Search

Additional file 1.

Additional file 1.

Additional file 2: Table S1. Primers for qRT-PCR.

Additional file 3.

Additional file 2.

The discharge in a full flow regime represents the discharge capacity of a vertical pipe, and the Darcy–Weisbach friction factor () is an important variable to calculate discharge. Since all existing equations for contain the Reynolds number (Re), it is problematic if the velocity is unknown. In this study, the performance of existing equations collected from studies on vertical pipes is assessed, and an approximation for the of vertical pipes in the full flow regime, without Re, is proposed. The performance of the Brkić and Praks equation is the best, with a maximum relative error (MRE) of 0.003% (extremely accurate). The MRE of the new approximation is 0.43%, and its assessment level is very accurate. This work is expected to provide a reference for the design and investigation of the drainage of vertical pipes.

Purpose To study the functional role and prognosis of EIF4G1 in lung squamous cell carcinoma (LSCC). Methods The clinical relevance of EIF4G1 in LSCC was investigated following detection of the expression levels of EIF4G1 by immunohistochemical staining (IHC). The expression levels of EIF4G1, AKT2, p-AKT, mTOR, cyclin D1 and β-actin were detected by western blot analysis. The cell proliferation and colony formation assays were used to detect the cell proliferative ability; flow-cytometry was used to assess the cell cycle; an invasion assay was used to detect cell invasive ability and the real-time quantitative polymerase chain reaction (Q-PCR) assay was used to assess the expression levels of EIF4G1 and β-actin. The role of EIF4G1 was verified by xenograft models. These experimental methods were employed to assess the functional role of EIF4G1 in LSCC pathogenesis. Results EIF4G1 was overexpressed in LSCC tumor tissues (P P = 0.002) and clinical stage (I vs II vs III + IV) (P P = 0.008, HR = 2.277, 95% CI = 1.250–4.145) could be used to predict the overall survival of LSCC patients as determined by the Cox’s proportional hazard model. High expression of EIF4G1 exhibited a lower survival (LogRank = 7.167, P = 0.007) in LSCC. Downregulation of EIF4G1 significantly inhibited LSCC proliferation, invasion and cell cycle progression. Conclusion EIF4G1 promotes LSCC cell proliferation and may represent an indicator of prognosis in LSCC.

On a global scale, the demand for mineral products has increased substantially with economic development. Consequently, the mining of mineral resources results in the production and accumulation of a large number of tailings, causing many problems with respect to mining, the environment, and the economy. In the mining process, tailings must be reasonably treated to prevent them from entering the water cycle through rivers. The storage of tailings under water can effectively hinder the chemical reactions that they undergo. Therefore, it is a critical practice to store these substances in ponds or impoundments behind dams. However, tailings dams frequently fail, resulting in the discharge of significant quantities of tailings into the natural environment, thereby causing grievous casualties and serious economic losses. This paper discusses reasons including seepage, foundation failure, overtopping, and earthquake for tailings dam failures and explores failure mechanisms by referring to the available literature. This research has determined that the failure of tailings dams is closely related to the state of the country’s economy. Most of the tailings dam breakages in developed countries occurred decades ago. In recent years, the proportion of tailings dam failures in developing countries has been relatively high. Considering the serious damages caused by tailings dam breakage, it is important to understand the main reasons and mechanisms for their failure. The purpose of this review is to provide a reference for the design and construction to the building of the tailing dams and to reduce the occurrences of their failure.