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2. 5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination

Author

Gao, Zhenfang, primary, Gao, Yang, additional, Li, Yuxiang, additional, Zhou, Jie, additional, Li, Ge, additional, Xie, Shun, additional, Jia, Ruiyan, additional, Wang, Lanying, additional, Jiang, Ziying, additional, Liang, Meng, additional, Du, Chunxiao, additional, Chen, Yaqiong, additional, Liu, Yinji, additional, Du, Lin, additional, Wang, Cong, additional, Dou, Shuaijie, additional, Lv, Zhonglin, additional, Wang, Lubin, additional, Wang, Renxi, additional, Shen, Beifen, additional, Wang, Zhiding, additional, Li, Yunfeng, additional, and Han, Gencheng, additional

Published
2024
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5. A Reconfigurable Metasurface Enhancing Signal Coverage for Wireless Communication Using Reduced Numbers of p-i-n Diodes

Author

Xue, Hao, Lu, Zeqing, Ma, Xiangjin, Wang, Zhiding, Zhu, Lihao, Yue, Shuyao, Han, Jiaqi, Liu, Haixia, and Li, Long

Abstract

This article proposes a reflective reconfigurable metasurface design that can reduce the number of p-i-n diodes required by up to 60% for enhancing wireless communication signal coverage. The metasurface is also optimized from two aspects of element and array and can achieve enhanced signal coverage in a variety of regions, which proposes a low-cost general-purpose scheme and device. The reconfigurable element with a relative bandwidth of 8.2% is designed in a “subarray” form to reduce the p-i-n diode loading by half, and the array is sparsely designed, resulting in a further reduction of 20%. The genetic algorithm (GA) optimization method suitable for the digital coding metasurface is proposed to optimize the element’s phase discretization scheme and the array’s sparse method. The proposed metasurface is loaded in familiar T-shaped corridor models, and the coverage enhancement is verified based on the co-simulation of different software, showing the device can be applied in different scenes. For the first time, systematic measurement in a realistic environment using a reconfigurable metasurface with a reduced number of p-i-n diodes is performed, which proves that it can achieve signal coverage improvement in the corridor and in the actual 5G communication environment. The results indicate that this design greatly reduces system complexity and cost, which can be compatible with existing communication optimization methods, providing a practical, scalable scheme and device for enhancing signal coverage in various scenes.

Published
2024
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13. Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation

Author

Li, Ge, primary, Tang, Lili, additional, Hou, Chunmei, additional, Wang, Zhiding, additional, Gao, Yang, additional, Dou, Shuaijie, additional, Mo, Rongliang, additional, Hao, Ying, additional, Gao, Zhenfang, additional, Li, Yuxiang, additional, Dong, Jie, additional, Zhang, Jiyan, additional, Shen, Beifen, additional, Wang, Renxi, additional, and Han, Gencheng, additional

Published
2021
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16. Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis

Author

Wang, Wei, primary, Shi, Qingzhu, additional, Dou, Shuaijie, additional, Li, Ge, additional, Shi, Xinhui, additional, Jiang, Xingwei, additional, Wang, Zhiding, additional, Yu, Dandan, additional, Chen, Guojiang, additional, Wang, Renxi, additional, Xiao, He, additional, Hou, Chunmei, additional, Feng, Jiannan, additional, Shen, Beifen, additional, Ma, Yuanfang, additional, and Han, Gencheng, additional

Published
2017
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18. Foxd3 suppresses interleukin-10 expression in B cells

Author

Zhang, Yu, primary, Wang, Zhiding, additional, Xiao, He, additional, Liu, Xiaoling, additional, Zhu, Gaizhi, additional, Yu, Dandan, additional, Han, Gencheng, additional, Chen, Guojiang, additional, Hou, Chunmei, additional, Ma, Ning, additional, Shen, Beifen, additional, Li, Yan, additional, Wang, Tianxiao, additional, and Wang, Renxi, additional

Published
2017
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20. 5-HT 7 R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination.

Author

Gao Z, Gao Y, Li Y, Zhou J, Li G, Xie S, Jia R, Wang L, Jiang Z, Liang M, Du C, Chen Y, Liu Y, Du L, Wang C, Dou S, Lv Z, Wang L, Wang R, Shen B, Wang Z, Li Y, and Han G

Abstract

Introduction: Excessive immune activation induces tissue damage during infection. Compared to external strategies to reconstruct immune homeostasis, host balancing ways remain largely unclear., Objectives: Here we found a neuroimmune way that prevents infection-induced tissue damage., Methods: By FACS and histopathology analysis of brain Streptococcus pneumonia meningitis infection model and behavioral testing. Western blot, co-immunoprecipitation, and ubiquitination analyze the Fluoxetine initiate 5-HT7R-STUB1-CCR5 K48-linked ubiquitination degradation., Results: Fluoxetine, a selective serotonin reuptake inhibitor, or the agonist of serotonin receptor 5-HT 7 R, protects mice from meningitis by inhibiting CCR5-mediated excessive immune response and tissue damage. Mechanistically, the Fluoxetine-5-HT 7 R axis induces proteasome-dependent degradation of CCR5 via mTOR signaling, and then recruits STUB1, an E3 ubiquitin ligase, to initiate K48-linked polyubiquitination of CCR5 at K138 and K322, promotes its proteasomal degradation. STUB1 deficiency blocks 5-HT 7 R-mediated CCR5 degradation., Conclusion: Our results reveal a neuroimmune pathway that balances anti-infection immunity via happiness neurotransmitter receptor and suggest the 5-HT 7 R-CCR5 axis as a potential target to promote neuroimmune resilience., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Production and hosting by Elsevier B.V.)

Published
2024
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