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The objective of this study was to explore the potential genetic link between Crohn's disease and breast cancer, with a focus on identifying druggable genes that may have therapeutic relevance. We assessed the causal relationship between these diseases through Mendelian randomization and investigated gene-drug interactions using computational predictions. This study sought to identify common genetic pathways possibly involved in immune responses and cancer progression, providing a foundation for future targeted treatment research. The dataset comprises single nucleotide polymorphisms used as instrumental variables for Crohn's disease, analyzed to explore their possible impact on breast cancer risk. Gene ontology and pathway enrichment analyses were conducted to identify genes shared between the two conditions, supported by protein–protein interaction networks, colocalization analyses, and deep learning-based predictions of gene-drug interactions. The identified hub genes and predicted gene-drug interactions offer preliminary insights into possible therapeutic targets for breast cancer and immune-related conditions. This dataset may be valuable for researchers studying genetic links between autoimmune diseases and cancer and for those interested in the early identification of potential drug targets. [ABSTRACT FROM AUTHOR]

The cyclic loading experiments on HP‐172B sealant bonded tubular butt‐joints were carried out with the strain‐controlled mode, and the effects of strain amplitude and mean strain on the cyclic relaxation stress and cyclic softening variable of the bonded butt‐joint were investigated. The experimental results show that the stress–strain response curve of the butt‐joint presents a corrugated shape under cyclic loading. The cyclic stress relaxation and cyclic softening of the bonded butt‐joint occur. The increase of mean strain and strain amplitude intensifies the cyclic stress relaxation and cyclic softening behaviors. According to the experimental observation, a nonlinear viscoelastic model is proposed to predict the mechanical behavior of butt‐joints under cyclic loading, which considers the cyclic stress relaxation and cyclic softening of the bonded butt‐joint. The comparisons between the model calculation and the experimental data show that the calculated stress–strain curve is in good agreement with the experimental data. Highlights: The cyclic loading experiments on adhesively bonded joints were carried out.The stress–strain curve presents a corrugated shape under cyclic loading.A viscoelastic model was proposed according to the experimental observation.The model can describe the mechanical behaviors of adhesively bonded joints. [ABSTRACT FROM AUTHOR]

The mechanical behaviors of TB991 weld sealant under cyclic loading conditions were experimentally investigated. The evolution of relaxation stress, cyclic softening, and dissipated energy was evaluated with the effect of strain amplitude and mean strain. The experimental results showed that the stress–strain response curves of the first loading‐unloading and cyclic loading‐unloading were significantly different. The phenomenon of stress relaxation and cyclic softening occurred under cyclic strain loading conditions. Furthermore, the relaxation stress and dissipated energy decreased rapidly during the initial cyclic loading and then steadily decreased with the increase of cycle number, while the cyclic softening increased rapidly at first and then steadily. Besides, a viscoelastic constitutive model was proposed which can describe the different shapes of stress–strain curve between the initial loading‐unloading and the cyclic loading‐unloading and also considers the cyclic stress relaxation and cyclic softening of the materials under cyclic loading condition. Comparisons between the numerical results and the experimental data demonstrated that the proposed model can better describe the mechanical behavior of TB991 weld sealant under cyclic loading conditions. TB991 weld sealant was experimentally investigated under cyclic loading conditions.The evolution of relaxation stress, cyclic softening, and dissipated energy was investigated.A constitutive model was proposed to describe the mechanical behavior of the material under cyclic loading conditions.The proposed model can consider the cyclic stress relaxation and cyclic softening of the materials. [ABSTRACT FROM AUTHOR]

With rapidly developing communication and autonomous-driving technology, traffic flow on road networks will change from homogeneous human-driven vehicle (HDV) traffic flow to heterogeneous mixed traffic flow (MTF) comprising HDVs, autonomous vehicles (AVs), and connective-and-autonomous vehicles (CAVs). To understand the changes in the MTF of transportation engineering, we investigated the reserved capacity (RC) and right-of-way (ROW) reallocation policy that should be utilized under MTF scenarios. We established an MTF-based theoretical model to calculate the expressway segment capacity, theoretically analyzed the influence of the market penetration rate (MPR) on capacity and validated the model through numerical analysis. The results showed that the MPR of AVs and CAVs can enhance the MTF RC that is within 0–200% and that the platooning rate of CAVs positively influences the MTF RC. CAV popularization does not necessarily lead to a rapid increase in the transportation system efficiency when the MPR is <40% but significantly improves the efficiency of existing urban transportation facilities. When the MPR is >40%, the greatest enhancement is 4800 pcu/h/lane in terms of RC. A ROW reallocation policy that equips CAV-dedicated lanes according to the MPR of AVs and CAVs can enhance the capacity of expressway systems by 500 pcu/h/lane in terms of RC. [ABSTRACT FROM AUTHOR]