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The metallic complex is widely used in agricultural applications. Due to the oxidation of the metal and environmental unfriendliness of ligand, maintaining an efficient mineral supply for plants without causing environmental damage is difficult. Herein, an antioxidative trimetallic complex with high stability was synthesized by interacting Ca2+, Fe2+, and Zn2+ with the biocompatible ligands from the Maillard reaction. The composite structure elucidation was carried out by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FTIR). Thermal stability was measured by thermogravimetric (TG). Antioxidative activities were evaluated by ferric reducing antioxidant power and radical scavenging activity assays. The three metals were successfully fabricated on the Maillard reaction products (MRPs) with contents of Ca (9.01%), Fe (8.25%), and Zn (9.67%). Microscopy images revealed that the three metals were uniformly distributed on the MRPs with partial aggregation of

This paper mainly investigated the propagation dynamics of the mixed-pattern solitons in strongly nonlocal nonlinear media. The propagation expression of the mixed-pattern soliton is derived, and its propagation characteristics are analyzed, including the evolution of the on-axis light intensity, the contour intensity distributions and the second-order moment beam width. It is found that the evolution behavior of the mixed-pattern soliton is periodic, which is closely related to the incident power and the transformation factor. The evolution of on-axis light intensity can be divided into three situations (depression situation, platform situation and raised situation) depending on the incident power. The evolution of the intensity distributions at the initial position can present three cases (Gaussian-like type, platform type and four-petal type) depending on the transformation factor. A series of numerical simulations are exhibited to explain these typical propagation characteristics. Keywords: Strongly nonlocal nonlinear media, Mixed-pattern soliton, Soliton propagation

We investigate the propagation and evolution of multiple modified hollow Gaussian beams (MHGBs) for the off-axis incident case in highly nonlocal nonlinear media. The propagation expression of the off-axis MHGB is obtained, the evolution characteristics, such as the optical field distribution, the motion track, the off-axis distance, the rotating angle, and the rotating speed of multiple MHGBs have been discussed analytically and graphically. The results of this paper may have potential applications in related research fields such as exploring the control of multi-beam motion track and designing novel high-order beam forms.

Introduction: Oncogenic mutations in the epidermal growth factor receptor (EGFR) occur frequently in patients with lung cancer. These mutations may serve as critical predictive biomarkers in patients with non-small cell lung cancer (NSCLC). Among them, EGFR exon 18–25 kinase domain duplication (EGFR-KDD) mutations have been identified as a novel EGFR gene subtype in NSCLC.Case Presentation: We reported a rare case of a 59-year-old male diagnosed with adenocarcinoma. A biopsy revealed an EGFR-KDD identified by the next generation sequencing (NGS). Effective treatment outcome has been observed after administration with afatinib.Conclusion: This case highlights that comprehensive NGS technique is valuable in detecting novel genetic mutations in tumors.

In this paper, the evolution dynamics of astigmatic four-petal Gaussian beams in isotropic nonlocal nonlinear media is investigated. A series of analytical expressions are derived to describe the beam evolution, the beam width, and the critical power. The anomalous transverse transformation is presented, i.e., an astigmatic four-petal Gaussian beam is compressed in one transverse direction and it is broadened in the other transverse direction. These evolution characteristics of astigmatic four-petal Gaussian beams are illustrated through some numerical simulations. Keywords: Isotropic nonlocal media, Astigmatic four-petal Gaussian beam, Anomalous transverse transformation

In this paper, we mainly investigate the propagation properties of shape-variable four-petal Gaussian vortex breathers in strongly nonlocal nonlinear media. The analytical expression of the shape-variable four-petal Gaussian vortex breather is derived in Cartesian coordinate system by means of mathematical integral method. A series of evolution properties are described analytically and numerically, such as the transverse intensity pattern, the phase distribution, the variation of the second-order moment beam width, and the on-axis light intensity. It is found that the topological charge number and the beam order of the shape-variable four-petal Gaussian vortex breather play important roles in the propagation process, and their effects on the propagation properties of the shape-variable four-petal Gaussian vortex breather are discussed graphically. Keywords: Nonlocal nonlinear media, Four-petal Gaussian vortex breather, Topological charge

In this paper, we focus on the on-axis intensity evolutions of anomalous hollow Gaussian beams in highly nonlocal nonlinear media. It is found that the evolution of on-axis intensity is always periodic and the incident power of the beams plays a key role. By selecting the different amplitude of the incident power, the on-axis intensity evolutions exhibit themselves as three different shapes in each evolution period, i.e. the protrusion situation, the platform situation and the indentation situation. We analyze the three situations in detail, and the extreme values of on-axis intensity and their positions are all given analytically. The influences of the beam ellipticity and the off-waist departure distance on the on-axis intensity evolutions are also discussed. It is found that the evolution of on-axis intensity becomes more complicated, and the on-axis intensity evolution in each period splits into two intensity peaks. Keywords: Highly nonlocal nonlinear medium, Beam propagation, On-axis intensity

In this paper, the interactional behaviors of anomalous vortex beams in highly nonlocal media are investigated. An analytical expression describing the interaction is given, and some numerical simulations are carried out to illustrate the interactional characteristics. It is found that two interactional anomalous vortex beams always attract each other, and their evolution is periodical. The influence of different relative phases between two anomalous vortex beams on their interaction is presented in details. Keywords: Interaction, Anomalous vortex beam, Nonlocal media

In this paper, we focus on the on-axis intensity evolutions of hollow beams in nonlinear media with a high nonlocality. It is found that, the evolutions of on-axis intensity with different beam powers are always periodic during propagation, whereas, depending on different beam powers, the evolution curves of on-axis intensity in each period may exhibit themselves as three different types, namely, a concave, a platform, or a convex shape. The critical power, the extreme values of on-axis intensity and their corresponding positions are all given analytically. Keywords: Nonlocal nonlinearity, Beam propagation, Hollow beams, On-axis intensity

A novel Chinese chestnut (Castanea mollissima Bl.) mutant with extreme short catkins, here was named sck1 and has been characterized in the present study. This sck1 caused 6-fold shorter than wild-type catkins. Endogenous gibberellic acids markedly decreased in the mutant, and application of exogenous GA(3) could partially restore the sck1 phenotype to the wild-type phenotype. Paclobutrazol (PP(333)), an antagonist of GAs biosynthesis, could significantly inhibit the wild-type catkins growth, and lead to a short catkins phenotype similar to the sck1. In addition, compared to the wild-type catkins, the mRNA expression level of ent-kaurenoic acid oxidase (KAO), a gibberellin biosynthesis key gene, was significantly down-regulated (P

BACKGROUND: The aim of the present study is to describe the clinical correlates of hypotension and its associated outcomes in patients with acute organophosphorus poisoning (AOPP). METHODS: In this retrospective cohort study, we analyzed data pertaining to 871 patients with AOPP who were treated at two hospitals. Data from hypotensive and non-hypotensive patients were compared to identify clinical correlates of hypotension. We also evaluated the association between clinical parameters (including hypotension) and in-hospital mortality. RESULTS: The incidence of hypotension in AOPP patients was 16.4%. Hypotensive patients showed significantly higher in-hospital mortality (1.1% vs. 39.9%, P<0.001). Advanced age (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.08-1.44), history of diabetes (OR 2.65, 95% CI 1.14-5.96), and increased white blood cell count (OR 1.06, 95% CI 1.03-1.09), plasma cholinesterase (OR 0.91, 95% CI 0.84-0.94), plasma albumin (OR 0.88, 95% CI 0.85-0.92), serum amylase (OR 1.01, 95% CI 1.01-1.02), and blood pH (OR 0.64, 95% CI 0.54-0.75) were significantly associated with hypotension. After adjusting for potential confounders, hypotension was associated with increased in-hospital mortality (hazard ratio 8.77-37.06, depending on the controlled variables). CONCLUSIONS: Hypotension is a common complication of AOPP and is associated with increased in-hospital mortality. Advanced age, history of diabetes, and changes in laboratory parameters were associated with hypotension in AOPP patients. [ABSTRACT FROM AUTHOR]

Background: Artemisinin-based combination therapy (ACT) is the recommended first-line treatment of falciparum malaria in all endemic countries. Artemisinin resistance in Plasmodium falciparum has been confirmed in the Greater Mekong subregion (GMS). Dihydroartemisinin-piperaquine (DAPQ) is the most commonly used ACT in China. To understand the DAPQ sensitivity of P. falciparum, DAPQ resistance was monitored in vivo along the China-Myanmar border from 2007 to 2013. Methods: Eligible patients with mono-infections of P. falciparum were recruited to this study after obtaining full informed consent. DAPQ tablets for different categories of kg body weight ranges were given once a day for three days. Patients were followed up for 42 days. Polymerase chain reaction (PCR) was conducted to distinguish between re-infection and recrudescence, to confirm the Plasmodium species. The data were entered and analysed by the Kaplan-Meier method. Treatment outcome was assessed according to the WHO recommended standards. Results: 243 patients were completed valid follow-up. The fever clearance time (FCT) and asexual parasite clearance times (APCT) were, respectively, 36.5 ± 10.9 and 43.5 ± 11.8 hours, and there was an increasing trend of both FCT (F = 268.41, P < 0.0001) and APCT (F = 88.6, P < 0.0001) from 2007 to 2013. Eight (3.3%, 95% confidence interval, 1.4-6.4%) patients present parasitaemia on day three after medication; however they were spontaneous cure on day four. 241 (99.2%; 95% CI, 97.1-99.9%) of the patients were adequate clinical and parasitological response (ACPR) and the proportions of ACPR had not changed significantly from 2007 to 2013 (X² = 2.81, P = 0.7288). Conclusion: In terms of efficacy, DAPQ is still an effective treatment for falciparum malaria. DAPQ sensitivity in P. falciparum had not significantly changed along the China-Myanmar border of Yunnan Province, China. However more attentions should be given to becoming slower fever and parasite clearance. [ABSTRACT FROM AUTHOR]

Background: Plasmodium vivax is the most widespread of the malaria parasites infecting human hosts. In malaria-eliminating settings, both imported and local malaria predominantly occurs in border areas, and most of them are P. vivax. Chloroquine (CQ) is the first-line drug for P. vivax treatment in China. To understand CQ sensitivity in P. vivax, in vivo monitoring of CQ resistance was conducted along the China-Myanmar border from 2008 to 2013. Methods: Eligible patients with mono-infections of P. vivax were recruited to this study after obtaining full informed consent. CQ tablets for different categories of kg body weight ranges were given once a day for three days. Patients were followed up for 28 days. PCR was conducted to distinguish between re-infection and recrudescence, to confirm the Plasmodium species. The data were entered and analysed by the Kaplan-Meier method. Treatment outcome and sensitivity were classified according to the WHO recommended standards. Results: 603 patients were completed valid follow-up. The fever clearance time and asexual parasite clearance times were, respectively, 22.2 ± 10.2 and 38.1 ± 12.6 hours. 594 (98.5%) patients were adequate clinical and parasitological response (ACPR), and nine (1.5%) patients, who were late clinical failure (LCF) or resistant response level I (RI), were imported from the neighbouring districts of Myanmar. Conclusion: In terms of efficacy, CQ is still effective for vivax malaria treatment. Plasmodium vivax CQ sensitivity had not significantly changed along the China-Myanmar border of Yunnan Province, China. [ABSTRACT FROM AUTHOR]