15,711 results on '"Williams, David"'
Search Results
2. Adaptive Self-Supervised Learning Strategies for Dynamic On-Device LLM Personalization
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Mendoza, Rafael, Cruz, Isabella, Liu, Richard, Deshmukh, Aarav, Williams, David, Peng, Jesscia, and Iyer, Rohan
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Large language models (LLMs) have revolutionized how we interact with technology, but their personalization to individual user preferences remains a significant challenge, particularly in on-device applications. Traditional methods often depend heavily on labeled datasets and can be resource-intensive. To address these issues, we present Adaptive Self-Supervised Learning Strategies (ASLS), which utilizes self-supervised learning techniques to personalize LLMs dynamically. The framework comprises a user profiling layer for collecting interaction data and a neural adaptation layer for real-time model fine-tuning. This innovative approach enables continuous learning from user feedback, allowing the model to generate responses that align closely with user-specific contexts. The adaptive mechanisms of ASLS minimize computational demands and enhance personalization efficiency. Experimental results across various user scenarios illustrate the superior performance of ASLS in boosting user engagement and satisfaction, highlighting its potential to redefine LLMs as highly responsive and context-aware systems on-device., Comment: First ASLS
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- 2024
3. Spline-based solution transfer for space-time methods in 2D+t
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Larose, Logan, Anderson, Jude T., and Williams, David M.
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Mathematics - Numerical Analysis - Abstract
This work introduces a new solution-transfer process for slab-based space-time finite element methods. The new transfer process is based on Hsieh-Clough-Tocher (HCT) splines and satisfies the following requirements: (i) it maintains high-order accuracy up to 4th order, (ii) it preserves a discrete maximum principle, (iii) it asymptotically enforces mass conservation, and (iv) it constructs a smooth, continuous surrogate solution in between space-time slabs. While many existing transfer methods meet the first three requirements, the fourth requirement is crucial for enabling visualization and boundary condition enforcement for space-time applications. In this paper, we derive an error bound for our HCT spline-based transfer process. Additionally, we conduct numerical experiments quantifying the conservative nature and order of accuracy of the transfer process. Lastly, we present a qualitative evaluation of the visualization properties of the smooth surrogate solution., Comment: 36 pages, 17 figures, 3 tables
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- 2024
4. Scalable Differential Privacy Mechanisms for Real-Time Machine Learning Applications
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Smith, Jessica, Williams, David, and Brown, Emily
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Computer Science - Cryptography and Security - Abstract
Large language models (LLMs) are increasingly integrated into real-time machine learning applications, where safeguarding user privacy is paramount. Traditional differential privacy mechanisms often struggle to balance privacy and accuracy, particularly in fast-changing environments with continuously flowing data. To address these issues, we introduce Scalable Differential Privacy (SDP), a framework tailored for real-time machine learning that emphasizes both robust privacy guarantees and enhanced model performance. SDP employs a hierarchical architecture to facilitate efficient noise aggregation across various learning agents. By integrating adaptive noise scheduling and gradient compression methods, our approach minimizes performance degradation while ensuring significant privacy protection. Extensive experiments on diverse datasets reveal that SDP maintains high accuracy levels while applying differential privacy effectively, showcasing its suitability for deployment in sensitive domains. This advancement points towards the potential for widespread adoption of privacy-preserving techniques in machine learning workflows., Comment: First v of SDP
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- 2024
5. How does the critical torus instability height vary with the solar cycle?
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James, Alexander W., Green, Lucie M., Barnes, Graham, van Driel-Gesztelyi, Lidia, and Williams, David R.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The ideal magnetohydrodynamic torus instability can drive the eruption of coronal mass ejections. The critical threshold of magnetic field strength decay for the onset of the torus instability occurs at different heights in different solar active regions, and understanding this variation could therefore improve space weather prediction. In this work, we aim to find out how the critical torus instability height evolves throughout the solar activity cycle. We study a significant subset of HMI and MDI Space-Weather HMI Active Region Patches (SHARPs and SMARPs) from 1996-2023, totalling 21584 magnetograms from 4436 unique active region patches. For each magnetogram, we compute the critical height averaged across the main polarity inversion line, the total unsigned magnetic flux and the separation between the positive and negative magnetic polarities. We find the critical height in active regions varies with the solar cycle, with higher (lower) average critical heights observed around solar maximum (minimum). We conclude this is because the critical height is proportional to the separation between opposite magnetic polarities, which in turn is proportional to the total magnetic flux in a region, and more magnetic regions with larger fluxes and larger sizes are observed at solar maximum. This result is noteworthy because, despite the higher critical heights, more CMEs are observed around solar maximum than at solar minimum., Comment: Accepted to ApJ. 14 pages, 6 Figures, 1 Table
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- 2024
6. Minimal Attached Primes of Local Cohomology Modules of Binomial Edge Ideals of Block Graphs
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Williams, David
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Mathematics - Commutative Algebra ,13C70 (Primary), 13D45, 13F65 (Secondary) - Abstract
We calculate the minimal attached primes of the local cohomology modules of the binomial edge ideals of block graphs. In particular, we obtain a combinatorial characterisation of which of these modules are non-vanishing. We also show that the main result of this paper follows from a recent result of Lax, Rinaldo, and Romeo (arXiv:2405.08671, Theorem 3.2), which was published independently during the writing of this paper. This provides a short alternative proof of our result., Comment: 16 pages, v2 replaces what was Section 5 in v1 to take into account recent work of Lax, Rinaldo, and Romeo (arXiv:2405.08671), in which they had in fact already proved a result we stated as a conjecture. Many thanks to Ernesto Lax for bringing this to our attention
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- 2024
7. LBT SHARK-VIS Observes a Major Resurfacing Event on Io
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Conrad, Al, Pedichini, Fernando, Causi, Gianluca Li, Antoniucci, Simone, de Pater, Imke, Davies, Ashley Gerard, de Kleer, Katherine, Piazzesi, Roberto, Testa, Vincenzo, Vaccari, Piero, Vicinanza, Martina, Power, Jennifer, Ertel, Steve, Shields, Joseph C., Ragland, Sam, Giorgi, Fabrizio, Jefferies, Stuart M., Hope, Douglas, Perry, Jason, Williams, David A., and Nelson, David M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes on Io's surface have been monitored from both spacecraft and ground-based telescopes. Here, we present the highest spatial resolution images of Io ever obtained from a ground-based telescope. These images, acquired by the SHARK-VIS instrument on the Large Binocular Telescope, show evidence of a major resurfacing event on Io's trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images show that a plume deposit from a powerful eruption at Pillan Patera has covered part of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io's surface using adaptive optics at visible wavelengths., Comment: 15 pages, 4 figures
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- 2024
8. Building the foundations of tikanga jurisprudence
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Down, Sarah and Williams, David V.
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- 2022
9. A novel high-titer, bifunctional lentiviral vector for autologous hematopoietic stem cell gene therapy of sickle cell disease.
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Hart, Kevyn, Liu, Boya, Brown, Devin, Campo-Fernandez, Beatriz, Tam, Kevin, Orr, Katherine, Hollis, Roger, Brendel, Christian, Williams, David, and Kohn, Donald
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BCL11A ,anti-sickling hemoglobin ,gene therapy ,hematopoietic stem cells ,lentiviral vector ,shmiR ,sickle cell disease - Abstract
A major limitation of gene therapy for sickle cell disease (SCD) is the availability and access to a potentially curative one-time treatment, due to high treatment costs. We have developed a high-titer bifunctional lentiviral vector (LVV) in a vector backbone that has reduced size, high vector yields, and efficient gene transfer to human CD34+ hematopoietic stem and progenitor cells (HSPCs). This LVV contains locus control region cores expressing an anti-sickling βAS3-globin gene and two microRNA-adapted short hairpin RNA simultaneously targeting BCL11A and ZNF410 transcripts to maximally induce fetal hemoglobin (HbF) expression. This LVV induces high levels of anti-sickling hemoglobins (HbAAS3 + HbF), while concurrently decreasing sickle hemoglobin (HbS). The decrease in HbS and increased anti-sickling hemoglobin impedes deoxygenated HbS polymerization and red blood cell sickling at low vector copy per cell in transduced SCD patient CD34+ cells differentiated into erythrocytes. The dual alterations in red cell hemoglobins ameliorated the SCD phenotype in the SCD Berkeley mouse model in vivo. With high titer and enhanced transduction of HSPC at a low multiplicity of infection, this LVV will increase the number of patient doses of vector from production lots to decrease costs and help improve accessibility to gene therapy for SCD.
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- 2024
10. An explicit construction of optimized interpolation points on the 4-simplex
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Gobel, Trenton J. and Williams, David M.
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Mathematics - Numerical Analysis ,76M10, 65D05, 65M12, 65M60 - Abstract
In this work, a family of symmetric interpolation points are generated on the four-dimensional simplex (i.e. the pentatope). These points are optimized in order to minimize the Lebesgue constant. The process of generating these points closely follows that outlined by Warburton in "An explicit construction of interpolation nodes on the simplex," Journal of Engineering Mathematics, 2006. Here, Warburton generated optimal interpolation points on the triangle and tetrahedron by formulating explicit geometric warping and blending functions, and applying these functions to equidistant nodal distributions. The locations of the resulting points were Lebesgue-optimized. In our work, we extend this procedure to four dimensions, and construct interpolation points on the pentatope up to order ten. The Lebesgue constants of our nodal sets are calculated, and are shown to outperform those of equidistant nodal distributions.
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- 2024
11. A Characterization of Quasi-homogeneous Bivariate Polynomials
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Bradley-Williams, David, Kovacsics, Pablo Cubides, and Halupczok, Immanuel
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Mathematics - Commutative Algebra ,Primary 12E10, 12E05: Secondary 14C17 - Abstract
If a reduced bivariate polynomial is quasi-homogeneous, then its discriminant is a monomial. Over fields of characteristic $0$, we show that if one adds another simple condition, this becomes an equivalence. We also give a third equivalent condition that is stated geometrically., Comment: Fixed minor mistakes, reordered the introduction, streamlined some terminology and extended the result to large positive characteristic
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- 2024
12. Physics-informed generative model for drug-like molecule conformers
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Williams, David C. and Inala, Neil
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Quantitative Biology - Biomolecules ,Computer Science - Machine Learning ,Physics - Chemical Physics - Abstract
We present a diffusion-based, generative model for conformer generation. Our model is focused on the reproduction of bonded structure and is constructed from the associated terms traditionally found in classical force fields to ensure a physically relevant representation. Techniques in deep learning are used to infer atom typing and geometric parameters from a training set. Conformer sampling is achieved by taking advantage of recent advancements in diffusion-based generation. By training on large, synthetic data sets of diverse, drug-like molecules optimized with the semiempirical GFN2-xTB method, high accuracy is achieved for bonded parameters, exceeding that of conventional, knowledge-based methods. Results are also compared to experimental structures from the Protein Databank (PDB) and Cambridge Structural Database (CSD)., Comment: To appear in the Journal of Chemical Information and Modeling
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- 2024
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13. Versatile mixed methods for compressible flows
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Miller, Edward A. and Williams, David M.
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Mathematics - Numerical Analysis ,76M10, 65M12, 65M60, 76D05 - Abstract
Versatile mixed finite element methods were originally developed by Chen and Williams for isothermal incompressible flows in "Versatile mixed methods for the incompressible Navier-Stokes equations," Computers & Mathematics with Applications, Volume 80, 2020. Thereafter, these methods were extended by Miller, Chen, and Williams to non-isothermal incompressible flows in "Versatile mixed methods for non-isothermal incompressible flows," Computers & Mathematics with Applications, Volume 125, 2022. The main advantage of these methods lies in their flexibility. Unlike traditional mixed methods, they retain the divergence terms in the momentum and temperature equations. As a result, the favorable properties of the schemes are maintained even in the presence of non-zero divergence. This makes them an ideal candidate for an extension to compressible flows, in which the divergence does not generally vanish. In the present article, we finally construct the fully-compressible extension of the methods. In addition, we demonstrate the excellent performance of the resulting methods for weakly-compressible flows that arise near the incompressible limit, as well as more strongly-compressible flows that arise near Mach 0.5., Comment: 28 pages, 4 figures, 4 tables
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- 2024
14. Mitigating Distributional Shift in Semantic Segmentation via Uncertainty Estimation from Unlabelled Data
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Williams, David S. W., De Martini, Daniele, Gadd, Matthew, and Newman, Paul
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Robotics - Abstract
Knowing when a trained segmentation model is encountering data that is different to its training data is important. Understanding and mitigating the effects of this play an important part in their application from a performance and assurance perspective - this being a safety concern in applications such as autonomous vehicles (AVs). This work presents a segmentation network that can detect errors caused by challenging test domains without any additional annotation in a single forward pass. As annotation costs limit the diversity of labelled datasets, we use easy-to-obtain, uncurated and unlabelled data to learn to perform uncertainty estimation by selectively enforcing consistency over data augmentation. To this end, a novel segmentation benchmark based on the SAX Dataset is used, which includes labelled test data spanning three autonomous-driving domains, ranging in appearance from dense urban to off-road. The proposed method, named Gamma-SSL, consistently outperforms uncertainty estimation and Out-of-Distribution (OoD) techniques on this difficult benchmark - by up to 10.7% in area under the receiver operating characteristic (ROC) curve and 19.2% in area under the precision-recall (PR) curve in the most challenging of the three scenarios., Comment: Accepted for publication in IEEE Transactions on Robotics (T-RO)
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- 2024
15. Masked Gamma-SSL: Learning Uncertainty Estimation via Masked Image Modeling
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Williams, David S. W., Gadd, Matthew, Newman, Paul, and De Martini, Daniele
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Robotics - Abstract
This work proposes a semantic segmentation network that produces high-quality uncertainty estimates in a single forward pass. We exploit general representations from foundation models and unlabelled datasets through a Masked Image Modeling (MIM) approach, which is robust to augmentation hyper-parameters and simpler than previous techniques. For neural networks used in safety-critical applications, bias in the training data can lead to errors; therefore it is crucial to understand a network's limitations at run time and act accordingly. To this end, we test our proposed method on a number of test domains including the SAX Segmentation benchmark, which includes labelled test data from dense urban, rural and off-road driving domains. The proposed method consistently outperforms uncertainty estimation and Out-of-Distribution (OoD) techniques on this difficult benchmark., Comment: Accepted for publication at 2024 IEEE International Conference on Robotics and Automation (ICRA)
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- 2024
16. Watershed Responses to Climate Change-Driven Disturbances in Temperate Montane Ecosystems of the Western United States
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Rock, Linnea A., Shoup, Bryce, Ajowele, Joshua A., Brédoire, Félix, Oleksy, Isabella A., Tetrick, Matthew, Williams, David G., and Collins, Sarah M.
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- 2024
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17. Why so slow? Models of parkinsonian bradykinesia
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Williams, David
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- 2024
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18. Racial and Ethnic Disparities in Patient Experiences in the United States: 4-Year Content Analysis of Twitter
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Hswen, Yulin, Hawkins, Jared B, Sewalk, Kara, Tuli, Gaurav, Williams, David R, Viswanath, K, Subramanian, S V, and Brownstein, John S
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundRacial and ethnic minority groups often face worse patient experiences compared with the general population, which is directly related to poorer health outcomes within these minority populations. Evaluation of patient experience among racial and ethnic minority groups has been difficult due to lack of representation in traditional health care surveys. ObjectiveThis study aims to assess the feasibility of Twitter for identifying racial and ethnic disparities in patient experience across the United States from 2013 to 2016. MethodsIn total, 851,973 patient experience tweets with geographic location information from the United States were collected from 2013 to 2016. Patient experience tweets included discussions related to care received in a hospital, urgent care, or any other health institution. Ordinary least squares multiple regression was used to model patient experience sentiment and racial and ethnic groups over the 2013 to 2016 period and in relation to the implementation of the Patient Protection and Affordable Care Act (ACA) in 2014. ResultsRacial and ethnic distribution of users on Twitter was highly correlated with population estimates from the United States Census Bureau’s 5-year survey from 2016 (r2=0.99; P
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- 2020
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19. The Cape Town Declaration on access to cardiac surgery in the developing world
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Zilla, Peter, Bolman, R. Morton, Yacoub, Magdi H., Beyersdorf, Friedhelm, Sliwa, Karen, Zühlke, Liesl, Higgins, Robert S.D., Mayosi, Bongani, Carpentier, Alain, and Williams, David
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Cardiac surgery ,scourge of rheumatic heart disease ,lifesaving cardiac surgery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The mission of this declaration is to urge all relevant entities within the international cardiac surgery, industry, and government sectors to commit to develop and implement an effective strategy to address the scourge of rheumatic heart disease in the developing world through increased access to lifesaving cardiac surgery.
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- 2018
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20. Anisotropic Delaunay hypervolume meshing for space-time applications: point insertion, quality heuristics, and bistellar flips
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Anderson, Jude T. and Williams, David M.
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Mathematics - Numerical Analysis ,65M50, 52B11, 31B99, 76M10 - Abstract
This paper provides a comprehensive guide to generating unconstrained, simplicial, four-dimensional (4D), hypervolume meshes for space-time applications. While several universal procedures for constructing unconstrained, d-dimensional, anisotropic Delaunay meshes are already known, many of the explicit implementation details are missing from the relevant literature for cases in which d >= 4. As a result, the purpose of this paper is to provide explicit descriptions of the key components in the 4D meshing algorithm: namely, the point-insertion process, geometric predicates, element quality heuristics, and bistellar flips. This paper represents a natural continuation of the work which was pioneered by Anderson et al. in "Surface and hypersurface meshing techniques for space-time finite element methods", Computer-Aided Design, 2023. In this previous paper, hypersurface meshes were generated using a novel, trajectory-tracking procedure. In the current paper, we are interested in generating coarse, 4D hypervolume meshes (boundary meshes) which are formed by sequentially inserting points from an existing hypersurface mesh. In the latter portion of this paper, we present numerical experiments which demonstrate the viability of this approach for a simple, convex domain. Although, our main focus is on the generation of hypervolume boundary meshes, the techniques described in this paper are broadly applicable to a much wider range of 4D meshing methods. We note that the more complex topics of constrained hypervolume meshing, and boundary recovery for non-convex domains will be covered in a companion paper., Comment: 65 pages, 33 figures, and 11 tables
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- 2023
21. Local Cohomology Modules of Binomial Edge Ideals of Complements of Connected Graphs of Girth at Least 5
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Williams, David
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Mathematics - Commutative Algebra ,13C70 (Primary) 13D45, 13F65 (Secondary) - Abstract
We calculate the local cohomology modules of the binomial edge ideals of the complements of connected graphs of girth at least 5 using the tools introduced by \`Alvarez Montaner in arXiv:1901.08645. We then use this calculation to compute the depth, dimension, and regularity of these binomial edge ideals., Comment: 15 pages, v2 includes small changes to several proofs for clarity, and reorganises section 2 into subsections (whilst some numbering has changed, no new results are introduced)
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- 2023
22. The dense and non-homogeneous circumstellar medium revealed in radio wavelengths around the Type Ib SN 2019oys
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Sfaradi, Itai, Horesh, Assaf, Sollerman, Jesper, Fender, Rob, Rhodes, Lauren, Williams, David R. A., Bright, Joe, Green, Dave A., Schulze, Steve, and Gal-Yam, Avishay
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present here broadband radio observations of the CSM interacting SN2019oys. SN2019oys was first detected in the optical and was classified as a Type Ib SN. Then, about $\sim 100$ days after discovery, it showed an optical rebrightening and a spectral transition to a spectrum dominated by strong narrow emission lines, which suggests strong interaction with a distant, dense, CSM shell. We modeled the broadband, multi-epoch, radio spectra, covering 2.2 to 36 GHz and spanning from 22 to 1425 days after optical discovery, as a synchrotron emitting source. Using this modeling we characterized the shockwave and the mass-loss rate of the progenitor. Our broadband radio observations show strong synchrotron emission. This emission, as observed 201 and 221 days after optical discovery, exhibits signs of free-free absorption from the material in front of the shock traveling in the CSM. In addition, the steep power law of the optically thin regime points towards synchrotron cooling of the radiating electrons. Analyzing these spectra in the context of the SN-CSM interaction model gives a shock velocity of 14,000 $\rm km \, s^{-1}$, and an electron number density of $2.6 \times 10^5 \, \rm cm^{-3}$ at a distance of $2.6 \times 10^{16}$ cm. This translates to a high mass-loss rate from the progenitor massive star of $6.7 \times 10^{-4} \, \rm M_{\odot} yr^{-1}$ for an assumed wind of 100 $\rm km s^{-1}$ (assuming constant mass-loss rate in steady winds). The late-time radio spectra, 392 and 557 days after optical discovery, are showing broad spectral peaks. We show that this can be explained by introducing a non-homogeneous CSM structure., Comment: 14 pages, 7 figures, 2 tables, submitted to Astronomy & Astrophysics
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- 2023
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23. User-Centric Deployment of Automated Program Repair at Bloomberg
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Williams, David, Callan, James, Kirbas, Serkan, Mechtaev, Sergey, Petke, Justyna, Prideaux-Ghee, Thomas, and Sarro, Federica
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Computer Science - Software Engineering - Abstract
Automated program repair (APR) tools have unlocked the potential for the rapid rectification of codebase issues. However, to encourage wider adoption of program repair in practice, it is necessary to address the usability concerns related to generating irrelevant or out-of-context patches. When software engineers are presented with patches they deem uninteresting or unhelpful, they are burdened with more "noise" in their workflows and become less likely to engage with APR tools in future. This paper presents a novel approach to optimally time, target, and present auto-generated patches to software engineers. To achieve this, we designed, developed, and deployed a new tool dubbed B-Assist, which leverages GitHub's Suggested Changes interface to seamlessly integrate automated suggestions into active pull requests (PRs), as opposed to creating new, potentially distracting PRs. This strategy ensures that suggestions are not only timely, but also contextually relevant and delivered to engineers most familiar with the affected code. Evaluation among Bloomberg software engineers demonstrated their preference for this approach. From our user study, B-Assist's efficacy is evident, with the acceptance rate of patch suggestions being as high as 74.56%; engineers also found the suggestions valuable, giving usefulness ratings of at least 4 out of 5 in 78.2% of cases. Further, this paper sheds light on persisting usability challenges in APR and lays the groundwork for enhancing the user experience in future APR tools.
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- 2023
24. EPPA numbers of graphs
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Bradley-Williams, David, Cameron, Peter J., Hubička, Jan, and Konečný, Matěj
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Mathematics - Combinatorics ,Computer Science - Discrete Mathematics - Abstract
If $G$ is a graph, $A$ and $B$ its induced subgraphs, and $f\colon A\to B$ an isomorphism, we say that $f$ is a \emph{partial automorphism} of $G$. In 1992, Hrushovski proved that graphs have the \emph{extension property for partial automorphisms} (\emph{EPPA}, also called the \emph{Hrushovski property}), that is, for every finite graph $G$ there is a finite graph $H$, an \emph{EPPA-witness} for $G$, such that $G$ is an induced subgraph of $H$ and every partial automorphism of $G$ extends to an automorphism of $H$. The EPPA number of a graph $G$, denoted by $\mathop{\mathrm{eppa}}\nolimits(G)$, is the smallest number of vertices of an EPPA-witness for $G$, and we put $\mathop{\mathrm{eppa}}\nolimits(n) = \max\{\mathop{\mathrm{eppa}}\nolimits(G) : \lvert G\rvert = n\}$. In this note we review the state of the area, prove several lower bounds (in particular, we show that $\mathop{\mathrm{eppa}}\nolimits(n)\geq \frac{2^n}{\sqrt{n}}$, thereby identifying the correct base of the exponential) and pose many open questions. We also briefly discuss EPPA numbers of hypergraphs, directed graphs, and $K_k$-free graphs., Comment: Minor revision
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- 2023
25. Film and the Mechanization of Time in the Myth of the Great War Canon
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Williams, David
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- 2016
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26. Real-World Clinical Experience of Oral Semaglutide in a Secondary Diabetes Clinic in the UK: A Retrospective Observational Study
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Williams, David M., Alberts, Barbara-Alex, Sharaf, Asem, Sharaf, Giselle, Bain, Stephen C., Kalhan, Atul, and Min, Thinzar
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- 2024
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27. LF-Covers and Binomial Edge Ideals of K\'{o}nig Type
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Williams, David
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Mathematics - Commutative Algebra ,13C70 (Primary) 13A35, 13D45, 13F65 (Secondary) - Abstract
We give a combinatorial characterisation of connected graphs whose binomial edge ideals are of K\"{o}nig type, developed independently to the similar characterisation given by LaClair in arXiv:2304.13299, and exhibit some classes of graphs satisfying our criteria. For any connected Hamiltonian graph $G$ on $n$ vertices, we compute an explicit root of $H_{J(G)}^{n-1}(R)$ as an $F$-finite $F$-module., Comment: 19 pages, v3 substantially reorganises v2, several proofs have been simplified or rewritten for clarity, and small errors have been corrected (whilst the numbering has changed, no new results are introduced)
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- 2023
28. Io's polar volcanic thermal emission indicative of magma ocean and shallow tidal heating models
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Davies, Ashley Gerard, Perry, Jason, Williams, David A., and Nelson, David M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The distribution of Io's volcanic activity likely reflects the position and magnitude of internal tidal heating. We use new observations of Io's polar regions by the Juno spacecraft Jovian Infrared Auroral Mapper (JIRAM) to complete near-infrared global coverage, revealing the global distribution and magnitude of thermal emission from Io's currently erupting volcanoes. We show that the distribution of volcanic heat flow from 266 active hot spots is consistent with the presence of a global magma ocean, and/or shallow asthenospheric heating. We find that Io's polar volcanoes are less energetic but about the same in number per unit area than at lower latitudes. We also find that volcanic heat flow in the north polar cap is greater than that in the south. The low volcanic advection seen at Io's poles is therefore at odds with measurements of background temperature showing Io's poles are anomalously warm. We suggest that the differences in volcanic thermal emission from Io's poles compared to that at lower latitudes is indicative of lithospheric dichotomies that inhibit volcanic advection towards Io's poles, particularly in the south polar region., Comment: 17 pages, two tables, 7 figures
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- 2023
29. Chasing Gravitational Waves with the Cherenkov Telescope Array
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Green, Jarred Gershon, Carosi, Alessandro, Nava, Lara, Patricelli, Barbara, Schüssler, Fabian, Seglar-Arroyo, Monica, Consortium, Cta, Abe, Kazuki, Abe, Shotaro, Acharyya, Atreya, Adam, Remi, Aguasca-Cabot, Arnau, Agudo, Ivan, Alfaro, Jorge, Alvarez-Crespo, Nuria, Batista, Rafael Alves, Amans, Jean-Philippe, Amato, Elena, Ambrosino, Filippo, Angüner, Ekrem Oguzhan, Antonelli, Lucio Angelo, Aramo, Carla, Arcaro, Cornelia, Arrabito, Luisa, Asano, Katsuaki, Aschersleben, Jann, Ashkar, Halim, Stuani, Luiz Augusto, Baack, Dominik, Backes, Michael, Balazs, Csaba, Balbo, Matteo, Larriva, Andres Baquero, Martins, Victor Barbosa, de Almeida, Ulisses Barres, Barrio, Juan Abel, Bastieri, Denis, Batista, Pedro Ivo, Batković, Ivana, Batzofin, Rowan William, Baxter, Joshua Ryo, Beck, Geoffrey, Tjus, Julia Becker, Beiske, Lukas, Belardinelli, Daniele, Benbow, Wystan, Bernardini, Elisa, Medrano, Juan Bernete, Bernlöhr, Konrad, Berti, Alessio, Beshley, Vasyl, Bhattacharjee, Pooja, Bhattacharyya, Saptashwa, Bi, Baiyang, Biederbeck, Noah, Biland, Adrian, Bissaldi, Elisabetta, Blanch, Oscar, Blazek, Jiri, Boisson, Catherine, Bolmont, Julien, Bonnoli, Giacomo, Bordas, Pol, Bošnjak, Željka, Bradascio, Federica, Braiding, Catherine, Bronzini, Ettore, Brose, Robert, Brown, Anthony M., Brun, Francois, Brunelli, Giulia, Bulgarelli, Andrea, Burelli, Irene, Burmistrov, Leonid, Burton, Michael, Bylund, Tomas, Calisse, Paolo Gherardo, Campoy-Ordaz, Anna, Cantlay, Brandon Khan, Capalbi, Milvia, Caproni, Anderson, Capuzzo-Dolcetta, Roberto, Carlile, Colin, Caroff, Sami, Carosi, Roberto, Carrasco, Marie-Sophie, Cascone, Enrico, Cassol, Franca, Castrejon, Noelia, Catalani, Fernando, Cerasole, Davide, Cerruti, Matteo, Chaty, Sylvain, Chen, Andrew W, Chernyakova, Maria, Chiavassa, Andrea, Chudoba, Jiří, Araujo, Carlos Henrique Coimbra, Conforti, Vito, Conte, Francesco, Contreras, Jose Luis, Cossou, Christophe, Costa, Alessandro, Costantini, Heide, Cristofari, Pierre, Cuevas, Omar, Curtis-Ginsberg, Zachary, D'Amico, Giacomo, D'Ammando, Filippo, Dadina, Mauro, Dalchenko, Mykhailo, David, Ludovic, Davids, Isak Delberth, Dazzi, Francesco, De Angelis, Alessandro, de Lavergne, Mathieu de Bony, De Caprio, Vincenzo, De Cesare, Giovanni, Pino, Elisabete M. de Gouveia Dal, De Lotto, Barbara, de Lucia, Mario, de Menezes, Raniere, de Naurois, Mathieu, Wilhelmi, Emma de Oña, De Simone, Nicola, de Souza, Vitor, Del Peral, Luis, del Valle, Maria Victoria, Delagnes, Eric, Giler, Andres Gabriel Delgado, Delgado, Carlos, Dell'aiera, Michael, Della Ceca, Roberto, Della Valle, Massimo, Della Volpe, Domenico, Depaoli, Davide, Dettlaff, Antonios, Di Girolamo, Tristano, Di Piano, Ambra, Di Pierro, Federico, Di Tria, Riccardo, Di Venere, Leonardo, Díaz-Bahamondes, Christian, Dib, Claudio, Diebold, Sebastian, Dima, Razvan, Dinesh, Adithiya, Djannati-Ataï, Arache, Djuvsland, Julia Isabel, Dominguez, Alberto, Dominik, Rune Michael, Donini, Alice, Dorner, Daniela, Dörner, Julien, Doro, Michele, Anjos, Rita de Cassia dos, Dournaux, Jean-Laurent, Dravins, Dainis, Duangchan, Chaimongkol, Dubos, Coline, Ducci, Lozenzo, Dwarkadas, Vikram V., Ebr, Jan, Eckner, Christopher, Egberts, Kathrin, Einecke, Sabrina, Elsässer, Dominik, Emery, Gabriel, Godoy, Miguel Escobar, Escudero, Juan, Esposito, Paolo, Falceta-Gonçalves, Diego, Ramazani, Vandad Fallah, Faure, Alice, Fedorova, Elena, Fegan, Stephen, Feijen, Kirsty, Feng, Qi, Ferrand, Gilles, Ferrarotto, Fabio, Fiandrini, Emanuele, Fiasson, Armand, Fioretti, Valentina, Foffano, Luca, Guiteras, Lluis Font, Fontaine, Gerard, Fröse, Stefan, Fukami, Satoshi, Fukui, Yasuo, Funk, Stefan, Gaggero, Daniele, Galanti, Giorgio, Galaz, Gaspar, Gallant, Yves A., Gallozzi, Stefano, Gammaldi, Viviana, Gasbarra, Claudio, Gaug, Markus, Ghalumyan, Arsen, Gianotti, Fulvio, Giarrusso, Marina, Giglietto, Nicola, Giordano, Francesco, Giuliani, Andrea, Glicenstein, Jean-Francois, Glombitza, Jonas, Goldoni, Paolo, González, José Mauricio, González, Maria Magdalena, Coelho, Jaziel Goulart, Granot, Jonathan, Grasso, Dario, Haro, Roger Grau, Green, David, Greenshaw, Tim, Grolleron, Guillaume, Grube, Jeff, Gueta, Orel, Gunji, Shuichi, Hadasch, Daniela, Hamal, Petr, Hanlon, William, Hara, Satoshi, Harvey, Violet M., Hashiyama, Kazuaki, Hassan, Tarek, Heller, Matthieu, Cadena, Sergio Hernández, Hie, Jonathan, Hiroshima, Nagisa, Hnatyk, Bohdan, Hnatyk, Roman, Hoffmann, Dirk, Hofmann, Werner, Holler, Markus, Horan, Deirdre, Horvath, Pavel, Hovatta, Talvikki, Hrupec, Dario, Hussain, Saqib, Iarlori, Marco, Inada, Tomohiro, Incardona, Federico, Inome, Yusuke, Inoue, Susumu, Iocco, Fabio, Ishio, Kazuma, Jamrozy, Marek, Janecek, Petr, Jankowsky, Felix, Jarnot, Christian, Jean, Pierre, Martínez, Irene Jiménez, Jin, Weidong, Jocou, Laurent, Juramy-Gilles, Claire, Jurysek, Jakub, KALEKIN, Oleg, Kantzas, Dimitrios, Karas, Vladimir, Kaufmann, Sarah, Kerszberg, Daniel, Khelifi, Bruno, Kieda, David B, Kleiner, Tobias Kai, Kluźniak, Włodzimierz, Kobayashi, Yukiho, Kohri, Kazunori, Komin, Nukri, Kornecki, Paula, Kosack, Karl, Kubo, Hidetoshi, Kushida, Junko, La Barbera, Antonino, La Palombara, Nicola, Lainez, Maria, Lamastra, Alessandra, Lapington, Jon S, Lazarevic, Sanja, Lazendic-Galloway, Jasmina, Leach, Steven, Lemoine-Goumard, Marianne, Lenain, Jean-Philippe, Leto, Giuseppe, Leuschner, Fabian, Lindfors, Elina, Linhoff, Maximilian, Liodakis, Ioannis, Loïc, Lozach, Lombardi, Saverio, Longo, Francesco, López-Coto, Rubén, López-Moya, Marcos, López-Oramas, Alicia, Loporchio, Serena, Bahilo, Julio Lozano, Luque-Escamilla, Pedro L., Macias, Oscar, Maier, Gernot, Majumdar, Pratik, Malyshev, Denys, Malyshev, Dmitry, Mandat, Dusan, Manicò, Giulio, Marinos, Peter David, Markoff, Sera, Márquez, Isabel, Marquez, Patricia, Marsella, Giovanni, Martí, Josep, Martin, Pierrick, Martínez, Gustavo Augusto, Martínez, Manel, Martinez, Oibar, Marty, Christophe, Mas-Aguilar, Alvaro, Mastropietro, Michele, Maurin, Gilles, Max-Moerbeck, Walter, Mazin, Daniel, Melkumyan, David, Menchiari, Stefano, Mestre, Enrique, Meunier, Jean-Luc, Meyer, Dominique M. -A., Miceli, Davide, Michailidis, Miltiadis, Michałowski, Jerzy, Miener, Tjark, Miranda, Jose Miguel, Mitchell, Alison, Mizote, Masaya, Mizuno, Tsunefumi, Moderski, Rafal, Mohrmann, Lars, Molero, Miguel, Molfese, Cesare, Molina, Edgar, Montaruli, Teresa, Moralejo, Abelardo, Morcuende, Daniel, Morik, Katharina, Morselli, Aldo, Moulin, Emmanuel, Zamanillo, Victor Moya, Mukherjee, Reshmi, Munari, Kevin, Muraczewski, Adam, Muraishi, Hiroshi, Nakamori, Takeshi, Nayak, Amrit, Nemmen, Rodrigo, Nickel, Lukas, Niemiec, Jacek, Nieto, Daniel, Rosillo, Mireia Nievas, Nikołajuk, Marek, Nishijima, Kyoshi, Noda, Koji, Nosek, Dalibor, Novosyadlyj, Bohdan, Novotný, Vladimír, Nozaki, Seiya, O'Brien, Paul, Ohishi, Michiko, Ohtani, Yoshiki, Okumura, Akira, Olive, Jean-François, Olmi, Barbara, Ong, Rene A., Orienti, Monica, Orito, Reiko, Orlandini, Mauro, Orlando, Elena, Ostrowski, Michal, Otte, Nepomuk, Oya, Igor, Pagano, Isabella, Pagliaro, Antonio, Palatiello, Michele, Panebianco, Gabriele, Paredes, Josep M., Parmiggiani, Nicolò, Patel, Sonal Ramesh, Pavlović, Dijana, Pe'er, Asaf, Pech, Miroslav, Pecimotika, Mario, Peresano, Michele, Pérez-Romero, Judit, Peron, Giada, Persic, Massimo, Petrucci, Pierre-Olivier, Petruk, Oleh, Pfeifle, Felix, Pintore, Fabio, Pirola, Giorgio, Pittori, Carlotta, Plard, Cyann, Podobnik, Franjo, Pohl, Martin, Pons, Estelle, Prandini, Elisa, Prast, Julie, Principe, Giacomo, Priyadarshi, Chaitanya, Produit, Nicolas, Prokhorov, Dmitry, Pueschel, Elisa, Pühlhofer, Gerd, Pumo, Maria Letizia, Punch, Michael, Quirrenbach, Andreas, Raino, Silvia, Randazzo, Nunzio, Rando, Riccardo, Ravel, Thierry, Razzaque, Soebur, Regeard, Maxime, Reichherzer, Patrick, Reimer, Anita, Reimer, Olaf, Reisenegger, Andreas, Reposeur, Thierry, Reville, Brian, Rhode, Wolfgang, Ribó, Marc, Richtler, Tom, Rieger, Frank, Roache, Emmet, Fernandez, Gonzalo Rodriguez, Frías, Maria Dolores Rodríguez, Rodríguez-Vázquez, Juan José, Romano, Patrizia, Romeo, Giuseppe, Rosado, Jaime, Rowell, Gavin P, Rudak, Bronislaw, Ruiter, Ashley J., Rulten, Cameron Boyd, Russo, Federico, Sadeh, Iftach, Saha, Lab, Saito, Takayuki, Sakurai, Shunsuke, Salzmann, Heiko, Sanchez, David, Sanchez-Conde, Miguel, Sangiorgi, Pierluca, Sano, Hidetoshi, Santander, Marcos, Santangelo, Andrea, Santos-Lima, Reinaldo, Sanuy, Andreu, Šarić, Toni, Sarkar, Arkadipta, Sarkar, Subir, Saturni, Francesco Gabriele, Savchenko, Volodymyr, Scherer, Andres, Schipani, Pietro, Schleicher, Bernd, Schovanek, Petr, Schubert, Jan Lukas, Schwanke, Ullrich, Schwefer, Georg, Scuderi, Salvatore, Arroyo, Monica Seglar, Seitenzahl, Ivo, Sergijenko, Olga, Sguera, Vito, Shang, Ruo-Yu, Sharma, Pooja, Sidibe, Guereguin Der Sylvestre, Sidoli, Lara, Siejkowski, Hubert, Siqueira, Clarissa, Sizun, Patrick, Sliusar, Vitalii, Slowikowska, Agnieszka, Sol, Helene, Specovius, Andreas, Spencer, Samuel Timothy, Spiga, Daniele, Stamerra, Antonio, Stanič, Samo, Starecki, Tomasz, Starling, Rhaana, Steppa, Constantin, Stolarczyk, Thierry, Strišković, Jelena, Strzys, Marcel C., Suda, Yusuke, Suomijarvi, Tiina, Tak, Donggeun, Takahashi, Mitsunari, Takeishi, Ryuji, Tam, Pak-Hin Thomas, Tanaka, Shuta J, Tanaka, Takaaki, Terauchi, Kenta, Testa, Vincenzo, Tibaldo, Luigi, Tibolla, Omar, Torradeflot, Francesc, Torres, Diego F., Torresi, Eleonora, Tothill, Nick, Toussenel, Francois, Touzard, Victoria, Tramacere, Andrea, Travnicek, Petr, Tripodo, Giovanni, Truzzi, Stefano, Tsiahina, Adellain, Tutone, Antonio, Vacula, Martin, Vallage, Bertrand, Vallania, Piero, Vallés, Ramon, van Eldik, Christopher, van Scherpenberg, Juliane, Vandenbroucke, Justin, Vassiliev, Vladimir, Venault, Philippe, Ventura, Sofia, Vercellone, Stefano, Verna, Gaia, Viana, Aion, Viaux, Nicolás, Vigliano, Alessandro, Vignatti, Jonatan, Vigorito, Carlo francesco, Vitale, Vincenzo, Vodeb, Veronika, Voisin, Vincent, Vorobiov, Serguei, Voutsinas, Georgios Gerasimos, Vovk, Ievgen, Waegebaert, Vincent, Wagner, Stefan Joachim, Walter, Roland, Ward, Martin, Wechakama, Maneenate, White, Richard, Wierzcholska, Alicja, Will, Martin, Williams, David A., Wohlleben, Frederik, Wolter, Anna, Yamamoto, Tokonatsu, Yamazaki, Ryo, Yang, Lili, Yoshida, Tatsuo, Yoshikoshi, Takanori, Zacharias, Michael, Sanchez, Ricardo Zanmar, Zavrtanik, Danilo, Zavrtanik, Marko, Zdziarski, Andrzej A., Zech, Andreas, Zhdanov, Valery I., Ziȩtara, Krzysztof, Živec, Miha, and Zuriaga-Puig, Jaume
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The detection of gravitational waves from a binary neutron star merger by Advanced LIGO and Advanced Virgo (GW170817), along with the discovery of the electromagnetic counterparts of this gravitational wave event, ushered in a new era of multimessenger astronomy, providing the first direct evidence that BNS mergers are progenitors of short gamma-ray bursts (GRBs). Such events may also produce very-high-energy (VHE, > 100GeV) photons which have yet to be detected in coincidence with a gravitational wave signal. The Cherenkov Telescope Array (CTA) is a next-generation VHE observatory which aims to be indispensable in this search, with an unparalleled sensitivity and ability to slew anywhere on the sky within a few tens of seconds. New observing modes and follow-up strategies are being developed for CTA to rapidly cover localization areas of gravitational wave events that are typically larger than the CTA field of view. This work will evaluate and provide estimations on the expected number of of gravitational wave events that will be observable with CTA, considering both on- and off-axis emission. In addition, we will present and discuss the prospects of potential follow-up strategies with CTA., Comment: Presented at the 38th International Cosmic Ray Conference (ICRC 2023), 2023 (arXiv:2309.08219)
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- 2023
30. Doppler-aware Odometry from FMCW Scanning Radar
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Rennie, Fraser, Williams, David, Newman, Paul, and De Martini, Daniele
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Computer Science - Robotics - Abstract
This work explores Doppler information from a millimetre-Wave (mm-W) Frequency-Modulated Continuous-Wave (FMCW) scanning radar to make odometry estimation more robust and accurate. Firstly, doppler information is added to the scan masking process to enhance correlative scan matching. Secondly, we train a Neural Network (NN) for regressing forward velocity directly from a single radar scan; we fuse this estimate with the correlative scan matching estimate and show improved robustness to bad estimates caused by challenging environment geometries, e.g. narrow tunnels. We test our method with a novel custom dataset which is released with this work at https://ori.ox.ac.uk/publications/datasets., Comment: Accepted to ITSC 2023
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- 2023
31. PeV Gamma-ray Astronomy With Panoramic Optical SETI Telescopes
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Korzoun, Nikolas, Benbow, Wystan, Brown, Aaron, Foote, Gregory, Hanlon, William F., Hervet, Olivier, Hoang, John, Holder, Jamie, Horowitz, Paul, Liu, Wei, Maire, Jérôme, Rault-Wang, Nicolas, Werthimer, Dan, Wiley, James, Williams, David A., and Wright, Shelley A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Panoramic Search for Extraterrestrial Intelligence (PANOSETI) experiment is designed to detect pulsed optical signals on nanosecond timescales. PANOSETI is therefore sensitive to Cherenkov radiation generated by extensive air showers, and can be used for gamma-ray astronomy. Each PANOSETI telescope uses a 0.5 m Fresnel lens to focus light onto a 1024 pixel silicon photomultiplier camera that images a 9.9$^\circ\times$9.9$^\circ$ square field of view. Recent detections of PeV gamma-rays from extended sources in the Galactic Plane motivate constructing an array with effective area and angular resolution surpassing current observatories. The PANOSETI telescopes are much smaller and far more affordable than traditional imaging atmospheric Cherenkov telescopes (IACT), making them ideal instruments to construct such an array. We present the results of coincident observations between two PANOSETI telescopes and the gamma-ray observatory VERITAS, along with simulations characterizing the performance of a PANOSETI IACT array., Comment: 8 pages, 5 figures, Proceedings for the 38th International Cosmic Ray Conference (ICRC2023) in Nagoya Japan, Jul 26 - Aug 3, 2023
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- 2023
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32. Conforming Finite Element Function Spaces in Four Dimensions, Part II: The Pentatope and Tetrahedral Prism
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Williams, David M. and Nigam, Nilima
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Mathematics - Numerical Analysis ,14F40, 52B11, 58A12, 65D05, 74S05 - Abstract
In this paper, we present explicit expressions for conforming finite element function spaces, basis functions, and degrees of freedom on the pentatope and tetrahedral prism elements. More generally, our objective is to construct finite element function spaces that maintain conformity with infinite-dimensional spaces of a carefully chosen de Rham complex. This paper is a natural extension of the companion paper entitled "Conforming Finite Element Function Spaces in Four Dimensions, Part I: Foundational Principles and the Tesseract" by Nigam and Williams, (2023). In contrast to Part I, in this paper we focus on two of the most popular elements which do not possess a full tensor-product structure in all four coordinate directions. We note that these elements appear frequently in existing space-time finite element methods. In order to build our finite element spaces, we utilize powerful techniques from the recently developed 'Finite Element Exterior Calculus'. Subsequently, we translate our results into the well-known language of linear algebra (vectors and matrices) in order to facilitate implementation by scientists and engineers., Comment: 44 pages, 2 figures, 1 table
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- 2023
33. Conforming Finite Element Function Spaces in Four Dimensions, Part 1: Foundational Principles and the Tesseract
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Nigam, Nilima and Williams, David M.
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Mathematics - Numerical Analysis ,14F40, 52B11, 58A12, 65D05, 74S05 - Abstract
The stability, robustness, accuracy, and efficiency of space-time finite element methods crucially depend on the choice of approximation spaces for test and trial functions. This is especially true for high-order, mixed finite element methods which often must satisfy an inf-sup condition in order to ensure stability. With this in mind, the primary objective of this paper and a companion paper is to provide a wide range of explicitly stated, conforming, finite element spaces in four-dimensions. In this paper, we construct explicit high-order conforming finite elements on 4-cubes (tesseracts); our construction uses tools from the recently developed `Finite Element Exterior Calculus'. With a focus on practical implementation, we provide details including Piola-type transformations, and explicit expressions for the volumetric, facet, face, edge, and vertex degrees of freedom. In addition, we establish important theoretical properties, such as the exactness of the finite element sequences, and the unisolvence of the degrees of freedom., Comment: 35 pages, 1 figure, 1 table
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- 2023
34. Tensile strength and dilative characteristics of compacted unsaturated clay-sized metalliferous tailings for bulk earthworks
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Tian, Hua, Williams, David J., and Mandisodza, Keith
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- 2024
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35. Chronic Inflammatory Enteropathy and Low-Grade Intestinal T-Cell Lymphoma Are Associated with Altered Microbial Tryptophan Catabolism in Cats.
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Barko, Patrick, Williams, David, Wu, Yu-An, Steiner, Joerg, Suchodolski, Jan, Gal, Arnon, and Marsilio, Sina
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alimentary small cell lymphoma ,chronic enteropathy ,indole ,inflammatory bowel disease ,microbial indole catabolites of tryptophan - Abstract
Chronic inflammatory enteropathy (CIE) and low-grade intestinal T-cell lymphoma (LGITL) are common chronic enteropathies (CE) in cats. Enteric microbiota dysbiosis is implicated in the pathogenesis of CE; however, the mechanisms of host-microbiome interactions are poorly understood in cats. Microbial indole catabolites of tryptophan (MICT) are gut bacterial catabolites of tryptophan that are hypothesized to regulate intestinal inflammation and mucosal barrier function. MICTs are decreased in the sera of humans with inflammatory bowel disease and previous studies identified altered tryptophan metabolism in cats with CE. We sought to determine whether MICTs were decreased in cats with CE using archived serum samples from cats with CIE (n = 44) or LGITL (n = 31) and healthy controls (n = 26). Quantitative LC-MS/MS was used to measure serum concentrations of tryptophan, its endogenous catabolites (kynurenine, kynurenate, serotonin) and MICTs (indolepyruvate, indolealdehyde, indoleacrylate, indoleacetamide, indoleacetate, indolelactate, indolepropionate, tryptamine). Serum concentrations of tryptophan, indolepropionate, indoleacrylate, indolealdehyde, indolepyruvate, indolelactate were significantly decreased in the CIE and LGITL groups compared to those in healthy controls. Indolelactate concentrations were significantly lower in cats with LGITL compared to CIE (p = 0.006). Significant correlations were detected among serum MICTs and cobalamin, folate, fPLI, and fTLI. Our findings suggest that MICTs are promising biomarkers to investigate the role of gut bacteria in the pathobiology of chronic enteropathies in cats.
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- 2023
36. Expression of two major isoforms of MYO7A in the retina: Considerations for gene therapy of Usher syndrome type 1B.
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Gilmore, W, Hultgren, Nan, Chadha, Abhishek, Barocio, Sonia, Zhang, Joyce, Kutsyr, Oksana, Flores-Bellver, Miguel, Canto-Soler, M, and Williams, David
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Gene therapy ,Isoforms ,MYO7A ,Retina ,Usher syndrome ,Humans ,Mice ,Animals ,Swine ,Usher Syndromes ,Myosin VIIa ,Retina ,Protein Isoforms ,Mutation ,Genetic Therapy - Abstract
Usher syndrome type 1B (USH1B) is a deaf-blindness disorder, caused by mutations in the MYO7A gene, which encodes the heavy chain of an unconventional actin-based motor protein. Here, we examined the two retinal isoforms of MYO7A, IF1 and IF2. We compared 3D models of the two isoforms and noted that the 38-amino acid region that is present in IF1 but absent from IF2 affects the C lobe of the FERM1 domain and the opening of a cleft in this potentially important protein binding domain. Expression of each of the two isoforms of human MYO7A and pig and mouse Myo7a was detected in the RPE and neural retina. Quantification by qPCR showed that the expression of IF2 was typically ∼ 7-fold greater than that of IF1. We discuss the implications of these findings for any USH1B gene therapy strategy. Given the current incomplete knowledge of the functions of each isoform, both isoforms should be considered for targeting both the RPE and the neural retina in gene augmentation therapies.
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- 2023
37. A VERITAS/Breakthrough Listen Search for Optical Technosignatures
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Acharyya, Atreya, Adams, Colin, Archer, Avery, Bangale, Priyadarshini, Batista, Pedro, Benbow, Wystan, Brill, Aryeh, Capasso, M, Errando, Manel, Falcone, Abraham, Feng, Qi, Finley, John, Foote, Gregory, Fortson, Lucy, Furniss, Amy, Griffin, Sean, Hanlon, William, Hanna, David, Hervet, Olivier, Hinrichs, Claire, Hoang, John, Holder, Jamie, Humensky, T., Jin, Weidong, Kaaret, Philip, Kertzman, Mary P., Kherlakian, Maria, Kieda, David, Kleiner, Tobias, Korzoun, Nikolas, Kumar, Sajan, Lang, Mark, Lundy, Matthew, Maier, Gernot, McGrath, Conor, Millard, Matthew, Miller, Hayden, Millis, John, Mooney, Connor, Moriarty, Patrick, Mukherjee, Reshmi, O'Brien, Stephan, Ong, Rene A., Pohl, Martin, Pueschel, Elisa, Quinn, John, Ragan, Kenneth J., Reynolds, Paul, Ribeiro, Deivid, Roache, Emmet Thomas, Ryan, Jamie, Sadeh, Iftach, Saha, Lab, Santander, Marcos, Sembroski, Glenn H, Shang, Ruo, Tak, Donggeun, Talluri, Anjana, Tucci, James, Vazquez, Nico, Williams, David, Wong, Sam, Woo, Jooyun, DeBoer, David, Isaacson, Howard, de Pater, Imke, Price, Danny, and Siemion, Andrew
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Breakthrough Listen Initiative is conducting a program using multiple telescopes around the world to search for "technosignatures": artificial transmitters of extraterrestrial origin from beyond our solar system. The VERITAS Collaboration joined this program in 2018, and provides the capability to search for one particular technosignature: optical pulses of a few nanoseconds duration detectable over interstellar distances. We report here on the analysis and results of dedicated VERITAS observations of Breakthrough Listen targets conducted in 2019 and 2020 and of archival VERITAS data collected since 2012. Thirty hours of dedicated observations of 136 targets and 249 archival observations of 140 targets were analyzed and did not reveal any signals consistent with a technosignature. The results are used to place limits on the fraction of stars hosting transmitting civilizations. We also discuss the minimum-pulse sensitivity of our observations and present VERITAS observations of CALIOP: a space-based pulsed laser onboard the CALIPSO satellite. The detection of these pulses with VERITAS, using the analysis techniques developed for our technosignature search, allows a test of our analysis efficiency and serves as an important proof-of-principle., Comment: 15 pages, 7 figures
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- 2023
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38. VERITAS discovery of very high energy gamma-ray emission from S3 1227+25 and multiwavelength observations
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Acharyya, Atreya, Adams, Colin, Archer, Avery, Bangale, Priyadarshini, Benbow, Wystan, Brill, Aryeh, Christiansen, Jodi, Chromey, Alisha, Errando, Manel, Falcone, Abe, Feng, Qi, Finley, John, Foote, Gregory, Fortson, Lucy, Furniss, Amy, Gallagher, Greg, Hanlon, William, Hanna, David, Hervet, Olivier, Hinrichs, Claire, Hoang, John, Holder, Jamie, Jin, Weidong, Johnson, Madalyn, Kaaret, Philip, Kertzman, Mary P., Kieda, David, Kleiner, Tobias, Korzoun, Nikolas, Krennrich, Frank, Lang, Mark, Lundy, Matthew, Maier, Gernot, McGrath, Conor, Millard, Matthew, Millis, John, Mooney, Connor, Moriarty, Patrick, Mukherjee, Reshmi, O'Brien, Stephan, Ong, Rene A., Pohl, Martin, Pueschel, Elisa, Quinn, John, Ragan, Kenneth J., Reynolds, Paul, Ribeiro, Deivid, Roache, Emmet Thomas, Sadeh, Iftach, Sadun, Alberto, Saha, Lab, Santander, Marcos, Sembroski, Glenn, Shang, Ruo, Splettstoesser, Megan, Talluri, Anjana, Tucci, James, Vassiliev, Vladimir, Williams, David, Wong, Sam, Hovatta, Talvikki, Jorstad, Svetlana, Kiehlmann, Sebastian, Lahteenmaki, Anne, Liodakis, Ioannis, Marscher, Alan, Max-Moerbeck, Walter, Readhead, Anthony, Reeves, Rodrigo, Smith, Paul S, and Tornikoski, Merja
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report the detection of very high energy gamma-ray emission from the blazar S3 1227+25 (VER J1230+253) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS). VERITAS observations of the source were triggered by the detection of a hard-spectrum GeV flare on May 15, 2015 with the Fermi-Large Area Telescope (LAT). A combined five-hour VERITAS exposure on May 16th and May 18th resulted in a strong 13$\sigma$ detection with a differential photon spectral index, $\Gamma$ = 3.8 $\pm$ 0.4, and a flux level at 9% of the Crab Nebula above 120 GeV. This also triggered target of opportunity observations with Swift, optical photometry, polarimetry and radio measurements, also presented in this work, in addition to the VERITAS and Fermi-LAT data. A temporal analysis of the gamma-ray flux during this period finds evidence of a shortest variability timescale of $\tau_{obs}$ = 6.2 $\pm$ 0.9 hours, indicating emission from compact regions within the jet, and the combined gamma-ray spectrum shows no strong evidence of a spectral cut-off. An investigation into correlations between the multiwavelength observations found evidence of optical and gamma-ray correlations, suggesting a single-zone model of emission. Finally, the multiwavelength spectral energy distribution is well described by a simple one-zone leptonic synchrotron self-Compton radiation model., Comment: 18 pages, 6 figures. Accepted for publication in the Astrophysical Journal (ApJ)
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- 2023
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39. AT 2021loi: A Bowen Fluorescence Flare with a Rebrightening Episode, Occurring in a Previously-Known AGN
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Makrygianni, Lydia, Trakhtenbrot, Benny, Arcavi, Iair, Ricci, Claudio, Lam, Marco C., Horesh, Assaf, Sfaradi, Itai, Bostroem, K. Azalee, Hosseinzadeh, Griffin, Howell, D. Andrew, Pellegrino, Craig, Fender, Rob, Green, David A., Williams, David R. A., and Bright, Joe
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
AT 2021loi is an optical-ultraviolet transient located at the center of its host galaxy. Its spectral features identify it as a member of the ``Bowen Fluorescence Flare'' (BFF) class. The first member of this class was considered to be related to a tidal disruption event, but enhanced accretion onto an already active supermassive black hole was suggested as an alternative explanation. AT 2021loi, having occurred in a previously-known unobscured AGN, strengthens the latter interpretation. Its light curve is similar to those of previous BFFs, showing a rebrightening approximately one year after the main peak (which was not explicitly identified, but might be the case, in all previous BFFs). An emission feature around 4680 A, seen in the pre-flare spectrum, strengthens by a factor of $\sim$2 around the optical peak of the flare, and is clearly seen as a double peaked feature then, suggesting a blend of NIII $\lambda 4640$ with HeII $\lambda4686$ as its origin. The appearance of OIII $\lambda$3133 and possible NIII $\lambda\lambda4097,4103$ (blended with H$\delta$) during the flare further support a Bowen Fluorescence classification. Here, we present ZTF, ATLAS, Keck, Las Cumbres Observatory, NEOWISE-R, $Swift$, AMI and VLA observations of AT 2021loi, making it one of the best observed BFFs to date. AT 2021loi thus provides some clarity on the nature of BFFs but also further demonstrates the diversity of nuclear transients., Comment: Submitted to ApJ. This version addresses comments from the referee
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- 2023
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40. Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis
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Pierce, Jennifer, Harte, Steven E, Afari, Niloofar, Bradley, Catherine S, Griffith, James W, Kim, Jayoung, Lutgendorf, Susan, Naliboff, Bruce D, Rodriguez, Larissa V, Taple, Bayley J, Williams, David, Harris, Richard E, and Schrepf, Andrew
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Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Clinical Research ,Women's Health ,Behavioral and Social Science ,Chronic Pain ,Pain Research ,2.1 Biological and endogenous factors ,Adult ,Child ,Female ,Humans ,Male ,Middle Aged ,Adverse Childhood Experiences ,Pain Threshold ,Pelvic Pain ,Psychological Trauma ,Sexual Trauma ,Trauma ,Childhood abuse ,Pain sensitivity ,Quantitative sensory testing ,MAPP Research Network ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Anesthesiology ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
AbstractUrologic chronic pelvic pain syndrome (UCPPS) is a complex, debilitating condition in which patients often report nonpelvic pain in addition to localized pelvic pain. Understanding differential predictors of pelvic pain only vs widespread pain may provide novel pathways for intervention. This study leveraged baseline data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network's Symptom Pattern Study to investigate the impact of childhood sexual and nonsexual violent trauma on pelvic and nonpelvic pain sensitivity among adult patients with UCPPS, as well as potential mediators of this association. Study participants who met inclusion criteria for UCPPS completed questionnaires assessing childhood and recent trauma, affective distress, cognitive dysfunction, and generalized sensory sensitivity. Experimental pain sensitivity was also evaluated using standardized pressure pain applied to the pubic region and the arm. Bivariate analyses showed that childhood violent trauma was associated with more nonviolent childhood trauma, more recent trauma, poorer adult functioning, and greater pain sensitivity at the pubic region, but not pain sensitivity at the arm. Path analysis suggested that childhood violent trauma was indirectly associated with pain sensitivity at both sites and that this indirect association was primarily mediated by generalized sensory sensitivity. More experiences of recent trauma also contributed to these indirect effects. The findings suggest that, among participants with UCPPS, childhood violent trauma may be associated with heightened pain sensitivity to the extent that trauma history is associated with a subsequent increase in generalized sensory sensitivity.
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- 2023
41. Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures
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Sluka, Kathleen A, Wager, Tor D, Sutherland, Stephani P, Labosky, Patricia A, Balach, Tessa, Bayman, Emine O, Berardi, Giovanni, Brummett, Chad M, Burns, John, Buvanendran, Asokumar, Caffo, Brian, Calhoun, Vince D, Clauw, Daniel, Chang, Andrew, Coffey, Christopher S, Dailey, Dana L, Ecklund, Dixie, Fiehn, Oliver, Fisch, Kathleen M, Law, Laura A Frey, Harris, Richard E, Harte, Steven E, Howard, Timothy D, Jacobs, Joshua, Jacobs, Jon M, Jepsen, Kristen, Johnston, Nicolas, Langefeld, Carl D, Laurent, Louise C, Lenzi, Rebecca, Lindquist, Martin A, Lokshin, Anna, Kahn, Ari, McCarthy, Robert J, Olivier, Michael, Porter, Linda, Qian, Wei-Jun, Sankar, Cheryse A, Satterlee, John, Swensen, Adam C, Vance, Carol GT, Waljee, Jennifer, Wandner, Laura D, Williams, David A, Wixson, Richard L, Zhou, Xiaohong Joe, and Consortium, the A2CPS
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Chronic Pain ,Clinical Research ,Prevention ,Pain Research ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,2.1 Biological and endogenous factors ,Aetiology ,Musculoskeletal ,Good Health and Well Being ,Humans ,Proteomics ,Pain ,Postoperative ,Acute Pain ,Biomarkers ,Pain ,Chronic pain ,Postsurgical pain ,Biomarker ,Biosignatures ,Omics ,Brain imaging ,Psychosocial ,A2CPS Consortium ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Anesthesiology ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
AbstractChronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken to date. Data and analytic resources generatedby A2CPS will be shared with the scientific community in hopes that other investigators will extract valuable insights beyond A2CPS's initial findings. This article will review the identified biomarkers and rationale for including them, the current state of the science on biomarkers of the transition from acute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.
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- 2023
42. The Back Pain Consortium (BACPAC) Research Program Data Harmonization: Rationale for Data Elements and Standards
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Batorsky, Anna, Bowden, Anton E, Darwin, Jessa, Fields, Aaron J, Greco, Carol M, Harris, Richard E, Hue, Trisha F, Kakyomya, Joseph, Mehling, Wolf, O'Neill, Conor, Patterson, Charity G, Piva, Sara R, Sollmann, Nico, Toups, Vincent, Wasan, Ajay D, Wasserman, Ronald, Williams, David A, Vo, Nam V, Psioda, Matthew A, and McCumber, Micah
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Allied Health and Rehabilitation Science ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Chronic Pain ,Pain Research ,Back Pain ,Networking and Information Technology R&D (NITRD) ,Neurosciences ,Clinical Research ,Humans ,Low Back Pain ,Outcome Assessment ,Health Care ,Research Design ,data integration ,harmonization ,common data elements ,low back pain ,data standards ,Pharmacology and Pharmaceutical Sciences ,Public Health and Health Services ,Anesthesiology ,Clinical sciences ,Health services and systems ,Clinical and health psychology - Abstract
ObjectiveOne aim of the Back Pain Consortium (BACPAC) Research Program is to develop an integrated model of chronic low back pain that is informed by combined data from translational research and clinical trials. We describe efforts to maximize data harmonization and accessibility to facilitate Consortium-wide analyses.MethodsConsortium-wide working groups established harmonized data elements to be collected in all studies and developed standards for tabular and nontabular data (eg, imaging and omics). The BACPAC Data Portal was developed to facilitate research collaboration across the Consortium.ResultsClinical experts developed the BACPAC Minimum Dataset with required domains and outcome measures to be collected by use of questionnaires across projects. Other nonrequired domain-specific measures are collected by multiple studies. To optimize cross-study analyses, a modified data standard was developed on the basis of the Clinical Data Interchange Standards Consortium Study Data Tabulation Model to harmonize data structures and facilitate integration of baseline characteristics, participant-reported outcomes, chronic low back pain treatments, clinical exam, functional performance, psychosocial characteristics, quantitative sensory testing, imaging, and biomechanical data. Standards to accommodate the unique features of chronic low back pain data were adopted. Research units submit standardized study data to the BACPAC Data Portal, developed as a secure cloud-based central data repository and computing infrastructure for researchers to access and conduct analyses on data collected by or acquired for BACPAC.ConclusionsBACPAC harmonization efforts and data standards serve as an innovative model for data integration that could be used as a framework for other consortia with multiple, decentralized research programs.
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- 2023
43. Biobehavioral Assessments in BACPAC: Recommendations, Rationale, and Methods
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Greco, Carol M, Wasan, Ajay D, Schneider, Michael J, Mehling, Wolf, Williams, David A, Darwin, Jessa, and Harte, Steven E
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Allied Health and Rehabilitation Science ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Neurosciences ,Clinical Research ,Pain Research ,Behavioral and Social Science ,Mind and Body ,Chronic Pain ,Mental Health ,Basic Behavioral and Social Science ,United States ,Humans ,Research Design ,Low Back Pain ,Advisory Committees ,Pain Measurement ,National Institutes of Health (U.S.) ,Behavioral Assessments ,Psychosocial Assessments ,Patient-Reported Outcomes ,Quantitative Sensory Testing ,Chronic Low Back Pain ,Pharmacology and Pharmaceutical Sciences ,Public Health and Health Services ,Anesthesiology ,Clinical sciences ,Health services and systems ,Clinical and health psychology - Abstract
The Biobehavioral Working Group of BACPAC was charged to evaluate a range of psychosocial, psychophysical, and behavioral domains relevant to chronic low back pain, and recommend specific assessment tools and procedures to harmonize biobehavioral data collection across the consortium. Primary references and sources for measure selection were the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials, the Minimum Data Set from the National Institutes of Health (NIH) Research Task Force on Standards for Chronic Low Back Pain, the Patient-Reported Outcomes Measurement Information System, and NeuroQOL. The questionnaire's recommendations supplemented the NIH HEAL Common Data Elements and BACPAC Minimum Data Set. Five domains were identified for inclusion: Pain Characteristics and Qualities; Pain-Related Psychosocial/Behavioral Factors; General Psychosocial Factors; Lifestyle Choices; and Social Determinants of Health/Social Factors. The Working Group identified best practices for required and optional Quantitative Sensory Testing of psychophysical pain processing for use in BACPAC projects.
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- 2023
44. Linking specific biological signatures to different childhood adversities: findings from the HERO project.
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de Mendonça Filho, Euclides, Pokhvisneva, Irina, Maalouf, Christina, Parent, Carine, Mliner, Shanna, Slopen, Natalie, Williams, David, Boyce, William, Levitt, Pat, Nelson, Charles, Gunnar, Megan, Meaney, Michael, Shonkoff, Jack, Silveira, Patricia, and Bush, Nicole
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Humans ,Child ,Hydrocortisone ,Cortisone ,Tumor Necrosis Factor-alpha ,Stress ,Psychological ,Saliva ,Hypothalamo-Hypophyseal System ,Pituitary-Adrenal System ,Dehydroepiandrosterone - Abstract
BACKGROUND: Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited. METHODS: Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children (N = 142; N = 145). RESULTS: Children exposed to higher SES-D had higher levels of TNF-α (B = 0.13, p = 0.011), IL-1β (B = 0.10, p = 0.033), and DHEA (B = 0.16, p = 0.011). Higher family dysfunction was associated with higher cortisol (B = 0.08, p = 0.033) and cortisone (B = 0.05, p = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels (p = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample. CONCLUSIONS: Our results indicate that these biological response systems may react differently to different forms of early-life adversity. IMPACT: Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking. Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA. Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage. Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities.
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- 2023
45. Surgical management of native aortic valve leaflet avulsion during TAVR
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Williams, David M., Castellano, Andrew, Phillips, William, Miller, Kelly, and Garg, Aakash
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- 2024
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46. Protocol for a pragmatic trial of Cannabidiol (CBD) to improve chronic pain symptoms among United States Veterans
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Bergmans, Rachel S., Wegryn-Jones, Riley, Klida, Catherine, Kurtz, Vivian, Thomas, Laura, Williams, David A., Clauw, Daniel J., Kidwell, Kelley M., Bohnert, Amy S. B., and Boehnke, Kevin F.
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- 2024
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47. Ribosomal DNA copy number is associated with body mass in humans and other mammals
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Law, Pui Pik, Mikheeva, Liudmila A., Rodriguez-Algarra, Francisco, Asenius, Fredrika, Gregori, Maria, Seaborne, Robert A. E., Yildizoglu, Selin, Miller, James R. C., Tummala, Hemanth, Mesnage, Robin, Antoniou, Michael N., Li, Weilong, Tan, Qihua, Hillman, Sara L., Rakyan, Vardhman K., Williams, David J., and Holland, Michelle L.
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- 2024
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48. Lab on a bead with oscillatory centrifugal microfluidics for fast and complete mixing enables fast and accurate biomedical assays
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Williams, David E., Li, Wei, Chandrasekhar, Mithileshwari, Corazza, Carsten Ma On Wong, Deijs, Gerrit Sjoerd, Djoko, Lionel, Govind, Bhavesh, Jose, Ellen, Kwon, Yong Je, Lowe, Tiffany, Panchal, Anil, Reshef, Gabrielle, Vargas, Matheus J. T., and Simpson, M. Cather
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- 2024
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49. Transitioning to home and beyond following stroke: a prospective cohort study of outcomes and needs
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O’Callaghan, Geraldine, Fahy, Martin, O’Meara, Sigrid, Chawke, Mairead, Waldron, Eithne, Corry, Marie, Gallagher, Sinead, Coyne, Catriona, Lynch, Julie, Kennedy, Emma, Walsh, Thomas, Cronin, Hilary, Hannon, Niamh, Fallon, Clare, Williams, David J, Langhorne, Peter, Galvin, Rose, and Horgan, Frances
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- 2024
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50. The cost of doubt: assessing the association between attributional ambiguity and mental health
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Cuevas, Adolfo G., Williams, David R., Krobath, Danielle M., Lyngdoh, Adiammi, Kaba-Diakité, Fatoumata, and Allen, Jennifer D.
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- 2024
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