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10. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

Author

Wise, Sarah K, Lin, Sandra Y, Toskala, Elina, Orlandi, Richard R, Akdis, Cezmi A, Alt, Jeremiah A, Azar, Antoine, Baroody, Fuad M, Bachert, Claus, Canonica, G Walter, Chacko, Thomas, Cingi, Cemal, Ciprandi, Giorgio, Corey, Jacquelynne, Cox, Linda S, Creticos, Peter Socrates, Custovic, Adnan, Damask, Cecelia, DeConde, Adam, DelGaudio, John M, Ebert, Charles S, Eloy, Jean Anderson, Flanagan, Carrie E, Fokkens, Wytske J, Franzese, Christine, Gosepath, Jan, Halderman, Ashleigh, Hamilton, Robert G, Hoffman, Hans Jürgen, Hohlfeld, Jens M, Houser, Steven M, Hwang, Peter H, Incorvaia, Cristoforo, Jarvis, Deborah, Khalid, Ayesha N, Kilpeläinen, Maritta, Kingdom, Todd T, Krouse, Helene, Larenas-Linnemann, Desiree, Laury, Adrienne M, Lee, Stella E, Levy, Joshua M, Luong, Amber U, Marple, Bradley F, McCoul, Edward D, McMains, K Christopher, Melén, Erik, Mims, James W, Moscato, Gianna, Mullol, Joaquim, Nelson, Harold S, Patadia, Monica, Pawankar, Ruby, Pfaar, Oliver, Platt, Michael P, Reisacher, William, Rondón, Carmen, Rudmik, Luke, Ryan, Matthew, Sastre, Joaquin, Schlosser, Rodney J, Settipane, Russell A, Sharma, Hemant P, Sheikh, Aziz, Smith, Timothy L, Tantilipikorn, Pongsakorn, Tversky, Jody R, Veling, Maria C, Wang, De Yun, Westman, Marit, Wickman, Magnus, and Zacharek, Mark

Subjects
Allergic Rhinitis (Hay Fever), Adrenal Cortex Hormones, Allergens, Biological Products, Complementary Therapies, Cytokines, Diagnosis, Differential, Drug Therapy, Combination, Endoscopy, Environmental Exposure, Epidemiologic Methods, Histamine Antagonists, Humans, Immunoglobulin E, Microbiota, Nasal Decongestants, Occupational Diseases, Physical Examination, Probiotics, Quality of Life, Respiratory Mucosa, Rhinitis, Allergic, Risk Factors, Saline Solution, Skin Tests, Socioeconomic Factors, allergen extract, allergy, allergen immunotherapy, allergic rhinitis, antihistamine, asthma, atopic dermatitis, avoidance, biologic, cockroach, conjunctivitis, consensus, corticosteroid, cough, cromolyn, decongestant, eosinophilic esophagitis, environment, epicutaneous immunotherapy, epidemiology, evidence-based medicine, food allergy, genetics, house dust mite, IgE, immunoglobulin E, immunotherapy, inhalant allergy, leukotriene, microbiome, occupational rhinitis, omalizumab, pathophysiology, perennial, pet dander, pollen, probiotic, quality of life, rhinitis, rhinosinusitis, risk factor, saline, seasonal, sensitization, sinusitis, sleep, socioeconomic, specific IgE, subcutaneous immunotherapy, sublingual immunotherapy, systematic review, total IgE, transcutaneous immunotherapy, validated survey, Immunology
Abstract

BackgroundCritical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).MethodsUsing previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.ResultsThe ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.ConclusionThis critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.

Published
2018

24. Multicenter effect analysis of one‐step acellular dermis combined with autologous ultra‐thin split thickness skin composite transplantation in treating burn and traumatic wounds.

Author

Chen, Lei, Yang, Jing, Wang, De‐yun, Jiang, Jun‐mei, Zhang, Bao‐de, Zhao, Zun‐jiang, Chen, Xu‐Lin, and Lv, Da‐lun

Subjects
TRAUMA surgery, WOUND healing, RESEARCH, SKIN grafting, HOMOGRAFTS, ACADEMIC medical centers, BURNS & scalds, SURGICAL complications, RETROSPECTIVE studies, MEDICAL care costs, AUTOGRAFTS, TREATMENT effectiveness, RESEARCH funding, WOUND care
Abstract

To evaluate the efficacy of one‐step acellular dermis combined with autologous split thickness skin grafting in the treatment of burn or trauma wounds by a multicenter controlled study. In patients with extensive burns, it is even difficult to repair the wounds due to the shortage of autologous skin. The traditional skin grafting method has the disadvantages of large damage to the donor site, insufficient skin source and unsatisfactory appearance, wear resistance and elasticity of the wound tissue after skin grafting. One‐step acellular dermis combined with autologous ultra‐thin split thickness skin graft can achieve better healing effect in the treatment of burn and trauma wounds. A total of 1208 patients who underwent single‐layer skin grafting and one‐step composite skin grafting in the First Affiliated Hospital of Wannan Medical College, Wuhan Third People's Hospital and Lu 'an People's Hospital from 2019 to 2022 were retrospectively analysed. The total hospitalization cost, total operation cost, hospitalization days after surgery, wound healing rate after 1 week of skin grafting and scar follow‐up at 6 months after discharge were compared and studied. The total cost of hospitalization and operation in the composite skin grafting group was significantly higher than those in the single‐layer autologous skin grafting group. The wound healing rate after 1 week of skin grafting and the VSS score of scar in the follow‐up of 6 months after discharge were better than those in the single‐layer skin grafting group. One‐step acellular dermis combined with autologous ultra‐thin split thickness skin graft has high wound healing rate, less scar, smooth appearance and good elasticity in repairing burn and trauma wounds, which can provide an ideal repair method for wounds. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Evaluation of In Vitro and In Vivo Antiviral Activities of Vitamin D for SARS-CoV-2 and Variants

Author

Mok, Chee-Keng, primary, Ng, Yan Ling, additional, Ahidjo, Bintou Ahmadou, additional, Aw, Zhen Qin, additional, Chen, Huixin, additional, Wong, Yi Hao, additional, Lee, Regina Ching Hua, additional, Loe, Marcus Wing Choy, additional, Liu, Jing, additional, Tan, Kai Sen, additional, Kaur, Parveen, additional, Wang, De Yun, additional, Hao, Erwei, additional, Hou, Xiaotao, additional, Tan, Yong Wah, additional, Deng, Jiagang, additional, and Chu, Justin Jang Hann, additional

Published
2023
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34. Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host–pathogen interactions in the bat airway epithelium

Author

Chan, Louisa L.Y., primary, Gamage, Akshamal M., additional, Tan, Chee Wah, additional, Tan, Kai Sen, additional, Liu, Jing, additional, Tay, Douglas Jie Wen, additional, Foo, Randy Jee Hiang, additional, Rénia, Laurent, additional, Wang, De Yun, additional, and Wang, Lin-Fa, additional

Published
2022
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35. Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Author

Bousquet, Jean, Melén, Erik, Haahtela, Tari, Koppelman, Gerard, Togias, Alkis, Valenta, Rudolf, Akdis, Cezmi, Czarlewski, Wienczyslawa, Rothenberg, Marc, Valiulis, Arunas, Wickman, Magnus, Vichyanond, Pakit, Moniuszko, Marcin, Ėmužytė, Regina, Bush, Andrew, Chu, Derek K, Viegi, Giovanni, Wallace, Dana, Durham, Stephen, Wang, De Yun, Vandenplas, O., Just, Jocelyne, Carlsen, Karin C. Lodrup, Passalacqua, Giovanni, Williams, Siân, Linnemann, Désirée Larenas, Loureiro, Cláudia Chaves, Sagara, Hironori, Worm, Margitta, Yiallouros, Panayiotis, Yusuf, Osman, Zaitoun, Fares, Bonini, Matteo, Hrubiško, Martin, Cingi, C., Dykewicz, Mark, Zernotti, Mario, Calderon, Moises, Halpin, David M.G., Zidarn, Mihaela, Patella, Vincenzo, Sheikh, Aziz, Zuberbier, Jaron, Papadopoulos, Nikolaos, Louis, Renaud, Suppli Ulrik, Charlotte, Fonseca, João P., Zuberbier, Torsten, Anto, M. J., Costa, Elisio, Eiwegger, Thomas, Bosnic-Anticevich, Sinthia, Cruz, Alvaro, Sousa, Jaime Correia de, Louis-Philippe, Boulet, Erhola, Marina, Cardona, Victoria, Carr, Warner, Gemicioglu, Bilun, Pawankar, Ruby, Fokkens, Wytske, Calvo, Mário, Garcia-Aymerich, J., Mäkelä, Mika J., Hofmann, Maja Ann, Klimek, Ludger, Makris, Michael, Mohamed Sayed, Zeinab, Maurer, Marcus, D'Amato, G., Momas, Isabelle, Siroux, Valérie, Almeida, Mário Morais, Corrigan, Chris, Mullol, Joaquim, Montefort, Stephen, Jutel, Marek, Pham Thi, Nhan, Hossny, Elham, Akdis, Mubeccel, Pfaar, Oliver, Ventura, Maria Teresa, Regateiro, Frederico S., Bindslev-Jensen, Carsten, Ring, Johannes, Bustamante, Mariona, Pinto, Bernardo Sousa, Kaidashev, Igor, Guerra, Stefano, Standl, Marie, Sunyer, J., Keil, Thomas, Barata, Luís Taborda, Camargos, Paulo, Weiss, Scott, Naclerio, Robert, Yorgancıoglu, Arzu, Zhang, Luo, Nadeau, Kari, Abdul Latiff, Amir, Aberer, Werner, Heinrich, Joachim, Sisul, Juan, Nunes, Elizabete, Plavec, Davor, Agache, Ioana, Al-Ahmad, Mona, Serpa, Faradiba, Alobid, Isam, Kalayci, Omer, Giacco, S. Del, Fiocchi, Alessandro, Ansotegui Zubeldia, Ignacio Javier, Custovic, Adnan, Martins, Pedro Carreiro, Rouadi, Philip, Arshad, Syed Hasan, Asayag, Estrella, Bárbara, Cristina, Abdullah, Baharudin, Tomazic, Peter Valentin, Popov, T. A., Sayah, Zineb, Lkhagvaa, Battur, Nyembue Tshipukane , Dieudonne, Thomas, Mike, Bennoor, Kazi Saifuddin, Fyhrquist, Nanna Theresia, Irani, Carla, Berghea, Elena Camelia, De Blay, Frédéric, Toppila-Salmi, Sanna Katriina, Bergmann, Karl-Christian, Bernstein, D., Bewick, M., Casale, Thomas, Scheire, Sophie, Bumbacea, Roxana Silvia, Cepeda Sarabia, Alfonso, Puggioni, Francesca, Chandrasekharan, Ramanathan, Ohta, Ken, Okubo, Kimihiro, Charpin, Denis, Gomez, R Maximiliano, Chen, Y. Z., O'Hehir, Robyn, Cherrez Ojeda, Ivan, Bedbrook, Anna, To, Teresa, Devillier, Philippe, Schmid-Grendelmeier, Peter, Didier, Alain, Repka-Ramirez, María Susana, Teixeira, Maria Do Céu, Ispayeva, Zhanat, Dokic, Dejan, Quirce, Santiago, Douagui , Habib, Ivancevich, Juan Carlos, Gotua, Maia, Todo-Bom, Ana, Blain, Hubert, Guzman, Maria Antonieta, Kalyoncu, Ali Fuat, Hagemann, Jan, Buhl, Roland, Hamamah, Samir, Caraballo, Luis, Jares, Edgardo, Chivato, Tomás, Jartti, Tuomas, Jassem, Ewa, Christoff, George, Julge, Kalev, Ogulur, Ismail, Kardas, Przemyslaw, Doulaptsi, Maria, Kirenga, Bruce, Helga, Kraxner, Kull, Inger, Kulus, Marek, Daniel, Aguilar, Shamji, Mohamed, Kuna, Piotr, Nadif, Rachel, La Grutta, Stefania, Brightling, Chris, Samoliński, Bolesław, Lau, Susanne, Cordeiro, Carlos Manuel Da Silva Robalo, Solé, Dirceu, Le Thi Tuyet, Lan, Recto, Marysia, Ouedraogo, Solange, Halken, Susanne, Levin, Michael, Lipworth, Brian, Lourenço, Olga, Mahboub, Bassam, Niedoszytko, Marek, Sastre, Joaquin, Martinez‐Infante, E., Kupczyk, Maciej, Torres, María Jose, Matricardi, Paolo Maria, Cecchi, Lorenzo, Celedón, Juan C, Miculinic, Neven, Roche, Nicolas, Migueres, Nicolas, Brussino, Luisa, Florin, Mihaltan, Olze, Heidi, Savouré, Marine, Nekam, Kristof, Pali, Isabella, Okamoto, Yoshitaka, Palomares, O., Lemonnier, Nathanaël, Palosuo, Kati, Soto-Martinez, Manuel, Panaitescu, Carmen, Kvedarienė, Violeta, Panzner, P., Braido, Fulvio, Tsiligianni, Ioanna, Rodriguez-Gonzalez, Monica, Scichilone, Nicola, Canonica, Giogio Walter, Romantowski, Jan, Urrutia-Pereira, Marilyn, Filho, Nelson Augusto Rosario, Ollert, Markus W., Rottem, Menachem, Chkhartishvili, Ekaterine, Sova, Milan, Valovirta, Erkka, Mohammad, Yousser, Sperl, Annette, Spranger, Otto, Neffen, Hugo, Stelmach, Rafael, Burte, Emilie, Valentin Rostan, Marylin, Park, Hae-Sim, Van Ganse, Eric, Van Hage, Marianne, Pitsios, Constantinos, Vasankari, Tuula, and uBibliorum

Subjects
IL-33, Multimorbidity, Asthma, Toll-like receptors, Rhinitis
Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

Published
2023

38. Neisseria species as pathobionts in bronchiectasis

Author

Liang Li, Micheál Mac Aogáin, Tengfei Xu, Tavleen Kaur Jaggi, Louisa L.Y. Chan, Jing Qu, Lan Wei, Shumin Liao, Hong Sheng Cheng, Holly R. Keir, Alison J. Dicker, Kai Sen Tan, Wang De Yun, Mariko Siyue Koh, Thun How Ong, Albert Yick Hou Lim, John A. Abisheganaden, Teck Boon Low, Tidi Maharani Hassan, Xiang Long, Peter A.B. Wark, Brian Oliver, Daniela I. Drautz-Moses, Stephan C. Schuster, Nguan Soon Tan, Mingliang Fang, James D. Chalmers, Sanjay H. Chotirmall, School of Biological Sciences, School of Civil and Environmental Engineering, Lee Kong Chian School of Medicine (LKCMedicine), and Singapore Centre for Environmental Life Sciences and Engineering (SCELSE)

Subjects
Microbiota, Immunology, Biological sciences [Science], Microbiology, Bronchiectasis, Mice, 0605 Microbiology, 1108 Medical Microbiology, Virology, Animals, Humans, Metagenome, Parasitology, Microbiome, Neisseria
Abstract

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group. Published version

Published
2022

39. Current perspectives on the management of allergic rhinitis in selected Asia-Pacific countries: a meeting report

Author

Chantaphakul, Hiroshi, primary, Wang, De Yun, additional, Chan, Hing Sang, additional, Ho, Hok-kung Marco, additional, Khoo, Phaik Choo, additional, Minh, Le Tran Quang, additional, Lee, Bee Wah, additional, Lobo, Rommel Crisenio M, additional, Muninnobpamasa, Tarit, additional, Nanthapisal, Sira, additional, Navarro-Locsin, C Gretchen, additional, Poblete, Danilo A, additional, Tang, Ing Ping, additional, Tang, Jenny Poh Lin, additional, Yeh, Te-Huei, additional, and Nagrale, Dinesh, additional

Published
2022
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41. Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease

Author

Peng, Yang, primary, Wang, Zhao-Ni, additional, Chen, Shi-Ying, additional, Xu, Ai-Ru, additional, Fang, Zhang-Fu, additional, Sun, Jing, additional, Zhou, Zi-Qing, additional, Hou, Xiao-Tao, additional, Cen, Lai-Jian, additional, Ma, Jian-Juan, additional, Zhao, Jin-Cun, additional, Guan, Wei-Jie, additional, Wang, De-Yun, additional, and Zhong, Nan-Shan, additional

Published
2022
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42. A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

Author

Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Riggioni, Carmen [0000-0002-8745-0228], Comberiat, Pasquale [0000-0001-5209-9733], Giovannini, Mattia [0000-0001-9568-6882], Agache, Ioana [0000-0001-7994-364X], Akdis, Mubeccel [0000-0003-0554-9943], Alves-Correia, Magna [0000-0002-7676-5558], Antó, Josep M. [0000-0002-4736-8529], Azkur, Ahmet Kursat [0000-0002-5597-8917], Azkur, Dilek [0000-0002-4396-9087], Boccabella, Cristina [0000-0003-1942-8886], Breiteneder, Heimo [0000-0003-2022-8689], Carvalho, Daniela [0000-0002-0432-3339], Vecillas, Leticia de las [0000-0003-4969-5678], Diamant, Zuzana [0000-0003-0133-0100], Eguiluz-Gracia, Ibon [0000-0002-3774-931X], Eiwegger, Thomas [0000-0002-2914-7829], Fokkens, Wytske [0000-0003-4852-229X], Gao, Ya-dong [0000-0003-1251-7608], Nadeau, Kari C. [0000-0002-2146-2955], O'Mahony, Liam [0000-0003-4705-3583], Pfaar, Oliver [0000-0003-4374-9639], Sanak, Marek [0000-0001-7635-8103], Schwarze, Jürgen [0000-0002-6899-748X], Sokolowska, Milena [0000-0001-9710-6685], Torres Jaén, María José [0000-0001-5228-471X], Veen, Willem van de [0000-0001-9951-6688], Zelm, Menno C. van [0000-0003-4161-1919], Wang, De Yun [0000-0002-0909-2963], Zhang, Luo [0000-0002-0910-9884], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Akdis, Cezmi A. [0000-0001-8020-019X], Riggioni, Carmen, Comberiat, Pasquale, Giovannini, Mattia, Agache, Ioana, Akdis, Mubeccel, Alves-Correia, Magna, Antó, Josep M., Arcolaci, Alessandra, Azkur, Ahmet Kursat, Azkur, Dilek, Beken, Burcin, Boccabella, Cristina, Bousquet, Jean, Breiteneder, Heimo, Carvalho, Daniela, Vecillas, Leticia de las, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Eiwegger, Thomas, Eyerich, Stephanie, Fokkens, Wytske, Gao, Ya-dong, Hannachi, Farah, Johnston, Sebastian L., Jutel, Marek, Karavelia, Aspasia, Klimek, Ludfger, Moya, Beatriz, Nadeau, Kari C., O'Hehir, Robin, O'Mahony, Liam, Pfaar, Oliver, Sanak, Marek, Schwarze, Jürgen, Sokolowska, Milena, Torres Jaén, María José, Veen, Willem van de, Zelm, Menno C. van, Wang, De Yun, Zhang, Luo, Jiménez Saiz, Rodrigo, Akdis, Cezmi A., Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Riggioni, Carmen [0000-0002-8745-0228], Comberiat, Pasquale [0000-0001-5209-9733], Giovannini, Mattia [0000-0001-9568-6882], Agache, Ioana [0000-0001-7994-364X], Akdis, Mubeccel [0000-0003-0554-9943], Alves-Correia, Magna [0000-0002-7676-5558], Antó, Josep M. [0000-0002-4736-8529], Azkur, Ahmet Kursat [0000-0002-5597-8917], Azkur, Dilek [0000-0002-4396-9087], Boccabella, Cristina [0000-0003-1942-8886], Breiteneder, Heimo [0000-0003-2022-8689], Carvalho, Daniela [0000-0002-0432-3339], Vecillas, Leticia de las [0000-0003-4969-5678], Diamant, Zuzana [0000-0003-0133-0100], Eguiluz-Gracia, Ibon [0000-0002-3774-931X], Eiwegger, Thomas [0000-0002-2914-7829], Fokkens, Wytske [0000-0003-4852-229X], Gao, Ya-dong [0000-0003-1251-7608], Nadeau, Kari C. [0000-0002-2146-2955], O'Mahony, Liam [0000-0003-4705-3583], Pfaar, Oliver [0000-0003-4374-9639], Sanak, Marek [0000-0001-7635-8103], Schwarze, Jürgen [0000-0002-6899-748X], Sokolowska, Milena [0000-0001-9710-6685], Torres Jaén, María José [0000-0001-5228-471X], Veen, Willem van de [0000-0001-9951-6688], Zelm, Menno C. van [0000-0003-4161-1919], Wang, De Yun [0000-0002-0909-2963], Zhang, Luo [0000-0002-0910-9884], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Akdis, Cezmi A. [0000-0001-8020-019X], Riggioni, Carmen, Comberiat, Pasquale, Giovannini, Mattia, Agache, Ioana, Akdis, Mubeccel, Alves-Correia, Magna, Antó, Josep M., Arcolaci, Alessandra, Azkur, Ahmet Kursat, Azkur, Dilek, Beken, Burcin, Boccabella, Cristina, Bousquet, Jean, Breiteneder, Heimo, Carvalho, Daniela, Vecillas, Leticia de las, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Eiwegger, Thomas, Eyerich, Stephanie, Fokkens, Wytske, Gao, Ya-dong, Hannachi, Farah, Johnston, Sebastian L., Jutel, Marek, Karavelia, Aspasia, Klimek, Ludfger, Moya, Beatriz, Nadeau, Kari C., O'Hehir, Robin, O'Mahony, Liam, Pfaar, Oliver, Sanak, Marek, Schwarze, Jürgen, Sokolowska, Milena, Torres Jaén, María José, Veen, Willem van de, Zelm, Menno C. van, Wang, De Yun, Zhang, Luo, Jiménez Saiz, Rodrigo, and Akdis, Cezmi A.

Abstract

In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID‐19). This disease, caused by the severe acute respiratory syndrome–related coronavirus 2 (SARS‐CoV‐2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID‐19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence‐based medical advice on SARS‐CoV‐2 and COVID‐19. Although the majority of the patients show a very mild, self‐limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID‐19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a “cytokine storm” leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID‐19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID‐19–related topics should be based on more coordinated high‐quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS‐CoV‐2, COVID‐19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID‐19 and allergic disease.

Published
2020

43. Moderate Dose Irradiation Induces DNA Damage and Impairments of Barrier and Host Defense in Nasal Epithelial Cells in vitro

Author

Yang,Yue-Ying, Liu,Jing, Liu,Yi-Tong, Ong,Hsiao-Hui, Chen,Qian-Min, Chen,Ce-Belle, Thong,Mark, Xu,Xinni, Zhou,Sui-Zi, Qiu,Qian-Hui, Wang,De-Yun, Yang,Yue-Ying, Liu,Jing, Liu,Yi-Tong, Ong,Hsiao-Hui, Chen,Qian-Min, Chen,Ce-Belle, Thong,Mark, Xu,Xinni, Zhou,Sui-Zi, Qiu,Qian-Hui, and Wang,De-Yun

Abstract

Yue-Ying Yang,1,2,* Jing Liu,2,* Yi-Tong Liu,3,4 Hsiao-Hui Ong,2 Qian-Min Chen,2,4 Ce-Belle Chen,5 Mark Thong,6 Xinni Xu,6 Sui-Zi Zhou,3,4 Qian-Hui Qiu,3,4 De-Yun Wang2 1Department of Otolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Otolaryngology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 3Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 4The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 5Centre for Ion Beam Applications, Department of Physics, National University of Singapore, Singapore; 6Department of Otolaryngology-Head and Neck Surgery, National University Hospital, National University Health System, Singapore*These authors contributed equally to this workCorrespondence: Qian-Hui Qiu, Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106 Zhongshan Road II, Guangzhou, 510080, People’s Republic of China, Tel +86 20 83827812, Email qiuqianhui@hotmail.com De-Yun Wang, Department of Otolaryngology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, NUHS Tower Block, 1E Kent Ridge Road, 119228, Singapore, Tel + 65 6772 5373/5370/5371, Fax +65 6775 3820, Email entwdy@nus.edu.sgPurpose: Radiotherapy (RT) is the mainstay treatment for head and neck cancers. However, chronic and recurrent upper respiratory tract infections and inflammation have been commonly reported in patients post-RT. The underlying mechanisms remain poorly understood.Method and Materials: We used a well-established model of human nasal epithelial cells (hNECs) that forms a pseudostratified lay

Published
2022

44. The microdissected gene expression landscape of nasopharyngeal cancer reveals vulnerabilities in FGF and noncanonical NF-κB signaling

Author

Tay, Joshua K., primary, Zhu, Chunfang, additional, Shin, June Ho, additional, Zhu, Shirley X., additional, Varma, Sushama, additional, Foley, Joseph W., additional, Vennam, Sujay, additional, Yip, Yim Ling, additional, Goh, Chuan Keng, additional, Wang, De Yun, additional, Loh, Kwok Seng, additional, Tsao, Sai Wah, additional, Le, Quynh-Thu, additional, Sunwoo, John B., additional, and West, Robert B., additional

Published
2022
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45. Sustained impact of subcutaneous immunotherapy among patients with allergic rhinitis who experienced treatment delay due to the COVID‐19 pandemic: A multicenter, two‐arm, real‐world study

Author

Zhou, Suizi, primary, Liu, Yibin, additional, Xue, Jianrong, additional, Tang, Jun, additional, Yu, Qingqing, additional, Qu, Shenhong, additional, Zhang, Shaojie, additional, Mo, Binyu, additional, Li, Jihui, additional, Liu, Yinhong, additional, Yang, Yueying, additional, Wang, De‐Yun, additional, and Qiu, Qianhui, additional

Published
2022
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46. Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro , despite Eliciting a Prolonged Antiviral Response

Author

Gamage, Akshamal M., primary, Tan, Kai Sen, additional, Chan, Wharton O. Y., additional, Lew, Zhe Zhang Ryan, additional, Liu, Jing, additional, Tan, Chee Wah, additional, Rajagopalan, Deepa, additional, Lin, Quy Xiao Xuan, additional, Tan, Le Min, additional, Venkatesh, Prasanna Nori, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Lin, Raymond Tzer Pin, additional, Prabhakar, Shyam, additional, Wang, De Yun, additional, and Wang, Lin-Fa, additional

Published
2022
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47. Additional file 1 of FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-��B pathway in airway epithelial cells

Author

Tan, Yuan-Yang, Zhou, Hui-Qin, Lin, Yu-Jing, Yi, Liu-Tong, Chen, Zhuang-Gui, Cao, Qing-Dong, Guo, Yan-Rong, Wang, Zhao-Ni, Chen, Shou-Deng, Li, Yang, Wang, De-Yun, Qiao, Yong-Kang, and Yan, Yan

Abstract

Additional file 1: Table S1. Clinical characteristics of patients with and without asthma.Table S2. Real-time quantitative PCR primer sequences of mouse and human genes.

Published
2022
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49. Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis

Author

Peng, Yang, primary, Wang, Zhao-Ni, additional, Xu, Ai-Ru, additional, Fang, Zhang-Fu, additional, Chen, Shi-Ying, additional, Hou, Xiao-Tao, additional, Zhou, Zi-Qing, additional, Lin, Hui-Min, additional, Xie, Jia-Xing, additional, Tang, Xiao Xiao, additional, Wang, De-Yun, additional, and Zhong, Nan-Shan, additional

Published
2022
Full Text
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