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19 results on '"Theofanous, Stavroula"'

1. Local immune response to food antigens drives meal-induced abdominal pain

Author

Aguilera-Lizarraga, Javier, Florens, Morgane V., Viola, Maria Francesca, Jain, Piyush, Decraecker, Lisse, Appeltans, Iris, Cuende-Estevez, Maria, Fabre, Naomi, Van Beek, Kim, Perna, Eluisa, Balemans, Dafne, Stakenborg, Nathalie, Theofanous, Stavroula, Bosmans, Goele, Mondelaers, Stéphanie U., Matteoli, Gianluca, Ibiza Martínez, Sales, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Talavera, Karel, Alpizar, Yeranddy A., Feyerabend, Thorsten B., Rodewald, Hans-Reimer, Farre, Ricard, Redegeld, Frank A., Si, Jiyeon, Raes, Jeroen, Breynaert, Christine, Schrijvers, Rik, Bosteels, Cédric, Lambrecht, Bart N., Boyd, Scott D., Hoh, Ramona A., Cabooter, Deirdre, Nelis, Maxim, Augustijns, Patrick, Hendrix, Sven, Strid, Jessica, Bisschops, Raf, Reed, David E., Vanner, Stephen J., Denadai-Souza, Alexandre, Wouters, Mira M., and Boeckxstaens, Guy E.

Published
2021
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2. Biochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase

Author

Kantsadi, Anastassia L., Apostolou, Anna, Theofanous, Stavroula, Stravodimos, George A., Kyriakis, Efthimios, Gorgogietas, Vyron A., Chatzileontiadou, Demetra S.M., Pegiou, Kalliope, Skamnaki, Vassiliki T., Stagos, Dimitrios, Kouretas, Dimitrios, Psarra, Anna-Maria G., Haroutounian, Serkos A., and Leonidas, Demetres D.

Published
2014
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3. Local immune response to food antigens drives meal-induced abdominal pain

Author

Afd Pharmacology, Pharmacology, Aguilera-Lizarraga, Javier, Florens, Morgane V, Viola, Maria Francesca, Jain, Piyush, Decraecker, Lisse, Appeltans, Iris, Cuende-Estevez, Maria, Fabre, Naomi, Van Beek, Kim, Perna, Eluisa, Balemans, Dafne, Stakenborg, Nathalie, Theofanous, Stavroula, Bosmans, Goele, Mondelaers, Stéphanie U, Matteoli, Gianluca, Ibiza Martínez, Sales, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Talavera, Karel, Alpizar, Yeranddy A, Feyerabend, Thorsten B, Rodewald, Hans-Reimer, Farre, Ricard, Redegeld, Frank A, Si, Jiyeon, Raes, Jeroen, Breynaert, Christine, Schrijvers, Rik, Bosteels, Cédric, Lambrecht, Bart N, Boyd, Scott D, Hoh, Ramona A, Cabooter, Deirdre, Nelis, Maxim, Augustijns, Patrick, Hendrix, Sven, Strid, Jessica, Bisschops, Raf, Reed, David E, Vanner, Stephen J, Denadai-Souza, Alexandre, Wouters, Mira M, Boeckxstaens, Guy E, Afd Pharmacology, Pharmacology, Aguilera-Lizarraga, Javier, Florens, Morgane V, Viola, Maria Francesca, Jain, Piyush, Decraecker, Lisse, Appeltans, Iris, Cuende-Estevez, Maria, Fabre, Naomi, Van Beek, Kim, Perna, Eluisa, Balemans, Dafne, Stakenborg, Nathalie, Theofanous, Stavroula, Bosmans, Goele, Mondelaers, Stéphanie U, Matteoli, Gianluca, Ibiza Martínez, Sales, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Talavera, Karel, Alpizar, Yeranddy A, Feyerabend, Thorsten B, Rodewald, Hans-Reimer, Farre, Ricard, Redegeld, Frank A, Si, Jiyeon, Raes, Jeroen, Breynaert, Christine, Schrijvers, Rik, Bosteels, Cédric, Lambrecht, Bart N, Boyd, Scott D, Hoh, Ramona A, Cabooter, Deirdre, Nelis, Maxim, Augustijns, Patrick, Hendrix, Sven, Strid, Jessica, Bisschops, Raf, Reed, David E, Vanner, Stephen J, Denadai-Souza, Alexandre, Wouters, Mira M, and Boeckxstaens, Guy E

Published
2021

5. Sa1597 - Upregulation of Mast Cell Related Genes in Irritable Bowel Syndrome

Author

Aguilera-Lizarraga, Javier, primary, Balemans, Dafne, additional, Florens, Morgane, additional, Perna, Eluisa, additional, Theofanous, Stavroula, additional, Decraecker, Lisse, additional, Denadai-Souza, Alexandre, additional, Jain, Piyush, additional, Lambrechts, Diether, additional, Wouters, Mira M., additional, and Boeckxstaens, Guy E., additional

Published
2018
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6. 1092 - Food Antigen-Specific Sensitization of Nociceptive Nerves as an Underlying Mechanism of Visceral Pain in Ibs

Author

Aguilera-Lizarraga, Javier, primary, Balemans, Dafne, additional, Lopez, Cintya D. Lopez, additional, Polanco, Josue O. Jaramillo, additional, Florens, Morgane, additional, Perna, Eluisa, additional, Denadai-Souza, Alexandre, additional, Theofanous, Stavroula, additional, Decraecker, Lisse, additional, Jain, Piyush, additional, Breynaert, Christine M., additional, Vanner, Stephen, additional, Reed, David E., additional, Wouters, Mira M., additional, and Boeckxstaens, Guy E., additional

Published
2018
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12. 259 Neuronal Sensitization of TRPV1 by Histamine Mediated by Histamine 1 Receptor in an Unique Cohort of PI-IBS Patients

Author

Balemans, Dafne, primary, Cibert-Goton, Vincent, additional, Mondelaers, Stephanie, additional, Perna, Eluisa, additional, Aguilera-Lizarraga, Javier, additional, Florens, Morgane, additional, Theofanous, Stavroula, additional, Stakenborg, Nathalie, additional, Bulmer, David, additional, Berghe, Pieter Vanden, additional, Wouters, Mira M., additional, and Boeckxstaens, Guy E., additional

Published
2016
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18. The σ-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

Author

Kantsadi, Anastasia L., Hayes, Joseph, Manta, Stella, Skamnaki, Vicky T., Kiritsis, Christos, Psarra, Anna-Maria G., Koutsogiannis, Zissis, Dimopoulou, Athina, Theofanous, Stavroula, Nikoleousakos, Nikolaos, Zoumpoulakis, Panagiotis, Kontou, Maria, Papadopoulos, George, Zographos, Spyros E., Komiotis, Dimitris, Leonidas, Demetres D., Kantsadi, Anastasia L., Hayes, Joseph, Manta, Stella, Skamnaki, Vicky T., Kiritsis, Christos, Psarra, Anna-Maria G., Koutsogiannis, Zissis, Dimopoulou, Athina, Theofanous, Stavroula, Nikoleousakos, Nikolaos, Zoumpoulakis, Panagiotis, Kontou, Maria, Papadopoulos, George, Zographos, Spyros E., Komiotis, Dimitris, and Leonidas, Demetres D.

Abstract

C5 halogen substituted glucopyranosyl nucleosides (1-(β-D-glucopyranosyl)-5-X-uracil; X=Cl, Br, I) have been discovered as some of the most potent active site inhibitors of glycogen phosphorylase (GP), with respective Ki values of 1.02, 3.27, and 1.94 μM. The ability of the halogen atom to form intermolecular electrostatic interactions through the σ-hole phenomenon rather than through steric effects alone forms the structural basis of their improved inhibitory potential relative to the unsubstituted 1-(β-D-glucopyranosyl)uracil (Ki=12.39 μM), as revealed by X-ray crystallography and modeling calculations exploiting quantum mechanics methods. Good agreement was obtained between kinetics results and relative binding affinities calculated by QM/MM-PBSA methodology for various substitutions at C5. Ex vivo experiments demonstrated that the most potent derivative (X=Cl) toward purified GP has no cytotoxicity and moderate inhibitory potency at the cellular level. In accordance, ADMET property predictions were performed, and suggest decreased polar surface areas as a potential means of improving activity in the cell.

Published
2012

19. Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS

Author

Piyush Jain, Morgane Florens, Mira M. Wouters, Javier Aguilera-Lizarraga, Yeranddy A. Alpizar, Pieter Vanden Berghe, Maya Berg, Guy E. Boeckxstaens, Joris G. De Man, Karel Talavera, Nikita Hanning, Benedicte Y. De Winter, Eluisa Perna, Stavroula Theofanous, Perna, Eluisa, Aguilera-Lizarraga, Javier, Florens, Morgane V, Jain, Piyush, Theofanous, Stavroula A, Hanning, Nikita, De Man, Joris G, Berg, Maya, De Winter, Benedicte, AGUIAR ALPIZAR, Yeranddy, Talavera, Karel, Vanden Berghe, Pieter, Wouters, Mira, and Boeckxstaens, Guy

Subjects
Adult, Male, Docosahexaenoic Acids, TRPV1, TRPV Cation Channels, Pharmacology, Pertussis toxin, Mice, Transient receptor potential channel, chemistry.chemical_compound, Dorsal root ganglion, neurogastroenterology, In vivo, Ganglia, Spinal, Hypersensitivity, medicine, Animals, Humans, Receptors, Cannabinoid, Biology, Irritable bowel syndrome, Inflammation, Neurons, irritable bowel syndrome, business.industry, Enterobacteriaceae Infections, Gastroenterology, Antagonist, abdominal pain, Middle Aged, medicine.disease, Rats, Disease Models, Animal, ION channels, medicine.anatomical_structure, Eicosapentaenoic Acid, chemistry, nervous system, visceral hypersensitivity, Female, Human medicine, Capsaicin, business, Histamine
Abstract

ObjectiveResolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation. To what extent these molecules could also have a beneficial effect on TRPV1 sensitisation and visceral hypersensitivity (VHS), mechanisms involved in IBS, remains unknown.DesignThe effect of RvD1, RvD2 and RvE1 on TRPV1 activation and sensitisation by histamine or IBS supernatants was assessed on murine dorsal root ganglion (DRG) neurons using live Ca2+ imaging. Based on the results obtained in vitro, we further studied the effect of RvD2 in vivo using a murine model of post-infectious IBS and a rat model of post-inflammatory VHS. Finally, we also tested the effect of RvD2 on submucosal neurons in rectal biopsies of patients with IBS.ResultsRvD1, RvD2 and RvE1 prevented histamine-induced TRPV1 sensitisation in DRG neurons at doses devoid of an analgesic effect. Of note, RvD2 also reversed TRPV1 sensitisation by histamine and IBS supernatant. This effect was blocked by the G protein receptor 18 (GPR18) antagonist O-1918 (3–30 µM) and by pertussis toxin. In addition, RvD2 reduced the capsaicin-induced Ca2+ response of rectal submucosal neurons of patients with IBS. Finally, treatment with RvD2 normalised pain responses to colorectal distention in both preclinical models of VHS.ConclusionsOur data suggest that RvD2 and GPR18 agonists may represent interesting novel compounds to be further evaluated as treatment for IBS.

Published
2021

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