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2. Extracellular DNA release, quorum sensing, and PrrF1/F2 small RNAs are key players in Pseudomonas aeruginosa tobramycin-enhanced biofilm formation

Author

Tahrioui, Ali, Duchesne, Rachel, Bouffartigues, Emeline, Rodrigues, Sophie, Maillot, Olivier, Tortuel, Damien, Hardouin, Julie, Taupin, Laure, Groleau, Marie-Christine, Dufour, Alain, Déziel, Eric, Brenner-Weiss, Gerald, Feuilloley, Marc, Orange, Nicole, Lesouhaitier, Olivier, Cornelis, Pierre, and Chevalier, Sylvie

Published
2019
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3. The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa

Author

Fléchard, Maud, Duchesne, Rachel, Tahrioui, Ali, Bouffartigues, Emeline, Depayras, Ségolène, Hardouin, Julie, Lagy, Coralie, Maillot, Olivier, Tortuel, Damien, Azuama, Cecil Onyedikachi, Clamens, Thomas, Duclairoir-Poc, Cécile, Catel-Ferreira, Manuella, Gicquel, Gwendoline, Feuilloley, Marc G. J., Lesouhaitier, Olivier, Heipieper, Hermann J., Groleau, Marie-Christine, Déziel, Éric, Cornelis, Pierre, and Chevalier, Sylvie

Published
2018
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4. Pf4 Phage Variant Infection Reduces Virulence-Associated Traits in Pseudomonas aeruginosa

Author

Tortuel, Damien, primary, Tahrioui, Ali, additional, David, Audrey, additional, Cambronel, Mélyssa, additional, Nilly, Flore, additional, Clamens, Thomas, additional, Maillot, Olivier, additional, Barreau, Magalie, additional, Feuilloley, Marc G. J., additional, Lesouhaitier, Olivier, additional, Filloux, Alain, additional, Bouffartigues, Emeline, additional, Cornelis, Pierre, additional, and Chevalier, Sylvie, additional

Published
2022
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5. Tackling Pseudomonas aeruginosa Virulence by Mulinane-Like Diterpenoids from Azorella atacamensis

Author

Azuama, Onyedikachi Cecil, primary, Ortiz, Sergio, additional, Quirós-Guerrero, Luis, additional, Bouffartigues, Emeline, additional, Tortuel, Damien, additional, Maillot, Olivier, additional, Feuilloley, Marc, additional, Cornelis, Pierre, additional, Lesouhaitier, Olivier, additional, Grougnet, Raphaël, additional, Boutefnouchet, Sabrina, additional, Wolfender, Jean-Luc, additional, Chevalier, Sylvie, additional, and Tahrioui, Ali, additional

Published
2020
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6. Activation of the Cell Wall Stress Response in Pseudomonas aeruginosa Infected by a Pf4 Phage Variant

Author

Tortuel, Damien, primary, Tahrioui, Ali, additional, Rodrigues, Sophie, additional, Cambronel, Mélyssa, additional, Boukerb, Amine M., additional, Maillot, Olivier, additional, Verdon, Julien, additional, Bere, Emile, additional, Nusser, Michael, additional, Brenner-Weiss, Gerald, additional, David, Audrey, additional, Azuama, Onyedikachi Cecil, additional, Feuilloley, Marc G. J., additional, Orange, Nicole, additional, Lesouhaitier, Olivier, additional, Cornelis, Pierre, additional, Chevalier, Sylvie, additional, and Bouffartigues, Emeline, additional

Published
2020
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7. The Temperature-Regulation of Pseudomonas aeruginosa cmaX-cfrX-cmpX Operon Reveals an Intriguing Molecular Network Involving the Sigma Factors AlgU and SigX

Author

Bouffartigues, Emeline, primary, Si Hadj Mohand, Ishac, additional, Maillot, Olivier, additional, Tortuel, Damien, additional, Omnes, Jordane, additional, David, Audrey, additional, Tahrioui, Ali, additional, Duchesne, Rachel, additional, Azuama, Cecil Onyedikachi, additional, Nusser, Michael, additional, Brenner-Weiss, Gerald, additional, Bazire, Alexis, additional, Connil, Nathalie, additional, Orange, Nicole, additional, Feuilloley, Marc G. J., additional, Lesouhaitier, Olivier, additional, Dufour, Alain, additional, Cornelis, Pierre, additional, and Chevalier, Sylvie, additional

Published
2020
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8. Membrane-Interactive Compounds From Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence

Author

Tahrioui, Ali, primary, Ortiz, Sergio, additional, Azuama, Onyedikachi Cecil, additional, Bouffartigues, Emeline, additional, Benalia, Nabiha, additional, Tortuel, Damien, additional, Maillot, Olivier, additional, Chemat, Smain, additional, Kritsanida, Marina, additional, Feuilloley, Marc, additional, Orange, Nicole, additional, Michel, Sylvie, additional, Lesouhaitier, Olivier, additional, Cornelis, Pierre, additional, Grougnet, Raphaël, additional, Boutefnouchet, Sabrina, additional, and Chevalier, Sylvie, additional

Published
2020
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9. Vers la compréhension du rôle de SigX dans la réponse au stress de l'enveloppe chez Pseudomonas aeruginosa

Author

Tortuel, Damien and STAR, ABES

Subjects
Extracytoplasmic function sigma factor, Facteur sigma à fonction extracytoplasmique, CpmX, Pseudomonas aeruginosa, Mechanosensitive channel, Canal mécanosensible, SigX, Stress d'enveloppe, CmpX, Cell wall stress, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

Pseudomonas aeruginosa is a very resistant opportunistic pathogen, for which it is critical to find new therapies. This bacterium easily adapts to its environment, through its large genome and proportion of regulators allowing a very fine regulation of its genes. The cell wall is the first barrier in contact with environment, and therefore represents a very important place ofexchange. The cell wall thus represents an interesting potential therapeutic target. SigX is an extracytoplasmic function sigma factor, responding to cell wall stresses detected by the bacterium, but the precise stimulus remains to discover. This sigma factor could be part of a new atypical signal transduction system that could couple SigX with a mechanosensitive channel. This work has led to the discovery of three new sigX activating conditions, which are Pf4 phage infection, loss of the CmpX mechanosensitive channel, and cold shock. These conditions seem to cause strong perturbations and an increase in membrane stiffness that could be the activating stimulus of SigX. This work has led to a better understanding of the activating condition of SigX, and to the clarification of the cellular and regulatory functions of the SigXCfrX-CmpX system members, highlighting the involvement of a mechanosensitive channel in the physiology of Pseudomonas aeruginosa., Pseudomonas aeruginosa est un pathogène opportuniste très résistant, pour lequel il est critique de trouver de nouvelles thérapies. Cette bactérie s’adapte facilement à son environnement grâce à son grand génome et à sa grande proportion de régulateurs permettant une régulation très fine de ses gènes. L’enveloppe est la première barrière au contact direct de l’environnement, et est un lieu d’échanges très important entre ce dernier et la bactérie. L’enveloppe représente donc une cible thérapeutique potentielle intéressante. SigX est un facteur sigma à fonction extracytoplasmique, permettant de répondre à des situations de stress d’enveloppe détectées par la bactérie, mais dont le stimulus exact reste à déterminer. Ce facteur sigma pourrait faire partie d’un nouveau système de transduction atypique du signal, qui pourrait coupler SigX à un canal mécanosensible. Ces travaux ont mené à la découverte de trois nouvelles conditions activatrices de SigX, l’infection par des phages Pf4, la perte du canal mécanosensible CmpX, et le choc froid. Ces dernières semblent provoquer de fortes perturbations et une augmentation de la rigidité membranaire qui pourrait être le stimulus activateur de SigX. Ces travaux ont permis d’étoffer les connaissances et de se rapprocher de la condition activatrice de SigX, et de préciser les fonctions cellulaires et régulatrices des membres du système SigX-CfrX-CmpX, mettant en exergue l’implication d’un canal mécanosensible dans la physiologie de Pseudomonas aeruginosa.

Published
2020

10. Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103

Author

Cambronel, Mélyssa, primary, Tortuel, Damien, additional, Biaggini, Kelly, additional, Maillot, Olivier, additional, Taupin, Laure, additional, Réhel, Karine, additional, Rincé, Isabelle, additional, Muller, Cécile, additional, Hardouin, Julie, additional, Feuilloley, Marc, additional, Rodrigues, Sophie, additional, and Connil, Nathalie, additional

Published
2019
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