIAL pathology, TELOMERES, TWIN studies, INTRACLASS correlation, PILOT projects
Abstract

Introduction: Recent experimental and population studies have highlighted the existence of telomere-mitochondria interplay. Besides studies revealing the molecular mechanisms underlying the associations of telomere defects and mitochondrial functions, investigations of mitochondrial DNA copy number (mtDNAcn) and telomere length (TL) in healthy and disease phenotypes have likewise begun, with the aim of gaining more insights about their relationship in humans.Material and Methods: A total of 142 asymptomatic adult twins, comprising 96 monozygotic (MZ) and 46 dizygotic (DZ) twins (mean age: 50.54 ±15.43 years), members of the Hungarian Twin Registry, were included in the analysis. Applying the qPCR standard curve method, we investigated the relationship of mtDNA copy number, telomere length and clinical data, besides assessing co-twin similarities of MZ and DZ twins for their mtDNAcn and TL measures.Results: We found that twins were similar in their intraclass correlation coefficients irrespective of zygosity, suggesting a possibly more important role of common (shared) environmental factors compared to non-shared (unique) environmental and to a smaller degree also individual genetic influences. We confirmed a significant positive association between mtDNAcn and TL (r = 0.28, p < 0.01) in age- and sex-corrected analysis. Following bivariate estimates and correction with significant predictors, the independent positive associations were further verified.Conclusions: Our results extend the until now modest number of studies investigating mtDNAcn and TL simultaneously in humans. In addition, we are the first to examine the relationship between mtDNAcn and telomere length in MZ and DZ twin subjects. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Genetically determined pattern of left ventricular function in normal and hypertensive hearts

Author

Kovács, Attila, primary, Molnár, Andrea Ágnes, additional, Kolossváry, Márton, additional, Szilveszter, Bálint, additional, Panajotu, Alexisz, additional, Lakatos, Bálint Károly, additional, Littvay, Levente, additional, Tárnoki, Ádám Domonkos, additional, Tárnoki, Dávid László, additional, Voros, Szilard, additional, Jermendy, György, additional, Sengupta, Partho P., additional, Merkely, Béla, additional, and Maurovich-Horvat, Pál, additional

Published
2018
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19. Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the CODATwins study

Author

Silventoinen, Karri, Lachance, Geneviève, Jelenkovic, Aline, Boivin, Michel, Sund, Reijo, Fradette, Catherine, Hur, Yoon-Mi, Dionne, Ginette, Yokoyama, Yoshie, Dubois, Lise, Honda, Chika, Hjelmborg, Jacob B., Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Fuling, Ji, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly Jane, Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin, Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Vlietinck, Robert, Loos, Ruth, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Stazi, Maria Antonietta, Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, L. J., Maes, Hermine H., Krueger, Robert F., McGue, Matthew, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, Beijsterveldt, C. E. M. van, Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, José António, Brendgen, Mara Rosemarie, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik, Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot Max, Öncel, Sevgi Y., Aliev, Fazil, Spector, T. D., Mangino, Massimo, Baker, Laura Ann, Tuvblad, Catherine, Silventoinen, Karri, Lachance, Geneviève, Jelenkovic, Aline, Boivin, Michel, Sund, Reijo, Fradette, Catherine, Hur, Yoon-Mi, Dionne, Ginette, Yokoyama, Yoshie, Dubois, Lise, Honda, Chika, Hjelmborg, Jacob B., Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Fuling, Ji, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly Jane, Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin, Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Vlietinck, Robert, Loos, Ruth, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Stazi, Maria Antonietta, Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, L. J., Maes, Hermine H., Krueger, Robert F., McGue, Matthew, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, Beijsterveldt, C. E. M. van, Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, José António, Brendgen, Mara Rosemarie, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik, Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot Max, Öncel, Sevgi Y., Aliev, Fazil, Spector, T. D., Mangino, Massimo, Baker, Laura Ann, and Tuvblad, Catherine

Abstract

BACKGROUND: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. OBJECTIVES: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. DESIGN: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. RESULTS: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. CONCLUSIONS: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

Published
2017

20. Tight co-twin similarity of monozygotic twins for hTERT protein level of T cell subsets, for telomere length and mitochondrial DNA copy number, but not for telomerase activity

Author

Melicher, Dóra, primary, Illés, Anett, additional, Pállinger, Éva, additional, Kovács, Árpád Ferenc, additional, Littvay, Levente, additional, Tárnoki, Ádám Domonkos, additional, Tárnoki, Dávid László, additional, Bikov, András, additional, Molnár, Mária Judit, additional, Buzás, Edit Irén, additional, and Falus, András, additional

Published
2017
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21. Van-e összefüggés az epikardiális zsírszövet és a koszorúér-betegség között?

Author

Drobni, Zsófia Dóra, primary, Kolossváry, Márton, additional, Karády, Júlia, additional, Jermendy, Ádám, additional, Littvay, Levente, additional, Tárnoki, Ádám Domonkos, additional, Tárnoki, Dávid László, additional, Voros, Szilard, additional, Jermendy, György, additional, Merkely, Béla, additional, and Maurovich-Horvat, Pál, additional

Published
2017
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22. Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the CODATwins study

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob B., Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Fuling, Ji, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly Jane, Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin, Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Derom, Catherine, Vlietinck, Robert, Loos, Ruth, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Stazi, Maria Antonietta, Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, L. J., Maes, Hermine H., Krueger, Robert F., McGue, Matthew, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, Beijsterveldt, C. E. M. van, Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, José António, Dubois, Lise, Boivin, Michel, Brendgen, Mara Rosemarie, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik, Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot Max, Öncel, Sevgi Y., Aliev, Fazil, Spector, T. D., Mangino, Massimo, Lachance, Geneviève, Baker, Laura Ann, Tuvblad, Catherine, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob B., Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Fuling, Ji, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly Jane, Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin, Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Derom, Catherine, Vlietinck, Robert, Loos, Ruth, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Stazi, Maria Antonietta, Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, L. J., Maes, Hermine H., Krueger, Robert F., McGue, Matthew, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, Beijsterveldt, C. E. M. van, Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, José António, Dubois, Lise, Boivin, Michel, Brendgen, Mara Rosemarie, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik, Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot Max, Öncel, Sevgi Y., Aliev, Fazil, Spector, T. D., Mangino, Massimo, Lachance, Geneviève, Baker, Laura Ann, and Tuvblad, Catherine

Abstract

BACKGROUND: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. OBJECTIVES: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. DESIGN: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. RESULTS: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. CONCLUSIONS: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

Published
2016

23. Heritability of Venous Biomechanics

Author

Molnár, Andrea Àgnes, primary, Tárnoki, Àdám Domonkos, additional, Tárnoki, Dávid László, additional, Kulcsár, Zoltán, additional, Littvay, Levente, additional, Garami, Zsolt, additional, Préda, István, additional, Kiss, Róbert Gábor, additional, Bérczi, Viktor, additional, Lannert, Àgnes, additional, Monos, Emil, additional, and Nádasy, György László, additional

Published
2013
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24. Hypertrophic Cardiomyopathy in a Monozygotic Twin Pair.

Author

Kovács, Attila, Molnár, Andrea Ágnes, Celeng, Csilla, Tóth, Attila, Vágó, Hajnalka, Apor, Astrid, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Kósa, János, Lakatos, Péter, Voros, Szilard, Jermendy, György, Merkely, Béla, and Maurovich-Horvat, Pál

Published
2016
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25. Lung imaging methods: indications, strengths and limitations.

Author

Tárnoki DL, Karlinger K, Ridge CA, Kiss FJ, Györke T, Grabczak EM, and Tárnoki ÁD

Abstract

Imaging methods are fundamental tools to detect and diagnose lung diseases, monitor their treatment and detect possible complications. Each modality, starting from classical chest radiographs and computed tomography, as well as the ever more popular and easily available thoracic ultrasound, magnetic resonance imaging and nuclear medicine methods, and new techniques such as photon counting computed tomography, radiomics and application of artificial intelligence, has its strong and weak points, which we should be familiar with to properly choose between the methods and interpret their results. In this review, we present the indications, strengths and main limitations of methods for chest imaging., Competing Interests: Conflict of interest: E.M. Grabczak is a current member of the Breathe editorial board. C.A. Ridge discloses that Cobalt Charity has provided her institution with an education grant to fund a fellow, she is the RSNA Image Wisely co-chair, a ECR Thoracic educational committee member, a European Society of Thoracic Imaging educational committee member and Lung Cancer Journal radiology editor. She is the Director of AI Radiology limited (radiology reporting services). Á.D. Tárnoki is the current chair of the ERS Imaging group. The other authors declare that there is no conflict of interest., (Copyright ©ERS 2024.)

Published
2024
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26. Positive association and future perspectives of mitochondrial DNA copy number and telomere length - a pilot twin study.

Author

Melicher D, Illés A, Littvay L, Tárnoki ÁD, Tárnoki DL, Bikov A, Kunos L, Csabán D, Buzás EI, Molnár MJ, and Falus A

Abstract

Introduction: Recent experimental and population studies have highlighted the existence of telomere-mitochondria interplay. Besides studies revealing the molecular mechanisms underlying the associations of telomere defects and mitochondrial functions, investigations of mitochondrial DNA copy number (mtDNAcn) and telomere length (TL) in healthy and disease phenotypes have likewise begun, with the aim of gaining more insights about their relationship in humans., Material and Methods: A total of 142 asymptomatic adult twins, comprising 96 monozygotic (MZ) and 46 dizygotic (DZ) twins (mean age: 50.54 ±15.43 years), members of the Hungarian Twin Registry, were included in the analysis. Applying the qPCR standard curve method, we investigated the relationship of mtDNA copy number, telomere length and clinical data, besides assessing co-twin similarities of MZ and DZ twins for their mtDNAcn and TL measures., Results: We found that twins were similar in their intraclass correlation coefficients irrespective of zygosity, suggesting a possibly more important role of common (shared) environmental factors compared to non-shared (unique) environmental and to a smaller degree also individual genetic influences. We confirmed a significant positive association between mtDNAcn and TL ( r = 0.28, p < 0.01) in age- and sex-corrected analysis. Following bivariate estimates and correction with significant predictors, the independent positive associations were further verified., Conclusions: Our results extend the until now modest number of studies investigating mtDNAcn and TL simultaneously in humans. In addition, we are the first to examine the relationship between mtDNAcn and telomere length in MZ and DZ twin subjects., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2019 Termedia & Banach.)

Published
2019
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