9 results on '"Xie, Yanle"'
Search Results
2. Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50
- Author
-
Yuan, Jingjing, primary, Liang, Zenghui, additional, Geoffrey, Muhoza, additional, Xie, Yanle, additional, Chen, Shuhan, additional, Liu, Jing, additional, Xia, Yuzhong, additional, Li, Huixin, additional, Zhao, Yanling, additional, Mao, Yuanyuan, additional, Xing, Na, additional, Yang, Jianjun, additional, Wang, Zhongyu, additional, and Xing, Fei, additional
- Published
- 2024
- Full Text
- View/download PDF
3. A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress
- Author
-
Chen,Shuhan, Xie,Yanle, Liang,Zenghui, Lu,Yu, Wang,Jingping, Xing,Fei, Mao,Yuanyuan, Wei,Xin, Wang,Zhongyu, Yang,Jianjun, Yuan,Jingjing, Chen,Shuhan, Xie,Yanle, Liang,Zenghui, Lu,Yu, Wang,Jingping, Xing,Fei, Mao,Yuanyuan, Wei,Xin, Wang,Zhongyu, Yang,Jianjun, and Yuan,Jingjing
- Abstract
Shuhan Chen,1,2 Yanle Xie,1,2 Zenghui Liang,1,2 Yu Lu,3 Jingping Wang,4 Fei Xing,1,2 Yuanyuan Mao,1,2 Xin Wei,1,2 Zhongyu Wang,1,2 Jianjun Yang,1,2 Jingjing Yuan1,2 1Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, Peopleâs Republic of China; 2Henan Province International Joint Laboratory of Pain, Cognition and Emotion, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, Peopleâs Republic of China; 3Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, Peopleâs Republic of China; 4Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USACorrespondence: Jingjing Yuan; Jianjun Yang, Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, No. 1, Eastern Jianshe Road, Zhengzhou, Henan Province, 450000, Peopleâs Republic of China, Tel +86 13513719631 ; +86 13783537619, Email yjingjing_99@163.com; yjyangjj@126.comAbstract: Sleep is crucial for human health, insufficient sleep or poor sleep quality may negatively affect sleep function and lead to a state of sleep deprivation. Sleep deprivation can result in various health problems, including chronic pain. The intricate relationship between sleep and pain is complex and intertwined, with daytime pain affecting sleep quality and poor sleep increasing pain intensity. The article first describes the influence of sleep on the onset and development of pain, and then explores the impact of daytime pain intensity on nighttime sleep quality and subsequent pain thresholds. However, the primary emphasis is placed on the pivotal role of oxidative stress in this bidirectional relationship. Although the exact mechanisms underlying sleep and chronic pain are unclear, this review focuses on the role of oxidative stress. Numerous studies on slee
- Published
- 2024
4. Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50
- Author
-
Yuan,Jingjing, Liang,Zenghui, Geoffrey,Muhoza, Xie,Yanle, Chen,Shuhan, Liu,Jing, Xia,Yuzhong, Li,Huixin, Zhao,Yanling, Mao,Yuanyuan, Xing,Na, Yang,Jianjun, Wang,Zhongyu, Xing,Fei, Yuan,Jingjing, Liang,Zenghui, Geoffrey,Muhoza, Xie,Yanle, Chen,Shuhan, Liu,Jing, Xia,Yuzhong, Li,Huixin, Zhao,Yanling, Mao,Yuanyuan, Xing,Na, Yang,Jianjun, Wang,Zhongyu, and Xing,Fei
- Abstract
Jingjing Yuan,1,2,* Zenghui Liang,1,* Muhoza Bertrand Geoffrey,1 Yanle Xie,1,2 Shuhan Chen,1,2 Jing Liu,1,2 Yuzhong Xia,1 Huixin Li,1 Yanling Zhao,1 Yuanyuan Mao,1,2 Na Xing,1,2 Jianjun Yang,1,2 Zhongyu Wang,1 Fei Xing1,2 1Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, Peopleâs Republic of China; 2Henan Province International Joint Laboratory of Pain, Cognition and Emotion, Zhengzhou, Henan Province, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Fei Xing; Zhongyu Wang, Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road Erqi District, Zhengzhou City, Henan Province, Peopleâs Republic of China, Tel +86-15936275656, Email fccxingf@zzu.edu.cn; wzy781217@163.comPurpose: Explore the median effective dose of ciprofol for inducing loss of consciousness in elderly patients and investigate how frailty influences the ED50 of ciprofol in elderly patients.Patients and Methods: A total of 26 non-frail patients and 28 frail patients aged 65â 78 years, with BMI ranging from 15 to 28 kg/m2, and classified as ASA grade II or III were selected. Patients were divided into two groups according to frailty: non-frail patients (CFS< 4), frail patients (CFS⥠4). With an initial dose of 0.3 mg/kg for elderly non-frail patients and 0.25 mg/kg for elderly frail patients, using the up-and-down Dixon method, and the next patientâs dose was dependent on the previous patientâs response. Demographic information, heart rate (HR), oxygen saturation (SpO2), mean blood pressure (MBP), and bispectral index (BIS) were recorded every 30 seconds, starting from the initiation of drug administration and continuing up to 3 minutes post-administration. Additionally, the total ciprofol dosage during induction, occurrences of hypotension, brady
- Published
- 2024
5. A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress.
- Author
-
Chen, Shuhan, Xie, Yanle, Liang, Zenghui, Lu, Yu, Wang, Jingping, Xing, Fei, Mao, Yuanyuan, Wei, Xin, Wang, Zhongyu, Yang, Jianjun, and Yuan, Jingjing
- Subjects
SLEEP deprivation ,OXIDATIVE stress ,CHRONIC pain ,SLEEP quality ,PAIN threshold - Abstract
Sleep is crucial for human health, insufficient sleep or poor sleep quality may negatively affect sleep function and lead to a state of sleep deprivation. Sleep deprivation can result in various health problems, including chronic pain. The intricate relationship between sleep and pain is complex and intertwined, with daytime pain affecting sleep quality and poor sleep increasing pain intensity. The article first describes the influence of sleep on the onset and development of pain, and then explores the impact of daytime pain intensity on nighttime sleep quality and subsequent pain thresholds. However, the primary emphasis is placed on the pivotal role of oxidative stress in this bidirectional relationship. Although the exact mechanisms underlying sleep and chronic pain are unclear, this review focuses on the role of oxidative stress. Numerous studies on sleep deprivation have demonstrated that it can lead to varying degrees of increased pain sensitivity, while chronic pain leads to sleep deprivation and further exacerbates pain. Further research on the role of oxidative stress in the mechanism of sleep deprivation-induced pain sensitization seems reasonable. This article comprehensively reviews the current research on the interrelationship between sleep deprivation, pain and the crucial role of oxidative stress. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50.
- Author
-
Yuan, Jingjing, Liang, Zenghui, Geoffrey, Muhoza Bertrand, Xie, Yanle, Chen, Shuhan, Liu, Jing, Xia, Yuzhong, Li, Huixin, Zhao, Yanling, Mao, Yuanyuan, Xing, Na, Yang, Jianjun, Wang, Zhongyu, and Xing, Fei
- Published
- 2024
- Full Text
- View/download PDF
7. Sleep deprivation and recovery sleep affect healthy male resident’s pain sensitivity and oxidative stress markers: The medial prefrontal cortex may play a role in sleep deprivation model
- Author
-
Chen, Shuhan, Xie, Yanle, Li, Yize, Fan, Xiaochong, Xing, Fei, Mao, Yuanyuan, Xing, Na, Wang, Jingping, Yang, Jianjun, Wang, Zhongyu, and Yuan, Jingjing
- Subjects
Cellular and Molecular Neuroscience ,Molecular Biology - Abstract
Sleep is essential for the body’s repair and recovery, including supplementation with antioxidants to maintain the balance of the body’s redox state. Changes in sleep patterns have been reported to alter this repair function, leading to changes in disease susceptibility or behavior. Here, we recruited healthy male physicians and measured the extent of the effect of overnight sleep deprivation (SD) and recovery sleep (RS) on nociceptive thresholds and systemic (plasma-derived) redox metabolism, namely, the major antioxidants glutathione (GSH), catalase (CAT), malondialdehyde (MDA), and superoxide dismutase (SOD). Twenty subjects underwent morning measurements before and after overnight total SD and RS. We found that one night of SD can lead to increased nociceptive hypersensitivity and the pain scores of the Numerical Rating Scale (NRS) and that one night of RS can reverse this change. Pre- and post-SD biochemical assays showed an increase in MDA levels and CAT activity and a decrease in GSH levels and SOD activity after overnight SD. Biochemical assays before and after RS showed a partial recovery of MDA levels and a basic recovery of CAT activity to baseline levels. An animal study showed that SD can cause a significant decrease in the paw withdrawal threshold and paw withdrawal latency in rats, and after 4 days of unrestricted sleep, pain thresholds can be restored to normal. We performed proteomics in the rat medial prefrontal cortex (mPFC) and showed that 37 proteins were significantly altered after 6 days of SD. Current findings showed that SD causes nociceptive hyperalgesia and oxidative stress, and RS can restore pain thresholds and repair oxidative stress damage in the body. However, one night of RS is not enough for repairing oxidative stress damage in the human body.
- Published
- 2022
8. Predicting postoperative pain in children: an observational study using the pain threshold Index.
- Author
-
Liang Z, Xie Y, Chen S, Liu J, Lv H, Muhoza BG, Xing F, Mao Y, Wei X, Xing N, Yang J, Wang Z, and Yuan J
- Abstract
Objective: While the pain threshold index (PTI) holds potential as a tool for monitoring analgesia-pain equilibrium, its precision in forecasting postoperative pain in children remains unconfirmed. This study's primary aim was to assess the PTI's predictive precision for postoperative pain., Methods: Children (aged 2-16 years) undergoing general surgery under general anesthesia were included. Within 5 min prior to the patient's emergence from surgery, data including PTI, wavelet index (WLI), heart rates (HR) and mean arterial pressure (MAP) were collected. Subsequently, a 15-min pain assessment was conducted following the patient's awakening. The accuracy of these indicators in discerning between mild and moderate to severe postoperative pain was evaluated through receiver operating characteristic (ROC) analysis., Results: The analysis encompassed data from 90 children. ROC analysis showed that PTI was slightly better than HR, MAP and WLI in predicting postoperative pain, but its predictive value was limited. The area under the curve (AUC) was 0.659 [0.537∼0.780] and the optimal threshold was 65[64-67]. Sensitivity and specificity were determined at 0.90 and 0.50, respectively. In a multivariable logistic regression model, a higher predictive accuracy was found for a multivariable predictor combining PTI values with gender, BMI, HR and MAP (AUC, 0.768; 95%CI, 0.669-0.866). Upon further scrutinizing the age groups, PTI's AUC was 0.796 for children aged 9-16, 0.656 for those aged 4-8, and 0.601 for younger individuals., Conclusions: PTI, when used alone, lacks acceptable accuracy in predicting postoperative pain in children aged 2 to 16 years. However, when combined with other factors, it shows improved predictive accuracy. Notably, PTI appears to be more accurate in older children., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Liang, Xie, Chen, Liu, Lv, Muhoza, Xing, Mao, Wei, Xing, Yang, Wang and Yuan.)
- Published
- 2024
- Full Text
- View/download PDF
9. Intraoperative Intravenous Infusion of Esmketamine Has Opioid-Sparing Effect and Improves the Quality of Recovery in Patients Undergoing Thoracic Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
- Author
-
Yuan J, Chen S, Xie Y, Wang Z, Xing F, Mao Y, Wang J, Yang J, Li Y, and Fan X
- Subjects
- Humans, Hydromorphone, Infusions, Intravenous, Pain, Postoperative drug therapy, Double-Blind Method, Analgesics, Opioid, Thoracic Surgery
- Abstract
Background: Postoperative thoracic surgery is often accompanied by severe pain, and opioids are a cornerstone of postoperative pain management, but their use may be limited by many adverse events. Several studies have shown that the perioperative application of esketamine adjuvant therapy can reduce postoperative opioid consumption. However, whether esketamine has an opioid-sparing effect after thoracic surgery is unclear., Objectives: To explore the opioid-sparing effect of different doses of esketamine infusion during thoracic surgery and its impact on patient recovery., Study Design: Randomized controlled study., Setting: A single-center study with a total of 120 patients., Methods: Patients were randomly allocated to 1 or 3 groups receiving intraoperative intravenous infusions of esketamine 0.15 mg · kg-1· h-1 (group K1), esketamine 0.25 mg · kg-1· h-1(group K2), or placebo (group C). Postoperative opioid consumption, and postoperative indicators like extubation time, PACU stay time, and adverse events were recorded for each group., Results: The consumption of hydromorphone during the first 24 and 48 postoperative hours was significantly reduced in patients of group K2 compared to those of group C and group K1. The time to extubation and post anesthesia care unit (PACU) stay were significantly shorter in group K2 than in group K1 and group C. The time to first feed and off the bed time after surgery were shorter in groups K1 and K2 than in group C. Patients in group K2 were significantly satisfied with patient controlled intravenous analgesia (PCIA) than in groups K1 and C., Limitations: The sample size calculation was based mainly on the index of hydromorphone consumption., Conclusions: Intraoperative intravenous esketamine at 0.25 mg · kg-1 · h-1 reduced postoperative opioids consumption by 34% in postoperative 24 hours and 30% in postoperative 48 hours in patients undergoing thoracic surgery. It also improved the quality of perioperative recovery.
- Published
- 2022
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.