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Your search keyword '"Xu, Song-Tao"' showing total 27 results
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27 results on '"Xu, Song-Tao"'

1. Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

Author

Liu, Si-Yang, Bao, Hua, Wang, Qun, Mao, Wei-Min, Chen, Yedan, Tong, Xiaoling, Xu, Song-Tao, Wu, Lin, Wei, Yu-Cheng, Liu, Yong-Yu, Chen, Chun, Cheng, Ying, Yin, Rong, Yang, Fan, Ren, Sheng-Xiang, Li, Xiao-Fei, Li, Jian, Huang, Cheng, Liu, Zhi-Dong, Xu, Shun, Chen, Ke-Neng, Xu, Shi-Dong, Liu, Lun-Xu, Yu, Ping, Wang, Bu-Hai, Ma, Hai-Tao, Yan, Hong-Hong, Dong, Song, Zhang, Xu-Chao, Su, Jian, Yang, Jin-Ji, Yang, Xue-Ning, Zhou, Qing, Wu, Xue, Shao, Yang, Zhong, Wen-Zhao, and Wu, Yi-Long

Published
2021
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2. The Unique Spatial-Temporal Treatment Failure Patterns of Adjuvant Gefitinib Therapy: A Post Hoc Analysis of the ADJUVANT Trial (CTONG 1104)

Author

Xu, Song-Tao, Xi, Jun-Jie, Zhong, Wen-Zhao, Mao, Wei-Min, Wu, Lin, Shen, Yi, Liu, Yong-Yu, Chen, Chun, Cheng, Ying, Xu, Lin, Wang, Jun, Fei, Ke, Li, Xiao-Fei, Li, Jian, Huang, Cheng, Liu, Zhi-Dong, Xu, Shun, Chen, Ke-Neng, Xu, Shi-Dong, Liu, Lun-Xu, Yu, Ping, Wang, Bu-Hai, Ma, Hai-Tao, Yan, Hong-Hong, Yang, Xue-Ning, Zhang, Yong-Xing, Yin, Jia-Cheng, Wang, Qun, and Wu, Yi-Long

Published
2019
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3. Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing*.

Author

ZHANG, Ya Li, SU, Wen Zhe, WANG, Rui Chen, LI, Yan, ZHANG, Jun Feng, LIU, Sheng Hui, HU, Dan He, XU, Chong Xiao, YIN, Jia Yu, YIN, Qi Kai, HE, Ying, LI, Fan, FU, Shi Hong, NIE, Kai, LIANG, Guo Dong, TAO, Yong, XU, Song Tao, MA, Chao Feng, and WANG, Huan Yu

Subjects
VIRAL encephalitis, CENTRAL nervous system infections, NUCLEOTIDE sequencing, PATHOGENIC bacteria, FLAVIVIRUSES, CLINICAL pathology, POLYMERASE chain reaction
Abstract

Viral encephalitis is an infectious disease severely affecting human health. It is caused by a wide variety of viral pathogens, including herpes viruses, flaviviruses, enteroviruses, and other viruses. The laboratory diagnosis of viral encephalitis is a worldwide challenge. Recently, high-throughput sequencing technology has provided new tools for diagnosing central nervous system infections. Thus, In this study, we established a multipathogen detection platform for viral encephalitis based on amplicon sequencing. We designed nine pairs of specific polymerase chain reaction (PCR) primers for the 12 viruses by reviewing the relevant literature. The detection ability of the primers was verified by software simulation and the detection of known positive samples. Amplicon sequencing was used to validate the samples, and consistency was compared with Sanger sequencing. The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×, and the sequence lengths were consistent with the sizes of the predicted amplicons. The sequences were verified using the National Center for Biotechnology Information BLAST, and all results were consistent with the results of Sanger sequencing. Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral encephalitis. It is also a useful tool for the high-volume screening of clinical samples. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Prognostic and clinicopathologic significance of PAQR3 and VEGF-A expression in pulmonary adenocarcinoma

Author

Shen, Xiao-Chun, Zhan, Sheng-Hua, Xu, Song-Tao, and Gu, Guo-Jian

Subjects
Original Article
Abstract

Progesterone and adipoQ receptor family member 3 (PAQR3) and vascular endothelial growth factor (VEGF)-A are associated with tumorigenesis and progression. The aim of this study is to investigate the expression of PAQR3 and VEGF-A in pulmonary adenocarcinoma (PA) and explore their clinical and pathologic significance. The expressions of PAQR3 and VEGF-A protein were detected in 86 cases of human PA and 26 cases of tumor-adjacent tissue by immunohistochemistry. The positive rate of PAQR3 was 39.5% in PA, which was lower than that in tumor-adjacent tissues (80.8%), P=0.001. Negative expression of PAQR3 was obviously linked to tumor TNM stage, differentiation, and lymphatic metastasis; and P values were 0.013, 0.025, and 0.034, respectively. The positive expression rate of VEGF-A was 68.6% in human PA whichwas higher than that of tumor-adjacent tissues (11.5%), P

Published
2020

16. The overexpression of uPA promotes the proliferation and fibrinolytic activity of human umbilical vein endothelial cells

Author

Song, Tao, Meng, Song, Xu, Song-Tao, Jin, Shao-Ju, Zeng, Qing-Zhong, and Gu, Guo-Jian

Subjects
Original Article
Abstract

The purpose of this article is to study whether the overexpression of urokinase-type plasminogen activator (uPA) can promote the proliferation and fibrinolytic activity of human umbilical vein endothelial cells (HUVECs). The recombinant adenovirus vectors containing the human uPA gene were constructed and transfected into HUVECs. In this study, the mRNA of uPA was detected by qPCR, and the uPA protein was measured by Western blot. The cell proliferation was measured using MTT. The fibrinolytic activity of uPA was quantified using a colorimetric assay. We also measured MMP2 (metalloproteinase-2), MMP9 (metalloproteinase-9), and VEGF (vascular endothelial growth factor) proteins using ELISA. The results showed that the levels of the uPA mRNA and the protein in the overexpression group were significantly higher compared to the other groups, (P < 0.05). The cell proliferation and uPA activity were increased significantly in the overexpression group, compared to the other groups, (P < 0.05). The secretions of MMP2, MMP9, and VEGF in the overexpression group were significantly higher than they were in the other two groups (P < 0.05). In conclusion, we successfully transfected a recombined adenovirus vector carrying uPA into a HUVEC. The exogenous uPA gene could transcribe and secrete the uPA protein in the HUVECs. The overexpression of uPA can increase cell proliferation and uPA activity. It can improve the invasion and angiogenesis ability in HUVECs by promoting their secretions of MMP2, MMP9, and VEGF.

Published
2019

17. Prognostic and clinicopathologic significance of AEG-1/MTDH and E-cadherin expression in human gallbladder carcinoma

Author

Xu, Song-Tao, Ma, Yong-Chao, Wang, Cai-Hong, Xu, Yue, and Gu, Guo-Jian

Subjects
Original Article
Abstract

Astrocyte elevated gene-1 (AEG-1) and E-cadherin are associated with tumorigenesis and progression. The aim of this study is to investigate the expression of AEG-1 and E-cadherin in human gallbladder cancer (GBC) and explore their clinical and pathological significance. The expression of AEG-1 and E-cadherin protein were detected in 71 cases of human GBC and 22 cases of tumor-adjacent tissue by the immunohistochemical method. Our results demonstrate that the positive expression (high expression) rate of AEG-1 was 62.0% in human GBC which was higher than that in tumor-adjacent tissues (13.6%), P

Published
2018

18. Japanese Encephalitis in China in the Period of 1950–2018: From Discovery to Control.

Author

CHEN, Xiao Jing, WANG, Huan Yu, LI, Xiao Long, GAO, Xiao Yan, LI, Ming Hua, FU, Shi Hong, HE, Ying, LI, Fan, YIN, Qi Kai, XU, Song Tao, WU, Dan, LI, Yi Xing, YIN, Zun Dong, YANG, Guang, and LIANG, Guo Dong

Subjects
JAPANESE B encephalitis
Abstract

Japanese Encephalitis in China in the Period of 1950-2018: From Discovery to Control. [Extracted from the article]

Published
2021
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26. Serological Investigation into the Infected Genotypes of Patients with Japanese Encephalitis in the Coastal Provinces of China.

Author

Zhang WJ, Zhao JR, Yin QK, Liu SH, Wang RC, Fu SH, Li F, He Y, Nie K, Liang GD, Xu ST, Yang G, and Wang HY

Subjects
Humans, China epidemiology, Female, Male, Adult, Middle Aged, Young Adult, Adolescent, Child, Child, Preschool, Aged, Antibodies, Viral blood, Encephalitis, Japanese epidemiology, Encephalitis, Japanese virology, Genotype, Encephalitis Virus, Japanese genetics, Encephalitis Virus, Japanese isolation & purification, Encephalitis Virus, Japanese immunology
Abstract

Objective: Genotypes (G) 1, 3, and 5 of the Japanese encephalitis virus (JEV) have been isolated in China, but the dominant genotype circulating in Chinese coastal areas remains unknown. We searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis (JE) in the coastal provinces of China., Methods: In this study, we collected serum specimens from patients with JE in three coastal provinces of China (Guangdong, Zhejiang, and Shandong) from 2018 to 2020 and conducted JEV cross-neutralization tests against G1, G3, and G5., Results: Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong (92 patients), Zhejiang (192 patients), and Guangdong (77 patients), China, from 2018 to 2020. Seventy of the 361 serum specimens were laboratory-confirmed to be infected with JEV. Two cases were confirmed to be infected with G1 JEV, 32 with G3 JEV, and two with G5 JEV., Conclusion: G3 was the primary infection genotype among JE cases with a definite infection genotype, and the infection caused by G5 JEV was confirmed serologically in China., (Copyright © 2024 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)

Published
2024
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