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2. Pre-operative anxiolysis in children through a combined pharmacological therapy with hydroxyzine and a non-pharmacological distraction technique with a clown (SONRISA): study protocol for randomised double-blind clinical trial

Author

Aleo Luján, Esther, Lopez-Picado, Amanda, Rivas, Ana, Joyanes Abancens, Belén, Rodríguez Rojo, Marina Laura, Fernández García, Patricia, Soto Beauregard, Carmen, Rodríguez Alarcón, Jaime, González Perrino, Carlos, San Pedro de Urquiza, Borja, Arias, Eva, Rodriguez, Diamelis, Esteban Polonio, Carmen, and Torrejón, Maria José

Published
2020
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3. At the Heart of It All: Emotions of Consequence for the Conceptualization of Caregiver-Reported Outcomes in the Context of Colorectal Cancer

Author

Howard, A. Fuchsia, primary, Lynch, Kelsey, additional, Beck, Scott, additional, Torrejón, Maria-José, additional, Avery, Jonathan, additional, Thorne, Sally, additional, Porcino, Antony, additional, De Vera, Mary, additional, Lambert, Leah, additional, Wolff, Angela, additional, McDonald, Melanie, additional, Lee, Joyce, additional, Hedges, Penelope, additional, and McKenzie, Michael, additional

Published
2021
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4. Serological Tests in the Detection of SARS-CoV-2 Antibodies

Author

Guevara-Hoyer, Kissy, primary, Fuentes-Antrás, Jesús, additional, De la Fuente-Muñoz, Eduardo, additional, Rodríguez de la Peña, Antonia, additional, Viñuela, Marcos, additional, Cabello-Clotet, Noemí, additional, Estrada, Vicente, additional, Culebras, Esther, additional, Delgado-Iribarren, Alberto, additional, Martínez-Novillo, Mercedes, additional, Torrejón, Maria José, additional, Pérez de Diego, Rebeca, additional, Fernández-Arquero, Miguel, additional, Ocaña, Alberto, additional, Pérez-Segura, Pedro, additional, and Sánchez-Ramón, Silvia, additional

Published
2021
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5. Effect of a Mediterranean Diet-Based Nutritional Intervention on the Risk of Developing Gestational Diabetes Mellitus and Other Maternal-Fetal Adverse Events in Hispanic Women Residents in Spain

Author

Melero, Verónica, primary, García de la Torre, Nuria, additional, Assaf-Balut, Carla, additional, Jiménez, Inés, additional, del Valle, Laura, additional, Durán, Alejandra, additional, Bordiú, Elena, additional, Valerio, Johanna J., additional, Herraiz, Miguel A, additional, Izquierdo, Nuria, additional, Torrejón, Maria José, additional, Runkle, Isabelle, additional, Barabash, Ana, additional, Rubio, Miguel A, additional, and Calle-Pascual, Alfonso L, additional

Published
2020
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6. Medical nutrition therapy for gestational diabetes mellitus based on Mediterranean Diet principles: a subanalysis of the St Carlos GDM Prevention Study

Author

Assaf-Balut, Carla, Garcia de la Torre, Nuria, Durán, Alejandra, Fuentes, Manuel, Bordiú, Elena, Del Valle, Laura, Valerio, Johanna, Familiar, Cristina, Jiménez, Inés, Herraiz, Miguel Angel, Izquierdo, Nuria, Torrejón, Maria José, Runkle, Isabelle, de Miguel, Maria Paz, Moraga, Inmaculada, Montañez, Maria Carmen, Barabash, Ana, Cuesta, Martín, Rubio, Miguel A, and Calle-Pascual, Alfonso Luis

Subjects
endocrine system diseases, nutritional and metabolic diseases
Abstract

To assess whether Mediterranean Diet (MedDiet)-based medical nutrition therapy facilitates near-normoglycemia in women with gestational diabetes mellitus (GDMw) and observe the effects on adverse pregnancy outcomes.

Published
2018

7. Effectiveness of Following Mediterranean Diet Recommendations in the Real World in the Incidence of Gestational Diabetes Mellitus (GDM) and Adverse Maternal-Foetal Outcomes: A Prospective, Universal, Interventional Study with a Single Group. The St Carlos Study

Author

García de la Torre, Nuria, primary, Assaf-Balut, Carla, additional, Jiménez Varas, Inés, additional, del Valle, Laura, additional, Durán, Alejandra, additional, Fuentes, Manuel, additional, del Prado, Náyade, additional, Bordiú, Elena, additional, Valerio, Johanna Josefina, additional, Herraiz, Miguel A., additional, Izquierdo, Nuria, additional, Torrejón, Maria José, additional, Cuadrado, Maria Angeles, additional, de Miguel, Paz, additional, Familiar, Cristina, additional, Runkle, Isabelle, additional, Barabash, Ana, additional, Rubio, Miguel A., additional, and Calle-Pascual, Alfonso L., additional

Published
2019
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8. Medical nutrition therapy for gestational diabetes mellitus based on Mediterranean Diet principles: a subanalysis of the St Carlos GDM Prevention Study

Author

Assaf-Balut, Carla, primary, Garcia de la Torre, Nuria, additional, Durán, Alejandra, additional, Fuentes, Manuel, additional, Bordiú, Elena, additional, del Valle, Laura, additional, Valerio, Johanna, additional, Familiar, Cristina, additional, Jiménez, Inés, additional, Herraiz, Miguel Angel, additional, Izquierdo, Nuria, additional, Torrejón, Maria José, additional, Runkle, Isabelle, additional, de Miguel, Maria Paz, additional, Moraga, Inmaculada, additional, Montañez, Maria Carmen, additional, Barabash, Ana, additional, Cuesta, Martín, additional, Rubio, Miguel A, additional, and Calle-Pascual, Alfonso Luis, additional

Published
2018
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9. Effectiveness of Following Mediterranean Diet Recommendations in the Real World in the Incidence of Gestational Diabetes Mellitus (GDM) and Adverse Maternal-Foetal Outcomes: A Prospective, Universal, Interventional Study with a Single Group. The St Carlos Study.

Author

de la Torre NG, Assaf-Balut C, Jiménez Varas I, Del Valle L, Durán A, Fuentes M, Del Prado N, Bordiú E, Valerio JJ, Herraiz MA, Izquierdo N, Torrejón MJ, Cuadrado MA, de Miguel P, Familiar C, Runkle I, Barabash A, Rubio MA, and Calle-Pascual AL

Subjects
Adult, Biomarkers blood, Blood Glucose metabolism, Diabetes, Gestational blood, Diabetes, Gestational diagnosis, Diabetes, Gestational epidemiology, Female, Glycated Hemoglobin metabolism, Health Knowledge, Attitudes, Practice, Humans, Incidence, Insulin blood, Maternal Nutritional Physiological Phenomena, Nutritional Status, Nutritive Value, Pregnancy, Prospective Studies, Recommended Dietary Allowances, Risk Assessment, Risk Factors, Spain epidemiology, Diabetes, Gestational prevention & control, Diet, Healthy, Diet, Mediterranean, Motivational Interviewing, Patient Education as Topic, Pregnancy Outcome
Abstract

We reported that a Mediterranean Diet (MedDiet), supplemented with extra-virgin olive oil (EVOO) and pistachios, reduces GDM incidence and several other adverse outcomes. In order to assess its translational effects in the real world we evaluated the effect of MedDiet from 1st gestational visit in GDM rate compared with control (CG) and intervention (IG) groups from the previously referred trial. As secondary objective we also compared adverse perinatal outcomes between normoglycemic and diabetic women. This trial is a prospective, clinic-based, interventional study with a single group. 1066 eligible normoglycaemic women before 12 gestational weeks were assessed. 932 women (32.4 ± 5.2 years old, pre-gestational BMI 22.5 ± 3.5 kg/m 2 ) received a motivational lifestyle interview with emphasis on daily consumption of EVOO and nuts, were followed-up and analysed. Binary regression analyses were used to examine the risk for each pregnancy outcome, pregnancy-induced hypertension, preeclampsia, gestational weight gain (GWG), caesarean-section, perineal trauma, preterm delivery, small (SGA) and large for gestational age (LGA), and Neonatal Intensive Care Unit admissions. GDM was diagnosed in 13.9%. This rate was significantly lower than the CG: RR 0.81 (0.73-0.93), p < 0.001 and no different from the IG: RR 0.96 (0.85-1.07), p = 0.468. GWG was lower in diabetic women (10.88 ± 6.46 vs. 12.30 ± 5.42 Kg; p = 0.013). Excessive weight gain (EWG) was also lower in GDM [RR 0.91 (0.86-0.96); p < 0.001] without a significant increase of insufficient weight gain. LGA were also lower (1 (0.8%) vs. 31 (3.9%); p < 0.05)), and SGA were similar (5 (3.8%) vs. 30 (3.7%)). LGA were associated to EWG (RR 1.61 (1.35-1.91), p < 0.001). Differences in other maternal-foetal outcomes were not found. In conclusions an early MedDiet nutritional intervention reduces GDM incidence and maternal-foetal adverse outcomes and should be universally applied as 1st line therapy. GDM might not be consider as a high risk pregnancy any longer.

Published
2019
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