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3. sj-pdf-1-tag-10.1177_1756284821993586 – Supplemental material for Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

Author

Hanning, Nikita, Edwinson, Adam L., Ceuleers, Hannah, Peters, Stephanie A., Man, Joris G. De, Hassett, Leslie C., Winter, Benedicte Y. De, and Madhusudan Grover

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tag-10.1177_1756284821993586 for Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review by Nikita Hanning, Adam L. Edwinson, Hannah Ceuleers, Stephanie A. Peters, Joris G. De Man, Leslie C. Hassett, Benedicte Y. De Winter and Madhusudan Grover in Therapeutic Advances in Gastroenterology

Published
2021
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4. Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis.

Author

Verleye, Arno, Wijtvliet, Veerle, Abrams, Steven, Hellemans, Rachel, Bougrea, Rania, Massart, Annick, Pipeleers, Lissa, Wissing, Karl Martin, Ariën, Kevin K, Winter, Benedicte Y De, Damme, Pierre Van, Abramowicz, Daniel, and Ledeganck, Kristien J

Subjects
TRANSPLANTATION of organs, tissues, etc., COVID-19 vaccines, SEROCONVERSION, VACCINATION, ANTIBODY titer
Abstract

Background In the general population, the seroconversion rate after primary vaccination with two doses of an anti-severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) vaccine reaches nearly 100%, with significantly higher antibody titers after mRNA-1273 vaccination compared to BNT162b2 vaccination. Here we performed a systematic review and meta-analysis to compare the antibody response after two-dose mRNA-1273 versus BNT162b2 vaccination in solid organ transplant (SOT) recipients. Methods A systematic literature review was performed using PubMed, Web of Science and the Cochrane Library and original research papers were included for a meta-analysis to calculate vaccine-specific seroconversion rates for each of the mRNA vaccines. Next, the pooled relative seroconversion rate was estimated. Results Eight studies that described the development of antibodies against receptor-binding domain (RBD) and/or spike protein were eligible for meta-analysis. Two of these studies also reported antibody titers. The meta-analysis revealed lower seroconversion rates in SOT recipients vaccinated with two doses of BNT162b2 {44.3% [95% confidence interval (CI) 34.1–54.7]} as compared with patients vaccinated with two doses of mRNA-1273 [58.4% (95% CI 47.2–69.2)]. The relative seroconversion rate was 0.795 (95% CI 0.732–0.864). Conclusions This systematic review and meta-analysis indicates that in SOT recipients, higher seroconversion rates were observed after vaccination with mRNA-1273 compared with BNT162b2. [ABSTRACT FROM AUTHOR]

Published
2022
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5. mRNA-1273 vaccine (Moderna): a better option than BNT162b2 (Pfizer) in kidney transplant recipients and dialysis patients?

Author

Wijtvliet, Veerle P W M, Ariën, Kevin K, Abrams, Steven, Couttenye, Marie M, Mestrez, Fabienne, Mariën, Joachim, Winter, Benedicte Y De, Damme, Pierre Van, Pipeleers, Lissa, Wissing, Karl Martin, Abramowicz, Daniel, and Ledeganck, Kristien J

Subjects
HEMODIALYSIS patients, KIDNEY transplantation, COVID-19 vaccines, COVID-19, VACCINES
Published
2022
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8. Effect of Inhibition of Inducible Nitric Oxide Synthase and Guanylyl Cyclase on Endotoxin-Induced Delay in Gastric Emptying and Intestinal Transit in Mice

Author

Winter, Benedicte Y. De, Bredenoord, Albert J., Man, Joris G. De, Moreels, Tom G., Herman, Arnold G., and Pelckmans, Paul A.

Abstract

Nitric oxide (NO) is postulated to play a role in endotoxin-induced ileus. We investigated the effect of selective blockade of inducible NO synthase (iNOS) and guanylyl cyclase on endotoxin-induced ileus in mice. Thirty minutes before injection of lipopolysaccharides (LPS), mice were pretreated with L-NAME (Nω-nitro-L-arginine methyl ester, non-selective NOS inhibitor), 1400W (N-(3-(aminomethyl)benzyl)acetamide, selective iNOS inhibitor), ODQ (1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one, guanylyl cyclase inhibitor), dimethyl sulfoxide (DMSO, vehicle), or dexamethasone. After 18 h, general well being deteriorated and the mice developed hypothermia and a significant delay in gastric emptying and intestinal transit as measured by Evans blue. 1400W completely reversed the endotoxin-induced delay in gastric emptying, while L-NAME did not have these beneficial effects. On the contrary, even in control mice, L-NAME delayed gastric emptying. Dexamethasone, DMSO, and ODQ mimicked the effect of 1400W on endotoxin-induced delay in gastric emptying. The endotoxin-induced delay in transit was significantly improved only by 1400W. None of the drugs reversed the hypothermia. In LPS mice treated with L-NAME, the behavior scale increased even further, while it decreased after treatment with 1400W. In conclusion, selective inhibition of iNOS reverses the endotoxin-induced delay in gastric emptying and transit and improves general well being. The pathway used by NO, derived from iNOS, may involve inhibition of guanylyl cyclase or radical scavenging.

Published
2002

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