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23 results on '"Ugur, Enes"'

1. Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

Author

Yamaguchi, Kosuke, Chen, Xiaoying, Rodgers, Brianna, Miura, Fumihito, Bashtrykov, Pavel, Bonhomme, Frédéric, Salinas-Luypaert, Catalina, Haxholli, Deis, Gutekunst, Nicole, Aygenli, Bihter Özdemir, Ferry, Laure, Kirsh, Olivier, Laisné, Marthe, Scelfo, Andrea, Ugur, Enes, Arimondo, Paola B., Leonhardt, Heinrich, Kanemaki, Masato T., Bartke, Till, Fachinetti, Daniele, Jeltsch, Albert, Ito, Takashi, and Defossez, Pierre-Antoine

Published
2024
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3. Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML

Author

Kempf, Julia M., Weser, Sabrina, Bartoschek, Michael D., Metzeler, Klaus H., Vick, Binje, Herold, Tobias, Völse, Kerstin, Mattes, Raphael, Scholz, Manuela, Wange, Lucas E., Festini, Moreno, Ugur, Enes, Roas, Maike, Weigert, Oliver, Bultmann, Sebastian, Leonhardt, Heinrich, Schotta, Gunnar, Hiddemann, Wolfgang, Jeremias, Irmela, and Spiekermann, Karsten

Published
2021
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4. Author Correction: Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals

Author

Mulholland, Christopher B., Nishiyama, Atsuya, Ryan, Joel, Nakamura, Ryohei, Yiğit, Merve, Glück, Ivo M., Trummer, Carina, Qin, Weihua, Bartoschek, Michael D., Traube, Franziska R., Parsa, Edris, Ugur, Enes, Modic, Miha, Acharya, Aishwarya, Stolz, Paul, Ziegenhain, Christoph, Wierer, Michael, Enard, Wolfgang, Carell, Thomas, Lamb, Don C., Takeda, Hiroyuki, Nakanishi, Makoto, Bultmann, Sebastian, and Leonhardt, Heinrich

Published
2020
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5. Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals

Author

Mulholland, Christopher B., Nishiyama, Atsuya, Ryan, Joel, Nakamura, Ryohei, Yiğit, Merve, Glück, Ivo M., Trummer, Carina, Qin, Weihua, Bartoschek, Michael D., Traube, Franziska R., Parsa, Edris, Ugur, Enes, Modic, Miha, Acharya, Aishwarya, Stolz, Paul, Ziegenhain, Christoph, Wierer, Michael, Enard, Wolfgang, Carell, Thomas, Lamb, Don C., Takeda, Hiroyuki, Nakanishi, Makoto, Bultmann, Sebastian, and Leonhardt, Heinrich

Published
2020
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8. Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components

Author

Ugur, Enes, de la Porte, Alexandra, Qin, Weihua, Bultmann, Sebastian, Ivanova, Alina, Drukker, Micha, Mann, Matthias, Wierer, Michael, Leonhardt, Heinrich, Ugur, Enes, de la Porte, Alexandra, Qin, Weihua, Bultmann, Sebastian, Ivanova, Alina, Drukker, Micha, Mann, Matthias, Wierer, Michael, and Leonhardt, Heinrich

Abstract

The establishment of cellular identity is driven by transcriptional and epigenetic regulators of the chromatin proteome - the chromatome. Comprehensive analyses of the chromatome composition and dynamics can therefore greatly improve our understanding of gene regulatory mechanisms. Here, we developed an accurate mass spectrometry (MS)-based proteomic method called Chromatin Aggregation Capture (ChAC) followed by Data-Independent Acquisition (DIA) and analyzed chromatome reorganizations during major phases of pluripotency. This enabled us to generate a comprehensive atlas of proteomes, chromatomes, and chromatin affinities for the ground, formative and primed pluripotency states, and to pinpoint the specific binding and rearrangement of regulatory components. These comprehensive datasets combined with extensive analyses identified phase-specific factors like QSER1 and JADE1/2/3 and provide a detailed foundation for an in-depth understanding of mechanisms that govern the phased progression of pluripotency. The technical advances reported here can be readily applied to other models in development and disease.

Published
2023

9. TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation

Author

Stolz, Paul, primary, Mantero, Angelo Salazar, additional, Tvardovskiy, Andrey, additional, Ugur, Enes, additional, Wange, Lucas E, additional, Mulholland, Christopher B, additional, Cheng, Yuying, additional, Wierer, Michael, additional, Enard, Wolfgang, additional, Schneider, Robert, additional, Bartke, Till, additional, Leonhardt, Heinrich, additional, Elsässer, Simon J, additional, and Bultmann, Sebastian, additional

Published
2022
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10. Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency

Author

Qin, Weihua, primary, Ugur, Enes, additional, Mulholland, Christopher B, additional, Bultmann, Sebastian, additional, Solovei, Irina, additional, Modic, Miha, additional, Smets, Martha, additional, Wierer, Michael, additional, Forné, Ignasi, additional, Imhof, Axel, additional, Cardoso, M Cristina, additional, and Leonhardt, Heinrich, additional

Published
2021
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11. HP1�� carries an acidic linker domain and requires H3K9me3 for phase separation

Author

Qin, Weihua, Stengl, Andreas, Ugur, Enes, Leidescher, Susanne, Ryan, Joel, Cardoso, M. Cristina, and Leonhardt, Heinrich

Subjects
endocrine system, animal structures, embryonic structures
Abstract

Liquid-liquid phase separation (LLPS) mediated formation of membraneless organelles has been proposed to coordinate biological processes in space and time. Previously, the formation of phase-separated droplets was described as a unique property of HP1��. Here, we demonstrate that the positive net charge of the intrinsically disordered hinge region (IDR-H) of HP1 proteins is critical for phase separation and that the exchange of four acidic amino acids is sufficient to confer LLPS properties to HP1��. Surprisingly, the addition of mono-nucleosomes promoted H3K9me3-dependent LLPS of HP1�� which could be specifically disrupted with methylated but not acetylated H3K9 peptides. HP1�� mutants defective in H3K9me3 binding were less efficient in phase separationin vitro and failed to accumulate at heterochromatin in vivo. We propose that multivalent interactions of HP1�� with H3K9me3-modified nucleosomes via its chromodomain and dimerization via its chromoshadow domain enable phase separation and contribute to the formation of heterochromatin compartments in vivo.

Published
2021
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