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4,768 results on '"Y, Kobayashi"'

1. Electrical conductivity anisotropy of InGaZn3O6 single crystals by pressurized optical floating zone growth and its oxygen annealing effect

Author: N. Kase, Y. Kawamura, Y. Kobayashi, T. Inoue, K. Tanaka, and N. Miyakawa
Subjects: Biotechnology, TP248.13-248.65, Physics, QC1-999
Abstract: Large bulk single crystals of InGaZn3O6 (InGaO3(ZnO)3 or IGZO-13) have been successfully grown using an optical floating zone method under a flow of dry-air at high pressure. These crystals exhibit a distinct blue hue in their as-grown state, with notable enhancement in transparency attainable through O2 annealing. Comparative analysis with IGZO-11 reveals a substantial reduction in conductivity following O2 annealing. Moreover, a pronounced in-plane/out-of-plane conductive anisotropy ranging from 100 to 450 is observed, surpassing that of IGZO-11 under similar in-plane conductivity conditions. This increase in electrical conducting anisotropy is ascribed to the incorporation of ZnO blocks amid the two InO layers, aligned along the c axis. Based on these findings, it is concluded that the contribution of In-5s orbitals likely assumes a predominant role, surpassing that of other cations from an experimental standpoint.
Published: 2024
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2. Efficacy of a 'provisional incision' for longitudinal flap division after free-flap surgery

Author: Y. Izawa, H. Murakami, T. Shirakawa, M. Nishida, K. Futamura, Y. Kobayashi, and Y. Tsuchida
Subjects: Open fracture, Free-flap surgery, Flap necrosis, Provisional incision, Surgery, RD1-811
Abstract: Summary: Fix and flap surgery for severe open limb fractures is already a standard treatment. In cases where the fracture is complicated or accompanied by bone defects, secondary surgery is required for fracture sites covered with a myocutaneous flap after the soft tissue condition has stabilized. We applied the delayed procedure concept used for distant flaps and attempted to prevent postoperative myocutaneous flap necrosis by performing a provisional incision prior to the longitudinal incision of the flap. We report the course of five cases of the longitudinal division of the myocutaneous flap using “provisional incision” after free-flap surgery for severe open fracture and verify its usefulness. In this case series, five patients with severe open limb fractures treated from 2020 to 2021 who underwent longitudinal incision of the myocutaneous flap using provisional incision after free-flap surgery were included. The types of flaps used for soft tissue reconstruction in the acute phase, the reasons for the need for secondary surgery, the period from soft tissue reconstruction to additional surgery, and the healing status of soft tissue after secondary surgery were all investigated retrospectively. The types of flaps used for soft tissue reconstruction were latissimus dorsi myocutaneous flap in four cases and anterolateral thigh flap in one case. The breakdown of secondary surgery was osteosynthesis in one case, plate removal in one case, and bone cement removal and autologous bone grafting in three cases. The period from soft tissue reconstruction to secondary surgery ranged from 6 weeks to 4 months. In all cases, the wound healed without necrosis of the myocutaneous flap. For the treatment of severe open limb fractures, longitudinal division of the myocutaneous flap using “provisional incision” is a safer approach to the necessary secondary surgery and reduces the possibility of necrosis of the flap.
Published: 2022
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3. APPLICATION OF PRE-TRAINED REAL-WORLD SUPER RESOLUTION MODELS TO OPTICAL SATELLITE IMAGE

Author: T. Shinohara, R. Ito, Y. Kobayashi, T. Satoh, Y. Shimazaki, and S. Nakamura
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: The single image super-resolution (SISR) technique refers to improving the resolution over the original image. In recent years, we use deep learning-based convolutional neural networks to improve the spatial resolution of images more reasonably. To train such deep learning models, we use training samples consisting of the original HR images and LR images obtained by bicubic downsampling. However, this method of training data using downsampling has a negative impact when applying the trained model to real images. That is because the downsampling function that occurs in the real image is unknown, and the hypothetically created LR image does not represent the resolution degradation that can realistically occur. Therefore, SISR methods that use realistic degradation called real-world super-resolution (RWSR) have been proposed. In this paper, we investigate how such RWSR methods using realistic degradation affect the SISR performance of satellite images. The results of applying the trained model to optical satellite images show that the RWSR method is not the most effective way to handle optical satellite images when compared to the deep learning method without modeling the degradation. In particular, we showed that the effect of RWSR with not only upsampling but also noise and blur removal is significant in the visibility of optical satellite images. Moreover, pre-trained RWSR models can be an aid in visually deciphering ground objects.
Published: 2022
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4. A new method to quantify particulate sodium and potassium salts (nitrate, chloride, and sulfate) by thermal desorption aerosol mass spectrometry

Author: Y. Kobayashi and N. Takegawa
Subjects: Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract: The reaction of sea salt (or biomass burning) particles with sulfuric acid and nitric acid leads to the displacement of chloride relative to sodium (or potassium). We have developed a new particle mass spectrometer to quantify non-refractory and refractory sulfate aerosols (referred to as refractory aerosol thermal desorption mass spectrometer: rTDMS). The combination of a graphite particle collector and a carbon dioxide laser enables high desorption temperature (blackbody equivalent radiation temperature of up to 930 ∘C). Ion signals originating from evolved gas molecules are detected by a quadrupole mass spectrometer. Here we propose a new method to quantify the mass concentrations of sodium nitrate (NaNO3: SN), sodium chloride (NaCl: SC), sodium sulfate (Na2SO4: SS), potassium nitrate (KNO3: PN), potassium chloride (KCl: PC), and potassium sulfate (K2SO4: PS) particles by using the rTDMS. Laboratory experiments were performed to test the sensitivities of the rTDMS to various types of particles. We measured ion signals originating from single-component particles for each compound and found a good linearity (r2>0.8) between the major ion signals and mass loadings. We also measured ion signals originating from internally mixed SN + SC + SS (or PN + PC + PS) particles and found that the temporal profiles of ion signals at m/z 23 (Na+) (or 39; K+) were characterized by three sequential peaks associated with the evolution of the desorption temperature. We tested potential interferences in the quantification of sea salt particles under real-world conditions by artificially generating “modified” sea salt particles from a mixture of diluted seawater and SN (or SS) solution. The SS/SC ratios estimated from the ion signals at m/z 23, 36 (H35Cl+), and 48 (SO+) agreed well with those predicted from the solution concentrations to within ∼10 %. The SN/SC ratios estimated from the ion signals at m/z 30 (NO+) and 36 also agreed with those predicted from the solution concentrations to within ∼15 %, whereas the SN/SC ratios estimated from m/z 23 were significantly lower than the predicted values. Based on these experimental results, the applicability of the rTDMS to ambient measurements of sea salt particles is discussed.
Published: 2022
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5. Volatile metabolites from new cultivars of catnip and oregano as potential antibacterial and insect repellent agents

Author: Harna K. Patel, Erik Nunes Gomes, Qingli Wu, Nrupali Patel, Donald Y. Kobayashi, Changlu Wang, and James E. Simon
Subjects: carvacrol, essential oil, nepetalactone, urban pest, bacterial plant pathogen, Pseudomonas, Plant culture, SB1-1110
Abstract: Plant based natural products have been widely used as antibacterial and insect repellent agents globally. Because of growing resistance in bacterial plant pathogens and urban pests to current methods of control, combined with the long- and short-term negative impact of certain chemical controls in humans, non-target organisms, and the environment, finding alternative methods is necessary to prevent and/or mitigate losses caused by these pathogens and pests. The antibacterial and insect repellent activities of essential oils of novel cultivars of catnip (Nepeta cataria L. cv. CR9) and oregano (Origanum vulgare L. cv. Pierre) rich in the terpenes nepetalactone and carvacrol, respectively, were evaluated using the agar well diffusion assay and petri dish repellency assay. The essential oils exhibit moderate to high antibacterial activity against three plant pathogens, Pseudomonas cichorii, Pseudomonas syringae and Xanthomonas perforans of economic interest and the individual essential oils, their mixtures and carvacrol possess strong insect repellent activity against the common bed bug (Cimex lectularius L.), an urban pest of major significance to public health. In this study, the essential oils of catnip and oregano were determined to be promising candidates for further evaluation and development as antibacterial agents and plant-based insect repellents with applications in agriculture and urban pest management.
Published: 2023
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6. Multiwavelength study of the gravitationally lensed blazar QSO B0218+357 between 2016 and 2020

Author: V A Acciari, S Ansoldi, L A Antonelli, A Arbet Engels, M Artero, K Asano, D Baack, A Babić, A Baquero, U Barres de Almeida, J A Barrio, I Batković, J Becerra González, W Bednarek, L Bellizzi, E Bernardini, M Bernardos, A Berti, J Besenrieder, W Bhattacharyya, C Bigongiari, A Biland, O Blanch, G Bonnoli, Ž Bošnjak, G Busetto, R Carosi, G Ceribella, M Cerruti, Y Chai, A Chilingarian, S Cikota, S M Colak, E Colombo, J L Contreras, J Cortina, S Covino, G D’Amico, V D’Elia, P Da Vela, F Dazzi, A De Angelis, B De Lotto, M Delfino, J Delgado, C Delgado Mendez, D Depaoli, F Di Pierro, L Di Venere, E Do Souto Espiñeira, D Dominis Prester, A Donini, D Dorner, M Doro, D Elsaesser, V Fallah Ramazani, A Fattorini, G Ferrara, M V Fonseca, L Font, C Fruck, S Fukami, R J García López, M Garczarczyk, S Gasparyan, M Gaug, N Giglietto, F Giordano, P Gliwny, N Godinović, J G Green, D Green, D Hadasch, A Hahn, L Heckmann, J Herrera, J Hoang, D Hrupec, M Hütten, T Inada, S Inoue, K Ishio, Y Iwamura, I Jiménez, J Jormanainen, L Jouvin, Y Kajiwara, M Karjalainen, D Kerszberg, Y Kobayashi, H Kubo, J Kushida, A Lamastra, D Lelas, F Leone, E Lindfors, S Lombardi, F Longo, R López-Coto, M López-Moya, A López-Oramas, S Loporchio, B Machado de Oliveira Fraga, C Maggio, P Majumdar, M Makariev, M Mallamaci, G Maneva, M Manganaro, K Mannheim, L Maraschi, M Mariotti, M Martínez, D Mazin, S Menchiari, S Mender, S Mićanović, D Miceli, T Miener, M Minev, J M Miranda, R Mirzoyan, E Molina, A Moralejo, D Morcuende, V Moreno, E Moretti, V Neustroev, C Nigro, K Nilsson, K Nishijima, K Noda, S Nozaki, Y Ohtani, T Oka, J Otero-Santos, S Paiano, M Palatiello, D Paneque, R Paoletti, J M Paredes, L Pavletić, P Peñil, C Perennes, M Persic, P G Prada Moroni, E Prandini, C Priyadarshi, I Puljak, W Rhode, M Ribó, J Rico, C Righi, A Rugliancich, L Saha, N Sahakyan, T Saito, S Sakurai, K Satalecka, F G Saturni, B Schleicher, K Schmidt, T Schweizer, J Sitarek, I Šnidarić, D Sobczynska, A Spolon, A Stamerra, D Strom, M Strzys, Y Suda, T Surić, M Takahashi, F Tavecchio, P Temnikov, T Terzić, M Teshima, L Tosti, S Truzzi, A Tutone, S Ubach, J van Scherpenberg, G Vanzo, M Vazquez Acosta, S Ventura, V Verguilov, C F Vigorito, V Vitale, I Vovk, M Will, C Wunderlich, D Zarić, F de Palma, F D’Ammando, A Barnacka, D K Sahu, M Hodges, T Hovatta, S Kiehlmann, W Max-Moerbeck, A C S Readhead, R Reeves, T J Pearson, A Lähteenmäki, I Björklund, M Tornikoski, J Tammi, S Suutarinen, K Hada, and K Niinuma
Published: 2021
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7. INVESTIGATING THE EFFECTS OF RIVER DISCHARGES ON SUBMERGED AQUATIC VEGETATION USING UAV IMAGES AND GIS TECHNIQUES

Author: A. Tamondong, T. Nakamura, Y. Kobayashi, M. Garcia, and K. Nadaoka
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: One of the major factors controlling the distribution and abundance of marine submerged aquatic vegetation (SAV) is light availability. Reduced water clarity due to sediment loading from rivers greatly affects the health and coverage of seagrasses and seaweeds. Monitoring SAV using unmanned aerial vehicles (UAV) has been getting attention because of its cost-effectiveness and ease of use. In this research, a low-cost UAV was utilized to assess the impacts of river discharges on SAV in Busuanga Island, Philippines. Linear regression was performed to determine the effectivity and accuracy of UAV-based percent cover estimation compared to established field survey methods of monitoring SAV. Water quality was estimated in the study area by performing spatial interpolation methods of in situ measurement of turbidity, chlorophyll, temperature, salinity, and dissolved oxygen using a multi-parameter water quality sensor. Current velocity and tidal fluctuations were monitored using bottom-mounted sensors deployed near the river mouth and in seagrass and seaweed areas with relatively good water clarities. Four stations were surveyed using automated UAV missions which were flown simultaneously with field observations. Each station surveyed has varying distances from the river mouth. Results from the classification of the UAV data and field survey show that SAV is more abundant as the distance from the river mouth increases and the turbidity decreases. Classification overall accuracies of UAV orthophotos ranging from 87.91–93.41% were achieved using Maximum Likelihood (ML) Classification. Comparison of field-based and UAV-based survey of percent cover of seagrasses show an overestimation of 1.75 times from the UAV compared to field observations.
Published: 2020
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8. Observations of the Crab Nebula and Pulsar with the Large-sized Telescope Prototype of the Cherenkov Telescope Array

Author: H. Abe, K. Abe, S. Abe, A. Aguasca-Cabot, I. Agudo, N. Alvarez Crespo, L. A. Antonelli, C. Aramo, A. Arbet-Engels, C. Arcaro, M. Artero, K. Asano, P. Aubert, A. Baktash, A. Bamba, A. Baquero Larriva, L. Baroncelli, U. Barres de Almeida, J. A. Barrio, I. Batkovic, J. Baxter, J. Becerra González, E. Bernardini, M. I. Bernardos, J. Bernete Medrano, A. Berti, P. Bhattacharjee, N. Biederbeck, C. Bigongiari, E. Bissaldi, O. Blanch, G. Bonnoli, P. Bordas, A. Borghese, A. Bulgarelli, I. Burelli, M. Buscemi, M. Cardillo, S. Caroff, A. Carosi, F. Cassol, D. Cauz, G. Ceribella, Y. Chai, K. Cheng, A. Chiavassa, M. Chikawa, L. Chytka, A. Cifuentes, J. L. Contreras, J. Cortina, H. Costantini, G. D’Amico, M. Dalchenko, A. De Angelis, M. de Bony de Lavergne, B. De Lotto, R. de Menezes, G. Deleglise, C. Delgado, J. Delgado Mengual, D. della Volpe, M. Dellaiera, D. Depaoli, A. Di Piano, F. Di Pierro, R. Di Tria, L. Di Venere, C. Díaz, R. M. Dominik, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsässer, G. Emery, J. Escudero, V. Fallah Ramazani, G. Ferrara, F. Ferrarotto, A. Fiasson, L. Freixas Coromina, S. Fröse, S. Fukami, Y. Fukazawa, E. Garcia, R. Garcia López, C. Gasbarra, D. Gasparrini, F. Geyer, J. Giesbrecht Paiva, N. Giglietto, F. Giordano, E. Giro, P. Gliwny, N. Godinovic, R. Grau, D. Green, J. Green, S. Gunji, J. Hackfeld, D. Hadasch, A. Hahn, K. Hashiyama, T. Hassan, K. Hayashi, L. Heckmann, M. Heller, J. Herrera Llorente, K. Hirotani, D. Hoffmann, D. Horns, J. Houles, M. Hrabovsky, D. Hrupec, D. Hui, M. Hütten, M. Iarlori, R. Imazawa, T. Inada, Y. Inome, K. Ioka, M. Iori, K. Ishio, Y. Iwamura, M. Jacquemont, I. Jimenez Martinez, J. Jurysek, M. Kagaya, V. Karas, H. Katagiri, J. Kataoka, D. Kerszberg, Y. Kobayashi, A. Kong, H. Kubo, J. Kushida, M. Lainez, G. Lamanna, A. Lamastra, T. Le Flour, M. Linhoff, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, P. L. Luque-Escamilla, P. Majumdar, M. Makariev, D. Mandat, M. Manganaro, G. Manicò, K. Mannheim, M. Mariotti, P. Marquez, G. Marsella, J. Martí, O. Martinez, G. Martínez, M. Martínez, P. Marusevec, A. Mas-Aguilar, G. Maurin, D. Mazin, E. Mestre Guillen, S. Micanovic, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, T. Mizuno, M. Molero Gonzalez, E. Molina, T. Montaruli, I. Monteiro, A. Moralejo, D. Morcuende, A. Morselli, K. Mrakovcic, K. Murase, A. Nagai, S. Nagataki, T. Nakamori, L. Nickel, M. Nievas, K. Nishijima, K. Noda, D. Nosek, S. Nozaki, M. Ohishi, Y. Ohtani, T. Oka, N. Okazaki, A. Okumura, R. Orito, J. Otero-Santos, M. Palatiello, D. Paneque, F. R. Pantaleo, R. Paoletti, J. M. Paredes, M. Pech, M. Pecimotika, M. Peresano, A. Pérez, E. Pietropaolo, G. Pirola, C. Plard, F. Podobnik, V. Poireau, M. Polo, E. Pons, E. Prandini, J. Prast, G. Principe, C. Priyadarshi, M. Prouza, R. Rando, W. Rhode, M. Ribó, V. Rizi, G. Rodriguez Fernandez, J. E. Ruiz, T. Saito, S. Sakurai, D. A. Sanchez, T. Šarić, Y. Sato, F. G. Saturni, B. Schleicher, F. Schmuckermaier, J. L. Schubert, F. Schussler, T. Schweizer, M. Seglar Arroyo, R. Silvia, J. Sitarek, V. Sliusar, A. Spolon, J. Strišković, M. Strzys, Y. Suda, Y. Sunada, H. Tajima, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, P. H. T. Tam, S. J. Tanaka, D. Tateishi, L. A. Tejedor, P. Temnikov, Y. Terada, K. Terauchi, T. Terzic, M. Teshima, M. Tluczykont, F. Tokanai, D. F. Torres, P. Travnicek, S. Truzzi, A. Tutone, G. Uhlrich, M. Vacula, P. Vallania, J. van Scherpenberg, M. Vázquez Acosta, V. Verguilov, I. Viale, A. Vigliano, C. F. Vigorito, V. Vitale, G. Voutsinas, I. Vovk, T. Vuillaume, R. Walter, M. Will, T. Yamamoto, R. Yamazaki, T. Yoshida, T. Yoshikoshi, N. Zywucka, K. Bernlöhr, O. Gueta, K. Kosack, G. Maier, and J. Watson
Subjects: Gamma-ray astronomy, Gamma-ray sources, Astronomy data analysis, Pulsar wind nebulae, Pulsars, Astrophysics, QB460-466
Abstract: The Cherenkov Telescope Array (CTA) is a next-generation ground-based observatory for gamma-ray astronomy at very high energies. The Large-Sized Telescope prototype (LST-1) is located at the CTA-North site, on the Canary Island of La Palma. LSTs are designed to provide optimal performance in the lowest part of the energy range covered by CTA, down to ≃20 GeV. LST-1 started performing astronomical observations in 2019 November, during its commissioning phase, and it has been taking data ever since. We present the first LST-1 observations of the Crab Nebula, the standard candle of very-high-energy gamma-ray astronomy, and use them, together with simulations, to assess the performance of the telescope. LST-1 has reached the expected performance during its commissioning period—only a minor adjustment of the preexisting simulations was needed to match the telescope’s behavior. The energy threshold at trigger level is around 20 GeV, rising to ≃30 GeV after data analysis. Performance parameters depend strongly on energy, and on the strength of the gamma-ray selection cuts in the analysis: angular resolution ranges from 0.°12–0.°40, and energy resolution from 15%–50%. Flux sensitivity is around 1.1% of the Crab Nebula flux above 250 GeV for a 50 hr observation (12% for 30 minutes). The spectral energy distribution (in the 0.03–30 TeV range) and the light curve obtained for the Crab Nebula agree with previous measurements, considering statistical and systematic uncertainties. A clear periodic signal is also detected from the pulsar at the center of the Nebula.
Published: 2023
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9. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author: H. Abe, S. Abe, V. A. Acciari, I. Agudo, T. Aniello, S. Ansoldi, L. A. Antonelli, A. Arbet-Engels, C. Arcaro, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Baxter, J. Becerra González, W. Bednarek, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, I. Burelli, G. Busetto, R. Carosi, M. Carretero-Castrillo, A. J. Castro-Tirado, G. Ceribella, Y. Chai, A. Chilingarian, S. Cikota, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, G. Emery, J. Escudero, V. Fallah Ramazani, L. Fariña, A. Fattorini, L. Foffano, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, J. G. Giesbrecht Paiva, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, R. Grau, D. Green, J. G. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, D. Hrupec, M. Hütten, R. Imazawa, T. Inada, R. Iotov, K. Ishio, I. Jiménez Martínez, J. Jormanainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, E. Lyard, B. Machado de Oliveira Fraga, P. Majumdar, M. Makariev, G. Maneva, N. Mang, M. Manganaro, S. Mangano, K. Mannheim, M. Mariotti, M. Martínez, A. Mas-Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, H. A. Mondal, A. Moralejo, D. Morcuende, V. Moreno, T. Nakamori, C. Nanci, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, T. Njoh Ekoume, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, A. Okumura, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, M. Persic, M. Pihet, G. Pirola, F. Podobnik, P. G. Prada Moroni, E. Prandini, G. Principe, C. Priyadarshi, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, F. Schmuckermaier, J. L. Schubert, T. Schweizer, J. Sitarek, V. Sliusar, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, H. Tajima, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, K. Terauchi, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, M. Vazquez Acosta, S. Ventura, V. Verguilov, I. Viale, C. F. Vigorito, V. Vitale, I. Vovk, R. Walter, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, The MAGIC Collaboration, M. Cerruti, J. A. Acosta-Pulido, G. Apolonio, R. Bachev, M. Baloković, E. Benítez, I. Björklund, V. Bozhilov, L. F. Brown, A. Bugg, W. Carbonell, M. I. Carnerero, D. Carosati, C. Casadio, W. Chamani, W. P. Chen, R. A. Chigladze, G. Damljanovic, K. Epps, A. Erkenov, M. Feige, J. Finke, A. Fuentes, K. Gazeas, M. Giroletti, T. S. Grishina, A. C. Gupta, M. A. Gurwell,, E. Heidemann, D. Hiriart, W. J. Hou, T. Hovatta, S. Ibryamov, M. D. Joner, S. G. Jorstad, J. Kania, S. Kiehlmann, G. N. Kimeridze, E. N. Kopatskaya, M. Kopp, M. Korte, B. Kotas, S. Koyama, J. A. Kramer, L. Kunkel, S. O. Kurtanidze, O. M. Kurtanidze, A. Lähteenmäki, J. M. López, V. M. Larionov, E. G. Larionova, L. V. Larionova, C. Leto, C. Lorey, R. Mújica, G. M. Madejski, N. Marchili, A. P. Marscher, M. Minev, A. Modaressi, D. A. Morozova, T. Mufakharov, I. Myserlis, A. A. Nikiforova, M. G. Nikolashvili, E. Ovcharov, M. Perri, C. M. Raiteri, A. C. S. Readhead, A. Reimer, D. Reinhart, S. Righini, K. Rosenlehner, A. C. Sadun, S. S. Savchenko, A. Scherbantin, L. Schneider, K. Schoch, D. Seifert, E. Semkov, L. A. Sigua, C. Singh, P. Sola, Y. Sotnikova, M. Spencer, R. Steineke, M. Stojanovic, A. Strigachev, M. Tornikoski, E. Traianou, A. Tramacere, Yu. V. Troitskaya, I. S. Troitskiy, J. B. Trump, A. Tsai, A. Valcheva, A. A. Vasilyev, F. Verrecchia, M. Villata, O. Vince, K. Vrontaki, Z. R. Weaver, E. Zaharieva, and N. Zottmann
Subjects: Active galaxies, BL Lacertae objects, Markarian galaxies, Active galactic nuclei, Blazars, Astrophysics, QB460-466
Abstract: We study the broadband emission of Mrk 501 using multiwavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi's Large Area Telescope (LAT), NuSTAR, Swift, GASP-WEBT, and the Owens Valley Radio Observatory. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wave bands, with the highest occurring at X-rays and very-high-energy (VHE) γ -rays. A significant correlation (>3 σ ) between X-rays and VHE γ -rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between the Swift X-Ray Telescope and Fermi-LAT. We additionally find correlations between high-energy γ -rays and radio, with the radio lagging by more than 100 days, placing the γ -ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE γ -rays from mid-2017 to mid-2019 with a stable VHE flux (>0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2 yr long low state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED toward the low state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock.
Published: 2023
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10. Undocumented immigrants suffering from inequality of vaccination access in Japan: measuring the institutional barriers and exploring the associated factors

Author: Y. Shimada and Y. Kobayashi
Subjects: Public Health, Environmental and Occupational Health, General Medicine
Published: 2023
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11. Comparison of inflammation-based prognostic score as predictors of survival outcome in patients with germ cell tumors

Author: K. Yoshinaga, T. Sadahira, Y. Maruyama, Y. Mitsui, S. Tomoko, K. Edamura, Y. Kobayashi, M. Araki, M. Watanabe, T. Watanabe, and Y. Nasu
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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12. Impact of sarcopenia on longitudinal erectile functional outcomes after nerve-sparing robot assisted radical prostatectomy

Author: Y. Mitsui, T. Sadahira, Y. Maruyama, M. Araki, Y. Kobayashi, M. Watanabe, T. Watanabe, and Y. Nasu
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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13. The second opinion pathology review improves concordance between prostate biopsy and radical prostatectomy specimens

Author: Y. Maruyama, T. Sadahira, M. Araki, Y. Mitsui, K. Wada, K. Edamura, Y. Kobayashi, M. Watanabe, T. Watanabe, and Y. Nasu
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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14. Multiwavelength Variability and Correlation Studies of Mrk 421 During Historically Low X-ray and Y-ray Activity in 2015–2016

Author: Janeth Valverde Quispe, V. A. Acciari, S. Ansoldi, L. A. Antonelli, K. Asano, A. Babic, B. Banerjee, A. Baquero, U.BarresdeAlmeida, J. A. Barrio, J. Becerra Gonzalez, W. Bednarek, L. Bellizzi, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, O. Blanch, G. Bonnoli, Z. Bosnjak, G. Busetto, R. Carosi, G. Ceribella, M. Cerruti, Y. Chai, A. Chilingarian, S. Cikota, S. M. Colak, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, T. Di Girolamo, F. Di Pierro, L. Di Venere, E. Do Souto Espineira, D. Dominis Prester, A. Donini, M. Doro, V. Fallah Ramazani, A. Fattorini, G. Ferrara, L. Foffano, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, R. J. Garcıa Lopez, M. Garczarczyk, S. Gasparyan, M. Gaug, N. Giglietto, F. Giordano, P. Gliwny, N. Godinovic, J. G. Green, D. Green, D. Hadasch, A. Hahn, L. Heckmann, J. Herrera, J. Hoang, D. Hrupec, M. Hutten, T. Inada, S. Inoue, K. Ishio, Y. Iwamura, J. Jormanainen, L. Jouvin, Y. Kajiwara, M. Karjalainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, S. Lombardi, F. Longo, M. Lopez, R. Lopez-Coto, A. Lopez-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, L. Maraschi, M. Mariotti, M. Martınez, D. Mazin, S. Mender, S. Micanovic, D. Miceli, T. Miener, M. Minev, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, P. Munar-Adrover, V. Neustroev, C. Nigro, K. Nilsson, D. Ninci, K. Nishijima, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, J. Otero-Santos, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletic, P. P enil, C. Perennes, M. Persic, P. G . Prada Moroni, E. Prandini, C. Priyadarshi, I. Puljak, W. Rhode, M. Ribo, J. Rico, C. Righi, A. Rugliancich, L. Saha, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, B. Schleicher, K. Schmidt, T. Schweizer, J. Sitarek, I. Snidaric, D. Sobczynska, A. Spolon, A. Stamerra, D. Strom, M. Strzys, Y. Suda, T. Suric, M. Takahashi, F. Tavecchio, P. Temnikov, T. Terzic, M. Teshima, N. Torres-Alba, L. Tosti, S. Truzzi, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, S. Ventura, V. Verguilov, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, D. Zaric, A. Arbet-Engels, D. Baack, M. Balbo, M. Beck, N. Biederbeck, A. Biland, T. Bretz, K. Bruegge, J. Buss, D. Dorner, D. Elsaesser, D. Hildebrand, R. Iotov, M. Klinger, K. Mannheim, D. Neise, A. Neronov, M. Noethe, A. Paravac, V. Sliusar, F. Theissen, R. Walter, J. Valverde, D. Horan, M. Giroletti, M. Perri, F. Verrecchia, C. Leto, A. C. Sadun, J. W. Moody, M. Joner, A. P. Marscher, S. G. Jorstad, A. Lahteenmaki, M. Tornikoski, V. Ramakrishnan, E. Jarvela, R. J. C. Vera, S. Righini, and A.Y.Lien
Subjects: Astronomy
Abstract: We report a characterization of the multiband flux variability and correlations of the nearby (z=0.031) blazar Markarian 421(Mrk 421) using data from Mets ̈ahovi, Swift, Fermi-LAT, MAGIC, FACT, and other collaborations and instruments from 2014November till 2016 June. Mrk 421 did not show any prominent flaring activity, but exhibited periods of historically low activity above 1 TeV (F>1TeV<1.7×10−12ph cm−2s−1) and in the 2–10 keV (X-ray) band (F2−10 keV<3.6×10−11erg cm−2s−1),during which the Swift-BAT data suggest an additional spectral component beyond the regular synchrotron emission. The highest flux variability occurs in X-rays and very high-energy (E>0.1 TeV)γ-rays, which, despite the low activity, show a significant positive correlation with no time lag. The HRkeV and HRTeV show the harder-when-brighter trend observed in many blazars, but the trend flattens at the highest fluxes, which suggests a change in the processes dominating the blazar variability. Enlarging our dataset with data from years 2007 to 2014, we measured a positive correlation between the optical and the GeV emission over a range of about 60 d centred at time lag zero, and a positive correlation between the optical/GeV and the radio emission over a range of about 60 d centred at a time lag of 43+9−6d. This observation is consistent with the radio-bright zone being located about 0.2 parsec downstream from the optical/GeV emission regions of the jet. The flux distributions are better described with a lognormal function in most of the energy bands probed, indicating that the variability in Mrk 421 is likely produced by a multiplicative process.
Published: 2020
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15. Relation between recovering right ventricular function and appropriate ICD Therapy

Author: T Chiba, T Kajiyama, Y Komai, Y Takanashi, Y Yoshino, S Ryuzaki, M Kitagawa, R Ito, M Nakano, Y Kondo, and Y Kobayashi
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Right ventricular fractional area change (RVFAC) as right ventricular function is recently referred as an independent predictor of sudden cardiac death (SCD). Light ventricular function is related with SCD and adopted as a criteria of ICD implantation for primary prophylaxis. The purpose of this study was to evaluate the association of RVFAC and appropriate ICD therapy. Methods Consecutive patients who underwent initial ICD implantation for any diseases except for hypertrophic cardiomyopathy and Brugada syndrome and long QT syndrome were retrospectively enrolled from 2012 to 2018. Transthoracic echocardiographic parameters before ICD implantation were evaluated to investigate the association with appropriate ICD therapy. We analyzed RV function of patients undergoing echocardiography one year after implantation. RVFAC was measured by one physician and one echocardiologist. Results In total, 172 patients (60.3±13.6 years, 131 males) including 63 ischemic cardiomyopathy were enrolled. Ninety patients received an ICD as a secondary prophylaxis. Mean LVEF and RVFAC were 38.3±14.3% and 35.8±8.82%, respectively. There was no correlation between RVFAC and LVEF (correlation coefficient =0.274). Regarding appropriate ICD therapy events, the best cut-off value of RVFAC was 34.8%. The odds ratio of low RVFAC was 2.731 (95%CI: 1.456-5.121, P Conclusion RVFAC and RV function improvement may be important to stratify the prognosis of ICD patients.
Published: 2023
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16. Uremic frost

Author: R Ono and Y Kobayashi
Subjects: General Medicine
Published: 2023
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17. Effect of hydrothermal process for inorganic alumina sol on crystal structure of alumina gel

Author: K. Yamamura, M. Hama, Y. Kobayashi, Y. Yasuda, and T. Morita
Subjects: Alumina, Homogeneous precipitation, Sol–gel, Hydrothermal process, Clay industries. Ceramics. Glass, TP785-869
Abstract: This paper reports the effect of a hydrothermal process for alumina sol on the crystal structure of alumina gel derived from hydrothermally treated alumina sol to help push forward the development of low temperature synthesis of α-Al2O3. White precipitate of aluminum hydroxide was prepared with a homogeneous precipitation method using aluminum nitrate and urea in aqueous solution. The obtained aluminum hydroxide precipitate was peptized by using acetic acid at room temperature, which resulted in the production of a transparent alumina sol. The alumina sol was treated with a hydrothermal process and transformed into an alumina gel film by drying at room temperature. Crystallization of the alumina gel to α-Al2O3 with 900 °C annealing was dominant for a hydrothermal temperature of 100 °C and a hydrothermal time of 60 min, as production of diaspore-like species was promoted with the hydrothermal temperature and time. Excess treatments with hydrothermal processes at higher hydrothermal temperature for longer hydrothermal time prevented the alumina gel from being crystallized to α-Al2O3 because the excess hydrothermal treatments promoted production of boehmite.
Published: 2016
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18. Fabrication of gadolinium hydroxide nanoparticles using ion-exchange resin and their MRI property

Author: Y. Kobayashi, H. Morimoto, T. Nakagawa, Y. Kubota, K. Gonda, and N. Ohuchi
Subjects: Gadolinium hydroxide, Nanoparticle, Anion exchange resin, Clay industries. Ceramics. Glass, TP785-869
Abstract: This paper describes a method to fabricate gadolinium hydroxide (Gd(OH)3) nanoparticles. An opaque solution was prepared by adding basic anion exchange resin (BAER) to a Gd(NO3)3 aqueous solution at room temperature and aging the solution for 12–24 h; the solution became basic because of the exchange of H2O with OH−. The particles in the opaque solution have a needle structure, and their crystal structure was hexagonal Gd(OH)3. Their longitudinal and lateral average particle sizes tend to increase in the ranges of 175.0–222.1 and 33.9–52.3 nm when the aging time increases from 12 to 24 h, respectively. The relaxivity value for T1-weighted imaging was 0.79 mM−1 s−1 for the solution that was prepared at the aging time of 18 h, which was ca. 20% of that for a commercial Gd complex contrast agent.
Published: 2016
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19. Long-term clinical course and prognostic factors of heart failure with reduced ejection fraction (HFrEF) patients underwent primary prophylactic implantable cardioverter defibrillator (ICD)

Author: M Sugawara, Y Kondo, Y Yoshino, S Ryuzaki, T Chiba, M Kitagawa, R Ito, M I Nakano, T Kajiyama, M A Nakano, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background For decades, ICD is a well-established therapy for improving prognosis of structural heart disease with severe cardiac dysfunction, and ICD for primary prophylaxis against sudden cardiac death were routinely provided. However, long-term prognosis and clinical course are different in each individual patient with an ICD, and it is moreover unclear what kind of factors might have influences on their clinical outcomes. Purpose The aim of this study is to clarify long-term prognosis and predictors of future major adverse cardiac events (MACEs) in HFrEF patients with an ICD as primary prophylaxis in Japanese population. Methods We retrospectively analyzed our ICD database. Patients underwent primary prophylactic ICD implantation from 2006 to 2020 at our institute and met the criteria of ICD recommendation of the latest Japanese guideline. Its requirements are receiving optimal medication therapy, symptomatic heart failure (New York Heart Association classification II or greater), and severe cardiac dysfunction (left ventricular ejection fraction (LVEF) is 35% or less). Additionally, prior NSVT is considered Class I ICD recommendation. In the case of ischemic cardiomyopathy (ICM), ICD implantation was done at least 40 days after myocardial infarction and at least 90 days after revascularization. MACEs were defined as composite outcome of cardiovascular death, heart failure hospitalization, and appropriate ICD therapies. Results A total of 148 consecutive patients were enrolled (male, 120 (81%); age, 62.1±11.8 years; LVEF, 23.0±5.86%; left ventricular end-diastolic diameter (LVDd), 67.6±9.26mm; paroxysmal or persistent atrial fibrillation (AF), 38 (26%); NSVT, 113 (76%); use of class III antiarrhythmic drugs, 48 (32%); ICM, 49 (33%); cardiac resynchronization therapy (CRT), 63 (43%)). One hundred twenty patients (81%) were programmed with a shock-only zone over 200 beats per minute. The median follow-up duration was 58.5 months. Among those 148 patients, MACEs were occurred to 60 patients (41%). As a result of dividing all patients into two groups by the occurrence of MACE, LVEF and LVDd were worse in MACE(+) group, whereas, MACE(−) had greater number of co morbidities. The results of cox-regression analysis showed LVDd (HR: 1.07, 95% CI: 1.03–1.12, p Conclusions The incidence of MACEs in patients with an ICD and severe HFrEF was substantially high in this Japanese population. Etiology of ICM, left ventricle size, and AF were the potential risk factors for future MACEs. Funding Acknowledgement Type of funding sources: None.
Published: 2022
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20. Prognosis of hypertrophic cardiomyopathy in Japanese patients with an implantable cardioverter defibrillator -focus on apical hypertrophic cardiomyopathy

Author: M Nakano, Y Kondo, T Kajiyama, R Ito, M Kitagawa, M Sugawara, T Chiba, S Ryuzaki, Y Yoshino, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background Patients with hypertrophic cardiomyopathy (HCM) are at high risk of lethal arrhythmias, and implantable cardioverter defibrillators (ICD) are widely used for prevention of sudden cardiac death (SCD). Apical HCM is a phenotype variant of HCM, with hypertrophy predominantly affecting apex, that was initially described 30 years ago. Apical HCM patients may have different clinical prognosis compared with other subsets of HCM. In previous studies, apical HCM patients seem to have a more benign prognosis than other types of HCM. However, little is known about the long-term outcomes of apical HCM patients and there are many unclear points. Moreover, there are few reports about the clinical prognosis in apical HCM patients with an ICD. Objective The aim of this study is to identify the difference between the prognosis of apical and the other types of HCM patients with an ICD. Methods We retrospectively analyzed the database of our ICD clinic. All subjects underwent ICD implantation between October 2006 and September 2018. We classified HCM patients into LV outflow tract obstruction (LVOTO) and midventricular obstruction (MVO), apical HCM and other non-obstructive types. We divided all the patients into apical and other types of HCM, and examined their background, incidence of appropriate ICD therapies, hospitalization for heart failure, electrical storm and death. Results A total of consecutive 64 Japanese HCM patients with an ICD (follow-up period, 86±24 months; age, 65±14 years; male sex, 83%; left ventricular ejection fraction, 56±14%; LV max wall-thickness, 19±7mm; LV apical aneurysm, 9.4%; 5-year risk of SCD, 4.4±2.1) were enrolled in this study. We classified them into 14 apical HCM and 50 other types of HCM patients. The clinical characteristics and major clinical events of these patients are shown in the Table 1. During the follow-up periods, there were no significant differences in the incidence of electrical storm, hospitalization for heart failure and death between the 2 groups (p=0.11; p=0.60; p=0.39). Appropriate ICD therapies occurred in 6 of 14 (43%) patients with apical HCM and 5 of 50 (10%) patients with other types of HCM (p=0.010). The risk factors of patients with apical HCM patients are shown in Table 2. Conclusions Appropriate ICD therapy was more prevalent in patients with apical HCM, compared to patients with other types of HCM. Aggressive intervention such as catheter ablation for ventricular tachycardia and ventricular fibrillation may be considered in patients with apical HCM and higher score of 5-year risk of SCD. Further studies are needed to clarify the manifestations and long-term outcome of apical HCM patients. Funding Acknowledgement Type of funding sources: None.
Published: 2022
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21. Clinical findings of triglyceride deposit cardiomyovasculopathy

Author: R Ono, H Miyauchi, T Iimori, K Hoshi, M Ohyama, K Hirano, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background Triglyceride (TG) deposit cardiomyovasculopathy (TGCV) is a novel cardiovascular disorder and was recently encoded as an orphan disease in Europe (ORPHA code: 565612). Defective intracellular lipolysis results in TG accumulation in the myocardium and coronary arteries in TGCV. The myocardial washout rate (WR) of iodine-123-β-methyl-p-iodophenylpentadecanoic acid (BMIPP) is an essential indicator to evaluate myocardial lipolysis in vivo, and decreased WR ( Purpose To clarify clinical findings of TGCV including comorbid conditions and laboratory findings. Methods We enrolled 234 patients who underwent BMIPP scintigraphy between September 2015 and July 2019. The distributions of TGCV in each comorbidity, cardiac functions and laboratory findings were investigated. Results In total, 104 patients were diagnosed with definitive TGCV. The BMIPP WR of TGCV patients was −1.37±10.6%. TGCV patients had various comorbid conditions, including coronary artery disease (75%), diabetes mellitus (56%), and heart failure (21%). Left ventricular ejection fraction (LVEF) of TGCV patients was significantly lower than that of non-TGCV patients (38.1±18.0% vs. 43.6±18.9%, p-value=0.026). Moreover, among those who did not take lipid-lowering drugs, there was no difference in the serum TG level between TGCV and non-TGCV patients (TGCV: n=44, 127±84.6 mg/dL, non-TGCV: n=66, 133±70.7 mg/dL, p-value=0.73). Conclusions TGCV patients showed multiple coexistence of coronary artery disease, diabetes mellitus, or heart failure with lower LVEF. Serum TG level was not significantly different between TGCV and non-TGCV patients. Serum TG did not affect the intracellular TG accumulation in TGCV patients directly, and this result was consistent with the pathophysiological hypothesis that the TG accumulation in the myocardial cytoplasm is due to intracellular lipase dysfunction. Funding Acknowledgement Type of funding sources: None.
Published: 2022
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22. Interactive Trunk Extraction from Forest Point Cloud

Author: T. Mizoguchi and Y. Kobayashi
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: For forest management or monitoring, it is required to constantly measure several parameters of each tree, such as height, diameter at breast height, and trunk volume. Terrestrial laser scanner has been used for this purpose instead of human workers to reduce time and cost for the measurement. In order to use point cloud captured by terrestrial laser scanner in the above applications, it is an important step to extract all trees or their trunks separately. For this purpose, we propose an interactive system in which a user can intuitively and efficiently extract each trunk by a simple editing on the distance image created from the point cloud. We demonstrate the effectiveness of our proposed system from various experiments.
Published: 2014
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23. Population trends of the Kuril harbour seal Phoca vitulina stejnegeri from 1974 to 2010 in southeastern Hokkaido, Japan

Author: Y Kobayashi, T Kariya, J Chishima, K Fujii, K Wada, S Baba, T Itoo, T Nakaoka, M Kawashima, S Saito, N Aoki, Si Hayama, Y Osa, H Osada, A Niizuma, M Suzuki, Y Uekane, K Hayashi, M Kobayashi, N Ohtaishi, and Y Sakurai
Subjects: Zoology, QL1-991, Botany, QK1-989
Abstract: The Kuril harbour seal Phoca vitulina stejnegeri is an endangered species which inhabits southeastern Hokkaido, Japan. Its population declined precipitously from between 1500 and 4800 individuals in the 1940s to a few hundred individuals in the early 1970s. The causes of this decline are thought to be commercial harvesting, bycatch in autumn set-net salmon fishing, and other human activities, including coastal fisheries. To quantify Kuril seal population trends, counts were performed each year at haul-out sites during the pupping season from 1974 to 2010 and during the moulting season from 1983 to 2010. The average population growth rate was ~4% per annum over the past 37 yr. Two haul-out sites (Kenbokki Island and Hattaushi) from which the species had disappeared in the early 1980s showed no evidence of being recolonized. Commercial harvesting ended in the late 1980s and probably had an effect on population trends until the 1990s. The bycatch of seals during autumn set-net salmon fishing in the 2000s remained similar to, or slightly greater than, that during the 1980s. Recently, seals have been observed at 9 haul-out sites during the pupping/moulting season along the coast of southeastern Hokkaido. Approximately 70% of the seals found were at Cape Erimo (~500 seals) and at Daikoku Island and Akkeshi (~250 seals).
Published: 2014
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24. Distinct bacterial-production–DOC–primary-production relationships and implications for biogenic C cycling in the South China Sea shelf

Author: C.-C. Lai, Y.-W. Fu, H.-B. Liu, H.-Y. Kuo, K.-W. Wang, C.-H. Lin, J.-H. Tai, G. T. F. Wong, K.-Y. Lee, T.-Y. Chen, Y. Yamamoto, M.-F. Chow, Y. Kobayashi, C.-Y. Ko, and F.-K. Shiah
Subjects: Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract: Based on two summer spatio-temporal data sets obtained from the northern South China Sea shelf and basin, this study reveals contrasting relationships among bacterial production (BP), dissolved organic (DOC) and primary production (PP) in the transition zone from the neritic to the oceanic regions. Inside the mid-shelf (bottom depth 100 days in the outer shelf, indicating that riverine (Pearl River) DOC might be more labile. The actual mechanism for this is unknown, but might relate to higher inorganic nutrient supply from river/terrestrial sources. The positive correlation of the BP / PP ratios vs. phosphate (and nitrate) concentrations in the inner shelf implies that if anthropogenic mineral loading keeps increasing in the foreseeable future, the near-shore zone may become more heterotrophic, rendering the system a stronger source of CO2.
Published: 2014
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25. 1415 Single cell transcriptome analyses identify an emergence of keratin 5-positive epithelioid fibroblasts in the subcutis of the necrotic skin

Author: Y. Hirose, A. Miura, Y. Kobayashi, T. Kitayama, Y. Ouchi, T. Shimbo, and K. Tamai
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2023
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26. 1418 Characterization of ectomesenchyme as an origin of epidermal stem cells

Author: A. Miura, Y. Kobayashi, Y. Hirose, A. Yamanishi, Y. Ouchi, R. Yamamoto, T. Kitayama, E. Takaki, T. Shimbo, and K. Tamai
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2023
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27. 324 Keratinocytes form a self-organized pattern through adherens junctions

Author: Y. Mai, Y. Kobayashi, J. Kumamoto, H. Kitahata, T. Nohara, S. Itamoto, S. Mai, T. Seo, K. Izumi, M. Nagayama, W. Nishie, H. Ujiie, and K. Natsuga
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2023
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28. O-080 Impact of age-limit policy change for assisted reproductive technology (ART) subsidy in Japan

Author: A Yanagisawa-Sugita, A Iba, E Maeda, S C Jwa, K Saito, A Kuwahara, H Saito, Y Terada, O Ishihara, and Y Kobayashi
Subjects: Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Abstract: Study question What was the impact on treatment age in Japan after a subsidy policy change that set age limits for assisted reproductive technology (ART) treatment? Summary answer The national policy introducing age limits in the subsidy may have promoted ART treatment among younger women. What is known already Japan has provided partial subsidies for ART treatment since 2004. To promote treatment at a younger age, the government introduced a subsidy policy in 2016 that set age limits: up to six treatment cycles for women younger than 40 years of age; and up to three cycles for women between 40 and 42 years old. However, two out of 47 prefectures continued to provide subsidies to women aged 43 and older. Study design, size, duration We conducted a time series analysis of the utilisation of ART before and after the introduction of age limits, using data from the Japanese national ART registry from 2012 to 2016. Participants/materials, setting, methods We described the number of fresh and frozen treatment cycles, comparing the number between 45 prefectures that followed the national policy change (hereafter, prefectures with age limits) and two prefectures that did not (hereafter, prefectures without age limits). Ordinary least squares regression models were used to assess the impact of the policy change by prefecture on the number of ART cycles by women of different ages. Main results and the role of chance The overall number of fresh and frozen ART cycles continuously increased in all age groups from 2012 to 2016. Meanwhile, the number of fresh ART cycles among women aged ≤ 36 and 37-39 years in 2016 increased from the previous year by + 4.0% and +1.8% in prefectures with age limits, whereas it decreased in prefectures without age limits: -3.1% and -2.3%, respectively. The number of fresh ART cycles among women aged 40-42 and 43-45 years in prefectures with age limits in 2016 changed by + 1.5% and -0.1%, respectively, whereas it increased considerably in prefectures without age limits by + 9.6% and +65.4%, respectively. Similar changes were shown for the frozen cycles. After controlling for underlying time trends and prefectural characteristics, the policy change significantly increased the number of fresh and frozen ART treatment cycles among women aged ≤ 36 years and decreased the treatment cycles of women aged 40-42 years. Limitations, reasons for caution We evaluated the change observed in the year of the policy change and could not assess longer-term trends. Additionally, unobserved factors might have contributed to the change in treatment numbers. Wider implications of the findings The introduction of a policy to set an age limit for the partial ART subsidy resulted in a significant increase in treatment even among age groups younger than the boundary groups. The policy change might have conveyed educational messages regarding the benefits of early treatment. Trial registration number not applicable
Published: 2022
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29. P-039 Male age is associated with sperm DNA integrity: Selection of high DNA integrity sperm by microfluidics sorting is critical to clinical outcomes in older patients

Author: N Morishita, M Miura, Y Kobayashi, R Matsunaga, T Maeda, M Ochi, and T Horiuchi
Subjects: Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Abstract: Study question Does sperm DNA integrity affect clinical outcomes of ICSI? Summary answer Use of high DNA integrity sperm selected by microfluidics sperm sorting results in lower miscarriage rates in the patients of 39-years old and more. What is known already High sperm DNA damage is associated with decreased normal fertilization, embryo development and pregnancy rates, and an increased miscarriage rate. On the other hand, oocytes from older women have decreased pregnancy rate, and increased miscarriage rate because of possibility of low ability to repair sperm with DNA fragmentation, and dramatical increases of aneuploidy as women age. A microfluidic sperm selection chamber (MSS, ZyMōt™; DxNow) is a device designed to collect sperm with higher chromatin integrity than density gradient centrifugation (DGC). Study design, size, duration Sperm analysis was performed by sperm chromatin dispersion (SCD) test and comet assay in the same sample of 15 cases between October 2020 and February 2021. ICSI outcomes by DGC and MSS were compared with blastocyst development, and pregnancy rates in vitrified-thawed single blastocyst transfers cycle for 518 cases between August 2018 and May 2021. Participants/materials, setting, methods SCD test was optimized as a rapid procedure, with sperm showing a halo deemed normal, and those without a halo abnormal. Comet assay results were analyzed using CometScore 2.0, with comparison of %Tail DNA. ICSI outcomes were analyzed using multiple logistics regressions of male and female ages. Main results and the role of chance We found a positive correlation between male age and sperm DNA fragmentation rates in raw semen using SCD test (r = 0.70) and Comet assay (r = 0.42). Higher DNA integrity sperm could select using MSS than DGC. In this study with ICSI outcomes, 170 of 318 (53.5%) blastocyst transfers resulted in pregnancy, and 49 (28.8%) subsequently miscarried. The data were classified according to less than or more than 39 years old of male age detected by multiple logistics regressions. In patients with ≥39 years of male age, the female age was significantly higher and blastocyst and pregnancy rates were significantly lower, and the miscarriage rate was significantly higher than Limitations, reasons for caution The sample size for each study was small. Analysis of sperm DNA fragmentation and samples in ICSI outcomes were not the same. The retrospective nature of ICSI outcomes in this study does not allow controlling of unknown confounders. Wider implications of the findings Sperm DNA fragmentation depended on male age affected fertility outcomes. However, when male age is higher, masking the effect of male age by female age. In this study, we found out the improvement of ICSI outcome by using high DNA integrity sperm selected by MSS in both ≥39 years. Trial registration number Not applicable
Published: 2022
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30. Association between right ventricular dysfunction and appropriate icd therapy

Author: T Chiba, T Kajiyama, Y Yutaka, S Ryuzaki, M Sugawara, M Kitagawa, R Ito, M Nakano, Y Kondo, and Y Kobayashi
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Right ventricular fractional area change (RVFAC) as right ventricular function is recently referred as an independent predictor of sudden cardiac death (SCD). The purpose of this study was to evaluate the association of RVFAC and appropriate ICD therapy in order to determine the cut-off value of RVFAC. Methods Consecutive patients who underwent initial ICD implantation for any diseases except for non-dilated phase hypertrophic cardiomyopathy and channelopathy were retrospectively enrolled from 2012 to 2018. Primary endpoint was an initial appropriate ICD therapy. Transthoracic echocardiographic parameters before ICD implantation were evaluated by one physician and one echocardiologist to be validated. Right ventricular dimensions and function were also measured to be analyzed. Results In total, 172 patients (60.3±13.6 years, 131 males) including 63 ischemic cardiomyopathy were enrolled. Ninety patients received an ICD as a secondary prophylaxis. Mean LVEF and RVFAC were 38.3±14.3% and 35.8±8.82%, respectively. There was little correlation between RVFAC and LVEF (correlation coefficient =0.274). Regarding appropriate ICD therapy events, the best cut-off value of RVFAC was 34.8%. The odds ratio of low RVFAC was 2.731 (95%CI: 1.456-5.121, P=0.00174). Secondary prophylactic cohort with low RVFAC showed highest incidence of appropriate ICD therapy as shown in the figure. In multivariate analysis, only low RVFAC is an independent predictor of appropriate ICD therapy (HR: 3.53, 95%CI:1.78- 6.99, P=0.0003). Conclusion Low RVFAC seemed independently associated with increased appropriate ICD therapy.
Published: 2022
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31. Negative prognostic implications of non-sustained ventricular tachycardias in patients after prophylactic defibrillator implantation

Author: M Sugawara, Y Kondo, S Ryuzaki, Y Yoshino, T Chiba, M Kitagawa, R Ito, MI Nakano, T Kajiyama, MA Nakano, and Y Kobayashi
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Non-sustained ventricular tachycardia (NSVT) is frequent phenomenon in severe heart failure with reduced ejection fraction (HFrEF) patients, and causes any negative impacts on such patients. In the Japanese Circulation Society (JCS) and Japanese Heart Rhythm Society (JHRS) guidelines, NSVT is regarded as a major component of indication for implantable cardioverter defibrillator (ICD) implantation. However, the long-term prognostic significance of NSVT in severe HFrEF is incompletely resolved. Purpose The aim of this study is to investigate the relation between prior NSVT episodes and major adverse cardiac events (MACEs) in HFrEF patients with an ICD as primary prophylaxis. Methods We retrospectively analyzed our ICD database. Patients underwent primary prophylactic ICD implantation from 2007 to 2018 following ICD recommendation of JCS and JHRS guidelines. Patients met the criteria of receiving optimal medication therapy, symptomatic heart failure (New York Heart Association classification II or greater), and severe cardiac dysfunction (left ventricular ejection fraction (LVEF) is 35% or less). In the case of ischemic cardiomyopathy (ICM), implantation of ICD was done at least 40 days after myocardial infarction and at least 90 days after revascularization. Incidence of NSVT episodes were identified through daily electrocardiogram (ECG), Holter ECG or monitor ECG in the hospital. MACEs were defined as composite outcome of cardiovascular death, heart failure hospitalization, and appropriate ICD therapies. Results A total of 148 consecutive patients were enrolled (male, 120 (81%); age, 62.1±11.8 years; LVEF, 23.0±5.86%; left ventricular end-diastolic diameter (LVDd), 67.6±9.26mm; paroxysmal or persistent atrial fibrillation (AF), 38 (26%); NSVT, 113 (76%); use of class III antiarrhythmic drugs, 48 (32%); ICM, 49 (33%); cardiac resynchronization therapy (CRT), 63 (43%)). The median follow-up duration was 58.5 months. As a result of comparison of the Kaplan-Meier curve between NSVT group (n=113) and non-NSVT group (n=35), cardiovascular death, heart failure hospitalization, and appropriate ICD therapy were not statistically different (Figures). Of those, MACEs were occurred to 60 patients (41%). The results of cox-regression analysis showed LVDd (HR: 1.07, 95% CI: 1.03-1.12, p Conclusions In this Japanese population, the long-term prognosis of severe HFrEF patients is considered to be comparable regardless of prior NSVT episodes. However, the incidence of MACEs in patients with severe HFrEF after ICD implantation was substantially high. ICM, left ventricle size, and atrial fibrillation were the potential risk factors for MACEs as the previous reports showed.
Published: 2022
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32. Model-based Cross-correlation Search for Gravitational Waves from the Low-mass X-Ray Binary Scorpius X-1 in LIGO O3 Data

Author: Abbott, R, Abe, H, Acernese, F, Ackley, K, Adhicary, S, Adhikari, N, Adhikari, R, Adkins, V, Adya, V, Affeldt, C, Agarwal, D, Agathos, M, Aguiar, O, Aiello, L, Ain, A, Ajith, P, Akutsu, T, Albanesi, S, Alfaidi, R, Alléné, C, Allocca, A, Altin, P, Amato, A, Anand, S, Ananyeva, A, Anderson, S, Anderson, W, Ando, M, Andrade, T, Andres, N, Andrés-Carcasona, M, Andrić, T, Ansoldi, S, Antelis, J, Antier, S, Apostolatos, T, Appavuravther, E, Appert, S, Apple, S, Arai, K, Araya, A, Araya, M, Areeda, J, Arène, M, Aritomi, N, Arnaud, N, Arogeti, M, Aronson, S, Asada, H, Ashton, G, Aso, Y, Assiduo, M, Assis de Souza Melo, S, Aston, S, Astone, P, Aubin, F, Aultoneal, K, Babak, S, Badaracco, F, Badger, C, Bae, S, Bae, Y, Bagnasco, S, Bai, Y, Baier, J, Baird, J, Bajpai, R, Baka, T, Ball, M, Ballardin, G, Ballmer, S, Baltus, G, Banagiri, S, Banerjee, B, Bankar, D, Barayoga, J, Barish, B, Barker, D, Barneo, P, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Barton, M, Bartos, I, Basak, S, Bassiri, R, Basti, A, Bawaj, M, Bayley, J, Bazzan, M, Bécsy, B, Bedakihale, V, Beirnaert, F, Bejger, M, Belahcene, I, Bell, A, Benedetto, V, Beniwal, D, Benoit, W, Bentley, J, Benyaala, M, Bera, S, Berbel, M, Bergamin, F, Berger, B, Bernuzzi, S, Beroiz, M, Bersanetti, D, Bertolini, A, Betzwieser, J, Beveridge, D, Bhandare, R, Bhandari, A, Bhardwaj, U, Bhatt, R, Bhattacharjee, D, Bhaumik, S, Bianchi, A, Bilenko, I, Bilicki, M, Billingsley, G, Bini, S, Birnholtz, O, Biscans, S, Bischi, M, Biscoveanu, S, Bisht, A, Biswas, B, Bitossi, M, Bizouard, M, Blackburn, J, Blair, C, Blair, D, Blair, R, Bobba, F, Bode, N, Boër, M, Bogaert, G, Boldrini, M, Bolingbroke, G, Bonavena, L, Bondarescu, R, Bondu, F, Bonilla, E, Bonnand, R, Booker, P, Bork, R, Boschi, V, Bose, N, Bose, S, Bossilkov, V, Boudart, V, Bouffanais, Y, Bozzi, A, Bradaschia, C, Brady, P, Bramley, A, Branch, A, Branchesi, M, Brau, J, Breschi, M, Briant, T, Briggs, J, Brillet, A, Brinkmann, M, Brockill, P, Brooks, A, Brooks, J, Brown, D, Brunett, S, Bruno, G, Bruntz, R, Bryant, J, Bucci, F, Buchanan, J, Bulik, T, Bulten, H, Buonanno, A, Burtnyk, K, Buscicchio, R, Buskulic, D, Buy, C, Byer, R, Cabourn Davies, G, Cabras, G, Cabrita, R, Cadonati, L, Cagnoli, G, Cahillane, C, Calderón Bustillo, J, Callaghan, J, Callister, T, Calloni, E, Camp, J, Canepa, M, Caneva, G, Cannavacciuolo, M, Cannon, K, Cao, H, Cao, Z, Capistran, L, Capocasa, E, Capote, E, Carapella, G, Carbognani, F, Carlassara, M, Carlin, J, Carpinelli, M, Carrillo, G, Carter, J, Carullo, G, Casanueva Diaz, J, Casentini, C, Castaldi, G, Caudill, S, Cavaglià, M, Cavalier, F, Cavalieri, R, Cella, G, Cerdá-Durán, P, Cesarini, E, Chaibi, W, Chakalis, W, Chalathadka Subrahmanya, S, Champion, E, Chan, C, Chan, K, Chan, M, Chandra, K, Chang, I, Chang, W, Chanial, P, Chao, S, Chapman-Bird, C, Charlton, P, Chassande-Mottin, E, Chatterjee, C, Chatterjee, D, Chaturvedi, M, Chaty, S, Chen, C, Chen, D, Chen, H, Chen, J, Chen, K, Chen, X, Chen, Y, Cheng, H, Chessa, P, Cheung, H, Chia, H, Chiadini, F, Chiang, C, Chiarini, G, Chierici, R, Chincarini, A, Chiofalo, M, Chiummo, A, Choudhary, R, Choudhary, S, Christensen, N, Chu, Q, Chu, Y, Chua, S, Chung, K, Ciani, G, Ciecielag, P, Cieślar, M, Cifaldi, M, Ciobanu, A, Ciolfi, R, Clara, F, Clark, J, Clarke, T, Clearwater, P, Clesse, S, Cleva, F, Coccia, E, Codazzo, E, Cohadon, P, Cohen, D, Colleoni, M, Collette, C, Colombo, A, Colpi, M, Compton, C, Conti, L, Cooper, S, Corban, P, Corbitt, T, Cordero-Carrión, I, Corezzi, S, Cornish, N, Corsi, A, Cortese, S, Coschizza, A, Cotesta, R, Cottingham, R, Coughlin, M, Coulon, J, Countryman, S, Cousins, B, Couvares, P, Coward, D, Cowart, M, Coyne, D, Coyne, R, Craig, K, Creighton, J, Creighton, T, Criswell, A, Croquette, M, Crowder, S, Cudell, J, Cullen, T, Cumming, A, Cummings, R, Cuoco, E, Curyło, M, Dabadie, P, Dal Canton, T, Dall'Osso, S, Dálya, G, Dana, A, D'Angelo, B, Danilishin, S, D'Antonio, S, Danzmann, K, Darsow-Fromm, C, Dasgupta, A, Datrier, L, Datta, S, Dattilo, V, Dave, I, Davier, M, Davis, D, Davis, M, Daw, E, Dax, M, Debra, D, Deenadayalan, M, Degallaix, J, De Laurentis, M, Deléglise, S, Del Favero, V, De Lillo, F, De Lillo, N, Dell'Aquila, D, Del Pozzo, W, De Matteis, F, D'Emilio, V, Demos, N, Dent, T, Depasse, A, De Pietri, R, De Rosa, R, De Rossi, C, Desalvo, R, De Simone, R, Dhurandhar, S, Diab, R, Díaz, M, Didio, N, Dietrich, T, Di Fiore, L, Di Fronzo, C, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Diksha, D, Di Lieto, A, Di Michele, A, Di Pace, S, Di Palma, I, Di Renzo, F, Divakarla, A, Dmitriev, A, Doctor, Z, Doleva, P, Donahue, L, D'Onofrio, L, Donovan, F, Dooley, K, Dooney, T, Doravari, S, Dorosh, O, Drago, M, Driggers, J, Drori, Y, Ducoin, J, Dunn, L, Dupletsa, U, Durante, O, D'Urso, D, Duverne, P, Dwyer, S, Eassa, C, Easter, P, Ebersold, M, Eckhardt, T, Eddolls, G, Edelman, B, Edo, T, Edy, O, Effler, A, Eguchi, S, Eichholz, J, Eikenberry, S, Eisenmann, M, Eisenstein, R, Ejlli, A, Engelby, E, Enomoto, Y, Errico, L, Essick, R, Estellés, H, Estevez, D, Etzel, T, Evans, M, Evans, T, Evstafyeva, T, Ewing, B, Fabrizi, F, Faedi, F, Fafone, V, Fair, H, Fairhurst, S, Fan, P, Farah, A, Farr, B, Farr, W, Favaro, G, Favata, M, Fays, M, Fazio, M, Feicht, J, Fejer, M, Fenyvesi, E, Ferguson, D, Fernandez-Galiana, A, Ferrante, I, Ferreira, T, Fidecaro, F, Figura, P, Fiori, A, Fiori, I, Fishbach, M, Fisher, R, Fittipaldi, R, Fiumara, V, Flaminio, R, Floden, E, Fong, H, Font, J, Fornal, B, Forsyth, P, Franke, A, Frasca, S, Frasconi, F, Freed, J, Frei, Z, Freise, A, Freitas, O, Frey, R, Fritschel, P, Frolov, V, Fronzé, G, Fujii, Y, Fujikawa, Y, Fujimoto, Y, Fulda, P, Fyffe, M, Gabbard, H, Gabella, W, Gadre, B, Gair, J, Gais, J, Galaudage, S, Gamba, R, Ganapathy, D, Ganguly, A, Gao, D, Gaonkar, S, Garaventa, B, García-Núñez, C, García-Quirós, C, Gardner, K, Gargiulo, J, Garufi, F, Gasbarra, C, Gateley, B, Gayathri, V, Ge, G, Gemme, G, Gennai, A, George, J, Gerberding, O, Gergely, L, Ghonge, S, Ghosh, A, Ghosh, S, Ghosh, T, Giacoppo, L, Giaime, J, Giardina, K, Gibson, D, Gier, C, Giri, P, Gissi, F, Gkaitatzis, S, Glanzer, J, Gleckl, A, Godoy, F, Godwin, P, Goetz, E, Goetz, R, Golomb, J, Goncharov, B, González, G, Gosselin, M, Gouaty, R, Gould, D, Goyal, S, Grace, B, Grado, A, Graham, V, Granata, M, Granata, V, Gras, S, Grassia, P, Gray, C, Gray, R, Greco, G, Green, A, Green, R, Gretarsson, A, Gretarsson, E, Griffith, D, Griffiths, W, Griggs, H, Grignani, G, Grimaldi, A, Grimm, S, Grote, H, Grunewald, S, Gruson, A, Guerra, D, Guidi, G, Guimaraes, A, Gulati, H, Gulminelli, F, Gunny, A, Guo, H, Guo, Y, Gupta, A, Gupta, P, Gupta, S, Gurs, J, Gustafson, R, Gutierrez, N, Guzman, F, Ha, S, Hadiputrawan, I, Haegel, L, Haino, S, Halim, O, Hall, E, Hamilton, E, Hammond, G, Han, W, Haney, M, Hanks, J, Hanna, C, Hannam, M, Hannuksela, O, Hansen, H, Hanson, J, Harada, R, Harder, T, Haris, K, Harms, J, Harry, G, Harry, I, Hartwig, D, Hasegawa, K, Haskell, B, Haster, C, Hathaway, J, Hattori, K, Haughian, K, Hayakawa, H, Hayama, K, Hayes, F, Healy, J, Heidmann, A, Heidt, A, Heintze, M, Heinze, J, Heinzel, J, Heitmann, H, Hellman, F, Hello, P, Helmling-Cornell, A, Hemming, G, Hendry, M, Heng, I, Hennes, E, Hennig, J, Hennig, M, Henshaw, C, Hernandez, A, Hernandez Vivanco, F, Heurs, M, Hewitt, A, Higginbotham, S, Hild, S, Hill, P, Himemoto, Y, Hines, A, Hirata, N, Hirose, C, Ho, T, Hochheim, S, Hofman, D, Hohmann, J, Holcomb, D, Holland, N, Hollows, I, Holmes, Z, Holt, K, Holz, D, Hong, Q, Hough, J, Hourihane, S, Howell, D, Howell, E, Hoy, C, Hoyland, D, Hreibi, A, Hsieh, B, Hsieh, H, Hsiung, C, Huang, H, Huang, P, Huang, Y, Hübner, M, Huddart, A, Hughey, B, Hui, D, Hui, V, Husa, S, Huttner, S, Huxford, R, Huynh-Dinh, T, Hyland, J, Iandolo, G, Ide, S, Idzkowski, B, Iess, A, Inayoshi, K, Inoue, Y, Iosif, P, Irwin, J, Gupta, I, Isi, M, Ito, K, Itoh, Y, Iyer, B, Jaberianhamedan, V, Jacqmin, T, Jacquet, P, Jadhav, S, Jain, T, James, A, Jan, A, Jani, K, Janquart, J, Janssens, K, Janthalur, N, Jaranowski, P, Jariwala, D, Jarov, S, Jaume, R, Jenkins, A, Jenner, K, Jeon, C, Jia, W, Jiang, J, Jin, H, Johns, G, Johnston, R, Johny, N, Jones, A, Jones, D, Jones, P, Jones, R, Joshi, P, Ju, L, Jung, K, Jung, P, Junker, J, Juste, V, Kaihotsu, K, Kajita, T, Kakizaki, M, Kalaghatgi, C, Kalogera, V, Kamai, B, Kamiizumi, M, Kanda, N, Kandhasamy, S, Kang, G, Kanner, J, Kao, Y, Kapadia, S, Kapasi, D, Karat, S, Karathanasis, C, Karki, S, Kashyap, R, Kasprzack, M, Kastaun, W, Kato, T, Katsanevas, S, Katsavounidis, E, Katzman, W, Kaur, T, Kawabe, K, Kawaguchi, K, Kéfélian, F, Keitel, D, Key, J, Khadka, S, Khalili, F, Khan, S, Khanam, T, Khazanov, E, Khetan, N, Khursheed, M, Kijbunchoo, N, Kim, C, Kim, J, Kim, K, Kim, P, Kim, W, Kim, Y, Kimball, C, Kimura, N, King, B, Kinley-Hanlon, M, Kirchhoff, R, Kissel, J, Klimenko, S, Klinger, T, Knee, A, Knust, N, Kobayashi, Y, Koch, P, Koehlenbeck, S, Koekoek, G, Kohri, K, 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Veitch, J. Venneberg, G. Venugopalan, P. Verdier, D. Verkindt, P. Verma, Y. Verma, S. M. Vermeulen, D. Veske, F. Vetrano, A. Viceré, S. Vidyant, A. D. Viets, A. Vijaykumar, V. Villa-Ortega, J. -Y. Vinet, A. Virtuoso, S. Vitale, H. Vocca, E. R. G. von Reis, J. S. A. von Wrangel, C. Vorvick, S. P. Vyatchanin, L. E. Wade, M. Wade, K. J. Wagner, R. C. Walet, M. Walker, G. S. Wallace, L. Wallace, J. Wang, J. Z. Wang, W. H. Wang, R. L. Ward, J. Warner, M. Was, T. Washimi, N. Y. Washington, K. Watada, D. Watarai, J. Watchi, K. E. Wayt, B. Weaver, C. R. Weaving, S. A. Webster, M. Weinert, A. J. Weinstein, R. Weiss, C. M. Weller, R. A. Weller, F. Wellmann, L. Wen, P. Weßels, K. Wette, J. T. Whelan, D. D. White, B. F. Whiting, C. Whittle, O. S. Wilk, D. Wilken, C. E. Williams, D. Williams, M. J. Williams, A. R. Williamson, J. L. Willis, B. Willke, C. C. Wipf, G. Woan, J. Woehler, J. K. Wofford, I. A. Wojtowicz, D. Wong, I. C. F. Wong, M. Wright, C. Wu, D. S. Wu, H. Wu, D. M. Wysocki, L. Xiao, N. Yadav, T. Yamada, H. Yamamoto, K. Yamamoto, T. Yamamoto, K. Yamashita, R. Yamazaki, F. W. Yang, K. Z. Yang, L. Yang, Y. -C. Yang, Y. Yang, Yang Yang, M. J. Yap, D. W. Yeeles, S. -W. Yeh, A. B. Yelikar, J. Yokoyama, T. Yokozawa, J. Yoo, T. Yoshioka, Hang Yu, Haocun Yu, H. Yuzurihara, A. Zadrożny, M. Zanolin, S. Zeidler, T. Zelenova, J. -P. Zendri, M. Zevin, M. Zhan, H. Zhang, J. Zhang, L. Zhang, R. Zhang, T. Zhang, Y. Zhang, C. Zhao, G. Zhao, Y. Zhao, Yue Zhao, Y. Zheng, R. Zhou, X. J. Zhu, Z. -H. Zhu, A. B. Zimmerman, M. E. Zucker, and J. Zweizig
Abstract: We present the results of a model-based search for continuous gravitational waves from the low-mass X-ray binary Scorpius X-1 using LIGO detector data from the third observing run of Advanced LIGO and Advanced Virgo. This is a semicoherent search that uses details of the signal model to coherently combine data separated by less than a specified coherence time, which can be adjusted to balance sensitivity with computing cost. The search covered a range of gravitational-wave frequencies from 25 to 1600 Hz, as well as ranges in orbital speed, frequency, and phase determined from observational constraints. No significant detection candidates were found, and upper limits were set as a function of frequency. The most stringent limits, between 100 and 200 Hz, correspond to an amplitude h(0) of about 10(-25) when marginalized isotropically over the unknown inclination angle of the neutron star's rotation axis, or less than 4 x 10(-26) assuming the optimal orientation. The sensitivity of this search is now probing amplitudes predicted by models of torque balance equilibrium. For the usual conservative model assuming accretion at the surface of the neutron star, our isotropically marginalized upper limits are close to the predicted amplitude from about 70 to 100 Hz; the limits assuming that the neutron star spin is aligned with the most likely orbital angular momentum are below the conservative torque balance predictions from 40 to 200 Hz. Assuming a broader range of accretion models, our direct limits on gravitational-wave amplitude delve into the relevant parameter space over a wide range of frequencies, to 500 Hz or more.
Published: 2022

33. Ectopic ovary presenting as mesenteric abscess

Author: N Ishimaru, Y Kobayashi, H Fujikawa, and S Kondo
Subjects: Adult, Gynecology, medicine.medical_specialty, Pregnancy, business.industry, Ovary, Ectopic ovary, General Medicine, Peritoneal Diseases, medicine.disease, Asymptomatic, Abscess, Menstruation, medicine.anatomical_structure, medicine, Humans, Female, Mesentery, Surgery, Mesenteric abscess, medicine.symptom, business, Diverticulum
Abstract: Ectopic ovary is a rare gynaecological condition that results in problems with menstruation and pregnancy and may develop into a malignant tumour. However, as the condition is often asymptomatic, diagnosis is difficult and frequently delayed. We report a case of a 42-year-old female who presented with a 10-day history of abdominal pain. The patient underwent surgery that confirmed the diagnosis of an ectopic ovary with an internal abscess. The findings of our study indicate that ectopic ovaries can present with an abscess. Ectopic ovaries should be included in the differential diagnosis of masses with internal abscesses.
Published: 2021
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34. Temperature dependence of ortho-Positronium Annihilation in Room Temperature Ionic Liquids

Author: Tetsuya Hirade, Nagayasu Oshima, K. Michishio, and Y. Kobayashi
Subjects: chemistry.chemical_compound, Annihilation, Materials science, chemistry, Chemical physics, Ionic liquid, General Physics and Astronomy, Positronium
Published: 2020
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35. Metastasis of Breast Cancer to the Bile Ducts—A Case Report

Author: Toru Terashima, Kazuko Mori, Yukinori Inadome, Y. Kobayashi, Satoshi Yoneyama, Shotaro Shima, and Ryo Mutou
Subjects: Pathology, medicine.medical_specialty, Breast cancer, business.industry, Medicine, business, medicine.disease, Metastasis
Published: 2020
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36. Methotrexate-associated pneumonitis

Author: S Hanai, Y Kobayashi, R Ito, Y Maejima, and D Nakagomi
Subjects: Methotrexate, Antirheumatic Agents, Humans, General Medicine, Pneumonia
Published: 2022

37. ECG education for first-grade medical students detecting Epsilon and J waves in patients with arrhythmogenic right ventricular cardiomyopathy in comparison with specialists for arrhythmia treatment

Author: N Funabashi, K Nakamura, T Sasaki, S Naito, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Medical students find Epsilon and J wave diagnoses by electrocardiogram (ECG) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) difficult. Purpose To evaluate the inter observer reliability for detecting Epsilon and J wave in patients with ARVC between medical students and specialists for arrhythmia treatment and seek the problem for the ECG education to the students. Methods Nine patients (six males, mean age 59 ± 17 years) meeting 2010 ARVC task-force criteria (Circulation. 2010; 121:1533-1541) underwent a retrospective ECG analysis. First-grade medical students undertook ECG studies for 9 months (4 h/week) by a cardiologist who was not a specialist in arrhythmia treatments according to the Japanese Heart Rhythm Society (JHRS). Medical students detected Epsilon and J waves in all nine ECGs. Two JHRS specialists in arrhythmia treatment independently detected Epsilon and J waves; when diagnoses differed, a final diagnosis was made together. Results Epsilon waves were detected in five and eight patients by medical students and specialists, respectively. The distribution of Epsilon waves was determined in inferior and right-side precordial leads by students, but in right-side precordial leads only by specialists (Table). J waves were detected in nine and three patients by medical students and specialists, respectively. The J wave distribution was wider for medical students than specialists. Conclusions With ECG findings by specialists as the gold standard, even with a substantial education, medical students tended to diagnose Epsilon waves or notches in QRS as J waves. Lecturers need to equip students with additional basic clinical knowledge, such as Epsilon waves are more frequent in right-side precordial leads in ARVC patients. Abstract Figure. CT and ECG in ARVC
Published: 2022
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38. Clinical manifestation of coronary pulmonary arterial fistula diagnosed by cardiac computed tomography

Author: N Funabashi and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Coronary pulmonary arterial fistula (CPAF) may cause enlargement of an aneurysm, which may rupture or compress other organs, or occurrence of steal phenomenon of coronary arterial (CA) blood flow. We hypothesize that there are various clinical characteristics of CPAF including patient age at diagnosis, method of diagnosis, observed symptoms, complications, and surgical interventions Methods From a total of >17,000 patients undergoing CT from 2000-2019 in our institute, 11 patients diagnosed as having CPAF were analyzed retrospectively. One was treated surgically prior to analysis, and the remaining 10 (3 males; 56 ± 12 years) were followed for a mean of 52 ± 64 months. Results 5 were diagnosed as having CPAF through cardiac CT and 2 were diagnosed by invasive coronary angiograms. One was diagnosed by TTE and another patient was diagnosed by TTE and cardiac CT to differentiate from a mediastinal tumor. 4 had dyspnea, 2 had chest pain, and 1 had palpitation. 5 showed other cardiovascular disease (1 with left ventricular non-compaction, and persistent left superior vena cava; 1 with vascular type Ehlers-Danlos syndrome; 1 with hypertrophic cardiomyopathy; 1 with aortic valve regurgitation (AR); and 1 with vasospastic angina pectoris). The occurrence of steal phenomenon of CA blood flow was diagnosed in 4. CA aneurysm was observed in 5. 2 had abnormal flow from descending aorta to pulmonary arteries through CA. Pulmonary arterial systolic pressure >30 mmHg was observed in 2. During the observed periods, 4 underwent surgical procedure to eliminate CA aneurysm (N = 2), or for significant steal phenomenon of CA blood flow (N = 1). A patient with AR underwent CPAF elimination simultaneously with aortic valve replacement. The mean periods between initial diagnoses and surgical intervention was 27 ± 36 months. The remaining 6 were followed without surgical intervention for a mean of 69 ± 76 months without any cardiac events. Conclusion CPAF was diagnosed at a mean age of 56 years and half were diagnosed incidentally by cardiac CT. Five of the 11 patients (45%) underwent a surgical procedure. Patients with CPAF showed various symptoms due to complicating diseases, anatomical configurations, and outcomes. Abstract Figure. Typical CT images of CPAF
Published: 2022
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39. Comparison of sites of wall thickening and abnormal late enhancement on cardiac CT and magnetic resonance imaging with electrocardiography findings in patients with confirmed cardiac amyloidosis

Author: N Funabashi and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Left ventricular (LV) wall thickening and diastolic dysfunction on a transthoracic echocardiogram (TTE) without a high voltage R wave on V5 leads on an ECG leads to a diagnosis of cardiac amyloidosis. A final diagnosis is made by endomyocardial biopsy. However, amyloid sometimes invades the right ventricle (RV), and left (LA) and right (RA) atria, causing ECG changes such as sick sinus syndrome (SSS), arrhythmia, and QRS wave axis deviation. Purpose To elucidate the relationship between sites of wall thickening and abnormal late enhancement (LE) on cardiac computed tomography (CT) and magnetic resonance imaging (MRI), suggesting amyloid invasion, with ECG findings in patients with cardiac amyloidosis confirmed by biopsy. Methods A total of 26 patients (11 females) with suspected cardiac amyloidosis, who had LV wall thickening by TTE without a high voltage R wave in V5 leads on ECG, underwent cardiac CT. LV wall thickening observed on CT in the early phase led to a late phase acquisition. Five patients (3 females, mean age 73 years) were diagnosed with cardiac amyloidosis: complicated multiple myeloma, 2; senile ATTR (transthyretin) amyloidosis, 1; immunoglobulin light chain (AL) amyloidosis, 1; and transthyretin mutation, 1. Four patients underwent cardiac MRI. Results Case 1 had wall thickening in the basal interventricular septum (IVS), LV inferior-posterior wall, LA on CT, abnormal LE in the endocardium in whole LV, RV, and RA on CT, and LE in the endocardium in whole LV, RV, LA, and IVS on MRI. ECG showed SSS (junctional rhythm), left axis QRS wave deviation, no low voltage R wave in limb leads, and a mild LA load. Case 2 had wall thickening in whole LV, RV, LA, and IVS on CT, and unclear (CT) or no (MRI) abnormal LE. ECG revealed SSS (junctional rhythm), a normal QRS axis, no low voltage R wave in limb leads, and no LA load. Case 3 had wall thickening in the LA and basal IVS on CT, abnormal LE in the LA and basal IVS on CT, and LE in the LA only on MRI. ECG revealed atrial tachycardia, a normal QRS axis with low voltage R wave in limb leads, and no LA load. Case 4 had wall thickening in the LA, an RV moderator band on CT, an unclear LE on CT, and LE in whole LV, endocardium in the RV, and whole IVS on MRI. ECG showed a normal sinus rhythm, left axis QRS wave deviation, with low voltage R wave in limb leads, and no LA load. Case 5 had wall thickening in the IVS, LV lateral wall, LV anterior wall, RA, RV outflow tract, and RA appendage, and no abnormal LE on CT (MRI not performed). ECG revealed a normal sinus rhythm, right axis QRS wave deviation, with low voltage R wave in limb leads, and a mild LA load. Conclusions In this pilot study of a small number of patients with cardiac amyloidosis, few relationships between sites of wall thickening and abnormal LE on ECG were found. However, a long-term follow-up study with more patients may reveal relationships between such parameters using this methodology. Abstract Figure. Classification by wall thickening on CT
Published: 2022
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40. Arrhythmogenic right ventricular cardiomyopathy patients with a markedly enlarged RV compressing LV to left side have an atypical distribution of epsilon waves and elevated plasma BNP

Author: N Funabashi, M Okamoto, K Nakamura, T Sasaki, S Naito, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background Epsilon waves on V1-3 leads are specific ECG findings in patients with arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) suggesting RV conduction delay. Four dimensional (4D) cardiac CT visualizes ARVC characteristics, such as fibro-fatty invasion into RV and left ventricular (LV) myocardium (RVM, LVM), an enlarged RV, reduced RV motion, and bulging. Purpose We hypothesize that Epsilon waves in V4-6 leads suggest LV invasion in ARVC. Alternatively, extreme RV enlargement may compress the LV and cause clockwise rotation; an enlarged RV may itself cause epsilon waves in V4-6 leads. Methods Retrospective analysis of 17 patients (11 males, 57 ± 17 yrs) with suspected ARVC undergoing cardiac CT and ECG, 9 of whom met 2010 ARVC task force criteria. Results All 9 patients had epsilon waves on ECG; 5 had fibro-fatty invasion into the LVM. We divided the 9 into 5 groups by CT: 1) markedly enlarged RV compressing the LV to the left side with fibro-fatty changes exclusively in RVM (N = 1); 2) similar findings in both RVM and LVM (N = 2); 3) moderately enlarged RV without compression of the LV to the left side and fibro-fatty changes exclusively in RVM (N = 3); 4) the same in both RVM and LVM (N = 2); 5) severe mitral valve regurgitation, a markedly enlarged LV, and a fibro-fatty change in both RVM and LVM (N = 1). The patient in group (gp) 1 showed epsilon waves in V1-6 leads, patients in gp 2 had epsilon waves in V1-6 (N = 1), and V3-5 (N = 1) leads; patients in gp 3 had epsilon waves in V1-4 (N = 2), and V1-3 (N = 1) leads, patients in gp 4 had epsilon waves in V1-3 (N = 1), and V1, 2 (N = 1) leads; finally, the patient in gp 5 had epsilon waves in V4-6 leads. Plasma brain natriuretic peptide (BNP) levels were significantly greater in patients in gp 1 & 2 than gp 3 & 4 (1255 ± 838 vs 80 ± 52 pg/ml, P = 0.016). Conclusions ARVC patients with a markedly enlarged RV compressing the LV to the left side (gp 1,2) had a broad (V1-6) or different range (V3-5) distribution of epsilon waves and significantly elevated plasma BNP independent of fibro-fatty invasion of the LV, different from typical ARVC (gp 3,4). Additionally, structural change due to complicated heart disease, such as valvular disease (gp5), may also influence the distribution of epsilon waves in ARVC. Abstract Figure. CT and ECG in ARVC group 1
Published: 2022
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41. Learning curve of visually-guided laser balloon ablation of paroxysmal atrial fibrillation

Author: Y Kondo, M Nakano, T Kajiyama, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Background The visually-guided laser balloon (VGLB) is a compliant, variable-diameter balloon that delivers laser energy around the pulmonary vein (PV) ostium under real-time endoscopic visualization. However, limited data exist in Japan thus far. Therefore, we determined the safety, efficacy, and learning curve of the VGLB for PV isolation. Methods A total of 52 consecutive patients with paroxysmal atrial fibrillation were prospectively enrolled and divided into 3 groups (T1 = 15 patients, T2 = 15 patients, T3 = 22 patients). All patients underwent PV isolation by 2 operators using the VGLB. The operators were experienced in radiofrequency and cryothermal procedures, but not in laser ablations. Results Tables show the acute clinical results. Reversible phrenic nerve palsy occurred in 3.8%, with a trend towards a lower complication rate with increasing experience. Conclusions The VGLB was safe and effective for PV isolation, even for operators without any previous experience. Procedure time decreased after a learning curve of 30 cases. Abstract Figure. Procedural data and isolation rates
Published: 2022
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42. Impact of perioperative interruption of antithrombotic therapy on thrombotic and bleeding events in non-cardiac surgery

Author: K Saito, Y Saito, T Muramatsu, H Kitahara, Y Fujimoto, S Isono, and Y Kobayashi
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: None. Introduction Antithrombotic therapy including antiplatelet agents and anticoagulants are prescribed for secondary prevention in patients with established cardiovascular disease. Although antithrombotic therapy is often interrupted before non-cardiac surgery with or without perioperative bridging anticoagulation, the impact on thrombotic and bleeding events remains uncertain. Purpose The aim of this study was to clarify the impact of perioperative interruption of anticoagulants on thrombotic and bleeding events in patients with established CVD undergoing elective non-cardiac surgery. Methods A total of 330 patients chronically treated with antithrombotic therapy for secondary prevention underwent elective non-cardiac surgery under general anesthesia, with the complete interruption of antithrombotic agents. The study endpoints included all-cause death, thrombotic events, and major bleeding complications after surgical procedures. Results Of 330 patients, 171 (51.8%) and 159 (48.2%) received antiplatelet agents and anticoagulants perioperatively. Atrial fibrillation (31.8%) and coronary artery disease (20.3%) were the major indications for antithrombotic regimens. Antithrombotic therapy was interrupted from 5 [2, 7] days before the surgery to 4 [2, 7] days postoperatively. Perioperative bridging therapy with unfractionated heparin was employed in 99 (30.0%) patients. During the hospitalization, 3 (0.9%) patients died due to non-cardiovascular causes. Thrombotic events and major bleeding occurred in 2 (0.6%) and 9 (2.7%) patients. Bridging therapy with heparin was non-significantly associated with an increased risk of bleeding events (5.1% vs. 1.7%, p = 0.09). In univariable and multivariable analyses, pre-operative hemoglobin level and operative duration were significantly associated with bleeding complications. Conclusions In the present study, complete interruption of antithrombotic therapy resulted in a few thrombotic events with a numerically higher rate of bleeding events in patients undergoing elective non-cardiac surgery. Pre-operative hemoglobin level and operative duration were significantly associated with post-operative bleeding complications.
Published: 2022
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43. Optical Characterization of OMT-Coupled TES Bolometers for LiteBIRD

Author: J. Hubmayr, P. A. R. Ade, A. Adler, E. Allys, D. Alonso, K. Arnold, D. Auguste, J. Aumont, R. Aurlien, J. E. Austermann, S. Azzoni, C. Baccigalupi, A. J. Banday, R. Banerji, R. B. Barreiro, N. Bartolo, S. Basak, E. Battistelli, L. Bautista, J. A. Beall, D. Beck, S. Beckman, K. Benabed, J. Bermejo-Ballesteros, M. Bersanelli, J. Bonis, J. Borrill, F. Bouchet, F. Boulanger, S. Bounissou, M. Brilenkov, M. L. Brown, M. Bucher, E. Calabrese, M. Calvo, P. Campeti, A. Carones, F. J. Casas, A. Catalano, A. Challinor, V. Chan, K. Cheung, Y. Chinone, C. Chiocchetta, S. E. Clark, L. Clermont, S. Clesse, J. Cliche, F. Columbro, J. A. Connors, A. Coppolecchia, W. Coulton, J. Cubas, A. Cukierman, D. Curtis, F. Cuttaia, G. D’Alessandro, K. Dachlythra, P. de Bernardis, T. de Haan, E. de la Hoz, M. De Petris, S. Della Torre, J. J. Daz Garca, C. Dickinson, P. Diego-Palazuelos, M. Dobbs, T. Dotani, D. Douillet, E. Doumayrou, L. Duband, A. Ducout, S. M. Duff, J. M. Duval, K. Ebisawa, T. Elleflot, H. K. Eriksen, J. Errard, T. Essinger-Hileman, S. Farrens, F. Finelli, R. Flauger, K. Fleury-Frenette, C. Franceschet, U. Fuskeland, L. Galli, S. Galli, M. Galloway, K. Ganga, J. R. Gao, R. T. Genova-Santos, M. Georges, M. Gerbino, M. Gervasi, T. Ghigna, S. Giardiello, E. Gjerlw, R. Gonzlez Gonzles, M. L. Gradziel, J. Grain, L. Grandsire, F. Grupp, A. Gruppuso, J. E. Gudmundsson, N. W. Halverson, J. Hamilton, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, S. Henrot-Versill, B. Hensley, D. Herman, D. Herranz, G. C. Hilton, E. Hivon, R. A. Hlozek, D. Hoang, A. L. Hornsby, Y. Hoshino, K. Ichiki, T. Iida, T. Ikemoto, H. Imada, K. Ishimura, H. Ishino, G. Jaehnig, M. Jones, T. Kaga, S. Kashima, N. Katayama, A. Kato, T. Kawasaki, R. Keskitalo, C. Kintziger, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, I. Kreykenbohm, C. L. Kuo, A. Kushino, L. Lamagna, J. V. Lanen, G. Laquaniello, M. Lattanzi, A. T. Lee, C. Leloup, F. Levrier, E. Linder, M. J. Link, A. I. Lonappan, T. Louis, G. Luzzi, J. Macias-Perez, T. Maciaszek, B. Maffei, D. Maino, M. Maki, S. Mandelli, M. Maris, B. Marquet, E. Martnez-Gonzlez, F. A. Martire, S. Masi, M. Massa, M. Masuzawa, S. Matarrese, F. T. Matsuda, T. Matsumura, L. Mele, A. Mennella, M. Migliaccio, Y. Minami, K. Mitsuda, A. Moggi, M. Monelli, A. Monfardini, J. Montgomery, L. Montier, G. Morgante, B. Mot, Y. Murata, J. A. Murphy, M. Nagai, Y. Nagano, T. Nagasaki, R. Nagata, S. Nakamura, R. Nakano, T. Namikawa, F. Nati, P. Natoli, S. Nerval, N. Neto Godry Farias, T. Nishibori, H. Nishino, F. Noviello, G. C. O’Neil, C. O’Sullivan, K. Odagiri, H. Ochi, H. Ogawa, S. Oguri, H. Ohsaki, I. S. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Pascual Cisneros, A. Passerini, G. Patanchon, V. Pelgrim, J. Peloton, V. Pettorino, F. Piacentini, M. Piat, G. Piccirilli, F. Pinsard, G. Pisano, J. Plesseria, G. Polenta, D. Poletti, T. Prouv, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Reinecke, C. D. Reintsema, M. Remazeilles, A. Ritacco, P. Rosier, G. Roudil, J. Rubino-Martin, M. Russell, H. Sakurai, Y. Sakurai, M. Sandri, M. Sasaki, G. Savini, D. Scott, J. Seibert, Y. Sekimoto, B. Sherwin, K. Shinozaki, M. Shiraishi, P. Shirron, A. Shitvov, G. Signorelli, G. Smecher, F. Spinella, J. Starck, S. Stever, R. Stompor, R. Sudiwala, S. Sugiyama, R. Sullivan, A. Suzuki, J. Suzuki, T. Suzuki, T. L. Svalheim, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takase, Y. Takeda, A. Tartari, D. Tavagnacco, A. Taylor, E. Taylor, Y. Terao, L. Terenzi, J. Thermeau, H. Thommesen, K. L. Thompson, B. Thorne, T. Toda, M. Tomasi, M. Tominaga, N. Trappe, M. Tristram, M. Tsuji, M. Tsujimoto, C. Tucker, R. Ueki, J. N. Ullom, K. Umemori, L. Vacher, J. Van Lanen, G. Vermeulen, P. Vielva, F. Villa, M. R. Vissers, N. Vittorio, B. Wandelt, W. Wang, I. K. Wehus, J. Weller, B. Westbrook, G. Weymann-Despres, J. Wilms, B. Winter, E. J. Wollack, N. Y. Yamasaki, T. Yoshida, J. Yumoto, K. Watanuki, A. Zacchei, M. Zannoni, A. Zonca, Hubmayr, J, Ade, P, Adler, A, Allys, E, Alonso, D, Arnold, K, Auguste, D, Aumont, J, Aurlien, R, Austermann, J, Azzoni, S, Baccigalupi, C, Banday, A, Banerji, R, Barreiro, R, Bartolo, N, Basak, S, Battistelli, E, Bautista, L, Beall, J, Beck, D, Beckman, S, Benabed, K, Bermejo-Ballesteros, J, Bersanelli, M, Bonis, J, Borrill, J, Bouchet, F, Boulanger, F, Bounissou, S, Brilenkov, M, Brown, M, Bucher, M, Calabrese, E, Calvo, M, Campeti, P, Carones, A, Casas, F, Catalano, A, Challinor, A, Chan, V, Cheung, K, Chinone, Y, Chiocchetta, C, Clark, S, Clermont, L, Clesse, S, Cliche, J, Columbro, F, Connors, J, Coppolecchia, A, Coulton, W, Cubas, J, Cukierman, A, Curtis, D, Cuttaia, F, D’Alessandro, G, Dachlythra, K, de Bernardis, P, de Haan, T, de la Hoz, E, De Petris, M, Della Torre, S, Daz Garca, J, Dickinson, C, Diego-Palazuelos, P, Dobbs, M, Dotani, T, Douillet, D, Doumayrou, E, Duband, L, Ducout, A, Duff, S, Duval, J, Ebisawa, K, Elleflot, T, Eriksen, H, Errard, J, Essinger-Hileman, T, Farrens, S, Finelli, F, Flauger, R, Fleury-Frenette, K, Franceschet, C, Fuskeland, U, Galli, L, Galli, S, Galloway, M, Ganga, K, Gao, J, Genova-Santos, R, Georges, M, Gerbino, M, Gervasi, M, Ghigna, T, Giardiello, S, Gjerlw, E, Gonzles, R, Gradziel, M, Grain, J, Grandsire, L, Grupp, F, Gruppuso, A, Gudmundsson, J, Halverson, N, Hamilton, J, Hargrave, P, Hasebe, T, Hasegawa, M, Hattori, M, Hazumi, M, Henrot-Versill, S, Hensley, B, Herman, D, Herranz, D, Hilton, G, Hivon, E, Hlozek, R, Hoang, D, Hornsby, A, Hoshino, Y, Ichiki, K, Iida, T, Ikemoto, T, Imada, H, Ishimura, K, Ishino, H, Jaehnig, G, Jones, M, Kaga, T, Kashima, S, Katayama, N, Kato, A, Kawasaki, T, Keskitalo, R, Kintziger, C, Kisner, T, Kobayashi, Y, Kogiso, N, Kogut, A, Kohri, K, Komatsu, E, Komatsu, K, Konishi, K, Krachmalnicoff, N, Kreykenbohm, I, Kuo, C, Kushino, A, Lamagna, L, Lanen, J, Laquaniello, G, Lattanzi, M, Lee, A, Leloup, C, Levrier, F, Linder, E, Link, M, Lonappan, A, Louis, T, Luzzi, G, Macias-Perez, J, Maciaszek, T, Maffei, B, Maino, D, Maki, M, Mandelli, S, Maris, M, Marquet, B, Martnez-Gonzlez, E, Martire, F, Masi, S, Massa, M, Masuzawa, M, Matarrese, S, Matsuda, F, Matsumura, T, Mele, L, Mennella, A, Migliaccio, M, Minami, Y, Mitsuda, K, Moggi, A, Monelli, M, Monfardini, A, Montgomery, J, Montier, L, Morgante, G, Mot, B, Murata, Y, Murphy, J, Nagai, M, Nagano, Y, Nagasaki, T, Nagata, R, Nakamura, S, Nakano, R, Namikawa, T, Nati, F, Natoli, P, Nerval, S, Neto Godry Farias, N, Nishibori, T, Nishino, H, Noviello, F, O’Neil, G, O’Sullivan, C, Odagiri, K, Ochi, H, Ogawa, H, Oguri, S, Ohsaki, H, Ohta, I, Okada, N, Pagano, L, Paiella, A, Paoletti, D, Pascual Cisneros, G, Passerini, A, Patanchon, G, Pelgrim, V, Peloton, J, Pettorino, V, Piacentini, F, Piat, M, Piccirilli, G, Pinsard, F, Pisano, G, Plesseria, J, Polenta, G, Poletti, D, Prouv, T, Puglisi, G, Rambaud, D, Raum, C, Realini, S, Reinecke, M, Reintsema, C, Remazeilles, M, Ritacco, A, Rosier, P, Roudil, G, Rubino-Martin, J, Russell, M, Sakurai, H, Sakurai, Y, Sandri, M, Sasaki, M, Savini, G, Scott, D, Seibert, J, Sekimoto, Y, Sherwin, B, Shinozaki, K, Shiraishi, M, Shirron, P, Shitvov, A, Signorelli, G, Smecher, G, Spinella, F, Starck, J, Stever, S, Stompor, R, Sudiwala, R, Sugiyama, S, Sullivan, R, Suzuki, A, Suzuki, J, Suzuki, T, Svalheim, T, Switzer, E, Takaku, R, Takakura, H, Takakura, S, Takase, Y, Takeda, Y, Tartari, A, Tavagnacco, D, Taylor, A, Taylor, E, Terao, Y, Terenzi, L, Thermeau, J, Thommesen, H, Thompson, K, Thorne, B, Toda, T, Tomasi, M, Tominaga, M, Trappe, N, Tristram, M, Tsuji, M, Tsujimoto, M, Tucker, C, Ueki, R, Ullom, J, Umemori, K, Vacher, L, Van Lanen, J, Vermeulen, G, Vielva, P, Villa, F, Vissers, M, Vittorio, N, Wandelt, B, Wang, W, Wehus, I, Weller, J, Westbrook, B, Weymann-Despres, G, Wilms, J, Winter, B, Wollack, E, Yamasaki, N, Yoshida, T, Yumoto, J, Watanuki, K, Zacchei, A, Zannoni, M, Zonca, A, and National Aeronautics and Space Administration (US)
Subjects: CMB, TES, OMT, Low temperature detector, Bolometer, FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, General Materials Science, Condensed Matter Physics, CMB, TES, OMT, Low temperature detector, Bolometer, Atomic and Molecular Physics, and Optics
Abstract: et al., Feedhorn- and orthomode transducer- (OMT) coupled transition edge sensor (TES) bolometers have been designed and micro-fabricated to meet the optical specifications of the LiteBIRD high frequency telescope (HFT) focal plane. We discuss the design and optical characterization of two LiteBIRD HFT detector types: dual-polarization, dual-frequency-band pixels with 195/280 GHz and 235/337 GHz band centers. Results show well-matched passbands between orthogonal polarization channels and frequency centers within 3% of the design values. The optical efficiency of each frequency channel is conservatively reported to be within the range 0.64−0.72, determined from the response to a cryogenic, temperature-controlled thermal source. These values are in good agreement with expectations and either exceed or are within 10% of the values used in the LiteBIRD sensitivity forecast. Lastly, we report a measurement of loss in Nb/SiNx/Nb microstrip at 100 mK and over the frequency range 200–350 GHz, which is comparable to values previously reported in the literature., This work is supported by NASA under grant no. 80NSSC18K0132.
Published: 2022

44. Cherenkov Telescope Array : the World’s largest VHE gamma-ray observatory

Author: Roberta Zanin, H. Abdalla, H. Abe, S. Abe, A. Abusleme, F. Acero, A. Acharyya, V. Acin Portella, K. Ackley, R. Adam, C. Adams, S.S. Adhikari, I. Aguado Ruesga, I. Agudo, R. Aguilera, A. Aguirre Santaella, F. Aharonian, A. Alberdi, R. Alfaro, J. Alfaro, C. Alispach, R. Aloisio, R. Alves Batista, J.P. Amans, L. Amati, E. Amato, L. Ambrogi, G. Ambrosi, M. Ambrosio, R. Ammendola, J. Anderson, M. Anduze, E.O. Anguner, L.A. Antonelli, V. Antonuccio, P. Antoranz, R. Anutarawiramkul, J. Aragunde Gutierrez, C. Aramo, A. Araudo, M. Araya, A. Arbet Engels, C. Arcaro, V. Arendt, C. Armand, T. Armstrong, F. Arqueros, L. Arrabito, B. Arsioli, M. Artero, K. Asano, Y. Ascasibar, J. Aschersleben, M. Ashley, P. Attina, P. Aubert, C. B. Singh, D. Baack, A. Babic, M. Backes, V. Baena, S. Bajtlik, A. Baktash, C. Balazs, M. Balbo, O. Ballester, J. Ballet, B. Balmaverde, A. Bamba, R. Bandiera, A. Baquero Larriva, P. Barai, C. Barbier, V. Barbosa Martins, M. Barcelo, M. Barkov, M. Barnard, L. Baroncelli, U. Barres de Almeida, J.A. Barrio, D. Bastieri, P.I. Batista, I. Batkovic, C. Bauer, R. Bautista González, J. Baxter, U. Becciani, J. Becerra González, Y. Becherini, G. Beck, J. Becker Tjus, W. Bednarek, A. Belfiore, L. Bellizzi, R. Belmont, W. Benbow, D. Berge, E. Bernardini, M.I. Bernardos, K. Bernlöhr, A. Berti, M. Berton, B. Bertucci, V. Beshley, N. Bhatt, S. Bhattacharyya, W. Bhattacharyya, B. Y. Bi, G. Bicknell, N. Biederbeck, C. Bigongiari, A. Biland, R. Bird, E. Bissaldi, J. Biteau, M. Bitossi, O. Blanch, M. Blank, J. Blazek, J. Bobin, C. Boccato, F. Bocchino, C. Boehm, M. Bohacova, C. Boisson, J. Boix, J.P. Bolle, J. Bolmont, G. Bonanno, C. Bonavolontà, L. Bonneau Arbeletche, G. Bonnoli, P. Bordas, J. Borkowski, R. Bose, D. Bose, Z. Bosnjak, E. Bottacini, Markus Böttcher, M.T. Botticella, C. Boutonnet, F. Bouyjou, V. Bozhilov, E. Bozzo, L. Brahimi, C. Braiding, S. Brau Nogue, S. Breen, J. Bregeon, M. Breuhaus, A. Brill, W. Brisken, E. Brocato, A.M. Brown, K. Brügge, P. Brun, F. Brun, L. Brunetti, G. Brunetti, P. Bruno, A. Bruno, A. Bruzzese, N. Bucciantini, J. H. Buckley, R. Bühler, A. Bulgarelli, T. Bulik, M. Bünning, M. Bunse, M. Burton, A. Burtovoi, M. Buscemi, S. Buschjager, G. Busetto, J. Buss, K. Byrum, A. Caccianiga, F. Cadoux, A. Calanducci, C. Calderon, J. Calvo Tovar, R. A. Cameron, P. Campana, R. Canestrari, F. Cangemi, B. Cantlay, M. Capalbi, M. Capasso, M. Cappi, A. Caproni, R. Capuzzo Dolcetta, P. Caraveo, V. Cárdenas, L. Cardiel, M. Cardillo, C. Carlile, S. Caroff, R. Carosi, A. Carosi, E. Carquin, M. Carrere, J.M. Casandjian, S. Casanova, F. Cassol, F. Catalani, O. Catalano, D. Cauz, A. Ceccanti, C. Celestino Silva, K. Cerny, M. Cerruti, E. Chabanne, P. Chadwick, Y. Chai, P. Chambery, C. Champion, S. Chaty, A. Chen, K. Cheng, M. Chernyakova, G. Chiaro, A. Chiavassa, M. Chikawa, V.R. Chitnis, J. Chudoba, L. Chytka, S. Cikota, A. Circiello, P. Clark, M. Colak, E. Colombo, S. Colonges, A. Comastri, A. Compagnino, V. Conforti, E. Congiu, R. Coniglione, J. Conrad, F. Conte, J.L. Contreras, P. Coppi, R. Cornat, J. Coronado Blazquez, J. Cortina, A. Costa, H. Costantini, G. Cotter, B. Courty, S. Covino, S. Crestan, P. Cristofari, R. Crocker, J. Croston, K. Cubuk, O. Cuevas, X. Cui, G. Cusumano, S. Cutini, G. D'Amico, F. D'Ammando, P. D'Avanzo, P. Da Vela, M. Dadina, S. Dai, M. Dalchenko, M. Dall'Ora, M.K. Daniel, J. Dauguet, I. Davids, J. Davies, B. Dawson, A. De Angelis, A.E. de Araujo Carvalho, M. de Bony de Lavergne, G. De Cesare, F. de Frondat, I. de la Calle, E. de Gouveia Dal Pino, B. De Lotto, A. De Luca, D. De Martino, M. de Naurois, E. de Ona Wilhelmi, F. De Palma Persio, N. De Simone, V. de Souza Valle, E. Delagnes, G. Deleglise Reznicek, C. Delgado, A.G. Delgado Giler, J. Delgado Mengual Valle, Domenico Della Volpe, D. Depaoli, J. Devin, T. Di Girolamo, C. Di Giulio Pierro, L. Di Venere, C. Díaz, C. Dib, S. Diebold, S. Digel, A. Djannati Atai, J. Djuvsland, A. Dmytriiev, K. Docher, A. Domínguez, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, Rita Cassia dos Anjos, J.L. Dournaux, T. Downes, G. Drake, H. Drass, D. Dravins, C. Duangchan, A. Duara, G. Dubus, L. Ducci, C. Duffy, D. Dumora, K. Dundas Mora, A. Durkalec, V.V. Dwarkadas, J. Ebr, C. Eckner, J. Eder, E. Edy, K. Egberts, S. Einecke, C. Eleftheriadis, D. Elsässer, G. Emery, D. Emmanoulopoulos, J.P. Ernenwein, M. Errando, P. Escarate, J. Escudero, C. Espinoza, S. Ettori, A. Eungwanichayapant, P. Evans, C. Evoli, M. Fairbairn, D. Falceta Goncalves, A. Falcone, V. Fallah Ramazanı, R. Falomo, K. Farakos, G. Fasola, A. Fattorini, Y. Favre, R. Fedora, E. Fedorova, K. Feijen, Q. Feng, G. Ferrand, G. Ferrara, O. Ferreira, M. Fesquet, E. Fiandrini, A. Fiasson, M. Filipovic, D. Fink, J.P. Finley, V. Fioretti, D.F.G. Fiorillo, M. Fiorini, S. Flis, H. Flores, L. Foffano, C. Fohr, M.V. Fonseca, L. Font, G. Fontaine, O. Fornieri, P. Fortin, L. Fortson, N. Fouque, B. Fraga, A. Franceschini, F.J. Franco, L. Freixas Coromina, L. Fresnillo, D. Fugazza, Y. Fujita, S. Fukami, Y. Fukazawa, D. Fulla, S. Funk, A. Furniss, S. Gabici, D. Gaggero, G. Galanti, P. Galdemard, Y. A. Gallant, D. Galloway, S. Gallozzi, V. Gammaldi, R. Garcia, L. E. García-Muñoz, E. Garcia Lopez, F. Gargano, C. Gargano, S. Garozzo, D. Gascon, T. Gasparetto, D. Gasparrini, H. Gasparyan, M. Gaug, N. Geffroy, A. Gent, S. Germani, A. Ghalumyan, A. Ghedina, G. Ghirlanda, F. Gianotti, S. Giarrusso, M. Giarrusso, G. Giavitto, B. Giebels, N. Giglietto, V. Gika, F. Gillardo, R. Gimenes, F. Giordano, E. Giro, M. Giroletti, Andrea Giuliani, M. Gjaja, J.F. Glicenstein, P. Gliwny, H. Goksu, P. Goldoni, J.L. Gomez, M.M. Gonzalez, Juan Manuel Gonzalez, K.S. Gothe, D. Gotz Coelho, T. Grabarczyk, R. Graciani, P. Grandi, G. Grasseau, D. Grasso, D. Green, J. Green, T. Greenshaw, P. Grespan, A. Grillo, M.H. Grondin, J. Grube, V. Guarino, B. Guest, O. Gueta, M. Günduz, S. Gunji, G. Gyuk, J. Hackfeld, D. Hadasch, L. Hagge, A. Hahn, J.E. Hajlaoui, A. Halim, P. Hamal, W. Hanlon, Y. Harada, M.J. Hardcastle, M. Harvey Collado, T. Haubold, A. Haupt, M. Havelka, K. Hayashi, M. Hayashida, H. He, L. Heckmann, M. Heller, F. Henault, Gilles Henri, G. Hermann, S. Hernández Cadena, J. Herrera Llorente, O. Hervet, J. Hinton, A. Hiramatsu, K. Hirotani, B. Hnatyk, R. Hnatyk, J.K. Hoang, D. H.H. Hoffmann, C. Hoischen, J. Holder, M. Holler, B. Hona, D. Horan, Dieter Horns, P. Horvath, J. Houles, M. Hrabovsky, D. Hrupec, Y. Huang, J.‑M. Huet, G. Hughes, G. Hull, T.B. Humensky, M. Hütten, M. Iarlori, J.M. Illa, R. Imazawa, T. Inada, F. Incardona, A. Ingallinera, S. Inoue, T. Inoue, Y. Inoue, F. Iocco, K. Ioka, M. Ionica, S. Iovenitti, A. Iriarte, K. Ishio, W. Ishizaki, Y. Iwamura, J. Jacquemier, M. Jacquemont, M. Jamrozy, P. Janecek, F. Jankowsky, A. JardinBlicq, C. Jarnot, P. Jean Martínez, L. Jocou, N. Jordana, M. Josselin, I. JungRichardt, F.J.P.A. Junqueira, C. Juramy Gilles, P. Kaaret, L.H.S. Kadowaki, M. Kagaya, R. Kankanyan, D. Kantzas, V. Karas, A. Karastergiou, S. Karkar, J. Kasperek, H. Katagiri, J. Kataoka, K. Katarzynski, S. Katsuda, N. Kawanaka, D. Kazanas, D. Kerszberg, B. Khélifi, M.C. Kherlakian, T.P. Kian, D.B. Kieda, T. Kihm, S. Kim, S. Kisaka, R. Kissmann, R. Kleijwegt, G. Kluge, W. Kluźniak, J. Knapp, A. Kobakhidze, Y. Kobayashi, B. Koch, J. Kocot, K. Kohri, N. Komin, A. Kong, K. Kosack, F. Krack, M. Krause, F. Krennrich, H. Kubo, V. N. Kudryavtsev, S. Kunwar, J. Kushida, P. Kushwaha, Barbera Parola, G. La Rosa, R. Lahmann, A. Lamastra, M. Landoni, D. Landriu, R.G. Lang, J. Lapington, P. Laporte, P. Lason, J. Lasuik, J. Lazendic Galloway, T. Le Flour, P. Le Sidaner, S. Leach, S.H. Lee, W.H. Lee, S. Lee Oliveira, A. Lemiere, M. Lemoine Goumard, J.P. Lenain, F. Leone, V. Leray, G. Leto, F. Leuschner, R. Lindemann, E. Lindfors, L. Linhoff, I. Liodakis, A. Lipniacka, M. Lobo, Thomas Lohse, S. Lombardi, A. Lopez, M. Lopez, R. Lopez Coto, F. Louis, M. Louys, F. Lucarelli, H. Ludwig Boudi, P.L. Luque Escamilla, M.C. Maccarone, E. Mach, A.J. Maciejewski, J. Mackey, P. Maeght, C. Maggio, G. Maier, P. Majumdar, M. Makariev, M. Mallamaci, R. Malta Nunes de Almeida, D. Malyshev, D. Mandat, G. Maneva, M. Manganaro, P. Manigot, K. Mannheim, N. Maragos, D. Marano, M. Marconi, A. Marcowith, M. Marculewicz, B. Marcun, J. Marin, N. Marinello, P. Marinos, S. Markoff, P. Marquez, G. Marsella, J. M. Martin, P. G. Martin, M. Martinez, G. Martinez, O. Martinez, H. Martinez Huerta, C. Marty, R. Marx, N. Masetti, P. Massimino, H. Matsumoto, N. Matthews, G. Maurin, W. Max Moerbeck, N. Maxted, M.N. Mazziotta, S.M. Mazzola, J.D. Mbarubucyeye, L. Mc Comb, I. McHardy, S. McKeague, S. McMuldroch, E. Medina, D. Medina Miranda, A. Melandri, C. Melioli, D. Melkumyan, S. Menchiari, S. Mereghetti, G. Merino Arevalo, E. Mestre, J.L. Meunier, T. Meures, S. Micanovic, M. Miceli, M. Michailidis, J. Michalowski, T. Miener, I. Mievre, J. D. Miller, T. Mineo, M. Minev, J.M. Miranda, A. Mitchell, T. Mizuno, B. A. Mode, R. Moderski, L. Mohrmann, E. Molinari, T. Montaruli, I. Monteiro, C. Moore, A. Moralejo, D. Morcuende Parrilla, E. Moretti, K. Mori, P. Moriarty, K. Morik, P. Morris, A. Morselli, K. Mosshammer, R. Mukherjee, J. Muller, C. Mundell, J. Mundet, T. Murach, A. Muraczewski, H. Muraishi, I. Musella, A. Musumarra, A. Nagai, S. Nagataki, T. Naito, T. Nakamori, K. Nakashima, K. Nakayama, N. Nakhjiri, G. Naletto, D. Naumann, L. Nava, M.A. Nawaz, H. Ndiyavala, D. Neise, L. Nellen, R. Nemmen, N. Neyroud, K. Ngernphat, T. Nguyen Trung, L. Nicastro, L. Nickel, J. Niemiec, D. Nieto, C. Nigro, M. Nikołajuk, D. Ninci, K. Noda, Y. Nogami, S. Nolan, R. P. Norris, D. Nosek, M. Nöthe, V. Novotny, S. Nozaki, F. Nunio, P. O'Brien, K. Obara, Y. Ohira, M. Ohishi, S. Ohm, T. Oka, N. Okazaki, A. Okumura, C. Oliver, G. Olivera, B. Olmi, M. Orienti, R. Orito, M. Orlandini, E. Orlando, J.P. Osborne, M. Ostrowski, N. Otte, E. Ovcharov, E. Owen, I. Oya, A. Ozieblo, M. Padovani, A. Pagliaro, A. Paizis, M. Palatiello, M. Palatka, E. Palazzi, J.‑L. Panazol, D. Paneque, S. Panny, Francesca Romana Pantaleo, M. Panter, M. Paolillo, A. Papitto, A. Paravac, J.M. Paredes, G. Pareschi, N. Parmiggiani, R.D. Parsons, P. Paśko, S. R. Patel, B. Patricelli, L. Pavletic, S. Pavy, A. Peer, M. Pecimotika, M.G. Pellegriti, P. Peñil Del Campo, A. Pepato, S. Perard, C. Perennes, M. Peresano, A. Perez Aguilera, J. Perez Romero, M.A. Perez Torres, M. Persic, P. O. Petrucci, O. Petruk, B. Peyaud, K. Pfrang, E. Pian, P. Piatteli, E. Pietropaolo, R. Pillera, D. Pimentel, F. Pintore, C. Pio Garcia, G. Pirola, F. Piron, S. Pita, M. Pohl, V. Poireau, A. Pollo, M. Polo, C. Pongkitivanichkul, J. Porthault, J. Powell, D. Pozo, R.R. Prado, E. Prandini, J. Prast, K. Pressard, G. Principe, N. Produit, D. Prokhorov, H. Prokoph, H. Przybilski, E. Pueschel, G. Pühlhofer, I. Puljak, M.L. Pumo, M. Punch, F. Queiroz, J. Quinn, A. Quirrenbach, P.J. Rajda, R. Rando, S. Razzaque, S. Recchia, P. Reichherzer, O. Reimer, A. Reisenegger, Q. Remy, M. Renaud, T. Reposeur, B. Reville, J.M. Reymond, J. Reynolds, D. Ribeiro, M. Ribo, G. Richards, J. Rico, F. Rieger, L. Riitano, M. Riquelme, D. Riquelme, S. Rivoire, V. Rizi, E. Roache, M. Roche, J. Rodriguez, G. Rodriguez Fernandez, J.C. Rodriguez Ramirez, J.J. Rodriguez Vazquez, G. Rojas, P. Romano, G. Romeo Lobato, C. Romoli, M. Roncadelli, J. Rosado, A. Rosales de Leon, G. Rowell, A. Rugliancich, J.E. Ruiz del Mazo, C. Rulten, C. Russell, F. Russo Hatlen, S. Safi Harb, L. Saha, V. Sahakian, S. Sailer, T. Saito, N. Sakaki, S. Sakurai, G. Salina, H. Salzmann, D. Sanchez, H. Sandaker, A. Sandoval, P. Sangiorgi, M. Sanguillon, H. Sano, M. Santander, A. Santangelo, R. Santos Lima, A. Sanuy, L. Sapozhnikov, T. Saric, S. Sarkar, H. Sasaki, N. Sasaki, Y. Sato, F.G. Saturni, M. Sawada, J. Schaefer, A. Scherer, J. Scherpenberg, P. Schipani, B. Schleicher, J. Schmoll, M. Schneider, H. Schoorlemmer, P. Schovanek, F. Schussler, B. Schwab, U. Schwanke, J. Schwarz, E. Sciacca, S. Scuderi, M. Seglar Arroyo, I. Seitenzahl, D. Semikoz, O. Sergijenko, J.E. Serna Franco, Karol Seweryn, V. Sguera, A. Shalchi, R.Y. Shang, P. Sharma, L. Sidoli, J. Sieiro, H. Siejkowski, A. Sillanpaa, B.B. Singh, K.K. Singh, A. Sinha, C. Siqueira, J. Sitarek, P. Sizun, V. Sliusar, D. Sobczynska, R.W. Sobrinho, H. Sol, G. Sottile, H. Spackman, S. Spencer, G. Spengler, D. Spiga, W. Springer, A. Stamerra, S. Stanic, R. Starling, Ł. Stawarz, Stanislav Stefanik, C. Stegmann, A. Steiner, S. Steinmassl, C. Stella, R. Sternberger, M. Sterzel, C. Stevens, B. Stevenson, T. Stolarczyk, G. Stratta, U. Straumann, J. Striskovic, M. Strzys, R. Stuik, M. Suchenek, Y. Sunada, Tiina Suomijarvi, T. Suric, H. Suzuki, P. Swierk, T. Szepieniec, K. Tachihara, G. Tagliaferri, H. Tajima, N. Tajima, D. Tak, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, T. Tam, M. Tanaka, T. Tanaka, S. Tanaka, M. Tavani, F. Tavecchio, T. Tavernier, A. Russ Taylor, L.A. Tejedor, P. Temnikov, K. Terauchi, J.C. Terrazas, R. Terrier, T. Terzic, M. Teshima, D. Thibaut, F. Thocquenne, W. Tian, L. Tibaldo, A. Tiengo, M. Tluczykont, C.J. Todero Peixoto, K. Toma, L. Tomankova, J. Tomastik, M. Tornikoski, D.F. Torres, E. Torresi, G. Tosti, L. Tosti, N. Tothill, F. Toussenel, G. Tovmassian, C. Trichard, M. Trifoglio, A. Trois, S. Truzzi, A. Tsiahina, B. Turk, A. Tutone, Y. Uchiyama, P. Utayarat, L. Vaclavek, M. Vacula, V. Vagelli, F. Vagnetti, J.A. Valdivia, M. Valentino, A. Valio, B. Vallage, P. Vallania Quispe, A.M. van den Berg, W. van Driel, C. van Eldik, C. van Rensburg, Brian van Soelen, J. Vandenbroucke, G. Vasileiadis, V. Vassiliev, M. Vazquez Acosta, M. Vecchi, A. Vega, J. Veh, P. Veitch, C. Venter, S. Ventura, S. Vercellone, V. Verguilov, G. Verna, S. Vernetto, V. Verzi, G.P. Vettolani, C. Veyssiere, I. Viale, A. Viana, N. Viaux, J. Vignatti, C.F. Vigorito, J. Villanueva, V. Vitale, V. Vittorini, V. Vodeb, N. Vogel, V. Voisin, S. Vorobiov, M. Vrastil, T. Vuillaume, S.J. Wagner, P. Wagner, K. Wakazono, S.P. Wakely, M. Ward, D. Warren, J. Watson, M. Wechakama, P. Wegner, A. Weinstein, C. Weniger, F. Werner, H. Wetteskind, M. L. White, A. Wierzcholska, S. Wiesand, R. Wijers, M. Wilkinson, M. Will, J. Williams, T. J. Williamson, A. Wolter, Y.W. Wong, M. Wood, T. Yamamoto, H. Yamamoto, Y. Yamane, R. Yamazaki, S. Yanagita, L. Yang, S. Yoo, T. Yoshida, T. Yoshikoshi, P. Yu, A. Yusafzai, Michael Zacharias, B. Zaldivar, L. Zampieri, R. Zanin, R. Zanmar Sanchez, D. Zaric, M. Zavrtanik, D. Zavrtanik, Andrzej Zdziarski, A. Zech, H. Zechlin, A. Zenin, A. Zerwekh, K. Ziętara, A. Zink, J. Ziolkowski, M. Zivec, A. Zmija, Współautorami artykułu są członkowie CTA Observatory, CTA Consortium i LST Collaboration w liczbie 1139, Astronomy, Research unit Nuclear & Hadron Physics, and Research unit Astroparticle Physics
Subjects: Physics, Observatory, Gamma ray, Astronomy
Abstract: Very-high Energy (VHE) gamma-ray astroparticle physics is a relatively young field, and observations over the past decade have surprisingly revealed almost two hundred VHE emitters which appear to act as cosmic particle accelerators. These sources are an important component of the Universe, influencing the evolution of stars and galaxies. At the same time, they also act as a probe of physics in the most extreme environments known - such as in supernova explosions, and around or after the merging of black holes and neutron stars. However, the existing experiments have provided exciting glimpses, but often falling short of supplying the full answer. A deeper understanding of the TeV sky requires a significant improvement in sensitivity at TeV energies, a wider energy coverage from tens of GeV to hundreds of TeV and a much better angular and energy resolution with respect to the currently running facilities. The next generation gamma-ray observatory, the Cherenkov Telescope Array Observatory (CTAO), is the answer to this need. In this talk I will present this upcoming observatory from its design to the construction, and its potential science exploitation. CTAO will allow the entire astronomical community to explore a new discovery space that will likely lead to paradigm-changing breakthroughs. In particular, CTA has an unprecedented sensitivity to short (sub-minute) timescale phenomena, placing it as a key instrument in the future of multi-messenger and multi-wavelength time domain astronomy. I will conclude the talk presenting the first scientific results obtained by the LST-1, the prototype of one CTAO telescope type - the Large-Sized Telescope, that is currently under commission., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference (ICRC2021)
Published: 2022

45. Enteric methane emission models for diverse beef cattle feeding systems in South-east Asia : A meta-analysis

Author: T.P. Tee, Y.M. Goh, M.H.M. Zainudin, S.C.L. Candyrine, K. Sommart, K. Kongphitee, W. Sumamal, I. Phaowphaisal, R. Namsilee, W. Angthong, S. Sunato, O. Keaokliang, K. Maeda, N.V. Thu, T.T. Trung, N.T.K. Dong, A. Purnomoadi, M. Kurihara, A. Jayanegara, K. Higuchi, Y. Kobayashi, F. Ohtani, H. Abe, F. Terada, H. Kumagai, H. Matsuyama, I. Nonaka, N. Takusari, N. Shiba, K. Hosoda, T. Suzuki, Y. Kamiya, T. Nishida, K. Hayasaka, M. Shibata, M. Wang, Z.L. Tan, R. Wang, E. Kebreab, H.J. van Lingen, A.N. Hristov, and J.B. Liang
Subjects: Enteric methane emission, Systeem en Synthetische Biologie, Animal Science and Zoology, Systems and Synthetic Biology, Methane intensity, Forage content, Prediction models, Methane yield, Developing countries
Abstract: Prediction models for enteric methane (CH4) emissions from beef cattle proposed by various groups may not perform with similar accuracy for the low- and middle-income countries in South-east Asia (SE-Asia) because beef cattle in these countries are raised under different climatic conditions with diverse feeding systems, and have different CH4 emission characteristics. The objectives of this study were to: i) predict CH4 emission (g d−1 animal−1), yield [g kg−1 dry matter intake; DMI)−1], intensity [g kg−1 average daily gain)−1], and CH4 conversion factor (Ym) using an intercountry database of individual animal records from SE-Asia; ii) evaluate the impact of different dietary forage contents (all-, high- and low-forage) representing the diverse feeding systems on CH4 emission, yield, intensity and Ym in SE-Asia; and iii) cross-validate equations from this study with published data. A total of 398 individual animal observations of beef cattle from SE-Asia were used for this analysis. Linear models developed by incrementally adding covariates revealed that CH4 emission model using only DMI fitted to all data had a root mean square prediction error (RMSPE) of 16.9%. Subsets containing data with 100% forage in the diet (all-forage), 50–85% (high-forage) and < 50% (low-forage) had an RMSPE of 16.5%, 14.7%, and 17.4%, respectively. Linear multiple equation based on DMI and dietary NDF concentration (DMI + NDF_C, RMSPE = 15.2%; all-data) improved prediction accuracy over that of DMI alone. The DMI + NDF_C models for all-forage (RMSPE = 14.6%) and high-forage subsets (RMSPE = 13.3%) except for low-forage (RMSPE = 16.4%), improved the precision and accuracy of CH4 emission prediction. Methane yield and CH4 emission intensity could not be reliably modelled with the current database. The present study provides improved CH4 prediction models for beef cattle managed under diverse feeding systems in SE-Asia and affirmed that region-specific models are needed to reliably predict beef cattle CH4 emission at national or regional levels, particularly for low- and middle-income countries.
Published: 2022
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46. Present status of J-PARC MUSE

Author: K Shimomura, A Koda, A D Pant, H Natori, H Fujimori, I Umegaki, J Nakamura, M Tampo, N Kawamura, N Teshima, P Strasser, R Kadono, R Iwai, S Matoba, S Nishimura, S Kanda, S Takeshita, T Yuasa, T Yamazaki, Y Miyake, Y Kobayashi, Y Oishi, Y Nagatani, Y Ikedo, W Higemoto, and T Ito
Subjects: History, Computer Science Applications, Education
Abstract: At J-PARC MUSE, since the µSR2017 conference and up to FY2022, there have been several new developments at the facility, including the completion of a new experimental area S2 at the surface muon beamline S-line and the first muon beam extraction to the H1 area in the H-line, mainly to carry out high-statistics fundamental physics experiments. Several new studies are also underway, such as applying negative muon non-destructive elemental analysis to the analysis of samples returned from the asteroid Ryugu in the D2 area of the D-line. This paper reports on the latest status of MUSE.
Published: 2023
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47. Atresia coli in a Japanese black calf diagnosed by a barium sulphate enema contrast radiograph in the standing position: a case report

Author: K. Abouelnasr, M. Ishii, H. Inokuma, Y. Kobayashi, K. Lee, and K. Yamada
Subjects: atresia coli, contrasts radiography, enema, japanese black calf, standing position, Veterinary medicine, SF600-1100
Abstract: A three day-old Japanese black calf was admitted with a history of abdominal distension and absence of defecation. Dilated loops of the small intestine and hypoplasia of the colon and rectum was observed upon a contrast radiographic examination in the standing position. At necropsy atresia coli with undeveloped rectum and patent anal opening was found. We conclude that a contrast radiograph in the standing position is useful for diagnosing atresia coli in such cases.
Published: 2012
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48. 1740P Bladder preservation therapy in combination with atezolizumab and radiation therapy for invasive bladder cancer (BPT-ART): An open-label, single-arm, multicenter, phase II trial

Author: Y. Nagumo, T. Kimura, H. Ishikawa, Y. Sekino, K. Maruo, B.J. Mathis, M. Takemura, Y. Kageyama, H. Ushijima, T. Kawai, H. Yamashita, H. Azuma, T. Naiki, Y. Kobayashi, J. Inokuchi, T. Osawa, Y. Kita, T. Tsuzuki, K. Hashimoto, and H. Nishiyama
Subjects: Oncology, Hematology
Published: 2022
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49. Steinberg sign and ectopia lentis: Marfan syndrome

Author: R Ono, T Iwahana, H Kato, and Y Kobayashi
Subjects: Visual Acuity, Humans, General Medicine, Ectopia Lentis, Marfan Syndrome
Published: 2022
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50. Low-intensity pulsed ultrasound stimulates cell proliferation, proteoglycan synthesis and expression of growth factor-related genes in human nucleus pulposus cell line

Author: Y Kobayashi, D Sakai, T Iwashina, S Iwabuchi, and J Mochida
Subjects: LIPUS, ultrasound, intervertebral disc, growth factor, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811
Abstract: Low-intensity pulsed ultrasound (LIPUS) stimulation has been shown to effect differentiation and activation of human chondrocytes. A study involving stimulation of rabbit disc cells with LIPUS revealed upregulation of cell proliferation and proteoglycan (PG) synthesis. However, the effect of LIPUS on human nucleus pulposus cells has not been investigated. In the present study, therefore, we investigated whether LIPUS stimulation of a human nucleus pulposus cell line (HNPSV-1) exerted a positive effect on cellular activity. HNPSV-1 cells were encapsulated in 1.2% sodium alginate solution at 1x105 cells/ml and cultured at 10 beads/well in 6-well plates. The cells were stimulated for 20 min each day using a LIPUS generator, and the effects of LIPUS were evaluated by measuring DNA and PG synthesis. Furthermore, mRNA expression was analyzed by cDNA microarray using total RNA extracted from the cultured cells. Our study revealed no significant difference in cell proliferation between the control and the ultrasound treated groups. However, PG production was significantly upregulated in HNPSV cells stimulated at intensities of 15, 30, 60, and 120 mW/cm2 compared with the control. The results of cDNA array showed that LIPUS significantly stimulated the gene expression of growth factors and their receptors (BMP2, FGF7, TGFbetaR1 EGFRF1, VEGF). These findings suggest that LIPUS stimulation upregulates PG production in human nucleus pulposus cells by the enhancement of several matrix-related genes including growth factor-related genes. Safe and non-invasive stimulation using LIPUS may be a useful treatment for delaying the progression of disc degeneration.
Published: 2009

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