1. Association between exposure to organophosphate flame retardants and epidermal growth factor receptor expression in lung cancer patients
- Author
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Po‐Ju Chen, Po‐Chen Lai, Yueh‐Chien Lu, Bo‐Lin Pan, Wan‐Ting Huang, Chia‐Te Kung, Jui‐Chin Chiang, Fu‐Jen Cheng, Liang‐Jen Wang, Shau‐Hsuan Li, Wen‐Chin Lee, Yu‐Che Ou, and Chin‐Chou Wang
- Subjects
epidermal growth factor receptor ,flame retardants ,lung neoplasms ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Organophosphate flame retardants (OPFRs) are extensively distributed in our environment, prompting concerns about potential health hazards, including lung injuries resulting from OPFR exposure. Methods The present study recruited 125 lung cancer patients, assessing their exposure to 10 OPFR compounds through urine samples. The final analysis comprised 108 participants after excluding those lacking epidermal growth factor receptor (EGFR) status and those with chronic kidney disease. Demographic and clinical characteristics, as well as urinary OPFR concentrations, were compared based on OPFR detection. Spearman correlation was conducted to explore the relationship between OPFR compounds, while logistic regression was used to identify OPFR compounds associated with EGFR mutation. Results The study revealed widespread OPFR exposure among lung cancer patients, with an overall detection frequency of 99.07%. Tris(2‐butoxyethyl) phosphate (TBEP) exhibited a strong correlation to its metabolite bis(2‐butoxyethyl) phosphate (r = 0.88, p
- Published
- 2024
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