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We Media is a way for the general public to disseminate their facts and news to the outside world through Internet or other means. It is a way for the general public to provide and share their information after being connected to the global knowledge system. This study is to explore the communicators, the content and effect of the dissemination of We Media. The dissemination of traditional culture not only provides the audience with rich cultural knowledge but also has great importance in shaping their values. From the cases of Li Ziqi and Dianxi Xiaoge, we can find that this strategy requires the vloggers to master a combination of skills, not only in filming and editing but also in cultural understanding and learning ability.

The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids with a poorly understood interfacial tension γ that determines how FDs interact with other organelles. Here, micron-sized FDs remain spherical as they indent peri-nuclear actomyosin and the nucleus, while causing local dilution of Lamin-B1 independent of Lamin-A,C and sometimes triggering nuclear rupture. Focal accumulation of the cytosolic DNA sensor cGAS at the rupture site is accompanied by sustained mislocalization of DNA repair factors to cytoplasm, increased DNA damage, and delayed cell cycle. Macrophages show FDs and engulfed rigid beads cause similar indentation dilution. Spherical shapes of small FDs indicate a high γ, which we measure for FDs mechanically isolated from fresh adipose tissue as ∼40 mN/m. This value is far higher than that of protein condensates, but typical of oils in water and sufficiently rigid to perturb cell structures including nuclei.

This work assesses several popular transformations for the velocity profile through their application to several types of non-canonical compressible wall-bounded turbulent flows. Specifically, this work explores DNS databases of high-enthalpy boundary layers with dissociation and vibrational excitation, supercritical channel and boundary-layer flows, and adiabatic boundary layers with pressure gradients. The transformations considered include the van Driest [Van Driest, J. Aeronaut. Sci., 18(1951):145-216], Zhang et al. [Zhang et al., Phys. Rev. Lett., 109(2012):054502], Trettel-Larsson [Trettel and Larsson, Phys. Fluids, 28(2016):026102], data-driven [Volpiani et al., Phys. Rev. Fluids, 5(2020):052602], and total-stress-based [Griffin et al., Proc. Natl. Acad. Sci. U.S.A., 118(2021):e2111144118] transformations. The Trettel-Larsson transformation collapses velocity profiles of high-enthalpy temporal boundary layers but not the spatial boundary layers considered. For supercritical channel flows, the Trettel-Larsson transformation also performs well over the entire inner layer. None of the transformations above works for supercritical boundary layers. For all the considered methods, the transformed velocity profiles of boundary layers with weak pressure gradients coincide well with the universal incompressible law of the wall. In summary, all these popular methods fail to deliver uniform performance for non-canonical compressible wall-bounded flows in the logarithmic region, and a more sophisticated version, which accounts for these different physics, is needed. The data-driven and total-stress-based transformations perform well in the viscous sublayer for all the considered flows., 26 pages, 15 figures, Accepted to be published in AIAA Journal

We prove a super-exponential decay of probabilities that there exist $n$ crossings of a given quad for a simple $\textrm {CLE}_\kappa (\Omega )$, $\frac {8}{3}

In this paper, we study the time required for a λ -biased ( λ > 1 ) walk to visit all the vertices of a supercritical Galton–Watson tree up to generation n . Inspired by the extremal landscape approach in Cortines et al. (2018) for the simple random walk on binary trees, we establish the scaling limit of the cover time in the biased setting.

ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes isolated to date pair one of six regulatory subunits with one of two highly similar ATPases. However, we find that each endogenously expressed ATPase co-purifies with every regulatory subunit, substantially increasing the diversity of ISWI complexes, and we additionally identify BAZ2B as a novel, seventh regulatory subunit. Through reconstitution of catalytically active human ISWI complexes, we demonstrate that the new interactions described here are stable and direct. Finally, we profile the nucleosome remodeling functions of the now expanded family of ISWI chromatin remodelers. By revealing the combinatorial nature of ISWI complexes, we provide a basis for better understanding ISWI function in normal settings and disease.

By introducing a new measure for the infinite Galton-Watson process and providing estimates for (discrete) Green's functions on trees, we establish the asymptotic behavior of the capacity of critical branching random walks: in high dimensions $d\ge 7$, the capacity grows linearly; and in the critical dimension $d=6$, it grows asymptotically proportional to $\frac{n}{\log n}$., Comment: 33 pages, 7 figures

Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage. However, it remains poorly understood how the non-catalytic ISWI subunits BAZ1A and BAZ1B might contact chromatin to direct the ATPase SMARCA5. Here, we find that the plant homeodomain of BAZ1A, but not that of BAZ1B, has the unusual function of binding DNA. Furthermore, the BAZ1A bromodomain has a non-canonical gatekeeper residue and binds relatively weakly to acetylated histone peptides. Using CRISPR-Cas9-mediated genome editing we find that BAZ1A and BAZ1B each recruit SMARCA5 to sites of damaged chromatin and promote survival. Genetic engineering of structure-designed bromodomain and plant homeodomain mutants reveals that reader modules of BAZ1A and BAZ1B, even when non-standard, are critical for DNA damage recovery in part by regulating ISWI factors loading at DNA lesions and supporting transcriptional programs required for survival., ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage repair. Here, the authors uncover functions, in response to DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromodomain modules of the paralog BAZ1A.

Defense engineering in Henan area is mainly the local fortress, but some areas have not form a fortress, but emphasize courtyard defense. This paper will analyze the composition and characteristics of courtyard defense engineering of Henan traditional dwellings through the on-the-spot investigation, hoping to show the defense engineering of Henan traditional dwellings which is different from fortress system.