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1,012 results on '"Tanaka, Kenichi A."'

9. Rationale and design of an investigator-initiated, multicenter, prospective, placebo-controlled, double-blind, randomized trial to evaluate the effects of finerenone on vascular stiffness and cardiorenal biomarkers in type 2 diabetes and chronic kidney disease (FIVE-STAR)

Author

Tanaka, Atsushi, Shibata, Hirotaka, Imai, Takumi, Yoshida, Hisako, Miyazono, Motoaki, Takahashi, Naohiko, Fukuda, Daiju, Okada, Yosuke, Teragawa, Hiroki, Suwa, Satoru, Kida, Keisuke, Moroi, Masao, Taguchi, Isao, Toyoda, Shigeru, Shimabukuro, Michio, Tanabe, Kengo, Tanaka, Kenichi, Nangaku, Masaomi, and Node, Koichi

Published
2023
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13. Achieving Explainability for Plant Disease Classification with Disentangled Variational Autoencoders

Author

Habaragamuwa, Harshana, Oishi, Yu, and Tanaka, Kenichi

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, I.2.6, I.2.10, I.2.1
Abstract

Agricultural image recognition tasks are becoming increasingly dependent on deep learning (DL); however, despite the excellent performance of DL, it is difficult to comprehend the type of logic or features of the input image it uses during decision making. Knowing the logic or features is highly crucial for result verification, algorithm improvement, training data improvement, and knowledge extraction. However, the explanations from the current heatmap-based algorithms are insufficient for the abovementioned requirements. To address this, this paper details the development of a classification and explanation method based on a variational autoencoder (VAE) architecture, which can visualize the variations of the most important features by visualizing the generated images that correspond to the variations of those features. Using the PlantVillage dataset, an acceptable level of explainability was achieved without sacrificing the classification accuracy. The proposed method can also be extended to other crops as well as other image classification tasks. Further, application systems using this method for disease identification tasks, such as the identification of potato blackleg disease, potato virus Y, and other image classification tasks, are currently being developed., Comment: 55 pages, 24 figures, 2 tables

Published
2021

14. Stochastic Threshold Model Trees: A Tree-Based Ensemble Method for Dealing with Extrapolation

Author

Numata, Kohei and Tanaka, Kenichi

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning, I.6.5
Abstract

In the field of chemistry, there have been many attempts to predict the properties of unknown compounds from statistical models constructed using machine learning. In an area where many known compounds are present (the interpolation area), an accurate model can be constructed. In contrast, data in areas where there are no known compounds (the extrapolation area) are generally difficult to predict. However, in the development of new materials, it is desirable to search this extrapolation area and discover compounds with unprecedented physical properties. In this paper, we propose Stochastic Threshold Model Trees (STMT), an extrapolation method that reflects the trend of the data, while maintaining the accuracy of conventional interpolation methods. The behavior of STMT is confirmed through experiments using both artificial and real data. In the case of the real data, although there is no significant overall improvement in accuracy, there is one compound for which the prediction accuracy is notably improved, suggesting that STMT reflects the data trends in the extrapolation area. We believe that the proposed method will contribute to more efficient searches in situations such as new material development., Comment: Code is available at https://github.com/funatsu-lab/Stochastic-Threshold-Model-Trees

Published
2020

15. Defining heparin resistance: communication from the ISTH SSC Subcommittee of Perioperative and Critical Care Thrombosis and Hemostasis

Author

Levy, Jerrold H., Sniecinski, Roman M., Rocca, Bianca, Ghadimi, Kamrouz, Douketis, James, Frere, Corinne, Helms, Julie, Iba, Toshiaki, Koster, Andreas, Lech, Tara K., Maier, Cheryl L., Neal, Mathew D., Scarlestscu, Ecatarina, Spyropoulos, Alex, Steiner, Marie E., Tafur, Alfonso J., Tanaka, Kenichi A., and Connors, Jean M.

Published
2023
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18. Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine

Author

Gondoh, Eizoh, Hamada, Yusuke, Mori, Tomohisa, Iwazawa, Yusuke, Shinohara, Asami, Narita, Michiko, Sato, Daisuke, Tezuka, Hiroyuki, Yamauchi, Takayasu, Tsujimura, Mayu, Yoshida, Sara, Tanaka, Kenichi, Yamashita, Kensuke, Akatori, Haruka, Higashiyama, Kimio, Arakawa, Kazuhiko, Suda, Yukari, Miyano, Kanako, Iseki, Masako, Inada, Eiichi, Kuzumaki, Naoko, and Narita, Minoru

Published
2022
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34. Texture Features of 18F-Fluorodeoxyglucose Positron Emission Tomography for Predicting Programmed Death-Ligand-1 Levels in Non-Small Cell Lung Cancer

Author

Norikane, Takashi, primary, Ishimura, Mariko, additional, Mitamura, Katsuya, additional, Yamamoto, Yuka, additional, Arai-Okuda, Hanae, additional, Manabe, Yuri, additional, Murao, Mitsumasa, additional, Morita, Riku, additional, Obata, Takafumi, additional, Tanaka, Kenichi, additional, Murota, Makiko, additional, Kanaji, Nobuhiro, additional, and Nishiyama, Yoshihiro, additional

Published
2024
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39. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis

Author

Fujimaru, Takuya, Kawanishi, Kunio, Mori, Takayasu, Mishima, Eikan, Sekine, Akinari, Chiga, Motoko, Mizui, Masayuki, Sato, Noriaki, Yanagita, Motoko, Ooki, Yuki, Nagahama, Kiyotaka, Ohnuki, Yuko, Hamano, Naoto, Watanabe, Saki, Mochizuki, Toshio, Nagatsuji, Katsushi, Tanaka, Kenichi, Tsukamoto, Tatsuo, Tsushima, Hideo, Shimamoto, Mamiko, Tsuji, Takahiro, Kuyama, Tamaki, Kawamoto, Shinya, Maki, Kenji, Katsuma, Ai, Oishi, Mariko, Yamamoto, Kouhei, Mandai, Shintaro, Kikuchi, Hiroaki, Ando, Fumiaki, Mori, Yutaro, Susa, Koichiro, Iimori, Soichiro, Naito, Shotaro, Rai, Tatemitsu, Hoshino, Junichi, Ubara, Yoshifumi, Miyazaki, Mariko, Nagata, Michio, Uchida, Shinichi, and Sohara, Eisei

Published
2021
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42. Comparative effects of fixed‐dose mitiglinide/voglibose combination and glimepiride on vascular endothelial function and glycemic variability in patients with type 2 diabetes: A randomized controlled trial.

Author

Tanaka, Kenichi, Okada, Yosuke, Umezu, Saeko, Hashimoto, Ryoma, Tomoyose, Yukiko, Tateyama, Rina, Hori, Yuri, Saito, Momo, Tokutsu, Akemi, Sonoda, Satomi, Uemura, Fumi, Kurozumi, Akira, and Tanaka, Yoshiya

Subjects
*TYPE 2 diabetes, *CONTINUOUS glucose monitoring, *RANDOMIZED controlled trials, *BLOOD sugar, *HYPEREMIA
Abstract

Introduction: The aim of this study was to compare the effects of mitiglinide/voglibose with those of glimepiride on glycemic variability and vascular endothelial function in patients with type 2 diabetes. Materials and Methods: It was a multicenter, open‐label, randomized, crossover study. Hospitalized patients received either mitiglinide/voglibose (three times daily administration of 10 mg mitiglinide and 0.2 mg voglibose) or glimepiride (once‐daily 2 mg) in random order, each for 5 days. The reactive hyperemia index (RHI) and the mean amplitude of glycemic excursions (MAGE) were measured as co‐primary endpoints using reactive hyperemia peripheral arterial tonometry and continuous glucose monitoring. Results: The analysis included 30 patients (15 in each group). The RHI was 1.670 ± 0.369 during treatment with mitiglinide/voglibose and 1.716 ± 0.492 during treatment with glimepiride, with no significant difference between the two. MAGE was significantly lower in the mitiglinide/voglibose group (47.6 ± 18.5 mg/dL) than in the glimepiride group (100.6 ± 32.2 mg/dL). Although the mean blood glucose levels over the entire 24 h period were comparable between the two groups, the use of mitiglinide/voglibose was associated with a lower standard deviation of mean glucose, coefficient of variation, and mean postprandial glucose excursion compared with glimepiride. The time below range (<70 mg/dL) and the time above range (>180, >200, and 250 mg/dL) were lower in the mitiglinide/voglibose group, while the time in range (70–180 mg/dL) was higher. Conclusions: In our short‐duration randomized crossover study, although not impacting vascular endothelial function, mitiglinide/voglibose demonstrated potential benefits in reducing glycemic variability, postprandial hyperglycemia, and hypoglycemia in patients with type 2 diabetes. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Comparative effects of fixed‐dose mitiglinide/voglibose combination and glimepiride on vascular endothelial function and glycemic variability in patients with type 2 diabetes: A randomized controlled trial

Author

Tanaka, Kenichi, primary, Okada, Yosuke, additional, Umezu, Saeko, additional, Hashimoto, Ryoma, additional, Tomoyose, Yukiko, additional, Tateyama, Rina, additional, Hori, Yuri, additional, Saito, Momo, additional, Tokutsu, Akemi, additional, Sonoda, Satomi, additional, Uemura, Fumi, additional, Kurozumi, Akira, additional, and Tanaka, Yoshiya, additional

Published
2023
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