406 results on '"Van Remmen, Holly"'
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2. Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice
3. A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment
4. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
5. Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness
6. Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice
7. Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function
8. Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems
9. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
10. The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
11. Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia
12. Molecular changes associated with spinal cord aging
13. Time-restricted feeding improves aortic endothelial relaxation by enhancing mitochondrial function and attenuating oxidative stress in aged mice
14. Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes
15. Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia
16. Senolytics do not prevent muscle loss in Sod1 knockout mice
17. Does Oxidative Damage to DNA Increase with Age?
18. Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress
19. Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis
20. Molecular changes associated with spinal cord aging
21. Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia
22. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy
23. A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
24. Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
25. Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation
26. Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle
27. Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma
28. Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis
29. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
30. Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing
31. Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease
32. Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia
33. Comparative Studies of Oxidative Stress and Mitochondrial Function in Aging
34. Insulin Resistance Is a Cellular Antioxidant Defense Mechanism
35. Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice
36. Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia
37. Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia
38. Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations
39. Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
40. Tumor burden negatively impacts protein turnover as a proteostatic process in non-cancerous liver, heart, and muscle, but not brain
41. Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation
42. Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function
43. Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions
44. Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts
45. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
46. A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis
47. Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation
48. Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice
49. Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice
50. Molecular events in matrix protein metabolism in the aging kidney
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