Search

Your search keyword '"Wilcox, C. Mel"' showing total 332 results
Start Over Author "Wilcox, C. Mel" Search Limiters Full Text
Sorry, I don't understand your search. ×
332 results on '"Wilcox, C. Mel"'

1. Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}

Author

Wilcox, C. Mel, Bang, Ji Young, Buxbaum, James, Gardner, Timothy B., Hawes, Robert, Kedia, Prashant, Mardini, Samuel H., Muniraj, Thiruvengadam, Navaneethan, Udayakumar, Oza, Veeral M., Tarnasky, Paul, Thakkar, Shyam, Waxman, Irving, and Varadarajulu, Shyam

Published
2024
Full Text
View/download PDF

2. Lifetime smoking history and cohort-based smoking prevalence in chronic pancreatitis

Author

Jeon, Christie Y, Feldman, Robert, Althouse, Andrew, AlKaade, Samer, Brand, Randall E, Guda, Nalini, Sandhu, Bimaljit S, Singh, Vikesh K, Wilcox, C Mel, Slivka, Adam, Gelrud, Andres, Whitcomb, David C, and Yadav, Dhiraj

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chronic Pain, Tobacco, Clinical Research, Substance Misuse, Pediatric, Cancer, Digestive Diseases, Pain Research, Tobacco Smoke and Health, Prevention, Respiratory, Chronic Pancreatitis, Epidemiology, Smoking, Cohort, Clinical Sciences, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background/objectiveSmoking prevalence in patients with chronic pancreatitis [CP] is high. We aimed to understand lifetime history of smoking and cohort trends in CP patients to inform effective strategies for smoking cessation.MethodData on 317 CP patients from the North American Pancreatitis Study 2 [NAPS2] Continuation and Validation Study and the NAPS2 Ancillary Study were analyzed. Smoking history was assessed for each phase of life from the onset of smoking to study enrollment. Data on second-hand smoke and drinking history were also collected. We compared demographic factors, drinking history, pain level and pancreas morphology by smoking status at age 25 (non-smoking,

Published
2021

3. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Author

AlKaade, Samer, Amann, Stephen T., Anderson, Michelle A., Banks, Peter, Conwell, Darwin, Brand, Randall E., Cote, Gregory A., Romagnuolo, Joseph, Forsmark, Christopher E., Gardner, Timothy, Gelrud, Andres, Guda, Nalini, Lewis, Michele, Muniraj, Thiruvengadam, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh, Wilcox, C. Mel, Yadav, Dhiraj, Whitcomb, David C., Tang, Gong, Slivka, Adam, and Bellin, Melena

Published
2023
Full Text
View/download PDF

4. SpHincterotomy for Acute Recurrent Pancreatitis Randomized Trial: Rationale, Methodology, and Potential Implications.

Author

Coté, Gregory A, Durkalski-Mauldin, Valerie L, Serrano, Jose, Klintworth, Erin, Williams, April W, Cruz-Monserrate, Zobeida, Arain, Mustafa, Buxbaum, James L, Conwell, Darwin L, Fogel, Evan L, Freeman, Martin L, Gardner, Timothy B, van Geenen, Erwin, Groce, J Royce, Jonnalagadda, Sreenivasa S, Keswani, Rajesh N, Menon, Shyam, Moffatt, Dana C, Papachristou, Georgios I, Ross, Andrew, Tarnasky, Paul R, Wang, Andrew Y, Wilcox, C Mel, Hamilton, Frank, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Prevention, Digestive Diseases, Clinical Research, Oral and gastrointestinal, Adult, Cholangiopancreatography, Endoscopic Retrograde, Cholangiopancreatography, Magnetic Resonance, Cohort Studies, Endosonography, Female, Humans, Internationality, Male, Outcome Assessment, Health Care, Pancreas, Pancreatitis, Recurrence, Risk Factors, Secondary Prevention, Sphincterotomy, Endoscopic, acute pancreatitis, acute recurrent pancreatitis, chronic pancreatitis, endoscopic retrograde cholangiopancreatography, pancreas divisum, SHARP Consortium, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesIn patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this study are to describe the rationale and methodology of a sham-controlled clinical trial designed to test the hypothesis that miES reduces the risk of acute pancreatitis.MethodsThe SpHincterotomy for Acute Recurrent Pancreatitis (SHARP) trial is a multicenter, international, sham-controlled, randomized trial comparing endoscopic ultrasound + ERCP with miES versus endoscopic ultrasound + sham for the management of ARP. A total of 234 consented patients having 2 or more discrete episodes of acute pancreatitis, pancreas divisum confirmed by magnetic resonance cholangiopancreatography, and no other clear etiology for acute pancreatitis will be randomized. Both cohorts will be followed for a minimum of 6 months and a maximum of 48 months.ResultsThe trial is powered to detect a 33% risk reduction of acute pancreatitis frequency.ConclusionsThe SHARP trial will determine whether ERCP with miES benefits patients with idiopathic ARP and pancreas divisum. Trial planning has informed the importance of blinded outcome assessors and long-term follow-up.

Published
2019

5. Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus

Author

Goodarzi, Mark O, Nagpal, Tanvi, Greer, Phil, Cui, Jinrui, Chen, Yii-Der I, Guo, Xiuqing, Pankow, James S, Rotter, Jerome I, Alkaade, Samer, Amann, Stephen T, Baillie, John, Banks, Peter A, Brand, Randall E, Conwell, Darwin L, Cote, Gregory A, Forsmark, Christopher E, Gardner, Timothy B, Gelrud, Andres, Guda, Nalini, LaRusch, Jessica, Lewis, Michele D, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Romagnuolo, Joseph, Sandhu, Bimaljit S, Sherman, Stuart, Singh, Vikesh K, Wilcox, C Mel, Pandol, Stephen J, Park, Walter G, Andersen, Dana K, Bellin, Melena D, Hart, Phil A, Yadav, Dhiraj, and Whitcomb, David C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Clinical Research, Diabetes, Genetics, Genetic Testing, Metabolic and endocrine, Aged, Case-Control Studies, Comorbidity, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Genotype, Humans, Male, Middle Aged, Pancreatitis, Chronic, Polymorphism, Single Nucleotide, Risk Factors, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical sciences
Abstract

IntroductionDiabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to manage CP-DM. We approached this question from a unique standpoint, hypothesizing that if CP-DM and T2DM are separate disorders, they should be genetically distinct. To test this hypothesis, we sought to determine whether a genetic risk score (GRS) based on validated single nucleotide polymorphisms for T2DM could distinguish between groups with CP-DM and T2DM.MethodsWe used 60 T2DM single nucleotide polymorphisms to construct a weighted GRS in 1,613 subjects from the North American Pancreatitis Study 2 and 2,685 subjects from the Multi-Ethnic Study of Atherosclerosis, all of European origin.ResultsThe mean GRS was identical between 321 subjects with CP-DM and 423 subjects with T2DM (66.53 vs 66.42, P = 0.95), and the GRS of both diabetic groups was significantly higher than that of nondiabetic controls (n = 3,554, P < 0.0001). Exploratory analyses attempting to enrich the CP-DM group for pancreatogenic diabetes, such as eliminating diabetes diagnosed before CP, requiring pancreas-specific comorbidities, or removing those with a family history of diabetes, did not improve the ability of the GRS to distinguish between CP-DM and T2DM.DiscussionRecognizing that we lacked a gold standard to define CP-DM, our study suggests that CP-DM may be a subtype of T2DM, a notion that should be tested in future, large prospective studies.

Published
2019

6. Chronic Pancreatitis

Author

Schwarzenberg, Sarah J, Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C Mel, Whitcomb, David C, Werlin, Steven L, Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K, Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S, Romagnuolo, Joseph, Rhee, Sue, Pohl, John F, Perito, Emily R, Ooi, Chee Y, Nathan, Jaimie D, Muniraj, Thiruvengadam, Morinville, Veronique D, McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Liu, Quin, Lin, Tom K, Lewis, Michele, Husain, Sohail Z, Himes, Ryan, Heyman, Melvin B, Guda, Nalini, Gonska, Tanja, Giefer, Matthew J, Gelrud, Andres, Gariepy, Cheryl E, Gardner, Timothy B, Freedman, Steven D, Forsmark, Christopher E, Fishman, Douglas S, Cote, Gregory A, Conwell, Darwin, Brand, Randall E, Bellin, Melena, Barth, Bradley, Banks, Peter A, Anderson, Michelle A, Amann, Stephen T, Alkaade, Samer, Abu-El-Haija, Maisam, Abberbock, Judah N, Lowe, Mark E, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases, Prevention, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Alcohol Drinking, Child, Cohort Studies, Cross-Sectional Studies, Demography, Disease Progression, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, North America, Pancreatitis, Chronic, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Tobacco Smoking, children, diabetes, endoscopy, environmental, genetic, pain, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics, Paediatrics
Abstract

ObjectivesThe aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.MethodsDemographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables.ResultsAlcohol was a risk in 53% of adults and 1% of children (P

Published
2019

7. Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort

Author

Lewis, Michele D., Talluri, Jyothsna, Wilcox, C. Mel, Abberbock, Judah N., Tang, Gong, Conwell, Darwin L., Banks, Peter A., Cote, Gregory A., Sherman, Stuart, Alkaade, Samer, Gardner, Timothy B., Anderson, Michelle A., Sandhu, Bimaljit S., Muniraj, Thiruvengadam, Forsmark, Chris E., Guda, Nalini, Gelrud, Andres, Romagnuolo, Joseph, Brand, Randall, LaRusch, Jessica, Amann, Stephen T., Slivka, Adam, Whitcomb, David C., and Yadav, Dhiraj

Published
2021
Full Text
View/download PDF

9. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Author

Whitcomb, David C, LaRusch, Jessica, Krasinskas, Alyssa M, Klei, Lambertus, Smith, Jill P, Brand, Randall E, Neoptolemos, John P, Lerch, Markus M, Tector, Matt, Sandhu, Bimaljit S, Guda, Nalini M, Orlichenko, Lidiya, Alkaade, Samer, Amann, Stephen T, Anderson, Michelle A, Baillie, John, Banks, Peter A, Conwell, Darwin, Coté, Gregory A, Cotton, Peter B, DiSario, James, Farrer, Lindsay A, Forsmark, Chris E, Johnstone, Marianne, Gardner, Timothy B, Gelrud, Andres, Greenhalf, William, Haines, Jonathan L, Hartman, Douglas J, Hawes, Robert A, Lawrence, Christopher, Lewis, Michele, Mayerle, Julia, Mayeux, Richard, Melhem, Nadine M, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Pericak-Vance, Margaret A, Romagnuolo, Joseph, Schellenberg, Gerard D, Sherman, Stuart, Simon, Peter, Singh, Vijay P, Slivka, Adam, Stolz, Donna, Sutton, Robert, Weiss, Frank Ulrich, Wilcox, C Mel, Zarnescu, Narcis Octavian, Wisniewski, Stephen R, O'Connell, Michael R, Kienholz, Michelle L, Roeder, Kathryn, Barmada, M Michael, Yadav, Dhiraj, and Devlin, Bernie

Subjects
Biological Sciences, Genetics, Clinical Research, Human Genome, Substance Misuse, Digestive Diseases, Alcoholism, Alcohol Use and Health, Prevention, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Good Health and Well Being, Claudins, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Homozygote, Humans, Male, Mutation, Pancreatitis, Alcoholic, Sex Factors, Trypsin, Trypsinogen, Alzheimer's Disease Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 (P < 1 × 10(-12)) and X-linked CLDN2 (P < 1 × 10(-21)) through a two-stage genome-wide study (stage 1: 676 cases and 4,507 controls; stage 2: 910 cases and 4,170 controls). The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous in males) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07).

Published
2012

11. Diagnosis and treatment in chronic pancreatitis: an international survey and case vignette study

Author

Moody, Frank G., Bertrand, Claude, Johnson, Colin, van Lander, Aude, Carter, Ross, Conneely, John B., Berrevoet, Frederik, Sousa Silva, Donzília, Li, Zong-Fang, Lévy, Philippe, Oppong, Kofi, Gardner, Timothy B., Wilcox, C. Mel, French, Jeremy, Steer, Michael, Bradley, Edward L., III, Layer, Peter, Napoleon, Bertrand, Mosquera, Jorge Antonio, Gouma, D.J., Andersson, Roland, Manzelli, Antonio, Klaase, J.M., Falconi, Massimo, de-Madaria, Enrique, Casadei, Riccardo, Malleo, Giuseppe, Pezzilli, Raffaele, Malecka-Panas, Ewa, Lohr, Matthias, Mayerle, Julia, Rauws, Erik A.J., Freeman, Martin L., Ariffin, Affirul Chairil, Vasavada, Bhavin, Lai, Paul Bo-San, Beristain-Hernandez, Jose Luis, Juan, Álvarez, Plaudis, Haralds, Vrochides, Dionisios, Neri, Vincenzo, Velayutham, Vimalraj, Andrianov, Aleksey, Figueras, Joan, Soreide, Kjetil, Shcherba, Aliaksei, Gachabayov, Mahir, Keith, Roger G., Tsoulfas, Georgios, Fink, Michael Anthony, Crippa, Stefano, Nikfarjam, Mehrdad, Bora, Dibyajyoti, Desai, Rajendra, Donati, Marcello, Bong, Jan Jin, Martínez Moneo, Emma, Morris-Stiff, Gareth, Coker, Ahmet, de Resende, Alexandre Prado, Bhalerao, Suryabhan Sakhahari, Sikora, Sadiq S., Kelemen, Dezső, Czakó, László, Ramesh, Hariharan, Rummo, Oleg, Fedaruk, Aliaksei, Hlinnik, Alexey, Chinthakindi, Madhusudhan, Dumitrascu, Traian, Egorov, Vyacheslav, Bettschart, Vincent, Molinari, Michele, Guillermo, E. Aldana D., Orloff, Susan L., Kostov, Daniel Vasilev, Sulpice, Laurent, Knowles, Brett, Kimura, Yasutoshi, Marangoni, Gabriele, Joshi, Rajeev, Gyökeres, Tibor, Bedin, Vladimir, V., Ivanecz, Arpad, Antonucci, Adelmo, Omoshoro-Jones, Jones A.O., Nakache, Richard, Del Chiaro, Marco, Johnstone, Marianne, Saito, Tomoaki, Balzano, Gianpaolo, Chooklin, Serge, Boraschi, Piero, Park, Walter, Pereira, Pedro Nuno Valente Reis, Pagano, Nico, Lykoudis, Pavlos, Partecke, Lars Ivo, Siatkouski, Aliaksandr, Martín, Rosa Jorba, Kawabata, Yasunari, Lourenço, Luís Carvalho, Marra-Lopez, Carlos, Lee, Jun Kyu, Habbe, Nils, Verdonk, Robert C., Rabotyagova, Yliya, Talukdar, Rupjyoti, Frulloni, Luca, Galeev, Shamil, Berger, Zoltán, Yasuda, Takeo, Hackert, Thilo, Saatov, Ziyovuddin, Raptis, Dimitri Aristotle, Boadas, Jaume, Vitali, Francesco, Archibugi, Livia, Ryska, Miroslav, Tihanyi, Balazs, Singh, Vikesh K., Masamune, Atsushi, Yeaton, Paul, Smith, Kerrington D., Modi, Shrey, Cosen-Binker, Laura, Barreto, Savio George, Morandi, Eugenio, Valeri, Sergio, Morioka, Cintia Yoko, Lara, Luis F., Takeyama, Yoshifumi, Gress, Frank G., Yu, Young-Dong, Gaia, Ezio, Barbu, Sorin Traian, İnce, Ali Tüzün, Deeprasertvit, Akkraporn, Chang, Yu-Ting, Abiola, Stephen Olusola, Kacar, Sabite, Muscarella, Peter, II, Braat, Henri, Han, Samuel, Aghdassi, Ali A., Frossard, Jean-Louis, Smith, Jill P., Schwartz, M.P., van Dullemen, H.M., Venneman, N.G., Spanier, B.W.M., Kuiken, Sjoerd, van Geenen, Erwin, Beilman, Greg, Papachristou, Georgios, Chapa Azuela, Oscar, van der Schaar, P., Oruc, Nevin, Anten, Marie-Paule, Nealon, William H., García-Cano, Jesús, Jovani, Manol, Melki, Ziad, Ibrahim, Mustafa Mohammed Ahmed, Awajdarip, M.U., Azam, Mohammad, Sabu, K.G., Ermolaev, Igor, Shetty, Shiran, Oana, Belei, Pokrotnieks, Juris, Lazuchiewicz-Kot, Malgorzata, Bouali, Riadh, Winiarski, Marek, Schmitt, Marcus, Rimbas, Mihai, Meining, Alexander, Erwan, Bories, Meier, Peter N., Schoefl, Rainer, Altonbary, Ahmed Youssef, Marsteller, Igor, Wallstabe, Ingo, Prifti, Skerdi, Lemmers, Arnaud, Horvath, M., Kumar, Ajay, Palermo, Joseph J., Issa, Yama, van Santvoort, Hjalmar C., Fockens, Paul, Besselink, Marc G., Bollen, Thomas L., Bruno, Marco J., and Boermeester, Marja A.

Published
2017
Full Text
View/download PDF

13. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Author

Yadav, Dhiraj, primary, Whitcomb, David C., additional, Tang, Gong, additional, Slivka, Adam, additional, Bellin, Melena, additional, AlKaade, Samer, additional, Amann, Stephen T., additional, Anderson, Michelle A., additional, Banks, Peter, additional, Conwell, Darwin, additional, Brand, Randall E., additional, Cote, Gregory A., additional, Romagnuolo, Joseph, additional, Forsmark, Christopher E., additional, Gardner, Timothy, additional, Gelrud, Andres, additional, Guda, Nalini, additional, Lewis, Michele, additional, Muniraj, Thiruvengadam, additional, Sandhu, Bimaljit S., additional, Sherman, Stuart, additional, Singh, Vikesh, additional, and Wilcox, C. Mel, additional

Published
2023
Full Text
View/download PDF

14. Chronic Pancreatitis Pain Pattern and Severity Are Independent of Abdominal Imaging Findings

Author

Wilcox, C. Mel, Yadav, Dhiraj, Ye, Tian, Gardner, Timothy B., Gelrud, Andres, Sandhu, Bimaljit S., Lewis, Michele D., Al-Kaade, Samer, Cote, Gregory A., Forsmark, Christopher E., Guda, Nalini M., Conwell, Darwin L., Banks, Peter A., Muniraj, Thiruvengadam, Romagnuolo, Joseph, Brand, Randall E., Slivka, Adam, Sherman, Stuart, Wisniewski, Stephen R., Whitcomb, David C., and Anderson, Michelle A.

Published
2015
Full Text
View/download PDF

17. NSAIDs and renal toxicity in the community setting: a practical guide for clinicians

Author

Devlin, John W., Wilcox, C. Mel, and Pallentino, Julia

Subjects
Ibuprofen -- Surveys -- Usage -- Complications and side effects, Anti-inflammatory drugs -- Usage -- Complications and side effects, Business, Economics, Health care industry
Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are a diverse group of medications widely used for controlling pain and inflammation associated with musculoskeletal conditions. (1) NSAIDs have common analgesic, anti-inflammatory, and anti-pyretic properties. [...]

Published
2013

23. Sa1377 LIFETIME SMOKING IN PERSONS WITH CHRONIC PANCREATITIS

Author

Jeon, Christie Y., primary, Feldman, Robert, additional, Tang, Gong, additional, Whitcomb, David C., additional, Alkaade, Samer, additional, Guda, Nalini M., additional, Singh, Vikesh, additional, Sandhu, Bimaljit S., additional, Wilcox, C. Mel, additional, and Yadav, Dhiraj, additional

Published
2020
Full Text
View/download PDF

24. Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.

Author

Schwarzenberg, Sarah J, Schwarzenberg, Sarah J, Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C Mel, Whitcomb, David C, Werlin, Steven L, Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K, Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S, Romagnuolo, Joseph, Rhee, Sue, Pohl, John F, Perito, Emily R, Ooi, Chee Y, Nathan, Jaimie D, Muniraj, Thiruvengadam, Morinville, Veronique D, McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Liu, Quin, Lin, Tom K, Lewis, Michele, Husain, Sohail Z, Himes, Ryan, Heyman, Melvin B, Guda, Nalini, Gonska, Tanja, Giefer, Matthew J, Gelrud, Andres, Gariepy, Cheryl E, Gardner, Timothy B, Freedman, Steven D, Forsmark, Christopher E, Fishman, Douglas S, Cote, Gregory A, Conwell, Darwin, Brand, Randall E, Bellin, Melena, Barth, Bradley, Banks, Peter A, Anderson, Michelle A, Amann, Stephen T, Alkaade, Samer, Abu-El-Haija, Maisam, Abberbock, Judah N, Lowe, Mark E, Yadav, Dhiraj, Schwarzenberg, Sarah J, Schwarzenberg, Sarah J, Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C Mel, Whitcomb, David C, Werlin, Steven L, Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K, Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S, Romagnuolo, Joseph, Rhee, Sue, Pohl, John F, Perito, Emily R, Ooi, Chee Y, Nathan, Jaimie D, Muniraj, Thiruvengadam, Morinville, Veronique D, McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Liu, Quin, Lin, Tom K, Lewis, Michele, Husain, Sohail Z, Himes, Ryan, Heyman, Melvin B, Guda, Nalini, Gonska, Tanja, Giefer, Matthew J, Gelrud, Andres, Gariepy, Cheryl E, Gardner, Timothy B, Freedman, Steven D, Forsmark, Christopher E, Fishman, Douglas S, Cote, Gregory A, Conwell, Darwin, Brand, Randall E, Bellin, Melena, Barth, Bradley, Banks, Peter A, Anderson, Michelle A, Amann, Stephen T, Alkaade, Samer, Abu-El-Haija, Maisam, Abberbock, Judah N, Lowe, Mark E, and Yadav, Dhiraj

Abstract

ObjectivesThe aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.MethodsDemographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables.ResultsAlcohol was a risk in 53% of adults and 1% of children (P < 0.0001); tobacco in 50% of adults and 7% of children (P < 0.0001). Obstructive factors were more common in children (29% vs 19% in adults, P = 0.001). Genetic risk factors were found more often in children. Exocrine pancreatic insufficiency was similar (children 26% vs adult 33%, P = 0.107). Diabetes was more common in adults than children (36% vs 4% respectively, P < 0.0001). Median emergency room visits, hospitalizations, and missed days of work/school were similar across the cohorts. As a secondary analysis, NAPS2 subjects with childhood onset (NAPS2-CO) were compared with INSPPIRE subjects. These 2 cohorts were more similar than the total INSPPIRE and NAPS2 cohorts, including for genetic risk factors. The only risk factor significantly more common in the NAPS2-CO cohort compared with the INSPPIRE cohort was alcohol (9% NAPS2-CO vs 1% INSPPIRE cohorts, P = 0.011).ConclusionsDespite disparity in age of onset, children and adults with CP exhibit similarity in demographics, CP treatment, and pain. Differences between groups in radiographic findings and diabetes prevalence may be related to differences in risk factors associated with disease and length of time of CP.

Published
2019

27. Declining CD4+ T-lymphocyte counts are associated with increased risk of enteric parasitosis and chronic diarrhea: results of a 3-year longitudinal study

Author

Navin, Thomas R., Weber, Rainer, Vugia, Duc J., Rimland, David, Roberts, Jacquelin M., Addiss, David G., Visvesvara, Govinda S., Wahlquist, Susanne P., Hogan, Susan E., Gallagher, Laura E., Juranek, Dennis D., Schwartz, David A., Wilcox, C. Mel, Stewart, James M., Thompson, Sumner E., III, and Bryan, Ralph T.

Subjects
HIV infection -- Complications, Diarrhea -- Causes of, Protozoan diseases -- Care and treatment, Immunosuppression -- Complications, Health
Abstract

Chronic diarrhea in HIV patients is often associated with intestinal parasites. Researchers collected monthly stool samples from 602 people infected with HIV, and found parasites in 35% of cases of chronic diarrhea and 14% of cases of acute diarrhea. Parasites were more common in samples from patients with greater immunosuppression. Cryptosporidium parvum was the protozoa most commonly causing the diarrhea.

Published
1999

28. Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole

Author

Worthington Julie, Mohnen Jean, Phadnis Milind, Martin Toni, Wilcox C Mel, and Hirschowitz Basil I

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background The relationship between proton pump inhibitor therapy and other acid suppressing medications and the risk of gastrointestinal infections remains controversial. Methods Patients enrolled in a long-term trial of lansoprazole for Zollinger-Ellison syndrome and other acid hypersecretory states had interval histories taken every six months regarding hospitalizations or other intercurrent medical conditions. All medications taken were also reviewed at each visit. In addition, available patients were specifically queried during the study period 2006–2007 regarding the development of any gastrointestinal infections, hospitalizations, and prescriptions for antibiotics. Results Ninety patients were enrolled in our long-term study and 81 were available for review. The median basal gastric pH for the cohort after stabilization on therapy was 2.9 and ranged from 1.1 – 8.4 with a median pentagastrin stimulated gastric pH of 1.60 (range 1.0 – 8.2). No patient developed a clinically significant gastrointestinal infection during the study. The median patient years of follow-up were 6.25 years. Conclusion In a cohort of patients with gastric acid hypersecretion in whom acid secretion status was monitored on lansoprazole, all were free of significant gastrointestinal infections on long-term follow-up. Trial registration NCT00204373

Published
2008
Full Text
View/download PDF

34. Recurrent Acute Pancreatitis Without Underlying Overt Chronic Pancreatitis Negatively Impacts Quality of Life

Author

Cote, Gregory A., primary, Yadav, Dhiraj, additional, Abberbock, Judah, additional, Tang, Gong, additional, Slivka, Adam, additional, Brand, Randall, additional, Anderson, Michelle A., additional, Banks, Peter A., additional, Lewis, Michele D., additional, Baillie, John, additional, Sherman, Stuart, additional, Alkaade, Samer, additional, Amann, Stephen, additional, Gelrud, Andres, additional, Forsmark, Chris, additional, Sandhu, Bimaljit S., additional, Guda, Nalini M., additional, Conwell, Darwin L., additional, Muniraj, Thiruvengadam, additional, Wilcox, C. Mel, additional, Whitcomb, David C., additional, and Gardner, Timothy B., additional

Published
2017
Full Text
View/download PDF

35. Patient and Disease Characteristics Associated with Presence of Diabetes Mellitus in Adults with Chronic Pancreatitis in the U.S

Author

Bellin, Melena, primary, Whitcomb, David C., additional, Abberbock, Judah, additional, Sherman, Stuart, additional, Sandhu, Bimaljit S., additional, Gardner, Timothy B., additional, Anderson, Michelle A., additional, Lewis, Michele D., additional, Alkaade, Samer, additional, Singh, Vikesh, additional, Baillie, John, additional, Banks, Peter A., additional, Conwell, Darwin L., additional, Cote, Gregory A., additional, Guda, Nalini M., additional, Muniraj, Thiruvengadam, additional, Tang, Gong, additional, Brand, Randall, additional, Gelrud, Andres, additional, Amann, Stephen, additional, Forsmark, Chris, additional, Wilcox, C. Mel, additional, Slivka, Adam, additional, and Yadav, Dhiraj, additional

Published
2017
Full Text
View/download PDF

36. Lifetime Drinking History of Persons With Chronic Pancreatitis.

Author

Jeon, Christie Y, Whitcomb, David C, Slivka, Adam, Brand, Randall E, Gelrud, Andres, Tang, Gong, Abberbock, Judah, AlKaade, Samer, Guda, Nalini, Wilcox, C Mel, Sandhu, Bimaljit S, and Yadav, Dhiraj

Subjects
COMPLICATIONS of alcoholism, PANCREATITIS diagnosis, DRINKING behavior, PANCREATITIS, QUESTIONNAIRES, SEX distribution, SMOKING, ACUTE diseases, PHYSICIANS' attitudes, DESCRIPTIVE statistics
Abstract

Aims Cumulative consumption of alcohol and variations of alcohol intake by age are unknown in chronic pancreatitis (CP) patients in North America. This study summarizes the lifetime drinking history (LDH) by physician attribution of alcohol etiology, smoking status and sex in persons with CP. Methods We analyzed data on 193 CP participants who completed the LDH questionnaire in the North American Pancreatitis Continuation and Validation Study (NAPS2-CV). We collected data on frequency of drinking and drinks per drinking day for each drinking phase of their lives. We examined differences in total number of alcoholic drinks and weight of ethanol consumed by physician's assessment of CP etiology, sex and smoking status. We also compared intensity of drinking in 20, 30 and 40s by timing of CP diagnosis. Results Persons diagnosed with alcoholic CP consumed median of 34,488 drinks (interquartile range 18,240–75,024) prior to diagnosis of CP, which occurred earlier than in persons with CP of other etiology (47 vs. 52 years). Cumulative drinking was greater in male vs. female patients. Male CP patients with a diagnosis of CP before the age of 45 drank more intensely in their 20s as compared to those with later onset of disease. Current smoking was prevalent (67%) among those diagnosed with alcoholic CP. Twenty-eight percent of patients without physician attribution of alcohol etiology reported drinking heavily in the past. Conclusions Lifetime cumulative consumption of alcohol and prevalence of current smoking are high in persons diagnosed with alcoholic pancreatitis. Intense drinking in early years is associated with earlier manifestation of the disease. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

37. Ulcers: making medical history

Author

Peura, David A. and Wilcox, C. Mel

Subjects
Helicobacter infections -- Care and treatment, Peptic ulcer -- Care and treatment, Helicobacter pylori -- Health aspects, General interest, News, opinion and commentary, Care and treatment, Health aspects
Abstract

Contrary to popular belief, most ulcers are not caused by the boss -- unless the boss is a bacterium. That's right: neither a demonic boss nor a burrito with jalapeno [...]

Published
1996

38. Translational and clinical perspectives on sphincter of Oddi dysfunction

Author

Kyanam Kabir Baig,Kondal, Wilcox,C. Mel, Kyanam Kabir Baig,Kondal, and Wilcox,C. Mel

Abstract

Kondal Rao Kyanam Kabir Baig,1,2 Charles Melbern Wilcox1 1Division of Gastroenterology and Hepatology, University of Alabama, 2Birmingham VA Medical Center, Birmingham, AL, USA Abstract: Sphincter of Oddi dysfunction is a complex pathophysiologic entity that is associated with significant morbidity causing abdominal pain, nausea, and vomiting. The purpose of this review is to describe the anatomy and physiology of the sphincter of Oddi, to understand the pathologic mechanisms thought to be responsible for symptomatology, review recent major studies, explore endoscopic and pharmacologic therapies and their efficacy, and to explore future research avenues. Keywords: SOD, abdominal pain, pancreatitis, sphincter dysfunction, abnormal liver tests, biliary dilation

Published
2016

39. 962 Racial Differences in the Clinical Profile, Causes and Outcome of Chronic Pancreatitis

Author

Wilcox, C. Mel, primary, Singh, Vikesh K., additional, Sandhu, Bimaljit S., additional, Gelrud, Andres, additional, Conwell, Darwin, additional, Muniraj, Thiruvengadam, additional, Guda, Nalini M., additional, Abberbock, Judah, additional, Tang, Gong, additional, Brand, Randall, additional, Slivka, Adam, additional, Whitcomb, David C., additional, and Yadav, Dhiraj, additional

Published
2016
Full Text
View/download PDF

40. 961 Quality of Life (QOL) in Chronic Pancreatitis (CP) Is Determined by Constant Pain, Disability, Current Smoking and Associated Co-Morbidities

Author

Machicado, Jorge D., primary, Amann, Stephen, additional, Anderson, Michelle, additional, Abberbock, Judah, additional, Sherman, Stuart, additional, Conwell, Darwin, additional, Cote, Gregory A., additional, Singh, Vikesh K., additional, Wilcox, C. Mel, additional, Lewis, Michele, additional, Alkaade, Samer, additional, Sandhu, Bimaljit S., additional, Guda, Nalini M., additional, Muniraj, Thiruvengadam, additional, Tang, Gong, additional, Baillie, John, additional, Brand, Randall, additional, Gardner, Timothy, additional, Gelrud, Andres, additional, Forsmark, Christopher E., additional, Banks, Peter A., additional, Slivka, Adam, additional, Whitcomb, David C., additional, and Yadav, Dhiraj, additional

Published
2016
Full Text
View/download PDF

43. Factors impacting treatment outcomes in the endoscopic management of walled-off pancreatic necrosis

Author

Bang, Ji Young, Wilcox, C Mel, Trevino, Jessica, Ramesh, Jayapal, Peter, Shajan, Hasan, Muhammad, Hawes, Robert H., and Varadarajulu, Shyam

Subjects
Adult, Male, Time Factors, Adolescent, Middle Aged, Article, Necrosis, Young Adult, Catheters, Indwelling, Treatment Outcome, Multivariate Analysis, Secondary Prevention, Drainage, Humans, Regression Analysis, Female, Stents, Endoscopy, Digestive System, Child, Pancreas, Aged, Retrospective Studies
Abstract

Treatment outcomes are suboptimal for patients undergoing endoscopic treatment of walled-off pancreatic necrosis (WOPN). The objective of this study is to identify factors that impact treatment outcomes in this patient subset.This is a retrospective study of patients with WOPN treated endoscopically over 10 years. Patients underwent placement of stents and nasocystic catheters within the necrotic cavity. In select patients, the multiple transluminal gateway technique (MTGT) was adopted to create several openings in the stomach or duodenum to facilitate drainage of necrosis. In patients with disconnected pancreatic duct syndrome (DPDS), the transmural stents were left in place indefinitely to decrease pancreatic fluid collection (PFC) recurrence.Endoscopic treatment was successful in 53 of 76 (69.7%) patients. Treatment success was higher in patients undergoing MTGT than in those in whom conventional drainage was used (94.4% vs. 62.1%, P = 0.009). On multivariate logistic regression analysis, only MTGT (OR 15.8, 95% CI 1.77-140.8; P = 0.01) and fewer endoscopic sessions being needed (OR 4.0, 95% CI 1.16-14.0; P = 0.03) predicted treatment success. PFC recurrence was significantly lower in patients with indwelling transmural stents than in patients in whom the stents were removed (0 vs. 20.8%; P = 0.02).Creating multiple gateways for drainage of necrotic debris improves treatment success, and not removing the transmural stents decreases PFC recurrence in patients undergoing endoscopic drainage of WOPN.

Published
2013

44. Endomicroscopy of the Pancreaticobiliary System

Author

Peter, Shajan, Bang, Ji Young, Mönkemuller, Klaus, Varardarajulu, Shyam, and Wilcox, C. Mel

Subjects
Article Subject
Abstract

It is often difficult to accurately differentiate between benign and malignant pancreaticobiliary strictures, and some are interpreted as indeterminate despite ERCP, EUS, or radiological imaging techniques, thereby making it difficult for the clinician to make appropriate management decisions. Probe-based confocal laser endomicroscopy (pCLE) is an innovative imaging tool integrating real-time in vivo imaging of these difficult-to-interpret strictures in the pancreaticobiliary system during endoscopy. Recent studies of endomicroscopy have shown a promising role with improved accuracy in distinguishing these lesions, thus paving the way for future research addressing improving precise interpretation, training, and long long-term impact.

Published
2013
Full Text
View/download PDF

48. Tu1498 Increased Awareness Enhances Physician Recognition of the Role of Smoking on Chronic Pancreatitis (CP)

Author

Yadav, Dhiraj, primary, Sandhu, Bimaljit, additional, Lewis, Michele D., additional, Wilcox, C. Mel, additional, Tian, Ye, additional, Gardner, Timothy B., additional, Gelrud, Andres, additional, Alkaade, Samer, additional, Cote, Gregory A., additional, Forsmark, Christopher E., additional, Guda, Nalini M., additional, Anderson, Michelle A., additional, Conwell, Darwin, additional, Banks, Peter A., additional, Muniraj, Thiruvengadam, additional, Romagnuolo, Joseph, additional, Brand, Randall, additional, Wisniewski, Stephen R., additional, Sherman, Stuart, additional, Slivka, Adam, additional, and Whitcomb, David C., additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results