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4. Palliative Sedation in Patients Hospitalized in Internal Medicine Departments

Author

Díez-Manglano, Jesús, de Isasmendi Pérez, Soledad Isasi, Gómez, Marta Rubio, Pérez, Magdalena Martín, Díez García, Luis Felipe, Maroto, Ignacio Vallejo, Losada, Cristina Ocaña, Roldán, Susana Moya, Pérez, Catalina Díaz, Granado, Javier Caballero, García Font, Resfa María, Jódar Lorente, Francisco J., Vázquez, Gloria Pérez, Expósito, Ana belén Ferro, Amaya González, María Luisa, Antiñolo, Fernando Gamboa, Molina, Álvaro González, Hernández, Mercedes Gómez, García, Marcos Guzmán, León, Lola Benítez, Rivas, Lorena Montero, Mariscal, María Ruiz, Aguirre, Noelia Gómez, González García, María Pilar, Algora, Isabel Martín, Bueno Castel, María Carmen, Laiglesia, Fernando Ruiz, Tello, Esperanza Bejarano, Cabrerizo García, José Luis, Fernández, Nuria Guiral, Camera, Luis, Gauna, Carla, Requejo, Pedro Abad, Gutiérrez, Rocío Martínez, Regueiro, Rebeca Fernández, Sánchez Vidal, María Teresa, Mejido, Joaquín Alfonso, Carús, Enrique García, Calvo Rodríguez, Carmen Elena, García, Paula Martínez, Olivares, Sixto Ruiz, Fullana Barcelo, María Isabel, Arencibia, Carmen González, Vilamajó, Rosa Ros, José Monedero Prieto, María, Becerra, Concepción González, Pérez, Sofía, Plata, Andrea Martín, Chocarro, Raquel Portilla, Gutiérrez, Carlos Dueñas, Álvarez, Francisco Estrada, Balbuena, Sonia Peña, Galindo, Raúl Rodríguez, Cobos Siles, Marta María, Sánchez Muñoz, Luis Ángel, López, Ana Castañón, Lobo, Celia Sanz, Chimeno Viñas, María Montserrat, Contreras Uriel, María Ángeles, Domínguez, Judit Gil, González, Francisco Medrano, Machín Lázaro, José Manuel, Gamboa, Jeffrey Magallanes, Galdeano, Mónica Rodríguez, Giménez, Joaquín Castro, Barberá Farré, José Ramón, Aragón, Raquel Núñez, Torán, Ferrán Masanés, Barbé, José, Farré, Elena Güell, Bonafonte, Olga Torres, Miñana, Ana lozano, Sarabia, Desirée Moras, Pérez, Rosa, Arnau i Fernández, Dolors, Formiga, Francesc, Fernández, Javier Fernández, Salomó, Antoni Castro, Qanneta, Rami, Pardo Ortega, María Victoria, Díaz, Cristina Estrada, Pintado, Yasmina Monterroso, Cors, Montserrat García, Almendros Rivas, María Cruz, Albin, Dolors Domingo, Morera, Jaume Roig, Álvaro, Nuria Galofré, Parodi, Aythami Toro, Sánchez, Mario Loureiro, Acebal, Carla de la Guerra, García, Javier Zubizarreta, Claveras, Iasone Benavente, Cabanes, Juan Martí, Lázaro, Ignacio Sanz, Romero, José Barquero, López-Alegría, Leticia Nevado, Arévalo Lorido, José Carlos, Vales, Emilio Casariego, Lorenzo Vizcaya, Ana María, Rodríguez, Cristina Macía, Fernández, Silvia Pérez, Sánchez, Pascual Sesma, Jiménez-Beatty, María Dolores, Vázquez, Laura González, Hernando, Ángel Brea, Herrero, Jesús Castiella, González Anglada, María Isabel, Gracia Lorenzo, Virginia M., Martín, Alejandro Pérez, Melcón, Gerardo García, Antúnez, María Gómez, Quesada Simón, María Angustias, Gil, Fuensanta Gil, Martínez, María Asenjo, Aragoneses, Lourdes Mancebo, Parra, Jorge Calderón, Pérez, María del Carmen Romero, García, José Curbelo, Cuesta, Fernando Laguna, Segovia Abad, María Eugenia, Ortega, María Fontecha, Martínez, Guillermina Lara, Blanco, Ana Pinos, Fraile, Raquel Rodil, Litago, Elisabel Martínez, Echeverría, Aitziber Echeverría, Valladares, Manuel Priego, Serrano, Carlos Trescoli, Mas, Josep Vicente, Suau, Óscar Torregrosa, Tomás, Eva Gil, Rubio, Rafael Castillo, Murcia Zaragoza, José Manuel, Sánchez, Pilar Román, Herola, Ana García, Tenllado Doblas, Pedro Pablo, Blázquez Encinar, Julio César, Vela, Enrique Castellano, Carrizo, Néstor, Galvañ, Vicente Giner, Roca Villanueva, Bernardino Manuel, Liaño, Francisco Pasquau, Pascual Izuel, José María, Isasi de Isasmendi Pérez, Soledad, García Fenoll, Rosa, Sánchez, Luis Ángel, Formiga, Françesc, Giner Galvañ, Vicente, Dueñas, Carlos, Roca, Bernardino, Estrada Díaz, Cristina, and Casariego Vales, Emilio

Published
2020
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5. Developmental trajectories of control of verbal and non-verbal interference in speech comprehension in monolingual and multilingual children

Author

Filippi, Roberto, Ceccolini, Andrea, Periche-Tomas, Eva, Papageorgiou, Andriani, and Bright, Peter

Abstract

Research on speech comprehension in noise indicates that a multilinguistic experience may confer advantages in filtering out verbal interference, an effect observed both in children acquiring two or more languages since birth (Filippi, Morris, Richardson, et al., 2015) and in second language learner adults (Filippi, Leech, Thomas, et al., 2012). A possible interpretation for this advantage is that the multilingual mind is “trained” to control interference from the language not in use. This constant effort may support optimization of cognitive resources that are necessary for successfully selecting, processing and interpreting complex linguistic information. The present study aimed to extend this line of research by including a non-verbal interference condition. 209 typically developing children (132 English monolinguals and 77 multilinguals from different linguistic backgrounds) carried out a sentence interpretation task in the presence of verbal and non-verbal interference. We found no evidence for a reliable group difference in our data. Instead, findings indicated that background cognitive ability and socioeconomic status were the best indicators of successful control of interference, irrespective of whether participants were bilingual or monolingual. These findings are discussed in the light of previous research and, more widely, on the account of the current debate on the bilingual advantage.

Published
2020

11. Rab11 Is Associated with GLUT4-Containing Vesicles and Redistributes in Response to Insulin

Author

KESSLER, ALEXANDRA, TOMAS, EVA, MUELLER, HEIDI, ZORZANO, ANTONIO, and ECKEL, JUERGEN

Subjects
Insulin -- Physiological aspects, Diabetes -- Research, Health
Abstract

Trafficking of the glucose transporter GLUT4 involves the insulin-regulated movement from intracellular vesicular structures to the cell surface and the subsequent reentry, endosomal processing, and recycling of the transporter. We [...]

Published
2000

12. FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

Author

Bernardo, Barbara, primary, Lu, Min, additional, Bandyopadhyay, Gautam, additional, Li, Pingping, additional, Zhou, Yingjiang, additional, Huang, Jie, additional, Levin, Nancy, additional, Tomas, Eva M., additional, Calle, Roberto A., additional, Erion, Derek M., additional, Rolph, Timothy P., additional, Brenner, Martin, additional, and Talukdar, Saswata, additional

Published
2015
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16. Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

Author

Nawrocki, Andrea R., primary, Rajala, Michael W., additional, Tomas, Eva, additional, Pajvani, Utpal B., additional, Saha, Asish K., additional, Trumbauer, Myrna E., additional, Pang, Zhen, additional, Chen, Airu S., additional, Ruderman, Neil B., additional, Chen, Howard, additional, Rossetti, Luciano, additional, and Scherer, Philipp E., additional

Published
2006
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19. Role of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling Specificity.

Author

Tsu-Shuen Tsao, Tomas, Eva, Murrey, Heather E., Hug, Christopher, Lee, David H., Ruderman, Neil B., Heuser, John E., and Lodish, Harvey F.

Subjects
*SULFIDES, *CHEMICAL bonds, *BLOOD proteins, *LIPIDS, *GLUCOSE, *METABOLISM
Abstract

Acrp30/adiponectin is an adipocyte-derived serum protein with important roles in regulation of lipid and glucose metabolism, but which of its isoforms are biologically active remains controversial. We addressed this issue by first characterizing the structure of each individual Acrp30 oligomer and the determinants responsible for multimer formation. Freeze etch electron microscopy showed the trimer to exhibit a ball-and-stick-like structure containing a large globular sphere, an extended collagen stalk, and a smaller sphere on the opposite end of the stalk. The hexamer consists of two adjacent trimeric globular domains and a single stalk composed of collagen domains from two trimers. Although not necessary for trimer formation or stability, two of the three monomers in an Acrp30 trimer are covalently linked by a disulfide bond between cysteine residues at position 22. In contrast, assembly of hexameric and higher molecular weight (HMW) forms of Acrp30 depends upon formation of Cys[sup 22]-mediated disulfide bonds because their reduction with dithiothreitol or substitution of Cys[sup 22] with alanine led exclusively to trimers. HMW and hexamer isoforms of Acrp30 activated NF-κB in C2C12 cells, but trimers, either natural, formed by reduction of Acrp30 hexamer, or formed by the C22A mutant, did not. In contrast, incubation of isolated rat extensor digitorum longus with naturally formed Acrp30 trimers or trimeric C22A Acrp30 led to increased phosphorylation of AMP-activated protein kinase-α at Thr[sup 172] and its activation. Hexameric and HMW Acrp30 could not activate AMP-activated protein kinase. Thus, trimeric and HMW/hexameric Acrp30 activate different signal transduction pathways, and Acrp30 represents a novel example of the control of ligand signaling via changes in its oligomerization state. [ABSTRACT FROM AUTHOR]

Published
2003
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20. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.

Author

Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, and Scherer PE

Subjects
Adenylate Kinase metabolism, Adiponectin deficiency, Adiponectin physiology, Animals, Cell Line, Dietary Fats pharmacology, Glucose Clamp Technique, Glucose Tolerance Test, Male, Mice, Muscles metabolism, PPAR gamma metabolism, Thiazolidinediones pharmacology, Insulin Resistance, Liver metabolism, PPAR gamma agonists
Abstract

The adipose tissue-derived hormone adiponectin improves insulin sensitivity and its circulating levels are decreased in obesity-induced insulin resistance. Here, we report the generation of a mouse line with a genomic disruption of the adiponectin locus. We aimed to identify whether these mice develop insulin resistance and which are the primary target tissues affected in this model. Using euglycemic/insulin clamp studies, we demonstrate that these mice display severe hepatic but not peripheral insulin resistance. Furthermore, we wanted to test whether the lack of adiponectin magnifies the impairments of glucose homeostasis in the context of a dietary challenge. When exposed to high fat diet, adiponectin null mice rapidly develop glucose intolerance. Specific PPARgamma agonists such as thiazolidinediones (TZDs) improve insulin sensitivity by mechanisms largely unknown. Circulating adiponectin levels are significantly up-regulated in vivo upon activation of PPARgamma. Both TZDs and adiponectin have been shown to activate AMP-activated protein kinase (AMPK) in the same target tissues. We wanted to address whether the ability of TZDs to improve glucose tolerance is dependent on adiponectin and whether this improvement involved AMPK activation. We demonstrate that the ability of PPARgamma agonists to improve glucose tolerance in ob/ob mice lacking adiponectin is diminished. Adiponectin is required for the activation of AMPK upon TZD administration in both liver and muscle. In summary, adiponectin is an important contributor to PPARgamma-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway.

Published
2006
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