15 results on '"Williams, Daniel M."'
Search Results
2. Perioperative and safety outcomes following tissue-sparing posterior cervical fusion to revise a pseudarthrosis: A multicenter retrospective review of 150 cases
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Lemons, Alexander C., primary, Haglund, Michael M., additional, McCormack, Bruce M., additional, Williams, Daniel M., additional, Bohr, Adam D., additional, and Summerside, Erik M., additional
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- 2024
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3. Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium
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Williams, Daniel M., primary, Gungordu, Lale, additional, Jackson-Crawford, Anthony, additional, and Lowe, Martin, additional
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- 2022
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4. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
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Gordon, David E., Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V., Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S., Obernier, Kirsten, Guo, Jeffrey Z., Batra, Jyoti, Kaake, Robyn M., Weckstein, Andrew R., Owens, Tristan W., Gupta, Meghna, Pourmal, Sergei, Titus, Erron W., Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O’Meara, Matthew J., Tummino, Tia A., Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Hüttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L., Fabius, Jacqueline M., Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M., Naing, Zun Zar Chi, Pulido, Ernst H., Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A., Azumaya, Caleigh M., Billesbølle, Christian, Brilot, Axel F., Campbell, Melody G., Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T., Liu, Yanxin, Merz, Gregory E., Moritz, Michelle, Nguyen, Henry C., Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N., Schulze-Gahmen, Ursula, Smith, Amber M., Sun, Ming, Young, Iris D., Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R., Chen, Jen, Chio, Cynthia M., Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L., Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E., Melo, Arthur A., Moss, Frank R., Nguyen, Phuong, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K., Pospiech, Thomas H., Safari, Maliheh, Sangwan, Smriti, Schaefer, Kaitlin, Thomas, Paul V., Thwin, Aye C., Trenker, Raphael, Tse, Eric, Tsui, Tsz Kin Martin, Wang, Feng, Whitis, Natalie, Yu, Zanlin, Zhang, Kaihua, Zhang, Yang, Zhou, Fengbo, Saltzberg, Daniel, Hodder, Anthony J., Shun-Shion, Amber S., Williams, Daniel M., White, Kris M., Rosales, Romel, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Patel, Arvind H., Rihn, Suzannah, Khalid, Mir M., Vallejo-Gracia, Albert, Fozouni, Parinaz, Simoneau, Camille R., Roth, Theodore L., Wu, David, Karim, Mohd Anisul, Ghoussaini, Maya, Dunham, Ian, Berardi, Francesco, Weigang, Sebastian, Chazal, Maxime, Park, Jisoo, Logue, James, McGrath, Marisa, Weston, Stuart, Haupt, Robert, Hastie, C. James, Elliott, Matthew, Brown, Fiona, Burness, Kerry A., Reid, Elaine, Dorward, Mark, Johnson, Clare, Wilkinson, Stuart G., Geyer, Anna, Giesel, Daniel M., Baillie, Carla, Raggett, Samantha, Leech, Hannah, Toth, Rachel, Goodman, Nicola, Keough, Kathleen C., Lind, Abigail L., Klesh, Reyna J., Hemphill, Kafi R., Carlson-Stevermer, Jared, Oki, Jennifer, Holden, Kevin, Maures, Travis, Pollard, Katherine S., Sali, Andrej, Agard, David A., Cheng, Yifan, Fraser, James S., Frost, Adam, Jura, Natalia, Kortemme, Tanja, Manglik, Aashish, Southworth, Daniel R., Stroud, Robert M., Alessi, Dario R., Davies, Paul, Frieman, Matthew B., Ideker, Trey, Abate, Carmen, Jouvenet, Nolwenn, Kochs, Georg, Shoichet, Brian, Ott, Melanie, Palmarini, Massimo, Shokat, Kevan M., García-Sastre, Adolfo, Rassen, Jeremy A., Grosse, Robert, Rosenberg, Oren S., Verba, Kliment A., Basler, Christopher F., Vignuzzi, Marco, Peden, Andrew A., Beltrao, Pedro, Krogan, Nevan J., Trinidad, Donovan, Damas, Joana, Hughes, Graham M., Painter, Corrie A., Persky, Nicole S., Corbo, Marco, Kirilenko, Bodgan, Hiller, Michael, Koepfli, Klaus-Peter, Kaplow, Irene, Wirthlin, Morgan, Pfenning, Andreas R., Zhao, Huabin, Genereux, Diane P., Swofford, Ross, Lind, Abigail, Ryderq, Oliver A., Nweeia, Martin T., Meadows, Jennifer, Dong, Michael, Wallerman, Ola, Marinescu, Vikki, Lindblad-Toh, Kerstin, Ray, David A., Power, Sarahjane, Teeling, Emma C., Chauhan, Gaurav, Li, Shirley Xue, Karlsson, Elinor K., Lewin, Harris A., Centre National de la Recherche Scientifique (CNRS), Quantitative Biosciences Institute [UC San Francisco, USA] (QBI), University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), Populations virales et Pathogenèse - Viral Populations and Pathogenesis, and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
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Infectious Medicine ,Middle East respiratory syndrome coronavirus ,Viral protein ,viruses ,[SDV]Life Sciences [q-bio] ,Infektionsmedicin ,medicine.disease_cause ,Conserved sequence ,Microbiology in the medical area ,03 medical and health sciences ,Mitochondrial membrane transport protein ,0302 clinical medicine ,Protein structure ,Pandemic ,medicine ,Mikrobiologi inom det medicinska området ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,Coronavirus ,0303 health sciences ,Multidisciplinary ,biology ,virus diseases ,Virology ,3. Good health ,biology.protein ,Viral disease ,030217 neurology & neurosurgery - Abstract
INTRODUCTION The emergence of three lethal coronaviruses in Jennifer Meadows, Michael Dong, Ola Wallerman, Vikki Marinescu & Kerstin Lindblad-Toh ingår i gruppen Zoonomia Consortium
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- 2020
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5. Concept validation experiment for small aircraft transportation system higher-volume operations
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Consiglio, Maria C., Williams, Daniel M., Murdoch, Jennifer L., and Adams, Catherine A.
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Transportation industry ,Flying-machines ,Aerospace and defense industries ,Business ,Science and technology - Abstract
DOI: 10.2514/1.20588 A human-in-the-loop simulation experiment was conducted at the NASA Langley Research Center's Air Traffic Operations Laboratory in an effort to comprehensively validate tools and procedures intended to enable the small aircraft transportation system higher-volume-operations concept of operations. These procedures were developed with the goal of increasing the rate of operations at nontowered, nonradar airports in near all-weather conditions. A key element of the new design is the establishment of a volume of airspace around designated airports at which pilots accept responsibility for self-separation. Flights operating at these airports are given approach-sequencing information computed by a ground-based automated system. The validation experiment was conducted to determine if a pilot could safely and proficiently fly an airplane while performing the newly developed procedures. Comparative measures of flight path error, perceived workload, and situation awareness were obtained for two types of simulated scenarios. Baseline scenarios were representative of today's system using procedure separation, in which air traffic control grants one approach or departure clearance at a time. Test scenarios represented the newly developed approach and departure procedures. Results from the experiment indicate that low-time pilots were able to fly the test procedures in a simulation environment and maintain self-separation as safely and proficiently as flying today's procedures.
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- 2008
6. Conflict prevention and separation assurance in small aircraft transportation systems
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Consiglio, Maria C., Carreno, Victor, Williams, Daniel M., and Munoz, Cesar
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Algorithms ,Transportation industry ,Flying-machines ,Algorithm ,Aerospace and defense industries ,Business ,Science and technology - Abstract
DOI: 10.2514/1.20586 A multilayer approach to the prevention of conflicts due to the loss of aircraft-to-aircraft separation that relies on procedures and onboard automation was implemented as part of the Small Aircraft Transportation Systems Higher-Volume-Operations concept. The multilayer system gives pilots support and guidance during the execution of normal operations and advance warning for procedure deviations or off-nominal operations. This paper describes the major concept elements of this multilayer approach to separation assurance and conflict prevention and provides the rationale for its design. All the algorithms and functionality described in this paper were implemented in an aircraft simulation in the Air Traffic Operations Laboratory at NASA Langley Research Center and on the NASA Cirrus SR22 research aircraft.
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- 2008
7. Incorporating data link messaging into a multi-function display to support the Small Aircraft Transportation System (SATS) and the self-separation of general aviation aircraft
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Adams, Catherine A., Murdoch, Jennifer L., Consiglio, Maria C., and Williams, Daniel M.
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Transportation industry -- Equipment and supplies ,Transportation industry -- Technology application ,Aeronautics -- Technology application ,Aeronautics -- Information management ,Ergonomic aid ,Ergonomics ,Technology application ,Company systems management ,Engineering and manufacturing industries ,Health ,Human resources and labor relations - Abstract
One objective of the Small Aircraft Transportation System (SATS) Project is to increase the capacity and utilization of small non-towered, non-radar equipped airports by transferring traffic management activities to an automated system and separation responsibilities to general aviation (GA) pilots. This paper describes the development of a research multi-function display (MED) to support the interaction between pilots and an automated Airport Management Module (AMM). Preliminary results of simulation and flight tests indicate that adding the responsibility of monitoring other traffic for self-separation does not increase pilots' subjective workload levels. Pilots preferred using the enhanced MFD to execute flight procedures, reporting improved situation awareness (SA) over conventional instrument flight rules (IFR) procedures. Keywords: Small Aircraft Transportation System; SATS Higher Volume Operations; MFD and SATS; Data link and general aviation; Data link messaging
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- 2007
8. Small Aircraft Transportation System Higher Volume Operations Flight Experiment
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Williams, Daniel M., Murdoch, Jennifer L., and Adams, Catherine H.
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Air traffic control -- Technology application ,Air traffic control -- Methods ,Air traffic control -- Testing ,Technology application ,Aerospace and defense industries ,Business ,Science and technology - Abstract
This paper summarizes findings from the Small Aircraft Transportation System Higher Volume Operations Flight Experiment. The higher volume operations concept improves efficiency at nontowered, nonradar airports in instrument meteorological conditions. The success of the higher volume operations concept is based on pilot acceptability as determined through objective and subjective assessments when compared with the procedural control operations in use today at nontowered, nonradar-controlled airfields in instrument meteorological conditions. Flight experiment data indicate that the concept is viable. The experiment, flown on a general aviation aircraft, used a subset of the Higher Volume Operations Simulation Experiment scenarios and evaluation pilots to validate the simulation experiment results. Results reveal that all 12 low-time instrument-rated pilots preferred Small Aircraft Transportation System Higher Volume Operations when compared with current procedural separation operations. These pilots also flew the higher volume operations procedures safely and proficiently without additional workload in comparison to today's system. Detailed results of pilot flight technical error and their subjective assessments of workload and situation awareness are presented. DOI: 10.2514/1.20403
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- 2006
9. Empirical Characterization of Unconstrained Tape Spring Deployment Dynamics
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Williams, Daniel M.
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Space Vehicles ,Springs (Mechanism)--Testing ,Expandable space structures ,Hinges - Abstract
Satellite cost and mission capability are very sensitive to mass requirements. Mass or volume savings in one component will either lower total spacecraft mass, or provide greater margin for design error in other components. Solar arrays and antennas in particular are often driven by launch vehicle volume constraints instead of mission needs. Deployable structures provide more on-orbit area for both solar arrays and antennas, while occupying less space during launch. These structures therefore, help address these constraints and have been proven as efficient solutions for many years. Tape springs are one example in this category of structures which offer greater reliability for less mass and for a variety of configurations. This thesis compares a large number of trials on bending tape springs to characterize the behavior with respect to the tape spring geometry (radius, subtended angle, thickness and width) and load conditions (inertia, bend angle and skew angle). These tape spring trials measure representative unconstrained deployment trajectories to provide a representative dataset for comparison against previous and future models. Error trends are identified with respect to bend angle, skew angle, tape spring width, and tape spring thickness. Then an optimized model which characterizes these trends is fitted to the experimental data. This optimized model supports the hinge dependence on bend angle and skew angle, but is inconclusive with respect to the remaining design parameters.
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- 2012
10. Paroxysmal Hypnogenic Dyskinesia Responsive to Doxylamine: A Case Report
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Williams, Daniel M.
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Article Subject ,otorhinolaryngologic diseases - Abstract
Paroxysmal hypnogenic dyskinesia is a rare clinical entity characterized by intermittent dystonia and choreoathetoid movements that begin exclusively during sleep, often with consciousness preserved once the patient is awakened during the episodes. They occur almost every night and are often misdiagnosed as sleeping disorders. Paroxysmal hypnogenic dyskinesia is currently known to be a form of frontal lobe epilepsy, but not in all cases. We present a 19-year-old male patient with paroxysmal hypnogenic dyskinesia who responded to antihistamines. This supports an alternative theory from 1977 (before the cases had been adequately described) that the disorder lies in dysregulation in the basal ganglia. This description now appears similar to acute dystonic reactions such as extrapyramidal symptoms from antipsychotic medications, which also respond to antihistamines.
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- 2012
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11. Bacillus anthracis Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function
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Langer, Marybeth, primary, Duggan, Elizabeth Stewart, additional, Booth, John Leland, additional, Patel, Vineet Indrajit, additional, Zander, Ryan A., additional, Silasi-Mansat, Robert, additional, Ramani, Vijay, additional, Veres, Tibor Zoltan, additional, Prenzler, Frauke, additional, Sewald, Katherina, additional, Williams, Daniel M., additional, Coggeshall, Kenneth Mark, additional, Awasthi, Shanjana, additional, Lupu, Florea, additional, Burian, Dennis, additional, Ballard, Jimmy Dale, additional, Braun, Armin, additional, and Metcalf, Jordan Patrick, additional
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- 2012
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12. Csk, a Critical Link of G Protein Signals to Actin Cytoskeletal Reorganization
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Lowry, William E., primary, Huang, Jianyun, additional, Ma, Yong-Chao, additional, Ali, Shariq, additional, Wang, Dongxia, additional, Williams, Daniel M., additional, Okada, Masato, additional, Cole, Philip A., additional, and Huang, Xin-Yun, additional
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- 2002
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13. Chemical Rescue of a Mutant Protein-tyrosine Kinase
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Williams, Daniel M., primary, Wang, Dongxia, additional, and Cole, Philip A., additional
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- 2000
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14. Bacillus anthracisLethal Toxin Reduces Human Alveolar Epithelial Barrier Function
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Langer, Marybeth, Duggan, Elizabeth Stewart, Booth, John Leland, Patel, Vineet Indrajit, Zander, Ryan A., Silasi-Mansat, Robert, Ramani, Vijay, Veres, Tibor Zoltan, Prenzler, Frauke, Sewald, Katherina, Williams, Daniel M., Coggeshall, Kenneth Mark, Awasthi, Shanjana, Lupu, Florea, Burian, Dennis, Ballard, Jimmy Dale, Braun, Armin, and Metcalf, Jordan Patrick
- Abstract
ABSTRACTThe lung is the site of entry for Bacillus anthracisin inhalation anthrax, the deadliest form of the disease. Bacillus anthracisproduces virulence toxins required for disease. Alveolar macrophages were considered the primary target of the Bacillus anthracisvirulence factor lethal toxin because lethal toxin inhibits mouse macrophages through cleavage of MEK signaling pathway components, but we have reported that human alveolar macrophages are not a target of lethal toxin. Our current results suggest that, unlike human alveolar macrophages, the cells lining the respiratory units of the lung, alveolar epithelial cells, are a target of lethal toxin in humans. Alveolar epithelial cells expressed lethal toxin receptor protein, bound the protective antigen component of lethal toxin, and were subject to lethal-toxin-induced cleavage of multiple MEKs. These findings suggest that human alveolar epithelial cells are a target of Bacillus anthracislethal toxin. Further, no reduction in alveolar epithelial cell viability was observed, but lethal toxin caused actin rearrangement and impaired desmosome formation, consistent with impaired barrier function as well as reduced surfactant production. Therefore, by compromising epithelial barrier function, lethal toxin may play a role in the pathogenesis of inhalation anthrax by facilitating the dissemination of Bacillus anthracisfrom the lung in early disease and promoting edema in late stages of the illness.
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- 2012
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15. Empirical Characterization of Unconstrained Tape Spring Deployment Dynamics
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Williams, Daniel M. and Williams, Daniel M.
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