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10 results on '"Vannozzi, Riccardo"'

1. Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary History

Author

Franceschi, Sara, primary, Civita, Prospero, additional, Pasqualetti, Francesco, additional, Lessi, Francesca, additional, Modena, Martina, additional, Barachini, Serena, additional, Morelli, Mariangela, additional, Santonocito, Orazio, additional, Vannozzi, Riccardo, additional, Pilkington, Geoffrey J., additional, Ortenzi, Valerio, additional, Naccarato, Antonio Giuseppe, additional, Aretini, Paolo, additional, and Mazzanti, Chiara Maria, additional

Published
2021
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2. Cancer astrocytes have a more conserved molecular status in long recurrence free survival (RFS) IDH1 wild-type glioblastoma patients: new emerging cancer players

Author

Franceschi, Sara, primary, Lessi, Francesca, additional, Aretini, Paolo, additional, Ortenzi, Valerio, additional, Scatena, Cristian, additional, Menicagli, Michele, additional, La Ferla, Marco, additional, Civita, Prospero, additional, Zavaglia, Katia, additional, Scopelliti, Claudia, additional, Apollo, Alessandro, additional, Carbone, Francesco Giovanni, additional, Vannozzi, Riccardo, additional, Bevilacqua, Generoso, additional, Pasqualetti, Francesco, additional, Naccarato, Antonio Giuseppe, additional, and Mazzanti, Chiara Maria, additional

Published
2018
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3. Investigating molecular alterations to profile short- and long-term recurrence-free survival in patients with primary glioblastoma

Author

FRANCESCHI, SARA, primary, MAZZANTI, CHIARA M., additional, LESSI, FRANCESCA, additional, ARETINI, PAOLO, additional, CARBONE, FRANCESCO G., additional, LA FERLA, MARCO, additional, SCATENA, CRISTIAN, additional, ORTENZI, VALERIO, additional, VANNOZZI, RICCARDO, additional, FANELLI, GIOVANNI, additional, PASQUALETTI, FRANCESCO, additional, BEVILACQUA, GENEROSO, additional, ZAVAGLIA, KATIA, additional, and NACCARATO, ANTONIO G., additional

Published
2015
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4. Abstract 1120: Glioblastoma whole transcriptome analysis: molecular mechanisms related to recurrence-free survival (RFS)

Author

Franceschi, Sara, primary, Lessi, Francesca, additional, Aretini, Paolo, additional, Carbone, Francesco G., additional, Scatena, Cristian, additional, La Ferla, Marco, additional, Ortenzi, Valerio, additional, Vannozzi, Riccardo, additional, Bevilacqua, Generoso, additional, Naccarato, Antonio G., additional, and Mazzanti, Chiara M., additional

Published
2015
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10. The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model

Author

Eleonora Vannini, Enrico Pracucci, Nicola Benedetto, Chiara Cerri, Simonetta Lisi, Anna Panighini, Mario Costa, Carla Fiorentini, Alessia Fabbri, Matteo Caleo, Riccardo Vannozzi, Panighini, Anna, Vannini, Eleonora, Costa, Mario, Fiorentini, Carla, Lisi, Simonetta, Pracucci, Enrico, Vannozzi, Riccardo, Cerri, Chiara, Benedetto, Nicola, Fabbri, Alessia, and Caleo, Matteo

Subjects
Cancer Research, Time Factors, Mouse, Bacterial Toxins, Antineoplastic Agents, temozolomide, Biology, Cell Line, Dose-Response Relationship, Mice, In vivo, Cell Movement, Cerebral cortex, CNF1, Glioma, Temozolomide, Animals, Cell Line, Tumor, Cell Proliferation, Cellular Senescence, Disease Models, Animal, Dose-Response Relationship, Drug, Escherichia coli Proteins, Humans, Tumor Stem Cell Assay, medicine, Genetics, Cytotoxic T cell, mouse, Tumor, Animal, Cell growth, medicine.disease, Oncology, glioma cells, Disease Models, Immunology, Cancer research, Syngenic, cerebral cortex, Drug, Stem cell, Cell aging, medicine.drug, Research Article
Abstract

Background: Glioblastomas are largely unresponsive to all available treatments and there is therefore an urgent need for novel therapeutics. Here we have probed the antineoplastic effects of a bacterial protein toxin, the cytotoxic necrotizing factor 1 (CNF1), in the syngenic GL261 glioma cell model. CNF1 produces a long-lasting activation of Rho GTPases, with consequent blockade of cytodieresis in proliferating cells and promotion of neuron health and plasticity. Methods: We have tested the antiproliferative effects of CNF1 on GL261 cells and human glioma cells obtained from surgical specimens. For the in vivo experiments, we injected GL261 cells into the adult mouse visual cortex, and five days later we administered either a single intracerebral dose of CNF1 or vehicle. To compare CNF1 with a canonical antitumoral drug, we infused temozolomide (TMZ) via minipumps for 1 week in an additional animal group. Results: In culture, CNF1 was very effective in blocking proliferation of GL261 cells, leading them to multinucleation, senescence and death within 15 days. CNF1 had a similar cytotoxic effect in primary human glioma cells. CNF1 also inhibited motility of GL261 cells in a scratch-wound migration assay. Low dose (2 nM) CNF1 and continuous TMZ infusion significantly prolonged animal survival (median survival 35 days vs. 28 days in vehicle controls). Remarkably, increasing CNF1 concentration to 80 nM resulted in a dramatic enhancement of survival with no obvious toxicity. Indeed, 57% of the CNF1-treated animals survived up to 60 days following GL261 glioma cell transplant. Conclusions: The activation of Rho GTPases by CNF1 represents a novel potential therapeutic strategy for the treatment of central nervous system tumors.

Published
2014

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