Search

Your search keyword '"Xing, Chengzhong"' showing total 143 results
Start Over Author "Xing, Chengzhong" Search Limiters Full Text
143 results on '"Xing, Chengzhong"'

1. The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

Author

Liu, Jingwei, Cao, Liangzi, Wang, Yubang, Zou, Yu, Guo, Qiqiang, Chen, Shu, Jiang, Bo, Wu, Xuan, Zheng, Lixia, Zhang, Siyi, Lu, Songming, Zhou, Keshen, Jiang, Pengcheng, Xiao, Yutong, Yang, Ruohan, Dong, Shiyuan, Li, Ziwei, Chen, Di, Zhang, Ying, Zhang, Naijin, Sun, Guozhe, Xing, Chengzhong, Song, Xiaoyu, Wang, Zhenning, and Cao, Liu

Published
2024
Full Text
View/download PDF

6. Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers.

Author

Cao, Liangzi, Li, Hao, Liu, Xiaofang, Wang, Yubang, Zheng, Bowen, Xing, Chengzhong, Zhang, Naijin, and Liu, Jingwei

Subjects
UBIQUITIN ligases, AUTOPHAGY, CELL junctions, GENE families, CANCER genes, PANCREATIC cancer, THYROID cancer
Abstract

NEDD4 family represent an important group of E3 ligases, which regulate various cellular pathways of cell proliferation, cell junction and inflammation. Emerging evidence suggested that NEDD4 family members participate in the initiation and development of tumor. In this study, we systematically investigated the molecular alterations as well as the clinical relevance regarding NEDD4 family genes in 33 cancer types. Finally, we found that NEDD4 members showed increased expression in pancreas cancer and decreased expression in thyroid cancer. NEDD4 E3 ligase family genes had an average mutation frequency in the range of 0-32.1%, of which HECW1 and HECW2 demonstrated relatively high mutation rate. Breast cancer harbors large amount of NEDD4 copy number amplification. NEDD4 family members interacted proteins were enriched in various pathways including p53, Akt, apoptosis and autophagy, which were confirmed by further western blot and flow cytometric analysis in A549 and H1299 lung cancer cells. In addition, expression of NEDD4 family genes were associated with survival of cancer patients. Our findings provide novel insight into the effect of NEDD4 E3 ligase genes on cancer progression and treatment in the future. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

11. Integrative analysis of somatic mutations and differential expression profiles in glioblastoma based on aging acceleration

Author

Wang, Huize, Li, Shiyan, Liu, Hongxin, Bian, Shiyu, Huang, Wanjiang, Xing, Chengzhong, and Wang, Yin

Subjects
urogenital system, Original Article, urologic and male genital diseases, female genital diseases and pregnancy complications, nervous system diseases
Abstract

Background: Glioblastoma (GBM) is an aggressive brain tumor and the mechanisms of progression are very complex. Accelerated aging is a driving factor of GBM. However, there has not been thorough research about the mechanisms of GBM progression based on aging acceleration. Methods: The aging predictor was modeled based on normal brain samples. Then an aging acceleration background network was constructed to explore GBM mechanisms. Results: The accelerated aging-related mechanisms provided an innovative way to study GBM, wherein integrative analysis of somatic mutations and differential expression revealed key pathologic characteristics. Moreover, the influence of the immune system, the nervous system and other critical factors on GBM were identified. The survival analysis also disclosed crucial GBM markers. Conclusion: An integrative analysis of multi-omics data based on aging acceleration identified new driving factors for GBM.

Published
2021

14. A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk

Author

Li, Yanke, Zhang, Fuqiang, and Xing, Chengzhong

Subjects
Article Subject
Abstract

As an important component of miRNA processing genes, RAN gene encodes the ras-related nuclear protein, which is a unique member of the Ras superfamily of GTPases. The mutations in RAN gene are very likely to play a critical role in pathology-related changes to miRNA transport and expression and thus participate in tumor genesis and development. Currently, accumulating studies have explored the association between RAN SNPs and cancer risk. However, the results are conflicting. In the present study, we performed a systematic review for the association of RAN SNPs with overall cancer risk. Meanwhile, a meta-analysis was conducted based on available data, aiming at clarifying the association between RAN SNPs and cancer susceptibility. After literature search and data extraction, 17 studies containing four RAN SNPs were involved in the systematic review. And 12 studies with two highly studied SNPs (RAN rs14035 C>T and rs3803012 A>G) were included in the final meta-analysis, consisting of 7662 cases and 9807 controls. The results showed that the rs14035 polymorphism was linked to a decreased cancer risk in overall subjects and hospital-based (HB) subgroup, while the rs3803012 polymorphism conferred to an increased cancer risk in overall subjects and population-based (PB) subgroup. Our findings suggested that the two SNPs had the potential to be predictive biomarkers for cancer risk. The study would provide novel clues for the identification of miRNA-related genetic biomarkers applied to predicting cancer susceptibility.

Published
2020
Full Text
View/download PDF

19. RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation

Author

Ren, Ling, primary, Zhou, Tingting, additional, Wang, Yang, additional, Wu, Yanmei, additional, Xu, Hongde, additional, Liu, Jingwei, additional, Dong, Xiang, additional, Yi, Fei, additional, Guo, Qiqiang, additional, Wang, Zhuo, additional, Li, Xiaoman, additional, Bai, Ning, additional, Guo, Wendong, additional, Guo, Min, additional, Jiang, Bo, additional, Wu, Xuan, additional, Feng, Yanling, additional, Song, Xiaoyu, additional, Zhang, Siyi, additional, Zhao, Yue, additional, Cao, Liu, additional, Han, Shuai, additional, and Xing, Chengzhong, additional

Published
2020
Full Text
View/download PDF

50. Association between PTEN Gene IVS4 Polymorphism and Risk of Cancer: A Meta-Analysis.

Author

Sun, Liping, Liu, Jingwei, Yuan, Quan, Xing, Chengzhong, and Yuan, Yuan

Subjects
CANCER risk factors, CANCER genetics, PHOSPHATASE genetics, COMPUTATIONAL biology, GENETIC polymorphisms, META-analysis
Abstract

Background: Phosphatase and tensin homolog (PTEN) is a well established tumor suppressor gene. Recently, increasing studies investigated the association between PTEN IVS4 polymorphism (rs3830675) and risk of various types of cancer. However, the results from the individual studies were controversial. The aim of this meta-analysis was to elucidate whether PTEN IVS4 polymorphism was associated with cancer risk. Methods: Databases including PubMed, Web of knowledge and Chinese National Knowledge Infrastructure (CNKI) were systematically searched to identify potentially eligible literatures. Odds ratios (OR) and their 95% confidence interval (CI) were used to assess the strength of association between PTEN IVS4 polymorphism and cancer risk. Results: A total of seven case-control studies were finally included in this meta-analysis. The pooled analysis suggested that individuals with PTEN IVS4 (−/−) genotype were significantly associated with increased risk of cancer (OR = 1.45, 95% CI = 1.19–1.76, P<0.001) and subgroup of digestive tract cancer (OR = 1.67, 95% CI = 1.28–2.18, P<0.001) compared with (+/+) genotype. The allele analysis revealed that (−) allele was significantly associated with increased risk of cancer (OR = 1.30, 95% CI = 1.12–1.50, P = 0.001) and subgroup of digestive tract cancer (OR = 1.42, 95% CI = 1.16–1.74, P = 0.001) compared with (+) allele. No significant association was observed between PTEN IVS4 (+/−) genotype and risk of cancer. Conclusion: PTEN IVS4 (−/−) genotype was significantly associated with increased risk of cancer especially for digestive tract cancer compared with (+/+) genotype. The (−) allele of PTEN IVS4 (rs3830675) polymorphism was significantly associated with increased risk of cancer especially for digestive tract cancer compared with (+) allele. The recessive effect model and dominant effect model also demonstrated significant association between PTEN IVS4 (rs3830675) polymorphism and increased cancer risk especially for digestive tract cancer. Further large-scale and well-designed studies regarding different ethnicities are still required to confirm the results of our meta-analysis. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results