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21 results on '"Takahashi, Chisato"'

3. Prevalence of thyroid diffuse goiter and its association with body mass index and the presence of cysts and nodules in children and adolescents: the Fukushima Health Management Survey

Author

Nakahata, Nana, primary, Asano, Mahiro, additional, Abe, Norikazu, additional, Ejiri, Haruka, additional, Ota, Hisashi, additional, Suzuki, Satoshi, additional, Sato, Ayako, additional, Tazaki, Rina, additional, Nagamine, Natsuki, additional, Takahashi, Chisato, additional, Yamaya, Yukie, additional, Iwadate, Manabu, additional, Matsuzuka, Takashi, additional, Ohira, Tetsuya, additional, Yasumura, Seiji, additional, Suzuki, Satoru, additional, Furuya, Fumihiko, additional, Shimura, Hiroki, additional, Suzuki, Shinichi, additional, Yokoya, Susumu, additional, Ohto, Hitoshi, additional, and Kamiya, Kenji, additional

Published
2024
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4. Stress hormones predict hyperbolic time-discount rates six months later in adults

Author

Takahashi, Taiki, Shinada, Mizuho, Inukai, Keigo, Tanida, Shigehito, Takahashi, Chisato, Mifune, Nobuhiro, Takagishi, Haruto, Horita, Yutaka, Hashimoto, Hirofumi, Yokota, Kunihiro, Kameda, Tatsuya, and Yamagishi, Toshio

Subjects
Quantitative Biology - Neurons and Cognition, Quantitative Biology - Other Quantitative Biology
Abstract

Objectives: Stress hormones have been associated with temporal discounting. Although time-discount rate is shown to be stable over a long term, no study to date examines whether individual differences in stress hormones could predict individuals' time-discount rates in the relatively distant future (e.g., six month later), which is of interest in neuroeconomics of stress-addiction association. Methods: We assessed 87 participants' salivary stress hormone (cortisol, cortisone, and alpha-amylase) levels and hyperbolic discounting of delayed rewards consisting of three magnitudes, at the time-interval of six months. For salivary steroid assays, we employed a liquid chromatography/ mass spectroscopy (LC/MS) method. The correlations between the stress hormone levels and time-discount rates were examined. Results: We observed that salivary alpha-amylase (sAA) levels were negatively associated with time-discount rates in never-smokers. Notably, salivary levels of stress steroids (i.e., cortisol and cortisone) negatively and positively related to time-discount rates in men and women, respectively, in never-smokers. Ever-smokers' discount rates were not predicted from these stress hormone levels. Conclusions: Individual differences in stress hormone levels predict impulsivity in temporal discounting in the future. There are sex differences in the effect of stress steroids on temporal discounting; while there was no sex defference in the relationship between sAA and temporal discounting.

Published
2011

6. Ultrasonography-based reference values for the cross-sectional area of the thyroid gland in children and adolescents: The Fukushima Health Management Survey

Author

Ejiri, Haruka, primary, Asano, Mahiro, additional, Nakahata, Nana, additional, Suzuki, Satoshi, additional, Sato, Ayako, additional, Nagamine, Natsuki, additional, Takahashi, Chisato, additional, Yamaya, Yukie, additional, Iwadate, Manabu, additional, Matsuzuka, Takashi, additional, Ohira, Tetsuya, additional, Yasumura, Seiji, additional, Suzuki, Satoru, additional, Furuya, Fumihiko, additional, Shimura, Hiroki, additional, Suzuki, Shinichi, additional, Yokoya, Susumu, additional, Ohto, Hitoshi, additional, and Kamiya, Kenji, additional

Published
2023
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11. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation

Author

Oda, Yukako, primary, Takahashi, Chisato, additional, Harada, Shota, additional, Nakamura, Shun, additional, Sun, Daxiao, additional, Kiso, Kazumi, additional, Urata, Yuko, additional, Miyachi, Hitoshi, additional, Fujiyoshi, Yoshinori, additional, Honigmann, Alf, additional, Uchida, Seiichi, additional, Ishihama, Yasushi, additional, and Toyoshima, Fumiko, additional

Published
2021
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13. Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin

Author

Muramatsu, Rieko, Takahashi, Chisato, Miyake, Shuzo, Fujimura, Harutoshi, Mochizuki, Hideki, and Yamashita, Toshihide

Subjects
Inflammation -- Risk factors -- Development and progression -- Genetic aspects -- Research, Prostacyclin -- Physiological aspects -- Genetic aspects -- Research, Central nervous system -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Angiogenesis is a prominent feature of central nervous system (CNS) disease and has roles in both the continued promotion of inflammation and the subsequent repair processes. Here we report that prostacyclin (or prostaglandin [I.sub.2] ([PGI.sub.2])) derived from new vessels promotes axonal remodeling of injured neuronal networks after CNS inflammation. In a localized model of experimental autoimmune encephalomyelitis (EAE), new vessels formed around the inflammatory lesion, followed by sprouting of adjacent corticospinal tract (CST) fibers. These sprouting fibers formed a compensatory motor circuit, leading to recovery of motor function. Capillary endothelial cell--derived prostacyclin bound to its receptor, the type I prostaglandin receptor (IP receptor), on CST neurons, promoting sprouting of CST fibers and contributing to the repair process. Inhibition of prostacyclin receptor signaling impaired motor recovery, whereas the IP receptor agonist iloprost promoted axonal remodeling and motor recovery after the induction of EAE. These findings reveal an important function of angiogenesis in neuronal rewiring and suggest that prostacyclin is a promising molecule for enhancing functional recovery from CNS disease., CNS inflammation leads to the disruption of intricate neural net-works, causing deficits in motor, sensory, cognitive and other functions (1). However, these deficits are often followed by limited, but substantial, [...]

Published
2012
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14. Biophysical Parameters of the Sec14 Phospholipid Exchange Cycle

Author

Sugiura, Taichi, primary, Takahashi, Chisato, additional, Chuma, Yusuke, additional, Fukuda, Masakazu, additional, Yamada, Makiko, additional, Yoshida, Ukyo, additional, Nakao, Hiroyuki, additional, Ikeda, Keisuke, additional, Khan, Danish, additional, Nile, Aaron H., additional, Bankaitis, Vytas A., additional, and Nakano, Minoru, additional

Published
2019
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21. A Short Peptide Derived from the ZorO Toxin Functions as an Effective Antimicrobial.

Author

Otsuka, Yuichi, Ishikawa, Tomohiro, Takahashi, Chisato, and Masuda, Michiaki

Subjects
PEPTIDE antibiotics, ESCHERICHIA coli O157:H7, TOXINS, GRAM-positive bacteria, GRAM-negative bacteria, CELL membranes
Abstract

Antimicrobial peptides are potential molecules for the development of novel antibiotic agents. The ZorO toxin of a type I toxin–antitoxin system in Escherichia coli O157:H7 is composed of 29 amino acids and its endogenous expression inhibits E. coli growth. However, little is known about its inhibitory mechanism. In this study, we demonstrate that the ZorO localized in the inner membrane affects the plasma membrane integrity and potential when expressed in E. coli cells, which triggers the production of cytotoxic hydroxyl radicals. We further show that five internal amino acids (Ala–Leu–Leu–Arg–Leu; ALLRL) of ZorO are necessary for its toxicity. This result prompted us to address the potential of the synthetic ALLRL peptide as an antimicrobial. Exogenously-added ALLRL peptide to Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and a fungus, Candida albicans, trigger cell membrane damage and exhibit growth defect, while having no effect on Gram-negative bacterium, E. coli. The ALLRL peptide retains its activity under the physiological salt concentrations, which is in contrast to natural antimicrobial peptides. Importantly, this peptide has no toxicity against mammalian cells. Taken together, an effective and short peptide, ALLRL, would be an attractive antimicrobial to Gram-positive bacteria and C. albicans. [ABSTRACT FROM AUTHOR]

Published
2019
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