4,095 results on '"Taylor, E"'
Search Results
2. Perspectives on Arts Entrepreneurship, Part 1
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Taylor, E. Andrew, Bonin-Rodriguez, Paul, and Essig, Linda
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- 2022
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3. A Comprehensive Investigation of Environmental Influences on Galaxies in Group Environments
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Van Kempen, W., Cluver, M. E., Jarrett, T. H., Croton, D. J., Lambert, T. S., Kilborn, V. A., Taylor, E. N., Magoulas, C., and Yao, H. F. M.
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Astrophysics - Astrophysics of Galaxies - Abstract
Environment has long been known to impact the evolution of galaxies, but disentangling its effects from mass evolution requires careful analysis of statistically significant samples. By implementing advanced visualisation methods to test group-finding algorithms, we utilise a mass-complete sample of galaxies to z < 0.1, comprising spectroscopic redshifts from prominent surveys such as the 2dFGRS and GAMA. Our group-finding methods identify 1,413 galaxy groups made up of 8,990 galaxies, corresponding to 36% of galaxies associated with group environments. We also search for close pairs, with separations of $r_{sep}$ < 50 h$^{-1}$ kpc and $v_{sep}$ < 500 km/s, and classify them into major ($M_{sec}/M_{prim} \leq$ 0.25) and minor ($M_{sec}/M_{prim}$ > 0.25) pairs. To examine the impact of environmental factors, we employ bespoke WISE photometry to derive a star-forming main sequence relation that shows star-formation (SF) within galaxies is pre-processed as a function of group membership. Our analysis reveals that SF in galaxies is pre-processed as a function of group membership. We observe an increase in the fraction of quiescent galaxies relative to the field as group membership rises, quantified using the environmental quenching efficiency metric ($\epsilon_{env}$). Within the star-forming population, we detect pre-processing with the relative difference in specific SF rates (${\Delta} sSFR$), showing a net decrease in SF as group membership increases, particularly at larger stellar masses. Our sample of close pairs at low stellar masses shows enhanced SF efficiencies compared to the field, while at larger masses, deficiencies are evident. Our results indicate that the small-scale environments of galaxies influence SF properties, demonstrating that galaxies do not evolve in isolation over cosmic time but are shaped by complex interactions between internal dynamics and external influences., Comment: Accepted by PASA 17/10/2024. 24 pages, 22 figures, 5 tables. Abridged abstract
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- 2024
4. Harmonically Induced Shape Morphing of Bistable Buckled Beam with Static Bias
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Hasan, Md Nahid, Paul, Sharat, Greenwood, Taylor E., Parker, Robert G., Kong, Yong Lin, and Wang, Pai
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Nonlinear Sciences - Chaotic Dynamics - Abstract
We investigate the effect of a constant static bias force on the dynamically induced shape morphing of a pre-buckled bistable beam, focusing on the beam's ability to change its vibration to be near different stable states under harmonic excitation. Our study explores four categories of oscillatory motions: switching, reverting, vacillating, and intra-well in the parameter space. We aim to achieve transitions between stable states of the pre-buckled bistable beam with minimal excitation amplitude. Our findings demonstrate the synergistic effects between dynamic excitation and static bias force, showing a broadening of the non-fractal region for switching behavior (i.e., switching from the first stable state to the second stable state) in the parameter space. This study advances the understanding of the dynamics of key structural components for multi-stable mechanical metamaterials, offering new possibilities for novel designs in adaptive applications.
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- 2024
5. Calibrating the Absolute Magnitude of Type Ia Supernovae in Nearby Galaxies using [OII] and Implications for $H_{0}$
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Dixon, M., Mould, J., Lidman, C., Taylor, E. N., Flynn, C., Duffy, A. R., Galbany, L., Scolnic, D., Davis, T. M., Möller, A., Kelsey, L., Lee, J., Wiseman, P., Vincenzi, M., Shah, P., Aguena, M., Allam, S. S., Alves, O., Bacon, D., Bocquet, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Carretero, J., Conselice, C., da Costa, L. N., Pereira, M. E. S., Diehl, H. T., Doel, P., Everett, S., Ferrero, I., Flaugher, B., Frieman, J., García-Bellido, J., Gatti, M., Gaztanaga, E., Giannini, G., Gruen, D., Gruendl, R. A., Gutierrez, G., Herner, K., Hinton, S. R., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Lima, M., Marshall, J. L., Mena-Fernández, J., Menanteau, F., Miquel, R., Myles, J., Nichol, R. C., Ogando, R. L. C., Palmese, A., Pieres, A., Malagón, A. A. Plazas, Samuroff, S., Sanchez, E., Cid, D. Sanchez, Sevilla-Noarbe, I., Smith, M., Sobreira, F., Suchyta, E., Swanson, M. E. C., Tarle, G., To, C., Tucker, B. E., Tucker, D. L., Vikram, V., Walker, A. R., and Weaverdyck, N.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The present state of cosmology is facing a crisis where there is a fundamental disagreement in measurements of the Hubble constant ($H_{0}$), with significant tension between the early and late universe methods. Type Ia supernovae (SNe Ia) are important to measuring $H_{0}$ through the astronomical distance ladder. However, there remains potential to better standardise SN Ia light curves by using known dependencies on host galaxy properties after the standard light curve width and colour corrections have been applied to the peak SN Ia luminosities. To explore this, we use the 5-year photometrically identified SNe Ia sample obtained by the Dark Energy Survey, along with host galaxy spectra obtained by the Australian Dark Energy Survey. Using host galaxy spectroscopy, we find a significant trend with the equivalent width (EW) of the [OII] $\lambda\lambda$ 3727, 29 doublet, a proxy for specific star formation rate, and Hubble residuals. We find that the correlation with [OII] EW is a powerful alternative to the commonly used mass step after initial light curve corrections. We applied our [OII] EW correction to a sample of 20 SN Ia hosted by calibrator galaxies observed using WiFeS, and examined the impact on both the SN Ia absolute magnitude and $H_{0}$. We then explored different [OII] EW corrections and found $H_{0}$ values ranging between $72.80$ to $73.28~\mathrm{km} \mathrm{s}^{-1} \mathrm{Mpc}^{-1}$. Notably, even after using an additional [OII] EW correction, the impact of host galaxy properties in standardising SNe Ia appears limited in reducing the current tension ($\sim$5$\sigma$) with the Cosmic Microwave Background result for $H_{0}$., Comment: 16 pages, 13 figures. Submitting to MNRAS
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- 2024
6. WALLABY Pilot Survey: the Tully-Fisher relation in the NGC 4808, Vela and NGC 5044 fields
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Mould, Jeremy, Jarrett, T. H., Courtois, Hélène, Bosma, Albert, Deg, Nathan, Dupuy, Alexandra, Staveley-Smith, Lister, Taylor, E. N., English, Jayanne, Rajohnson, S. H. A., Kraan-Korteweg, Renée, Forbes, Duncan, Dénes, Helga, Lee-Waddell, Karen, Shen, Austin, Wong, O. I., Holwerda, Benne, Koribalski, Bärbel, Leahy, Denis, Piña, Pavel Mancera, and Yu, Niankun
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Astrophysics - Astrophysics of Galaxies - Abstract
The Tully-Fisher Relation (TFR) is a well-known empirical relationship between the luminosity of a spiral galaxy and its circular velocity, allowing us to estimate redshift independent distances. Here we use high signal-to-noise HI 21-cm integrated spectra from the second pilot data release (PDR2, 180 deg2) of the Widefield ASKAP L-band Legacy All-sky Blind surveY (WALLABY). In order to prepare for the full WALLABY survey, we have investigated the TFR in phase 2 of the pilot survey with a further three fields. The data were obtained with wide-field Phased Array Feeds on the Australian Square Kilometre Array Pathfinder (ASKAP) and have an angular resolution of 30 arcsec and a velocity resolution of ~4 km/s. Galaxy luminosities have been measured from the Wide-field Infrared Survey Explorer (WISE), and optical galaxy inclinations from the Dark Energy Camera Legacy Survey. We present TFRs for wavelengths from 0.8-3.4{\mu}m. We examine sources of galaxy inclination data and investigate magnitudes from the DECam Local Volume Exploration Survey (DELVE) and DENIS catalogues and the 4HS target catalogue based on the VISTA Hemisphere Survey (VHS). We consider the baryonic TFR. These are all of interest for TFR using the full WALLABY survey of 200,000 galaxies. We demonstrate that WALLABY TFR distances can take their place among state of the art studies of the local velocity field., Comment: to appear in MNRAS. One figure removed
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- 2024
7. Do galaxy mergers prefer under-dense environments?
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Sureshkumar, U., Durkalec, A., Pollo, A., Pearson, W. J., Farrow, D. J., Narayanan, A., Loveday, J., Taylor, E. N., and Suelves, L. E.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Galaxy mergers play a crucial role in galaxy evolution. However, the correlation between mergers and the local environment of galaxies is not fully understood. We aim to address the question of whether galaxy mergers prefer denser or less dense environments by quantifying the spatial clustering of mergers and non-mergers. We use two different indicators to classify mergers and non-mergers - classification based on a deep learning technique ($f$) and non-parametric measures of galaxy morphology, Gini-$M_{20}$ ($g$). We used a set of galaxy samples in the redshift range $0.1 < z < 0.15$ from the Galaxy and Mass Assembly (GAMA) survey with a stellar mass cut of $\log (M_{\star}/M_{\odot} ) > 9.5$. We measured and compared the two-point correlation function (2pCF) of mergers and non-mergers classified using the two merger indicators $f$ and $g$. We measured the marked correlation function (MCF), in which the galaxies are weighted by $f$ to probe the environmental dependence of galaxy mergers. We do not observe a statistically significant difference between the clustering strengths of mergers and non-mergers obtained using 2pCF. However, using the MCF measurements with $f$ as a mark, we observe an anti-correlation between the likelihood of a galaxy being a merger and its environment. Our results emphasise the advantage of MCF over 2pCF in probing the environmental correlations. Based on the MCF measurements, we conclude that the galaxy mergers prefer to occur in the under-dense environments on scales $> 50 \, h^{-1} \mathrm{kpc}$ of the large-scale structure (LSS). We attribute this observation to the high relative velocities of galaxies in the densest environments that prevent them from merging., Comment: 13 pages, 9 figures, matches the version published in A&A
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- 2024
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8. Two-dimensional perovskitoids enhance stability in perovskite solar cells
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Liu, Cheng, Yang, Yi, Chen, Hao, Spanopoulos, Ioannis, Bati, Abdulaziz S. R., Gilley, Isaiah W., Chen, Jianhua, Maxwell, Aidan, Vishal, Badri, Reynolds, Robert P., Wiggins, Taylor E., Wang, Zaiwei, Huang, Chuying, Fletcher, Jared, Liu, Yuan, Chen, Lin X., De Wolf, Stefaan, Chen, Bin, Zheng, Ding, Marks, Tobin J., Facchetti, Antonio, Sargent, Edward H., and Kanatzidis, Mercouri G.
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- 2024
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9. Social determinants of health inequalities in early phase clinical trials in Northern England
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Rae, S., Shaya, S., Taylor, E., Hoben, J., Oluwashegun, D., Lowe, H., Haris, N., Bashir, S., Oing, C., Krebs, M. G., Thistlethwaite, F. C., Carter, L., Cook, N., Greystoke, A., Graham, D. M., and Plummer, R.
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- 2024
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10. EMU/GAMA: Radio detected galaxies are more obscured than optically selected galaxies
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Ahmed, U. T., Hopkins, A. M., Ware, J., Gordon, Y. A., Bilicki, M., Brown, M. J. I., Cluver, M., Gürkan, G., López-Sánchez, Á. R., Leahy, D. A., Marchetti, L., Phillipps, S., Prandoni, I., Seymour, N., Taylor, E. N., and Vardoulaki, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
We demonstrate the importance of radio selection in probing heavily obscured galaxy populations. We combine Evolutionary Map of the Universe (EMU) Early Science data in the Galaxy and Mass Assembly (GAMA) G23 field with the GAMA data, providing optical photometry and spectral line measurements, together with Wide-field Infrared Survey Explorer (WISE) infrared (IR) photometry, providing IR luminosities and colours. We investigate the degree of obscuration in star forming galaxies, based on the Balmer decrement (BD), and explore how this trend varies, over a redshift range of 0
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- 2023
11. Molecular Insights into O‑Linked Sialoglycans Recognition by the Siglec-Like SLBR‑N (SLBRUB10712) of Streptococcus gordonii
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Di Carluccio, Cristina, Cerofolini, Linda, Moreira, Miguel, Rosu, Frédéric, Padilla-Cortés, Luis, Gheorghita, Giulia Roxana, Xu, Zhuojia, Santra, Abhishek, Yu, Hai, Yokoyama, Shinji, Gray, Taylor E, St. Laurent, Chris D, Manabe, Yoshiyuki, Chen, Xi, Fukase, Koichi, Macauley, Matthew S, Molinaro, Antonio, Li, Tiehai, Bensing, Barbara A, Marchetti, Roberta, Gabelica, Valérie, Fragai, Marco, and Silipo, Alba
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Chemical Sciences ,Clinical Research ,Infectious Diseases ,Dental/Oral and Craniofacial Disease ,Chemical sciences - Abstract
Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but can also cause local or systemic diseases. Serine-rich repeat (SRR) glycoproteins exposed on the S. gordonii bacterial surface bind to sialylated glycans on human salivary, plasma, and platelet glycoproteins, which may contribute to oral colonization as well as endocardial infections. Despite a conserved overall domain organization of SRR adhesins, the Siglec-like binding regions (SLBRs) are highly variable, affecting the recognition of a wide range of sialoglycans. SLBR-N from the SRR glycoprotein of S. gordonii UB10712 possesses the remarkable ability to recognize complex core 2 O-glycans. We here employed a multidisciplinary approach, including flow cytometry, native mass spectrometry, isothermal titration calorimetry, NMR spectroscopy from both protein and ligand perspectives, and computational methods, to investigate the ligand specificity and binding preferences of SLBR-N when interacting with mono- and disialylated core 2 O-glycans. We determined the means by which SLBR-N preferentially binds branched α2,3-disialylated core 2 O-glycans: a selected conformation of the 3'SLn branch is accommodated into the main binding site, driving the sTa branch to further interact with the protein. At the same time, SLBR-N assumes an open conformation of the CD loop of the glycan-binding pocket, allowing one to accommodate the entire complex core 2 O-glycan. These findings establish the basis for the generation of novel tools for the detection of specific complex O-glycan structures and pave the way for the design and development of potential therapeutics against streptococcal infections.
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- 2024
12. Author Correction: Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult carriers
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Weary, Taylor E., Pappas, Tressa, Tusiime, Patrick, Tuhaise, Shamilah, Otali, Emily, Emery Thompson, Melissa, Ross, Elizabeth, Gern, James E., and Goldberg, Tony L.
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- 2024
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13. Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult carriers
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Weary, Taylor E., Pappas, Tressa, Tusiime, Patrick, Tuhaise, Shamilah, Otali, Emily, Emery Thompson, Melissa, Ross, Elizabeth, Gern, James E., and Goldberg, Tony L.
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- 2024
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14. A Geometric Calibration of the Tip of the Red Giant Branch in the Milky Way using Gaia DR3
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Dixon, M., Mould, J., Flynn, C., Taylor, E. N., Lidman, C., and Duffy, A. R.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We use the latest parallaxes measurements from Gaia DR3 to obtain a geometric calibration of the tip of the red giant branch (TRGB) in Cousins $I$ magnitudes as a standard candle for cosmology. We utilise the following surveys: SkyMapper DR3, APASS DR9, ATLAS Refcat2, and Gaia DR3 synthetic photometry to obtain multiple zero-point calibrations of the TRGB magnitude, $M_{I}^{TRGB}$. Our sample contains Milky Way halo stars at high galactic latitudes ($|b| > 36$) where the impact of metallicity, dust, and crowding are minimised. The magnitude of the TRGB is identified using Sobel edge detection, but this approach introduced a systematic offset. To address this issue, we utilised simulations with PARSEC isochrones and showed how to calibrate and remove this bias. Applying our method within the colour range where the slope of the TRGB is relatively flat for metal-poor halo stars (1.55 $<$ $(BP-RP)$ $<$ 2.25), we find a weighted average $M_{I}^{TRGB} = -4.042 \pm 0.041$ (stat) $\pm0.031$ (sys) mag. A geometric calibration of the Milky Way TRGB has the benefit of being independent of other distance indicators and will help probe systematics in the local distance ladder, leading to improved measurements of the Hubble constant., Comment: 14 pages, 13 figures. Accepted for publication in MNRAS
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- 2023
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15. The role of mass and environment in the build up of the quenched galaxy population since cosmic noon
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Taylor, E., Almaini, O., Merrifield, M., Maltby, D., Wild, V., Hartley, W. G., and Rowlands, K.
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Astrophysics - Astrophysics of Galaxies - Abstract
We conduct the first study of how the relative quenching probability of galaxies depends on environment over the redshift range $0.5 < z < 3$, using data from the UKIDSS Ultra-Deep Survey. By constructing the stellar mass functions for quiescent and post-starburst (PSB) galaxies in high, medium and low density environments to $z = 3$, we find an excess of quenched galaxies in dense environments out to at least $z \sim 2$. Using the growth rate in the number of quenched galaxies, combined with the star-forming galaxy mass function, we calculate the probability that a given star-forming galaxy is quenched per unit time. We find a significantly higher quenching rate in dense environments (at a given stellar mass) at all redshifts. Massive galaxies (M$_* > 10^{10.7}$ M$_{\odot}$) are on average 1.7 $\pm$ 0.2 times more likely to quench per Gyr in the densest third of environments compared to the sparsest third. Finally, we compare the quiescent galaxy growth rate to the rate at which galaxies pass through a PSB phase. Assuming a visibility timescale of 500 Myr, we find that the PSB route can explain $\sim$ 50\% of the growth in the quiescent population at high stellar mass (M$_* > 10^{10.7}$ M$_{\odot}$) in the redshift range $0.5 < z < 3$, and potentially all of the growth at lower stellar masses., Comment: 12 pages, 8 figures. Accepted for publication in MNRAS
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- 2023
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16. Truth or Lie: Ability of Listeners to Detect Deceptive Emergency Calls of Missing Children
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Daniel E. O’Donnell, Michelle C. Huffman, Taylor E. Burd, and Colleen L. O’Shea
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emergency calls ,911 ,child ,deception ,homicide ,Criminal law and procedure ,K5000-5582 ,Psychology ,BF1-990 - Abstract
Background: Emergency calls may help law enforcement determine the proper response and provide investigative leads. Time may be wasted and appropriate resources misallocated if callers provide untruthful information. However, human ability to detect deception is generally weak. Objectives: We compared the abilities of law enforcement officers and non-law enforcement staff abilities to correctly identify truthful or deceptive emergency calls reporting missing children using Grice’s maxims of communication (quantity, manner, relation, and quality of information). Method: Forty participants listened to 32 emergency calls reporting a missing child. Sixteen callers truthfully reported not knowing the child’s whereabouts, and sixteen were responsible for killing the child before falsely reporting the child missing. Participants rated the quantity (insufficient, appropriate, excessive), manner (clear/orderly, unclear/disorderly), relation (relevant, irrelevant), and quality (truthful, deceptive) of information. Participants also provided a written narrative of their impressions of the call. Results: Accuracy in identifying truthful and deceptive callers was consistent with prior research, with sworn law enforcement slightly outperforming non-sworn staff. Participant agreement on Grice’s maxims was poor. Ratings of quantity, manner, and relation of information predicted judgments of call quality, but were not associated with accurately identifying calls. Participant narratives describing reasons for judging a call to be truthful or deceptive were also not associated with accurate identification. Conclusions: Our findings do not support the use of Grice’s maxims for determining deception in emergency calls. Although law enforcement officers outperformed non-sworn staff, both groups showed inconsistent rationales to support veracity judgments and relied on cues not associated with accuracy.
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- 2024
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17. Mary Astell’s Work Toward a New Edition of A Serious Proposal to the Ladies, Part II
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Taylor, E. Derek
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- 2008
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18. Fractal Patterns in the Parameter Space of Bi-stable Duffing Oscillator
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Hasan, Md Nahid, Greenwood, Taylor E., Parker, Robert G., Wang, Pai, and Kong, Yong Lin
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Nonlinear Sciences - Pattern Formation and Solitons - Abstract
We study the dissipative bi-stable Duffing oscillator with equal energy wells and observe fractal patterns in the parameter space of driving frequency, forcing amplitude, and damping ratio. Our numerical investigation reveals the Hausdorff fractal dimension of the boundaries that separate the oscillator's intra-well and inter-well behaviors. Furthermore, we categorize the inter-well behaviors as three steady-state types: switching, reverting, and vacillating. While fractal patterns in the phase space are well-known and heavily studied, our results point to a new research direction about fractal patterns in the parameter space. Another implication of this study is that the vibration of a continuous bi-stable system modeled using a single-mode approximation also manifests fractal patterns in the parameter space. In addition, our findings can guide the design of next-generation bi-stable and multi-stable mechanical metamaterials.
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- 2023
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19. Diverse responses of hypoxia-inducible factor alpha mRNA abundance in fish exposed to low oxygen: the importance of reporting methods
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Taylor E. Murphy and Bernard B. Rees
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oxygen ,gene expression ,transcription factor ,hypoxia inducible factor ,quantitative PCR ,Physiology ,QP1-981 - Abstract
Low dissolved oxygen (hypoxia) poses significant challenges to aquatic ecosystems, affecting the behavior, reproduction, and survival of aquatic organisms. Some fishes respond to hypoxia by changes in gene expression, which may be regulated by the hypoxia inducible factor (HIF) family of transcription factors. HIF abundance and activity depends upon the post-translational modification of the alpha protein subunit, although several studies indicate that HIFA mRNA abundance increases in tissues of fishes exposed to hypoxia. This study reviewed reports of laboratory exposures of adult ray-finned fishes to hypoxia and used generalized linear mixed effects models to examine the influence of HIFA gene, tissue sampled, and exposure conditions in explaining the diversity of responses seen in HIFA mRNA abundance. The frequency of hypoxia-induced increases in HIFA mRNA was poorly explained by gene, tissue, or the severity of the hypoxic exposure. Rather, the frequency of reported increases was strongly related to the extent to which studies adhered to guidelines for documenting quantitative real-time PCR methods: the frequency of hypoxia-induced increases in HIFA mRNA decreased sharply in studies with more thorough description of experimental design. Future research should (a) adhere to stringent reporting of experimental design, (b) address the relative paucity of data on HIF2A and HIF3A, and (c) determine levels of HIF alpha protein subunits. By following these recommendations, it is hoped that a more complete understanding will be gained of the role of the HIF family of transcription factors in the response of fish to hypoxia.
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- 2024
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20. Mary Astell's Ironic Assault on John Locke's Theory of Thinking Matter
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Taylor, E. Derek
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- 2001
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21. Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult carriers
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Taylor E. Weary, Tressa Pappas, Patrick Tusiime, Shamilah Tuhaise, Emily Otali, Melissa Emery Thompson, Elizabeth Ross, James E. Gern, and Tony L. Goldberg
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Respiratory infections ,COVID-19 ,Reverse zoonosis ,Uganda ,Paediatrics ,One Health ,Medicine ,Science - Abstract
Abstract Reverse zoonotic respiratory diseases threaten great apes across Sub-Saharan Africa. Studies of wild chimpanzees have identified the causative agents of most respiratory disease outbreaks as “common cold” paediatric human pathogens, but reverse zoonotic transmission pathways have remained unclear. Between May 2019 and August 2021, we conducted a prospective cohort study of 234 children aged 3–11 years in communities bordering Kibale National Park, Uganda, and 30 adults who were forest workers and regularly entered the park. We collected 2047 respiratory symptoms surveys to quantify clinical severity and simultaneously collected 1989 nasopharyngeal swabs approximately monthly for multiplex viral diagnostics. Throughout the course of the study, we also collected 445 faecal samples from 55 wild chimpanzees living nearby in Kibale in social groups that have experienced repeated, and sometimes lethal, epidemics of human-origin respiratory viral disease. We characterized respiratory pathogens in each cohort and examined statistical associations between PCR positivity for detected pathogens and potential risk factors. Children exhibited high incidence rates of respiratory infections, whereas incidence rates in adults were far lower. COVID-19 lockdown in 2020–2021 significantly decreased respiratory disease incidence in both people and chimpanzees. Human respiratory infections peaked in June and September, corresponding to when children returned to school. Rhinovirus, which caused a 2013 outbreak that killed 10% of chimpanzees in a Kibale community, was the most prevalent human pathogen throughout the study and the only pathogen present at each monthly sampling, even during COVID-19 lockdown. Rhinovirus was also most likely to be carried asymptomatically by adults. Although we did not detect human respiratory pathogens in the chimpanzees during the cohort study, we detected human metapneumovirus in two chimpanzees from a February 2023 outbreak that were genetically similar to viruses detected in study participants in 2019. Our data suggest that respiratory pathogens circulate in children and that adults become asymptomatically infected during high-transmission times of year. These asymptomatic adults may then unknowingly carry the pathogens into forest and infect chimpanzees. This conclusion, in turn, implies that intervention strategies based on respiratory symptoms in adults are unlikely to be effective for reducing reverse zoonotic transmission of respiratory viruses to chimpanzees.
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- 2024
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22. Does terminology matter when measuring stigmatizing attitudes about weight? Validation of a brief, modified attitudes toward obese persons scale
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Caitlin A. Martin‐Wagar, Katelyn A. Melcher, Sarah E. Attaway, Brooke L. Bennett, Connor J. Thompson, Oscar Kronenberger, and Taylor E. Penwell
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anti‐fat bias ,weight bias ,weight stigma ,weight‐related prejudice ,Internal medicine ,RC31-1245 - Abstract
Abstract Objective Commonly used terms like “obese person” have been identified as stigmatizing by those with lived experience. Thus, this study sought to revise a commonly used measure of weight stigmatizing attitudes, the Attitudes Toward Obese Persons (ATOP) scale. Methods The original terminology in the 20‐item ATOP (e.g., “obese”) was compared to a modified version using neutral terms (e.g., “higher weight”). Participants (N = 832) were randomized to either receive the original or modified ATOP. Results There was a statistically significant difference, with a small effect size (d = −0.22), between the scores of participants who received the original ATOP (M = 69.25) and the modified ATOP (M = 72.85), t(414) = −2.27, p = 0.024. Through principal component analysis, the modified ATOP was best used as a brief, 8‐item unidimensional measure. In a second sample, confirmatory factor analysis verified the fit of the brief, 8‐item factor structure. Conclusions Findings suggest that a modified, brief version of the ATOP (ATOP‐Heigher Weight; ATOP‐HW) with neutral language is suitable for assessing negative attitudes about higher‐weight people. The ATOP‐HW may slightly underestimate weight stigma compared to the original ATOP, or the language in the ATOP may magnify negative attitudes. Further examination of the terminology used in weight stigma measures is needed to determine how to best assess weight stigma without reinforcing stigmatizing attitudes. The present study's findings suggest that the use of neutral terms in measures of anti‐fat bias is a promising solution that warrants further investigation.
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- 2024
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23. Rapid prototyping of perfusion cell culture devices for three-dimensional imaging of mesenchymal stem cell deposition and proliferation
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Taylor E. Scott, Tim Boccarossa, David Florian, Melissa A. Fischer, Sun H. Peck, Michael R. Savona, Georg Pingen, and Scott A. Guelcher
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Rapid prototyping ,Injection molding ,3D printing ,Computational fluid dynamics ,Cell imaging ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Perfusion of porous scaffolds transports cells to the surface to yield cellular constructs for 3D models of disease and for tissue engineering applications. While ceramic scaffolds mimic the structure and composition of trabecular bone, their opacity and tortuous pores limit the penetration of light into the interior. Scaffolds that are both perfusable and amenable to fluorescence microscopy are therefore needed to visualize the spatiotemporal dynamics of cells in the bone microenvironment. In this study, a hybrid injection molding approach was designed to enable rapid prototyping of collector arrays with variable configurations that are amenable to longitudinal imaging of attached human mesenchymal stem cells (hMSCs) using fluorescence microscopy. Cylindrical collectors were arranged in an array that is permeable to perfusion in the xy-plane and to light in the z-direction for imaging from below. The effects of the collector radius, number, and spacing on the collection efficiency of perfused hMSCs was simulated using computational fluid dynamics (CFD) and measured experimentally using fluorescence microscopy. The effect of collector diameter on simulated and experimental cell collection efficiencies followed a trend similar to that predicted by interception theory corrected for intermolecular and hydrodynamic forces for the arrays with constant collector spacing. In contrast, arrays designed with constant collector number yielded collection efficiencies that poorly fit the trend with collector radius predicted by interception theory. CFD simulations of collection efficiency agreed with experimental measurements within a factor of two. These findings highlight the utility of CFD simulations and hybrid injection molding for rapid prototyping of collector arrays to optimize the longitudinal imaging of cells without the need for expensive and time-consuming tooling.
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- 2024
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24. Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.
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Ranran Wang, Taylor E Senay, Tiana T Luo, Wei Liu, James M Regan, Nicholas J H Salisbury, Denise A Galloway, and Jianxin You
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Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,QH301-705.5 - Abstract
While Merkel cell polyomavirus (MCPyV or MCV) is an abundant virus frequently shed from healthy skin, it is one of the most lethal tumor viruses in immunocompromised individuals, highlighting the crucial role of host immunity in controlling MCPyV oncogenic potential. Despite its prevalence, very little is known about how MCPyV interfaces with the host immune response to maintain asymptomatic persistent infection and how inadequate control of MCPyV infection triggers MCC tumorigenesis. In this study, we discovered that the MCPyV protein, known as the Alternative Large Tumor Open Reading Frame (ALTO), also referred to as middle T, effectively primes and activates the STING signaling pathway. It recruits Src kinase into the complex of STING downstream kinase TBK1 to trigger its autophosphorylation, which ultimately activates the subsequent antiviral immune response. Combining single-cell analysis with both loss- and gain-of-function studies of MCPyV infection, we demonstrated that the activity of ALTO leads to a decrease in MCPyV replication. Thus, we have identified ALTO as a crucial viral factor that modulates the STING-TBK1 pathway, creating a negative feedback loop that limits viral infection and maintains a delicate balance with the host immune system. Our study reveals a novel mechanism by which a tumorigenic virus-encoded protein can link Src function in cell proliferation to the activation of innate immune signaling, thereby controlling viral spread, and sustaining persistent infection. Our previous findings suggest that STING also functions as a tumor suppressor in MCPyV-driven oncogenesis. This research provides a foundation for investigating how disruptions in the finely tuned virus-host balance, maintained by STING, could alter the fate of MCPyV infection, potentially encouraging malignancy.
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- 2024
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25. Using Host Galaxy Spectroscopy to Explore Systematics in the Standardisation of Type Ia Supernovae
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Dixon, M., Lidman, C., Mould, J., Kelsey, L., Brout, D., Möller, A., Wiseman, P., Sullivan, M., Galbany, L., Davis, T. M., Vincenzi, M., Scolnic, D., Lewis, G. F., Smith, M., Kessler, R., Duffy, A., Taylor, E., Flynn, C., Abbott, T. M. C., Aguena, M., Allam, S., Andrade-Oliveir, F., Annis, J., Asorey, J., Bertin, E., Bocquet, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Carollo, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., Pereira, M. E. S., Doel, P., Everett, S., Ferrero, I., Flaugher, B., Friedel, D., Frieman, J., García-Bellido, J., Gatti, M., Gerdes, D. W., Glazebrook, K., Gruen, D., Gschwend, J., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Honscheid, K., Huterer, D., James, D. J., Kuehn, K., Kuropatkin, N., Malik, U., March, M., Menanteau, F., Miquel, R., Morgan, R., Nichol, B., Ogando, R. L. C., Palmese, A., Paz-Chinchón, F., Pieres, A., Malagón, A. A. Plazas, Rodriguez-Monroy, M., Romer, A. K., Sanchez, E., Scarpine, V., Sevilla-Noarbe, I., Soares-Santos, M., Suchyta, E., Tarle, G., To, C., Tucker, B. E., Tucker, D. L., and Varga, T. N.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We use stacked spectra of the host galaxies of photometrically identified type Ia supernovae (SNe Ia) from the Dark Energy Survey (DES) to search for correlations between Hubble diagram residuals and the spectral properties of the host galaxies. Utilising full spectrum fitting techniques on stacked spectra binned by Hubble residual, we find no evidence for trends between Hubble residuals and properties of the host galaxies that rely on spectral absorption features ($< 1.3\sigma$), such as stellar population age, metallicity, and mass-to-light ratio. However, we find significant trends between the Hubble residuals and the strengths of [OII] ($4.4\sigma$) and the Balmer emission lines ($3\sigma$). These trends are weaker than the well known trend between Hubble residuals and host galaxy stellar mass ($7.2\sigma$) that is derived from broad band photometry. After light curve corrections, we see fainter SNe Ia residing in galaxies with larger line strengths. We also find a trend (3$\sigma$) between Hubble residual and the Balmer decrement (a measure of reddening by dust) using H${\beta}$ and H${\gamma}$. The trend, quantified by correlation coefficients, is slightly more significant in the redder SNe Ia, suggesting that bluer SNe Ia are relatively unaffected by dust in the interstellar medium of the host and that dust contributes to current Hubble diagram scatter impacting the measurement of cosmological parameters., Comment: 15 pages, 10 figures. Accepted for publication in MNRAS
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- 2022
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26. The lasting effects of growing up in a military-connected home: A qualitative study of college-aged American military kids
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Zurlinden, Taylor E, Firmin, Michael W, Shell, Aubrey L, and Grammer, Hannah W
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- 2021
27. Molecular Insights into O‑Linked Sialoglycans Recognition by the Siglec-Like SLBR‑N (SLBRUB10712) of Streptococcus gordonii
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Cristina Di Carluccio, Linda Cerofolini, Miguel Moreira, Frédéric Rosu, Luis Padilla-Cortés, Giulia Roxana Gheorghita, Zhuojia Xu, Abhishek Santra, Hai Yu, Shinji Yokoyama, Taylor E. Gray, Chris D. St. Laurent, Yoshiyuki Manabe, Xi Chen, Koichi Fukase, Matthew S. Macauley, Antonio Molinaro, Tiehai Li, Barbara A. Bensing, Roberta Marchetti, Valérie Gabelica, Marco Fragai, and Alba Silipo
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Chemistry ,QD1-999 - Published
- 2024
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28. High-dose amphotericin: yay or nay? A case series and literature review
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Kayla R Stover, Taylor E Jordan, Jamie L Wagner, and Katie E Barber
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amphotericin ,antifungal agents ,drug resistance ,fungal ,maximally tolerated dose ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Invasive fungal infections pose significant morbidity and mortality risks, particularly those caused by moulds. Available antifungal classes are limited by toxicities and are increasingly susceptible to resistance, particularly amongst challenging fungal pathogens. The purpose of this case series and literature review was to characterize the use of a high-dose lipid formulation of amphotericin B. A case series is presented including patients who received high-dose lipid formulation amphotericin B (≥7.5 mg/kg/day) between June 2012 and August 2021. Additionally, a systematic literature review was conducted by searching the PubMed database for English-language studies involving individuals who received high-dose amphotericin B therapy (≥7.5 mg/kg) using lipid formulations. Nine patients were included in the case series, receiving an average of 8.9 ± 1.3 mg/kg liposomal amphotericin B over a mean of 11.0 ± 10.8 days predominantly for mould infections including Mucorales, aspergillosis and Fusarium. The patients were primarily cared for in intensive care units, with varying treatment histories and outcomes. A total of 11 studies (n=260 patients) met inclusion criteria for the literature review. Responses to high-dose liposomal amphotericin B ranged from 8% to 100%, often showing favourable outcomes. High doses of liposomal amphotericin B were well tolerated both in the case series and in published literature, with serum creatinine changes being the most commonly reported adverse event. However, multi-patient studies continue to report less than favourable (range 8–62%) response rates. High-dose liposomal amphotericin B, either alone or in combination with other antifungal agents, might be a viable strategy for managing invasive fungal infections when few treatment choices exist. This article is part of the Challenges and strategies in the management of invasive fungal infections Special Issue: https://www.drugsincontext.com/special_issues/challenges-and-strategies-in-the-management-of-invasive-fungal-infections
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- 2024
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29. Deep ASKAP EMU Survey of the GAMA23 field: Properties of radio sources
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Gürkan, Gülay, Prandoni, I., O'Brien, A., Raja, W., Marchetti, L., Vaccari, M., Driver, S., Taylor, E., Franzen, T., Brown, M. J. I., Shabala, S., Andernach, H., Hopkins, A. M., Norris, R. P., Leahy, D., Bilicki, M., Farajollahi, H., Galvin, T., Heald, G., Koribalski, B. S., An, T., and Warhurst, K.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the Australian Square Kilometre Array Pathfinder (ASKAP) observations of the Galaxy and Mass Assembly (GAMA)-23h field. The survey was carried out at 887.5 MHz and covers a 83 square degree field. We imaged the calibrated visibility data, taken as part of the Evolutionary Mapping of Universe (EMU) Early Science Programme, using the latest version of the ASKAPSoft pipeline. The final mosaic has an angular resolution of 10 arcsec and a central rms noise of around 38 $\mu$Jy beam$^{-1}$. The derived radio source catalogue has 39812 entries above a peak flux density threshold of 5$\sigma$. We searched for the radio source host galaxy counterparts using the GAMA spectroscopic (with an i-band magnitude limit of 19.2 mag) and multi-wavelength catalogues that are available as part of the collaboration. We identified hosts with GAMA spectroscopic redshifts for 5934 radio sources. We describe the data reduction, imaging, and source identification process, and present the source counts. Thanks to the wide area covered by our survey, we obtain very robust counts down to 0.2 mJy. ASKAP's exceptional survey speed, providing efficient, sensitive and high resolution mapping of large regions of the sky in conjunction with the multi-wavelength data available for the GAMA23 field, allowed us to discover 63 giant radio galaxies. The data presented here demonstrate the excellent capabilities of ASKAP in the pre-SKA era., Comment: 18 pages, 15 figures, accepted by MNRAS
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- 2022
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30. Galaxy and Mass Assembly (GAMA): Mid-infrared properties as tracers of galaxy environment
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Sureshkumar, U., Durkalec, A., Pollo, A., Bilicki, M., Cluver, M. E., Bellstedt, S., Farrow, D. J., Loveday, J., Taylor, E. N., and Bland-Hawthorn, J.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We investigate how different mid-infrared (mid-IR) properties of galaxies trace the environment in which the galaxies are located. For this purpose, we first study the dependence of galaxy clustering on the absolute magnitude at 3.4 $\mu$m and redshift. Then, we look into the environmental dependence of mid-IR luminosities and the galaxy properties derived from these luminosities. We also explore how various infrared galaxy luminosity selections influence the galaxy clustering measurements. We use a set of W1 (3.4 $\mu$m) absolute magnitude ($M_\text{W1}$) selected samples from the Galaxy and Mass Assembly (GAMA) survey matched with mid-IR properties from the Wide-field Infrared Survey Explorer (WISE) in the redshift range $0.07 \leq z < 0.43$. We compute the galaxy two-point correlation function (2pCF) and compare the clustering lengths between subsamples binned in $M_\text{W1}$ and in redshift. We also measure the marked correlation functions (MCFs) using the luminosities in the WISE W1 to W4 (3.4 to 22 $\mu$m) bands as marks. Additionally, we compare the measurements of MCFs with different estimates of stellar mass and star formation rate used as marks. Finally, we check how different selections applied to the sample affect the clustering measurements. We show strong clustering dependence on the W1 absolute magnitude: galaxies brighter in the W1 band are more strongly clustered than their fainter counterparts. We also observe a lack of significant redshift dependence of clustering in the redshift range $0.07 \leq z < 0.43$. We show that although W1 and W2 bands are direct indicators of stellar mass, a galaxy sample selected based on W1 or W2 bands does not perfectly show the clustering behaviour of a stellar mass selected sample. Similar is the case with the proxy relation between W3 and W4 bands and star formation rate., Comment: 18 pages, 12 figures, matches the version published in A&A
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- 2022
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31. The detection of a massive chain of dark HI clouds in the GAMA G23 Field
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Jozsa, Gyula I. G., Jarrett, T. H., Cluver, Michelle, Wong, O. Ivy, Havenga, Okkert, Yao, H. F. M., Marchetti, L., Taylor, E. N., Kamphuis, Peter, Maccagni, Filippo M., Ramaila, Athanaseus J. T., Serra, Paolo, Smirnov, Oleg M., White, Sarah V., Kilborn, Virginia, Holwerda, B. W., Hopkins, A. M., Brough, S., Pimbblet, K. A., Driver, Simon P., and Kuijken, K.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report on the detection of a large, extended HI cloud complex in the GAMA G23 field, located at a redshift of $z\,\sim\,0.03$, observed as part of the MeerHOGS campaign (a pilot survey to explore the mosaicing capabilities of MeerKAT). The cloud complex, with a total mass of $10^{10.0}\,M_\odot$, lies in proximity to a large galaxy group with $M_\mathrm{dyn}\sim10^{13.5}\,M_\odot$. We identify seven HI peak concentrations, interconnected as a tenuous 'chain' structure, extending $\sim 400\,\mathrm{kpc}$ from east-to-west, with the largest (central) concentration containing $10{^{9.7}}\,M_\odot$ in HI gas distributed across $50\,\mathrm{kpc}$. The main source is not detected in ultra-violet, optical or infrared imaging. The implied gas mass-to-light ($M_\mathrm{HI}$/$L_\mathrm{r}$) is extreme ($>$1000) even in comparison to other 'dark clouds'. The complex has very little kinematic structure ($110\,\mathrm{km}\,\mathrm{s}^{-1}$), making it difficult to identify cloud rotation. Assuming pressure support, the total mass of the central concentration is $>10^{10.2}\,M_\odot$, while a lower limit to the dynamical mass in the case of full rotational support is $10^{10.4}\,M_\odot$. If the central concentration is a stable structure, it has to contain some amount of unseen matter, but potentially less than is observed for a typical galaxy. It is, however, not clear whether the structure has any gravitationally stable concentrations. We report a faint UV--optical--infrared source in proximity to one of the smaller concentrations in the gas complex, leading to a possible stellar association. The system nature and origins is enigmatic, potentially being the result of an interaction with or within the galaxy group it appears to be associated with., Comment: 25 pages, 10 figures, accepted for publication in ApJ, minor corrections
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- 2021
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32. Binary fabrication of decellularized lung extracellular matrix hybridgels for in vitro chronic obstructive pulmonary disease modeling
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Antczak, Leigh-Ann M., Moore, Karah N., Hendrick, Taylor E., and Heise, Rebecca L.
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- 2024
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33. Rapid prototyping of perfusion cell culture devices for three-dimensional imaging of mesenchymal stem cell deposition and proliferation
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Scott, Taylor E., Boccarossa, Tim, Florian, David, Fischer, Melissa A., Peck, Sun H., Savona, Michael R., Pingen, Georg, and Guelcher, Scott A.
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- 2024
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34. High frequencies of nonviral colds and respiratory bacteria colonization among children in rural Western Uganda
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Taylor E. Weary, Tressa Pappas, Patrick Tusiime, Shamilah Tuhaise, Elizabeth Ross, James E. Gern, and Tony L. Goldberg
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respiratory disease ,pediatrics ,Uganda ,COVID-19 ,asthma ,COPD ,Pediatrics ,RJ1-570 - Abstract
IntroductionRespiratory illness is the most common childhood disease globally, especially in developing countries. Previous studies have detected viruses in approximately 70-80% of respiratory illnesses.MethodsIn a prospective cohort study of 234 young children (ages 3-11 years) and 30 adults (ages 22-51 years) in rural Western Uganda sampled monthly from May 2019 to August 2021, only 24.2% of nasopharyngeal swabs collected during symptomatic disease had viruses detectable by multiplex PCR diagnostics and metagenomic sequencing. In the remaining 75.8% of swabs from symptomatic participants, we measured detection rates of respiratory bacteria Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae by quantitative PCR.Results100% of children tested positive for at least one bacterial species. Detection rates were 87.2%, 96.8%, and 77.6% in children and 10.0%, 36.7%, and 13.3% for adults for H. influenzae, M. catarrhalis, and S. pneumoniae, respectively. In children, 20.8% and 70.4% were coinfected with two and three pathogens, respectively, and in adults 6.7% were coinfected with three pathogens but none were coinfected with two. Detection of any of the three pathogens was not associated with season or respiratory symptoms severity, although parsing detection status by symptoms was challenged by children experiencing symptoms in 80.3% of monthly samplings, whereas adults only reported symptoms 26.6% of the time. Pathobiont colonization in children in Western Uganda was significantly more frequent than in children living in high-income countries, including in a study of age-matched US children that utilized identical diagnostic methods. Detection rates were, however, comparable to rates in children living in other Sub-Saharan African countries.DiscussionOverall, our results demonstrate that nonviral colds contribute significantly to respiratory disease burden among children in rural Uganda and that high rates of respiratory pathobiont colonization may play a role. These conclusions have implications for respiratory health interventions in the area, such as increasing childhood immunization rates and decreasing air pollutant exposure.
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- 2024
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35. Respiratory disease patterns in rural Western Uganda, 2019–2022
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Taylor E. Weary, Patrick Tusiime, Shamilah Tuhaise, Juan Francisco Mandujano Reyes, Elizabeth Ross, James E. Gern, and Tony L. Goldberg
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respiratory symptoms ,pediatrics ,cohort study ,Africa ,COVID-19 ,Pediatrics ,RJ1-570 - Abstract
IntroductionRespiratory disease is a major cause of morbidity and mortality in the developing world, but prospective studies of temporal patterns and risk factors are rare.MethodsWe studied people in rural Western Uganda, where respiratory disease is pervasive. We followed 30 adults (ages 22–51 years; 534 observations) and 234 children (ages 3–11 years; 1,513 observations) between May 2019 and July 2022 and collected monthly data on their respiratory symptoms, for a total of 2,047 case records. We examined associations between demographic and temporal factors and respiratory symptoms severity.ResultsThe timing of our study (before, during, and after the emergence of COVID-19) allowed us to document the effects of public health measures instituted in the region. Incidence rates of respiratory symptoms before COVID-19 lockdown were 568.4 cases per 1,000 person-months in children and 254.2 cases per 1,000 person-months in adults. These rates were 2.6 times higher than the 2019 global average for children but comparable for adults. Younger children (ages 3–6 years) had the highest frequencies and severities of respiratory symptoms. Study participants were most likely to experience symptoms in February, which is a seasonal pattern not previously documented. Incidence and severity of symptoms in children decreased markedly during COVID-19 lockdown, illustrating the broad effects of public health measures on the incidence of respiratory disease.DiscussionOur results demonstrate that patterns of respiratory disease in settings such as Western Uganda resemble patterns in developed economies in some ways (age-related factors) but not in others (increased incidence in children and seasonal pattern). Factors such as indoor air quality, health care access, timing of school trimesters, and seasonal effects (rainy/dry seasons) likely contribute to the differences observed.
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- 2024
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36. Glioma progression is shaped by genetic evolution and microenvironment interactions
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Varn, Frederick S, Johnson, Kevin C, Martinek, Jan, Huse, Jason T, Nasrallah, MacLean P, Wesseling, Pieter, Cooper, Lee AD, Malta, Tathiane M, Wade, Taylor E, Sabedot, Thais S, Brat, Daniel, Gould, Peter V, Wöehrer, Adelheid, Aldape, Kenneth, Ismail, Azzam, Sivajothi, Santhosh K, Barthel, Floris P, Kim, Hoon, Kocakavuk, Emre, Ahmed, Nazia, White, Kieron, Datta, Indrani, Moon, Hyo-Eun, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Garofano, Luciano, Anderson, Kevin J, Nehar-Belaid, Djamel, Barnholtz-Sloan, Jill S, Bakas, Spyridon, Byrne, Annette T, D’Angelo, Fulvio, Gan, Hui K, Khasraw, Mustafa, Migliozzi, Simona, Ormond, D Ryan, Paek, Sun Ha, Van Meir, Erwin G, Walenkamp, Annemiek ME, Watts, Colin, Weiss, Tobias, Weller, Michael, Palucka, Karolina, Stead, Lucy F, Poisson, Laila M, Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel GW, Consortium, The GLASS, Alfaro, Kristin D, Amin, Samirkumar B, Ashley, David M, Bock, Christoph, Brodbelt, Andrew, Bulsara, Ketan R, and Castro, Ana Valeria
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Biological Sciences ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Rare Diseases ,Brain Disorders ,Brain Cancer ,Genetics ,Cancer ,Neurosciences ,2.1 Biological and endogenous factors ,Aetiology ,Adult ,Brain Neoplasms ,Evolution ,Molecular ,Genes ,p16 ,Glioma ,Humans ,Isocitrate Dehydrogenase ,Mutation ,Neoplasm Recurrence ,Local ,Tumor Microenvironment ,GLASS Consortium ,genomics ,glioblastoma ,glioma ,hypermutation ,macrophages ,microenvironment ,neurons ,single-cell ,spatial imaging ,treatment resistance ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.
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- 2022
37. Racial disparities in emergency mental healthcare utilization among birthing people with preterm infants
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Karvonen, Kayla L, Baer, Rebecca J, Blebu, Bridgette, Calthorpe, Lucia, Fuchs, Jonathan D, Jelliffe-Pawlowski, Laura, Karasek, Deborah, McKenzie-Sampson, Safyer, Oltman, Scott P, Rand, Larry, Shannon, Maureen T, Washington, Taylor E, Woolridge, Tiana, Rogers, Elizabeth E, and Pantell, Matthew S
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Paediatrics ,Biomedical and Clinical Sciences ,Health Services ,Preterm ,Low Birth Weight and Health of the Newborn ,Clinical Research ,Infant Mortality ,Behavioral and Social Science ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Mental Health ,Prevention ,Mental health ,Good Health and Well Being ,Cohort Studies ,Female ,Gestational Age ,Humans ,Infant ,Infant ,Newborn ,Infant ,Premature ,Patient Acceptance of Health Care ,Pregnancy ,Premature Birth ,United States ,emergency department ,neonatal intensive care unit ,parental leave ,postpartum depression ,prematurity ,preterm hospitalization ,rehospitalizations ,structural racism ,Reproductive medicine - Abstract
BackgroundBirthing people of color are more likely to deliver low birthweight and preterm infants, populations at significant risk of morbidity and mortality. Birthing people of color are also at higher risk for mental health conditions and emergency mental healthcare utilization postpartum. Although this group has been identified as high risk in these contexts, it is not known whether racial and ethnic disparities exist in mental healthcare utilization among birthing people who have delivered preterm.ObjectiveWe sought to determine if racial and ethnic disparities exist in postpartum mental healthcare-associated emergency department visits or hospitalizations for birthing people with preterm infants in a large and diverse population.Study designThis population-based historic cohort study used a sample of Californian live-born infants born between 2011 and 2017 with linked birth certificates and emergency department visit and hospital admission records from the California Statewide Health Planning and Development database. The sample was restricted to preterm infants (
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- 2022
38. WALLABY Pilot Survey: First Look at the Hydra I Cluster and Ram Pressure Stripping of ESO 501-G075
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Reynolds, T. N., Westmeier, T., Elagali, A., Catinella, B., Cortese, L., Deg, N., For, B. -Q., Kamphuis, P., Kleiner, D., Koribalski, B. S., Lee-Waddell, K., Oh, S. -H., Rhee, J., Serra, P., Spekkens, K., Staveley-Smith, L., Stevens, A. R. H., Taylor, E. N., Wang, J., and Wong, O. I.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present results from neutral atomic hydrogen (HI) observations of Hydra I, the first cluster observed by the Widefield ASKAP L-band Legacy All-sky Blind Survey (WALLABY) on the Australian Square Kilometre Array Pathfinder. For the first time we show that WALLABY can reach its final survey sensitivity. Leveraging the sensitivity, spatial resolution and wide field of view of WALLABY, we identify a galaxy, ESO 501-G075, that lies near the virial radius of Hydra I and displays an HI tail. ESO 501-G075 shows a similar level of morphological asymmetry as another cluster member, which lies near the cluster centre and shows signs of experiencing ram pressure. We investigate possible environmental processes that could be responsible for producing the observed disturbance in the HI morphology of ESO 501-G075. We rule out tidal interactions, as ESO 501-G075 has no nearby neighbours within $\sim0.34$Mpc. We use a simple model to determine that ram pressure can remove gas from the disc at radii $r\gtrsim25$kpc. We conclude that, as ESO 501-G075 has a typical HI mass compared to similar galaxies in the field and its morphology is compatible with a ram pressure scenario, ESO 501-G075 is likely recently infalling into the cluster and in the early stages of experiencing ram pressure., Comment: 14 pages, 11 figures, accepted for publication in MNRAS
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- 2021
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39. Measuring Cosmic Density of Neutral Hydrogen via Stacking the DINGO-VLA Data
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Chen, Qingxiang, Meyer, Martin, Popping, Attila, Staveley-Smith, Lister, Bryant, Julia, Delhaize, Jacinta, Holwerda, B. W., Cluver, M. E., Loveday, J., Lopez-Sanchez, Angel R., Zwaan, Martin, Taylor, E. N., Hopkins, A. M., Wright, Angus, Driver, Simon, and Brough, S.
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Astrophysics - Astrophysics of Galaxies - Abstract
We use the 21 cm emission line data from the DINGO-VLA project to study the atomic hydrogen gas H\,{\textsc i} of the Universe at redshifts $z<0.1$. Results are obtained using a stacking analysis, combining the H\,{\textsc i} signals from 3622 galaxies extracted from 267 VLA pointings in the G09 field of the Galaxy and Mass Assembly Survey (GAMA). Rather than using a traditional one-dimensional spectral stacking method, a three-dimensional cubelet stacking method is used to enable deconvolution and the accurate recovery of average galaxy fluxes from this high-resolution interferometric dataset. By probing down to galactic scales, this experiment also overcomes confusion corrections that have been necessary to include in previous single dish studies. After stacking and deconvolution, we obtain a $30\sigma$ H\,{\textsc i} mass measurement from the stacked spectrum, indicating an average H\,{\textsc i} mass of $M_{\rm H\,{\textsc i}}=(1.674\pm 0.183)\times 10^{9}~{\Msun}$. The corresponding cosmic density of neutral atomic hydrogen is $\Omega_{\rm H\,{\textsc i}}=(0.377\pm 0.042)\times 10^{-3}$ at redshift of $z=0.051$. These values are in good agreement with earlier results, implying there is no significant evolution of $\Omega_{\rm H\,{\textsc i}}$ at lower redshifts., Comment: 13 pages, 9 figures, submitted to MNRAS
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- 2021
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40. Galaxy and Mass Assembly (GAMA): Tracing galaxy environment using the marked correlation function
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Sureshkumar, U., Durkalec, A., Pollo, A., Bilicki, M., Loveday, J., Farrow, D. J., Holwerda, B. W., Hopkins, A. M., Liske, J., Pimbblet, K. A., Taylor, E. N., and Wright, A. H.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We investigate how different galaxy properties - luminosities in u, g, r, J, K-bands, stellar mass, star formation rate and specific star formation rate trace the environment in the local universe. We also study the effect of survey flux limits on galaxy clustering measurements. We measure the two-point correlation function (2pCF) and marked correlation functions (MCFs) using the aforementioned properties as marks. We use nearly stellar-mass-complete galaxy sample in the redshift range 0.1 < z < 0.16 from the Galaxy And Mass Assembly (GAMA) survey with a flux limit of r < 19.8. Further, we impose a brighter flux limit of r < 17.8 to our sample and repeat the measurements to study how this affects galaxy clustering analysis. We compare our results to measurements from the Sloan Digital Sky Survey (SDSS) with flux limits of r < 17.8 and r < 16.8. We show that the stellar mass is the best tracer of galaxy environment, the K-band luminosity being a good substitute, although such a proxy sample misses close pairs of evolved, red galaxies. We also confirm that the u-band luminosity is a good, but not a perfect proxy of star formation rate in the context of galaxy clustering. We observe an effect of the survey flux limit on clustering studies - samples with a higher flux limit (smaller magnitude) miss some information about close pairs of starburst galaxies., Comment: 15 pages, 7 figures, matches the version published in A&A
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- 2021
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41. Overview of the Medium and High Frequency Telescopes of the LiteBIRD satellite mission
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Montier, L., Mot, B., de Bernardis, P., Maffei, B., Pisano, G., Columbro, F., Gudmundsson, J. E., Henrot-Versillé, S., Lamagna, L., Montgomery, J., Prouvé, T., Russell, M., Savini, G., Stever, S., Thompson, K. L., Tsujimoto, M., Tucker, C., Westbrook, B., Ade, P. A. R., Adler, A., Allys, E., Arnold, K., Auguste, D., Aumont, J., Aurlien, R., Austermann, J., Baccigalupi, C., Banday, A. J., Banerji, R., Barreiro, R. B., Basak, S., Beall, J., Beck, D., Beckman, S., Bermejo, J., Bersanelli, M., Bonis, J., Borrill, J., Boulanger, F., Bounissou, S., Brilenkov, M., Brown, M., Bucher, M., Calabrese, E., Campeti, P., Carones, A., Casas, F. J., Challinor, A., Chan, V., Cheung, K., Chinone, Y., Cliche, J. F., Colombo, L., Cubas, J., Cukierman, A., Curtis, D., D'Alessandro, G., Dachlythra, N., De Petris, M., Dickinson, C., Diego-Palazuelos, P., Dobbs, M., Dotani, T., Duband, L., Duff, S., Duval, J. M., Ebisawa, K., Elleflot, T., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Finelli, F., Flauger, R., Franceschet, C., Fuskeland, U., Galloway, M., Ganga, K., Gao, J. R., Genova-Santos, R., Gerbino, M., Gervasi, M., Ghigna, T., Gjerløw, E., Gradziel, M. L., Grain, J., Grupp, F., Gruppuso, A., de Haan, T., Halverson, N. W., Hargrave, P., Hasebe, T., Hasegawa, M., Hattori, M., Hazumi, M., Herman, D., Herranz, D., Hill, C. A., Hilton, G., Hirota, Y., Hivon, E., Hlozek, R. A., Hoshino, Y., de la Hoz, E., Hubmayr, J., Ichiki, K., Iida, T., Imada, H., Ishimura, K., Ishino, H., Jaehnig, G., Kaga, T., Kashima, S., Katayama, N., Kato, A., Kawasaki, T., Keskitalo, R., Kisner, T., Kobayashi, Y., Kogiso, N., Kogut, A., Kohri, K., Komatsu, E., Komatsu, K., Konishi, K., Krachmalnicoff, N., Kreykenbohm, I., Kuo, C. L., Kushino, A., Lanen, J. V., Lattanzi, M., Lee, A. T., Leloup, C., Levrier, F., Linder, E., Louis, T., Luzzi, G., Maciaszek, T., Maino, D., Maki, M., Mandelli, S., Martinez-Gonzalez, E., Masi, S., Matsumura, T., Mennella, A., Migliaccio, M., Minami, Y., Mitsuda, K., Morgante, G., Murata, Y., Murphy, J. A., Nagai, M., Nagano, Y., Nagasaki, T., Nagata, R., Nakamura, S., Namikawa, T., Natoli, P., Nerval, S., Nishibori, T., Nishino, H., O'Sullivan, C., Ogawa, H., Oguri, S., Ohsaki, H., Ohta, I. S., Okada, N., Pagano, L., Paiella, A., Paoletti, D., Patanchon, G., Peloton, J., Piacentini, F., Polenta, G., Poletti, D., Puglisi, G., Rambaud, D., Raum, C., Realini, S., Reinecke, M., Remazeilles, M., Ritacco, A., Roudil, G., Rubino-Martin, J. A., Sakurai, H., Sakurai, Y., Sandri, M., Sasaki, M., Scott, D., Seibert, J., Sekimoto, Y., Sherwin, B., Shinozaki, K., Shiraishi, M., Shirron, P., Signorelli, G., Smecher, G., Stompor, R., Sugai, H., Sugiyama, S., Suzuki, A., Suzuki, J., Svalheim, T. L., Switzer, E., Takaku, R., Takakura, H., Takakura, S., Takase, Y., Takeda, Y., Tartari, A., Taylor, E., Terao, Y., Thommesen, H., Thorne, B., Toda, T., Tomasi, M., Tominaga, M., Trappe, N., Tristram, M., Tsuji, M., Ullom, J., Vermeulen, G., Vielva, P., Villa, F., Vissers, M., Vittorio, N., Wehus, I., Weller, J., Wilms, J., Winter, B., Wollack, E. J., Yamasaki, N. Y., Yoshida, T., Yumoto, J., Zannoni, M., and Zonca, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
LiteBIRD is a JAXA-led Strategic Large-Class mission designed to search for the existence of the primordial gravitational waves produced during the inflationary phase of the Universe, through the measurements of their imprint onto the polarization of the cosmic microwave background (CMB). These measurements, requiring unprecedented sensitivity, will be performed over the full sky, at large angular scales, and over 15 frequency bands from 34GHz to 448GHz. The LiteBIRD instruments consist of three telescopes, namely the Low-, Medium- and High-Frequency Telescope (respectively LFT, MFT and HFT). We present in this paper an overview of the design of the Medium-Frequency Telescope (89-224GHz) and the High-Frequency Telescope (166-448GHz), the so-called MHFT, under European responsibility, which are two cryogenic refractive telescopes cooled down to 5K. They include a continuous rotating half-wave plate as the first optical element, two high-density polyethylene (HDPE) lenses and more than three thousand transition-edge sensor (TES) detectors cooled to 100mK. We provide an overview of the concept design and the remaining specific challenges that we have to face in order to achieve the scientific goals of LiteBIRD., Comment: SPIE Conference
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- 2021
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42. LiteBIRD: JAXA's new strategic L-class mission for all-sky surveys of cosmic microwave background polarization
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Hazumi, M., Ade, P. A. R., Adler, A., Allys, E., Arnold, K., Auguste, D., Aumont, J., Aurlien, R., Austermann, J., Baccigalupi, C., Banday, A. J., Banjeri, R., Barreiro, R. B., Basak, S., Beall, J., Beck, D., Beckman, S., Bermejo, J., de Bernardis, P., Bersanelli, M., Bonis, J., Borrill, J., Boulanger, F., Bounissou, S., Brilenkov, M., Brown, M., Bucher, M., Calabrese, E., Campeti, P., Carones, A., Casas, F. J., Challinor, A., Chan, V., Cheung, K., Chinone, Y., Cliche, J. F., Colombo, L., Columbro, F., Cubas, J., Cukierman, A., Curtis, D., D'Alessandro, G., Dachlythra, N., De Petris, M., Dickinson, C., Diego-Palazuelos, P., Dobbs, M., Dotani, T., Duband, L., Duff, S., Duval, J. M., Ebisawa, K., Elleflot, T., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Finelli, F., Flauger, R., Franceschet, C., Fuskeland, U., Galloway, M., Ganga, K., Gao, J. R., Genova-Santos, R., Gerbino, M., Gervasi, M., Ghigna, T., Gjerløw, E., Gradziel, M. L., Grain, J., Grupp, F., Gruppuso, A., Gudmundsson, J. E., de Haan, T., Halverson, N. W., Hargrave, P., Hasebe, T., Hasegawa, M., Hattori, M., Henrot-Versillé, S., Herman, D., Herranz, D., Hill, C. A., Hilton, G., Hirota, Y., Hivon, E., Hlozek, R. A., Hoshino, Y., de la Hoz, E., Hubmayr, J., Ichiki, K., Iida, T., Imada, H., Ishimura, K., Ishino, H., Jaehnig, G., Kaga, T., Kashima, S., Katayama, N., Kato, A., Kawasaki, T., Keskitalo, R., Kisner, T., Kobayashi, Y., Kogiso, N., Kogut, A., Kohri, K., Komatsu, E., Komatsu, K., Konishi, K., Krachmalnicoff, N., Kreykenbohm, I., Kuo, C. L., Kushino, A., Lamagna, L., Lanen, J. V., Lattanzi, M., Lee, A. T., Leloup, C., Levrier, F., Linder, E., Louis, T., Luzzi, G., Maciaszek, T., Maffei, B., Maino, D., Maki, M., Mandelli, S., Martinez-Gonzalez, E., Masi, S., Matsumura, T., Mennella, A., Migliaccio, M., Minami, Y., Mitsuda, K., Montgomery, J., Montier, L., Morgante, G., Mot, B., Murata, Y., Murphy, J. A., Nagai, M., Nagano, Y., Nagasaki, T., Nagata, R., Nakamura, S., Namikawa, T., Natoli, P., Nerval, S., Nishibori, T., Nishino, H., Noviello, F., O'Sullivan, C., Ogawa, H., Oguri, S., Ohsaki, H., Ohta, I. S., Okada, N., Pagano, L., Paiella, A., Paoletti, D., Patanchon, G., Peloton, J., Piacentini, F., Pisano, G., Polenta, G., Poletti, D., Prouvé, T., Puglisi, G., Rambaud, D., Raum, C., Realini, S., Reinecke, M., Remazeilles, M., Ritacco, A., Roudil, G., Rubino-Martin, J. A., Russell, M., Sakurai, H., Sakurai, Y., Sandri, M., Sasaki, M., Savini, G., Scott, D., Seibert, J., Sekimoto, Y., Sherwin, B., Shinozaki, K., Shiraishi, M., Shirron, P., Signorelli, G., Smecher, G., Stever, S., Stompor, R., Sugai, H., Sugiyama, S., Suzuki, A., Suzuki, J., Svalheim, T. L., Switzer, E., Takaku, R., Takakura, H., Takakura, S., Takase, Y., Takeda, Y., Tartari, A., Taylor, E., Terao, Y., Thommesen, H., Thompson, K. L., Thorne, B., Toda, T., Tomasi, M., Tominaga, M., Trappe, N., Tristram, M., Tsuji, M., Tsujimoto, M., Tucker, C., Ullom, J., Vermeulen, G., Vielva, P., Villa, F., Vissers, M., Vittorio, N., Wehus, I., Weller, J., Westbrook, B., Wilms, J., Winter, B., Wollack, E. J., Yamasaki, N. Y., Yoshida, T., Yumoto, J., Zannoni, M., and Zonca, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
LiteBIRD, the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. JAXA selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with its expected launch in the late 2020s using JAXA's H3 rocket. LiteBIRD plans to map the cosmic microwave background (CMB) polarization over the full sky with unprecedented precision. Its main scientific objective is to carry out a definitive search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with an insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. To this end, LiteBIRD will perform full-sky surveys for three years at the Sun-Earth Lagrangian point L2 for 15 frequency bands between 34 and 448 GHz with three telescopes, to achieve a total sensitivity of 2.16 micro K-arcmin with a typical angular resolution of 0.5 deg. at 100GHz. We provide an overview of the LiteBIRD project, including scientific objectives, mission requirements, top-level system requirements, operation concept, and expected scientific outcomes., Comment: 20 pages, 9 figures
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- 2021
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43. Concept Design of Low Frequency Telescope for CMB B-mode Polarization satellite LiteBIRD
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Sekimoto, Y., Ade, P. A. R., Adler, A., Allys, E., Arnold, K., Auguste, D., Aumont, J., Aurlien, R., Austermann, J., Baccigalupi, C., Banday, A. J., Banerji, R., Barreiro, R. B., Basak, S., Beall, J., Beck, D., Beckman, S., Bermejo, J., de Bernardis, P., Bersanelli, M., Bonis, J., Borrill, J., Boulanger, F., Bounissou, S., Brilenkov, M., Brown, M., Bucher, M., Calabrese, E., Campeti, P., Carones, A., Casas, F. J., Challinor, A., Chan, V., Cheung, K., Chinone, Y., Cliche, J. F., Colombo, L., Columbro, F., Cubas, J., Cukierman, A., Curtis, D., D'Alessandro, G., Dachlythra, N., De Petris, M., Dickinson, C., Diego-Palazuelos, P., Dobbs, M., Dotani, T., Duband, L., Duff, S., Duval, J. M., Ebisawa, K., Elleflot, T., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Finelli, F., Flauger, R., Franceschet, C., Fuskeland, U., Galloway, M., Ganga, K., Gao, J. R., Genova-Santos, R., Gerbino, M., Gervasi, M., Ghigna, T., Gjerløw, E., Gradziel, M. L., Grain, J., Grupp, F., Gruppuso, A., Gudmundsson, J. E., de Haan, T., Halverson, N. W., Hargrave, P., Hasebe, T., Hasegawa, M., Hattori, M., Hazumi, M., Henrot-Versillé, S., Herman, D., Herranz, D., Hill, C. A., Hilton, G., Hirota, Y., Hivon, E., Hlozek, R. A., Hoshino, Y., de la Hoz, E., Hubmayr, J., Ichiki, K., iida, T., Imada, H., Ishimura, K., Ishino, H., Jaehnig, G., Kaga, T., Kashima, S., Katayama, N., Kato, A., Kawasaki, T., Keskitalo, R., Kisner, T., Kobayashi, Y., Kogiso, N., Kogut, A., Kohri, K., Komatsu, E., Komatsu, K., Konishi, K., Krachmalnicoff, N., Kreykenbohm, I., Kuo, C. L., Kushino, A., Lamagna, L., Lanen, J. V., Lattanzi, M., Lee, A. T., Leloup, C., Levrier, F., Linder, E., Louis, T., Luzzi, G., Maciaszek, T., Maffei, B., Maino, D., Maki, M., Mandelli, S., Martinez-Gonzalez, E., Masi, S., Matsumura, T., Mennella, A., Migliaccio, M., Minanmi, Y., Mitsuda, K., Montgomery, J., Montier, L., Morgante, G., Mot, B., Murata, Y., Murphy, J. A., Nagai, M., Nagano, Y., Nagasaki, T., Nagata, R., Nakamura, S., Namikawa, T., Natoli, P., Nerval, S., Nishibori, T., Nishino, H., O'Sullivan, C., Ogawa, H., Oguri, S., Ohsaki, H., Ohta, I. S., Okada, N., Pagano, L., Paiella, A., Paoletti, D., Patanchon, G., Peloton, J., Piacentini, F., Pisano, G., Polenta, G., Poletti, D., Prouvé, T., Puglisi, G., Rambaud, D., Raum, C., Realini, S., Reinecke, M., Remazeilles, M., Ritacco, A., Roudil, G., Rubino-Martin, J. A., Russell, M., Sakurai, H., Sakurai, Y., Sandri, M., Sasaki, M., Savini, G., Scott, D., Seibert, J., Sherwin, B., Shinozaki, K., Shiraishi, M., Shirron, P., Signorelli, G., Smecher, G., Stever, S., Stompor, R., Sugai, H., Sugiyama, S., Suzuki, A., Suzuki, J., Svalheim, T. L., Switzer, E., Takaku, R., Takakura, H., Takakura, S., Takase, Y., Takeda, Y., Tartari, A., Taylor, E., Terao, Y., Thommesen, H., Thompson, K. L., Thorne, B., Toda, T., Tomasi, M., Tominaga, M., Trappe, N., Tristram, M., Tsuji, M., Tsujimoto, M., Tucker, C., Ullom, J., Vermeulen, G., Vielva, P., Villa, F., Vissers, M., Vittorio, N., Wehus, I., Weller, J., Westbrook, B., Wilms, J., Winter, B., Wollack, E. J., Yamasaki, N. Y., Yoshida, T., Yumoto, J., Zannoni, M., and Zonca, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
LiteBIRD has been selected as JAXA's strategic large mission in the 2020s, to observe the cosmic microwave background (CMB) $B$-mode polarization over the full sky at large angular scales. The challenges of LiteBIRD are the wide field-of-view (FoV) and broadband capabilities of millimeter-wave polarization measurements, which are derived from the system requirements. The possible paths of stray light increase with a wider FoV and the far sidelobe knowledge of $-56$ dB is a challenging optical requirement. A crossed-Dragone configuration was chosen for the low frequency telescope (LFT : 34--161 GHz), one of LiteBIRD's onboard telescopes. It has a wide field-of-view ($18^\circ \times 9^\circ$) with an aperture of 400 mm in diameter, corresponding to an angular resolution of about 30 arcminutes around 100 GHz. The focal ratio f/3.0 and the crossing angle of the optical axes of 90$^\circ$ are chosen after an extensive study of the stray light. The primary and secondary reflectors have rectangular shapes with serrations to reduce the diffraction pattern from the edges of the mirrors. The reflectors and structure are made of aluminum to proportionally contract from warm down to the operating temperature at $5\,$K. A 1/4 scaled model of the LFT has been developed to validate the wide field-of-view design and to demonstrate the reduced far sidelobes. A polarization modulation unit (PMU), realized with a half-wave plate (HWP) is placed in front of the aperture stop, the entrance pupil of this system. A large focal plane with approximately 1000 AlMn TES detectors and frequency multiplexing SQUID amplifiers is cooled to 100 mK. The lens and sinuous antennas have broadband capability. Performance specifications of the LFT and an outline of the proposed verification plan are presented., Comment: 21 pages, 14 figures
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- 2021
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44. Author Correction: Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult carriers
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Taylor E. Weary, Tressa Pappas, Patrick Tusiime, Shamilah Tuhaise, Emily Otali, Melissa Emery Thompson, Elizabeth Ross, James E. Gern, and Tony L. Goldberg
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Medicine ,Science - Published
- 2024
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45. COVID-19 Stroke Apical Lung Examination Study 2: a national prospective CTA biomarker study of the lung apices, in patients presenting with suspected acute stroke (COVID SALES 2)
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Ratneswaren, T., Chan, N., Aeron-Thomas, J., Sait, S., Adesalu, O., Alhawamdeh, M., Benger, M., Garnham, J., Dixon, L., Tona, F., McNamara, C., Taylor, E., Lobotesis, K., Lim, E., Goldberg, O., Asmar, N., Evbuomwan, O., Banerjee, S., Holm-Mercer, L., Senor, J., Tsitsiou, Y., Tantrige, P., Taha, A., Ballal, K., Mattar, A., Daadipour, A., Elfergani, K., Barker, R., Chakravartty, R., Murchison, A.G., Kemp, B.J., Simister, R., Davagnanam, I., Wong, O.Y., Werring, D., Banaras, A., Anjari, M., Mak, J.K.C., Falzon, A.M., Rodrigues, J.C.L., Thompson, C.A.S., Haines, I.R., Burnett, T.A., Zaher, R.E.Y., Reay, V.L., Banerjee, M., Sew Hee, C.S.L., Oo, A.P., Lo, A., Rogers, P., Hughes, T., Marin, A., Mukherjee, S., Jaber, H., Sanders, E., Owen, S., Bhandari, M., Sundayi, S., Bhagat, A., Elsakka, M., Hashmi, O.H., Lymbouris, M., Gurung-Koney, Y., Arshad, M., Hasan, I., Singh, N., Patel, V., Rahiminejad, M., and Booth, T.C.
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- 2024
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46. Effectiveness of Immune Checkpoint Inhibitor with Anti-PD-1 Monotherapy or in Combination with Ipilimumab in Younger versus Older Adults with Advanced Melanoma
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Taylor E. Woo, Igor Stukalin, Philip Q. Ding, Siddhartha Goutam, Michael Sander, Benjamin Ewanchuk, Winson Y. Cheung, Daniel Y. C. Heng, and Tina Cheng
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melanoma ,immune checkpoint inhibitor ,nivolumab ,pembrolizumab ,ipilimumab plus nivolumab ,age ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The majority of melanoma is diagnosed in individuals between 55 and 84 years old. Current data varied in reporting differences in survival outcomes amongst different age groups. Methods: A retrospective, multi-center, provincial cohort database was used to investigate the relationship between age (Results: From August 2013 to May 2020, we identified 497 patients (median age = 64 [range 12–96 years]; 65.2% men; 36.4% with a BRAF mutation (V600E and V600K)). Of these, 260 were < 65 years old, and 237 were ≥65 years old. A total of 39.1% of the patients in the younger cohort received combination ICI compared with 10.2% in the older cohort, and the difference was statistically significant. Median survival amongst individuals aged ≥65 years old was shorter compared to individuals p = 0.04), at a median follow-up of 34.4 months (range: 1.84–81.4 months). The survival difference was present in the cutaneous melanoma cohort where median OS was 18.2 months (95% CI 12.3–30.4 months) in patients ≥65 years old and 23.8 months (95% CI 19.2–48.2 months) in patients p = 0.04. There were no significant differences by age in the non-cutaneous melanoma cohort. A combination of nivolumab plus ipilimumab was associated with an improved overall survival hazard ratio of 0.48 (95% CI 0.36–0.65) as compared to anti-PD-1 monotherapy alone (p < 0.001). In the cutaneous cohort treated with anti-PD-1 monotherapy (n = 306), no significant differences were seen with median OS at 16.1 months (95% CI 11.4–25.7 months) in patients ≥65 years old and 17.1 months (95% CI 12.0–22.2 months) in patients p = 0.84). Tumor response to anti-PD-1 was higher in the older patients compared with the response in younger patients with cutaneous melanoma. Conclusions: Older melanoma patients have similar survival compared with younger patients after receiving the same treatment with anti-PD-1 monotherapy. The superior survival observed in the younger patients is possibly related to the higher utilization of combination ICI. Tumor response to immunotherapy is superior in older patients with cutaneous melanoma; however, younger patients may improve their survival by using combination ICI.
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- 2023
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47. The aging ovary impairs acute stroke outcomes
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Taylor E. Branyan, Jocelyn Aleksa, Esteban Lepe, Kelby Kosel, and Farida Sohrabji
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Reproductive senescence ,MCAo ,Sensorimotor impairment ,Ovarian cytokines ,T cells ,Macrophages ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract In experimental stroke, ovariectomized (OVX) adult rats have larger infarct volumes and greater sensory-motor impairment as compared to ovary-intact females and is usually interpreted to indicate that ovarian hormones are neuroprotective for stroke. Previous work from our lab shows that middle-aged, acyclic reproductively senescent (RS) females have worse stroke outcomes as compared to adult (normally cycling) females. We hypothesized that if loss of ovarian estrogen is the critical determinant of stroke outcomes, then ovary-intact middle-aged acyclic females, who have reduced levels of estradiol, should have similar stroke outcomes as age-matched OVX. Instead, the data demonstrated that OVX RS animals showed better sensory-motor function after stroke and reduced infarct volume as compared to ovary-intact females. Inflammatory cytokines were decreased in the aging ovary after stroke as compared to non-stroke shams, which led to the hypothesis that immune cells may be extravasated from the ovaries post-stroke. Flow cytometry indicated reduced overall T cell populations in the aging ovary after middle cerebral artery occlusion (MCAo), with a paradoxical increase in regulatory T cells (Tregs) and M2-like macrophages. Moreover, in the brain, OVX RS animals showed increased Tregs, increased M2-like macrophages, and increased MHC II + cells as compared to intact RS animals, which have all been shown to be correlated with better prognosis after stroke. Depletion of ovary-resident immune cells after stroke suggests that there may be an exaggerated response to ischemia and possible increased burden of the inflammatory response via extravasation of these cells into circulation. Increased anti-inflammatory cells in the brain of OVX RS animals further supports this hypothesis. These data suggest that stroke severity in aging females may be exacerbated by the aging ovary and underscore the need to assess immunological changes in this organ after stroke.
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- 2023
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48. Inferring neural dynamics during burst suppression using a neurophysiology-inspired switching state-space model
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Schamberg, Gabriel, Chakravarty, Sourish, Baum, Taylor E., and Brown, Emery N.
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Quantitative Biology - Quantitative Methods ,Quantitative Biology - Neurons and Cognition - Abstract
Burst suppression is an electroencephalography (EEG) pattern associated with profoundly inactivated brain states characterized by cerebral metabolic depression. Its distinctive feature is alternation between short temporal segments of near-isoelectric inactivity (suppressions) and relatively high-voltage activity (bursts). Prior modeling studies suggest that burst-suppression EEG is a manifestation of two alternating brain states associated with consumption (during a burst) and production (during a suppression) of adenosine triphosphate (ATP). This finding motivates us to infer latent states characterizing alternating brain states and underlying ATP kinetics from instantaneous power of multichannel EEG using a switching state-space model. Our model assumes Gaussian distributed data as a broadcast network manifestation of one of two global brain states. The two brain states are allowed to stochastically alternate with transition probabilities that depend on the instantaneous ATP level, which evolves according to first-order kinetics. The rate constants governing the ATP kinetics are allowed to vary as first-order autoregressive processes. Our latent state estimates are determined from data using a sequential Monte Carlo algorithm. Our neurophysiology-informed model not only provides unsupervised segmentation of multi-channel burst-suppression EEG but can also generate additional insights on the level of brain inactivation during anesthesia., Comment: To appear in the proceedings of the 2020 IEEE Asilomar Conference on Signals, Systems, and Computers
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- 2020
49. The MAGPI Survey -- science goals, design, observing strategy, early results and theoretical framework
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Foster, C., Mendel, J. T., Lagos, C. D. P., Wisnioski, E., Yuan, T., D'Eugenio, F., Barone, T. M., Harborne, K. E., Vaughan, S. P., Schulze, F., Remus, R. -S., Gupta, A., Collacchioni, F., Khim, D. J., Taylor, P., Bassett, R., Croom, S. M., McDermid, R. M., Poci, A., Battisti, A. J., Bland-Hawthorn, J., Bellstedt, S., Colless, M., Davies, L. J. M., Derkenne, C., Driver, S., Ferré-Mateu, A., Fisher, D. B., Gjergo, E., Johnston, E. J., Khalid, A., Kobayashi, C., Oh, S., Peng, Y., Robotham, A. S. G., Sharda, P., Sweet, S. M., Taylor, E. N., Tran, K. -V. H., Trayford, J. W., van de Sande, J., Yi, S. K., and Zanisi, L.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present an overview of the Middle Ages Galaxy Properties with Integral Field Spectroscopy (MAGPI) survey, a Large Program on ESO/VLT. MAGPI is designed to study the physical drivers of galaxy transformation at a lookback time of 3-4 Gyr, during which the dynamical, morphological, and chemical properties of galaxies are predicted to evolve significantly. The survey uses new medium-deep adaptive optics aided MUSE observations of fields selected from the GAMA survey, providing a wealth of publicly available ancillary multi-wavelength data. With these data, MAGPI will map the kinematic and chemical properties of stars and ionised gas for a sample of 60 massive (> 7 x 10^10 M_Sun) central galaxies at 0.25 < z <0.35 in a representative range of environments (isolated, groups and clusters). The spatial resolution delivered by MUSE with Ground Layer Adaptive Optics (GLAO, 0.6-0.8 arcsec FWHM) will facilitate a direct comparison with Integral Field Spectroscopy surveys of the nearby Universe, such as SAMI and MaNGA, and at higher redshifts using adaptive optics, e.g. SINS. In addition to the primary (central) galaxy sample, MAGPI will deliver resolved and unresolved spectra for as many as 150 satellite galaxies at 0.25 < z <0.35, as well as hundreds of emission-line sources at z < 6. This paper outlines the science goals, survey design, and observing strategy of MAGPI. We also present a first look at the MAGPI data, and the theoretical framework to which MAGPI data will be compared using the current generation of cosmological hydrodynamical simulations including EAGLE, Magneticum, HORIZON-AGN, and Illustris-TNG. Our results show that cosmological hydrodynamical simulations make discrepant predictions in the spatially resolved properties of galaxies at z ~ 0.3. MAGPI observations will place new constraints and allow for tangible improvements in galaxy formation theory., Comment: 31 pages, 13 figures, PASA accepted
- Published
- 2020
- Full Text
- View/download PDF
50. Centrally concentrated molecular gas driving galactic-scale ionised gas outflows in star-forming galaxies
- Author
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Hogarth, L. M., Saintonge, A., Cortese, L., Davis, T. A., Croom, S. M., Bland-Hawthorn, J., Brough, S., Bryant, J. J., Catinella, B., Fletcher, T. J., Groves, B., Lawrence, J. S., Lopez-Sanchez, A. R., Owers, M. S., Richards, S. N., Roberts-Borsani, G. W., Taylor, E. N., van de Sande, J., and Scott, N.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We perform a joint-analysis of high spatial resolution molecular gas and star-formation rate (SFR) maps in main-sequence star-forming galaxies experiencing galactic-scale outflows of ionised gas. Our aim is to understand the mechanism that determines which galaxies are able to launch these intense winds. We observed CO(1-0) at 1" resolution with ALMA in 16 edge-on galaxies, which also have 2" spatial resolution optical integral field observations from the SAMI Galaxy Survey. Half the galaxies in the sample were previously identified as harbouring intense and large-scale outflows of ionised gas ("outflow-types"), the rest serve as control galaxies. The dataset is complemented by integrated CO(1-0) observations from the IRAM 30-m telescope to probe the total molecular gas reservoirs. We find that the galaxies powering outflows do not possess significantly different global gas fractions or star-formation efficiencies when compared with a control sample. However, the ALMA maps reveal that the molecular gas in the outflow-type galaxies is distributed more centrally than in the control galaxies. For our outflow-type objects, molecular gas and star-formation is largely confined within their inner effective radius ($\rm r_{eff}$), whereas in the control sample the distribution is more diffuse, extending far beyond $\rm r_{eff}$. We infer that outflows in normal star-forming galaxies may be caused by dynamical mechanisms that drive molecular gas into their central regions, which can result in locally-enhanced gas surface density and star-formation., Comment: 21 pages
- Published
- 2020
- Full Text
- View/download PDF
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