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7. Performance of the Unified Readout System of Belle II

Author

Nakao, Mikihiko, Itoh, Ryosuke, Yamada, Satoru, Suzuki, Soh Y., Konno, Tomoyuki, Zhou, Qi-Dong, Kunigo, Takuto, Sugiura, Ryohei, Park, Seokhee, Liu, Zhen-An, Zhao, Jingzhou, Konorov, Igor, Levit, Dmytro, Nakamura, Katsuro, Tanigawa, Hikaru, Taniguchi, Nanae, Uchida, Tomohisa, Nishimura, Kurtis, Hartbrich, Oskar, Lai, Yun-Tsung, Shoji, Masayoshi, Kuzmin, Alexander, Zhulanov, Vladimir, Kunkler, Brandon, Mostafanezhad, Isar, Nakazawa, Hideyuki, and Unno, Yuji

Subjects
Physics - Instrumentation and Detectors
Abstract

The Belle II experiment at the SuperKEKB collider at KEK, Tsukuba, Japan has successfully started taking data with the full detector in March 2019. Belle II is a luminosity frontier experiment of the new generation to search for physics beyond the Standard Model of elementary particles, from precision measurements of a huge number of B and charm mesons and tau leptons. In order to read out the events at a high rate from the seven subdetectors of Belle II, we adopt a highly unified readout system, including a unified trigger timing distribution system (TTD), a unified high speed data link system (Belle2link), and a common backend system to receive Belle2link data. Each subdetector frontend readout system has a field-programmable gate array (FPGA) in which unified firmware components of the TTD receiver and Belle2link transmitter are embedded. The system is designed for data taking at a trigger rate up to 30 kHz with a dead-time fraction of about 1% in the frontend readout system. The trigger rate is still much lower than our design. However, the background level is already high due to the initial vacuum condition and other accelerator parameters, and it is the most limiting factor of the accelerator and detector operation. Hence the occupancy and radiation effects to the frontend electronics are rather severe, and they cause various kind of instabilities. We present the performance of the system, including the achieved trigger rate, dead-time fraction, stability, and discuss the experience gained during the operation., Comment: IEEE Real Time 2020 Conference, 7 pages

Published
2020
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9. Improved HLT Framework for Belle II Experiment

Author

Itoh Ryosuke, Baur Anselm, Park Seokhee, Nakao Mikihiko, Yamada Satoru, Suzuki Soh Y., Kunigo Takuto, and Levit Dmytro

Subjects
Physics, QC1-999
Abstract

The original Belle II HLT framework was formally upgraded replacing the old IPC based ring buffer with the ZeroMQ data transport to overcome the unexpected IPC locking problem. The new framework has been working stably in the beam run so far, but it lacks the capability to recover the processing fault without stopping the on-going data taking. In addition, the compatibility with the offline framework (basf2) was lost which was maintained in the original. In order to solve these, an improved core processing framework is developed based on original basf2, while keeping the existing ZeroMQ data transport between the servers unchanged. A new core framework zmq-basf2 is developed with a lock-free 1-to-N and N-to-1 data transport using the ZeroMQ IPC socket so that it keeps a 100% compatibility with the original ring-buffer based framework. When a processing fault occurs, the affected faulty event is salvaged from the input buffer and sent directly to the output using the ZeroMQ broadcast. The terminated process is automatically restarted without stopping data taking. This contribution describes the detail of the improved Belle II HLT framework with the result of the performance test in the real Belle II DAQ data flow.

Published
2024
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10. Upgrade of Online Storage and Express-Reconstruction System for the Belle II experiment

Author

Park Seokhee, Itoh Ryosuke, Suzuki Soh Yamagata, Jacobi Daniel, Yamada Satoru, Kunigo Takuto, and Levit Dmytro

Subjects
Physics, QC1-999
Abstract

The backend of the Belle II data acquisition system consists of a high-level trigger system, online storage, and an express-reconstruction system for online data processing. The high-level trigger system was updated to use the ZeroMQ networking library from the old ring buffer and TCP/IP socket, and the new system is successfully operated. However, the online storage and express-reconstruction system use the old type of data transportation. For future maintainability, we expand the same ZeroMQ library-based system to the online storage and express-reconstruction system. At the same time, we introduce two more updates in the backend system. First, online side raw data output becomes compressed ROOT format which is the official format of the Belle II data. The update helps to reduce the bandwidth of the online to offline data transfer and offline-side computing resource usage for data format conversion and compression. Second, high-level trigger output-based event selection is included in the online storage. The event selection allows more statistics of data quality monitoring from the express-reconstruction system. In the presentation, we show the description and test result of the upgrade before applying it to the beam operation and data taking.

Published
2024
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11. Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis.

Author

Li, Jiajun, Sakisaka, Yukihiko, Nemoto, Eiji, Maruyama, Kentaro, Suzuki, Shigeki, Xiong, Kaixin, Tada, Hiroyuki, Tenkumo, Taichi, and Yamada, Satoru

Subjects
BONE morphogenetic proteins, PROGENITOR cells, ACID phosphatase, EXTRACELLULAR vesicles, METABOLIC regulation, BONE resorption
Abstract

Cementum shares many properties with bone; however, in contrast to bone, it is not innervated or vascularized and has a limited capacity for remodeling. Osteocytes located in the lacunae-canalicular system of bone tissue play a central role in bone remodeling by communicating with osteoblasts and osteoclasts. Although cementocytes are present in cellular cementum and are morphologically similar to osteocytes, it remains unclear whether they are involved in the dynamic functional regulation of metabolism in cementum. The present study focused on the extracellular vesicles (EVs) secreted by cementocytes and examined their effects on osteoclasts and osteoblasts. EVs were extracted from the mouse cementocyte cell line, IDG-CM6. The effects of EVs on recombinant RANKL-induced osteoclastogenesis and recombinant Bone morphogenetic protein (BMP)-2-mediated osteoblastogenesis were investigated using the mouse osteoclast progenitor cell line, RAW264.7 and mouse pre-osteoblast cell line, MC3T3-E1, respectively. EVs enhanced the formation of tartrate-resistant acid phosphatase activity-positive cells. Real-time PCR revealed that EVs up-regulated the expression of osteoclast-related genes. On the other hand, the cell culture supernatant of cementocytes significantly inhibited the differentiation of osteoclasts. Regarding osteoblastogenesis, EVs suppressed the expression of alkaline phosphatase, bone sialoprotein, and osteocalcin induced by recombinant BMP-2 at the gene and protein levels. A network of cementocytes, osteoblasts, and osteoclasts may exist in cellular cementum, which suggests the involvement of cementocytes in dynamic metabolism of cementum through EVs. [ABSTRACT FROM AUTHOR]

Published
2024
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15. A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings

Author

Inagaki, Koji, Kikuchi, Takeshi, Noguchi, Toshihide, Mitani, Akio, Naruse, Keiko, Matsubara, Tatsuaki, Kawanami, Masamitsu, Negishi, Jun, Furuichi, Yasushi, Nemoto, Eiji, Yamada, Satoru, Yoshie, Hiromasa, Tabeta, Koichi, Tomita, Sachiyo, Saito, Atsushi, Katagiri, Sayaka, Izumi, Yuichi, Nitta, Hiroshi, Iwata, Takanori, Numabe, Yukihiro, Yamamoto, Matsuo, Yoshinari, Nobuo, Fujita, Tsuyoshi, Kurihara, Hidemi, Nishimura, Fusanori, Nagata, Toshihiko, Yumoto, Hiromichi, Naito, Toru, Noguchi, Kazuyuki, Ito, Koichi, Murakami, Shinya, Nishimura, Rimei, and Tajima, Naoko

Published
2021
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16. Expression-Based Genome-Wide Association Study Links Vitamin D–Binding Protein With Autoantigenicity in Type 1 Diabetes

Author

Kodama, Keiichi, Zhao, Zhiyuan, Toda, Kyoko, Yip, Linda, Fuhlbrigge, Rebecca, Miao, Dongmei, Fathman, C Garrison, Yamada, Satoru, Butte, Atul J, and Yu, Liping

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Diabetes, Autoimmune Disease, Nutrition, Prevention, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adolescent, Animals, Autoantigens, Autoimmune Diseases, Autoimmunity, Case-Control Studies, Cells, Cultured, Child, Child, Preschool, Colorado, Diabetes Mellitus, Type 1, Female, Gene Expression Regulation, Developmental, Genome-Wide Association Study, Glucagon-Secreting Cells, Humans, Male, Mice, Inbred NOD, Organ Specificity, Seasons, Spleen, T-Lymphocytes, Vitamin D, Vitamin D-Binding Protein, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences
Abstract

Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression in the thymus and pancreatic lymph nodes (PLNs). The autoantigens known to be involved include a set of islet proteins, such as insulin, GAD65, IA-2, and ZnT8. In an attempt to identify additional antigenic proteins, we performed an expression-based genome-wide association study using microarray data from 118 arrays of the thymus and PLNs of T1D mice. We ranked all 16,089 protein-coding genes by the likelihood of finding repeated differential expression and the degree of tissue specificity for pancreatic islets. The top autoantigen candidate was vitamin D-binding protein (VDBP). T-cell proliferation assays showed stronger T-cell reactivity to VDBP compared with control stimulations. Higher levels and frequencies of serum anti-VDBP autoantibodies (VDBP-Abs) were identified in patients with T1D (n = 331) than in healthy control subjects (n = 77). Serum vitamin D levels were negatively correlated with VDBP-Ab levels in patients in whom T1D developed during the winter. Immunohistochemical localization revealed that VDBP was specifically expressed in α-cells of pancreatic islets. We propose that VDBP could be an autoantigen in T1D.

Published
2016

18. Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model

Author

Kashiwagi, Yoichiro, Aburaya, Shunsuke, Sugiyama, Naoyuki, Narukawa, Yuki, Sakamoto, Yuta, Takahashi, Masatomo, Uemura, Hayato, Yamashita, Rentaro, Tominaga, Shotaro, Hayashi, Satoko, Nozaki, Takenori, Yamada, Satoru, Izumi, Yoshihiro, Kashiwagi, Atsunori, Bamba, Takeshi, Ishihama, Yasushi, and Murakami, Shinya

Published
2021
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20. Author Correction: Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model

Author

Kashiwagi, Yoichiro, Aburaya, Shunsuke, Sugiyama, Naoyuki, Narukawa, Yuki, Sakamoto, Yuta, Takahashi, Masatomo, Uemura, Hayato, Yamashita, Rentaro, Tominaga, Shotaro, Hayashi, Satoko, Nozaki, Takenori, Yamada, Satoru, Izumi, Yoshihiro, Kashiwagi, Atsunori, Bamba, Takeshi, Ishihama, Yasushi, and Murakami, Shinya

Published
2021
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26. Lipase-a single-nucleotide polymorphism rs143793106 is associated with increased risk of aggressive periodontitis by negative influence on the cytodifferentiation of human periodontal ligament cells

Author

Matsumoto, Masahiro, Fujihara, Chiharu, Nantakeeratipat, Teerachate, Kitagaki, Jirouta, Yamamoto, Yu, Yamada, Satoru, Kitamura, Masahiro, and Murakami, Shinya

Subjects
genome-wide association study, lipase a (LIPA), human periodontal ligament cells, aggressive periodontitis
Abstract

This is the peer reviewed version of the following article: Journal of Periodontal Research, which has been published in final form at https://doi.org/10.1111/jre.13079. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited., Background and Objective: Aggressive periodontitis (AgP) is characterized by general health and rapid destruction of periodontal tissue. The familial aggregation of this disease highlights the involvement of genetic factors in its pathogeny. We conducted a genome-wide association study (GWAS) to identify AgP-related genes in a Japanese population, and the lipid metabolism-related gene, lipase-a, lysosomal acid type (LIPA), was suggested as an AgP candidate gene. However, there is no report about the expression and function(s) of LIPA in periodontal tissue. Hence, we studied the involvement of how LIPA and its single-nucleotide polymorphism (SNP) rs143793106 in AgP by functional analyses of LIPA and its SNP in human periodontal ligament (HPDL) cells. Materials and Methods: GWAS was performed using the genome database of Japanese AgP patients, and the GWAS result was confirmed using Sanger sequencing. We examined the mRNA expression level of LIPA and the protein expression level of the encoded protein lysosomal acid lipase (LAL) in periodontium-composing cells using conventional and real-time polymerase chain reaction (PCR) and western blotting, respectively. Lentiviral vectors expressing LIPA wild-type (LIPA WT) and LIPA SNP rs143793106 (LIPA mut) were transfected into HPDL cells. Western blotting was performed to confirm the transfection. LAL activity of transfected HPDL cells was determined using the lysosomal acid lipase activity assay. Transfected HPDL cells were cultured in mineralization medium. During the cytodifferentiation of transfected HPDL cells, mRNA expression of calcification-related genes, alkaline phosphatase (ALPase) activity and calcified nodule formation were assessed using real-time PCR, ALPase assay, and alizarin red staining, respectively. Results: The GWAS study identified 11 AgP-related candidate genes, including LIPA SNP rs143793106. The minor allele frequency of LIPA SNP rs143793106 in AgP patients was higher than that in healthy subjects. LIPA mRNA and LAL protein were expressed in HPDL cells; furthermore, they upregulated the cytodifferentiation of HPDL cells. LAL activity was lower in LIPA SNP-transfected HPDL cells during cytodifferentiation than that in LIPA WT-transfected HPDL cells. In addition, ALPase activity, calcified nodule formation, and calcification-related gene expression levels were lower during cytodifferentiation in LIPA SNP-transfected HPDL cells than those in LIPA WT-transfected HPDL cells. Conclusion: LIPA, identified as an AgP-related gene in a Japanese population, is expressed in HPDL cells and is involved in regulating cytodifferentiation of HPDL cells. LIPA SNP rs143793106 suppressed cytodifferentiation of HPDL cells by decreasing LAL activity, thereby contributing to the development of AgP.

Published
2022

28. Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress

Author

Sasaki, Yuto, Takagane, Kurara, Konno, Takumi, Itoh, Go, Kuriyama, Sei, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Yamada, Satoru, Murakami, Shinya, Tanaka, Masamitsu, Sasaki, Yuto, Takagane, Kurara, Konno, Takumi, Itoh, Go, Kuriyama, Sei, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Yamada, Satoru, Murakami, Shinya, and Tanaka, Masamitsu

Abstract

Asporin (ASPN), a small leucine-rich proteoglycan expressed predominantly by cancer associated fibroblasts (CAFs), plays a pivotal role in tumor progression. ASPN is also expressed by some cancer cells, but its biological significance is unclear. Here, we investigated the effects of ASPN expression in gastric cancer cells. Overexpression of ASPN in 2 gastric cancer cell lines, HSC-43 and 44As3, led to increased migration and invasion capacity, accompanied by induction of CD44 expression and activation of Rac1 and MMP9. ASPN expression increased resistance of HSC-43 cells to oxidative stress by reducing the amount of mitochondrial reactive oxygen species. ASPN induced expression of the transcription factor HIF1 alpha and upregulated lactate dehydrogenase A (LDHA) and PDH-E1 alpha, suggesting that ASPN reprograms HSC-43 cells to undergo anaerobic glycolysis and suppresses ROS generation in mitochondria, which has been observed in another cell line HSC-44PE. By contrast, 44As3 cells expressed high levels of HIF1 alpha in response to oxidant stress and escaped apoptosis regardless of ASPN expression. Examination of xenografts in the gastric wall of ASPN(-/-) mice revealed that growth of HSC-43 tumors with increased micro blood vessel density was significantly accelerated by ASPN; however, ASPN increased the invasion depth of both HSC-43 and 44As3 tumors. These results suggest that ASPN has 2 distinct effects on cancer cells: HIF1 alpha-mediated resistance to oxidative stress via reprogramming of glucose metabolism, and activation of CD44-Rac1 and MMP9 to promote cell migration and invasion. Therefore, ASPN may be a new therapeutic target in tumor fibroblasts and cancer cells in some gastric carcinomas.

Published
2023

29. El orientalismo de Luis Feito, sobre sus bases del zen y las influencias taoístas.

Author

Yamada, Satoru, Cerrillo Rubio, Lourdes, Cabañas Moreno, María Pilar, Yamada, Satoru, Cerrillo Rubio, Lourdes, and Cabañas Moreno, María Pilar

Abstract

The thesis approaches the study of Luis Feito's work from the perspective of East Asian thought, tracing the traces left by the philosophy of Tao and Zen Buddhism in his work. It also questions and responds to the way in which the Spanish artist approached them in Paris through the work of two important Asian painters, Zao Wou Ki, of Chinese origin, and Sugai Kumi, of Japanese origin, as well as the Japanese calligraphic group Bokujinkai. Also the work of other Western artists, who had already absorbed Eastern philosophy, such as Kazimir Malévich and Mark Rothko. The Parisian environment in the 1950s and 1960s was very permeable to these new thoughts that were spreading and becoming popular. He also analyses the work of the Zen monk Shitao, entitled "Discourse on the painting of the monk Bitter Gourd", which was written in the 17th century and published in Spanish in 2012. For Luis Feito it became a bedside book of which he said it contained everything he had learned over time about East Asian painting and gesture. The methodology underpinning the bulk of this research has been phenomenological in nature, which in Husserl's words is a way of approaching the world. It has allowed us to tackle the specific study of the subject by considering the point of view of each of those involved, from artists to artists, studying all kinds of experiences, emotions, reasoning and perceptions, all conveniently contextualised in the corresponding artistic period. The texts and plastic creations of the creators involved in the research have been the objects of study. The great difficulty that the study manages to overcome is the lack of publications on the subject of Zen and Taoism in Spain, overcome with the use of primary and secondary sources in Chinese and Japanese. After the work carried out, there is a great final conclusion which leads to the affirmation that Luis Feito's intuitive character in his work was strengthened by his deepening in the thought of Zen and Tao, as well, La tesis aborda el estudio de la obra de Luis Feito desde la perspectiva del pensamiento de Asia Oriental, rastreando los posos que la filosofía del tao y del budismo zen han dejado en su obra. Así mismo se interroga y responde al modo en que el artista español se aproximó a ellos en París a través de la obra de dos importantes pintores asiáticos, Zao Wou Ki, de origen chino, y Sugai Kumi, de origen japonés, así como del grupo caligráfico japonés Bokujinkai. También la obra de otros artstas occidentales, que ya habían absorbido la filosofía oriental, como Kazimir Malevich y Mark Rothko. El ambiente parisino en los años cincuenta y sesenta fue muy permeable a estos nuevos pensamientos que se estaban difundiendo y popularizando. Así mismo, se analiza la obra del monje zen Shitao, titulada Discurso acerca de la pintura del monje Calabaza amarga, que escrita en el siglo XVII, fue publicada en castellano en 2012. Para Luis Feito se convirtió en un libro de cabecera del que dijo que contenía todo lo que a lo largo del tiempo había aprendido de la pintura y el gesto de Asia Oriental. La metodología sobre la que se sustenta el grueso de esta investigación ha sido de carácter fenomenológico, que en palabras de Husserl resulta una forma de acercarse al mundo. Nos ha permitido afrontar el estudio específico del tema consideranto el punto de vista de cada uno de los involucrados, desde artistas a ponsadores, estudiando todo tipo de experiencias, emociones, razonamientos o percepciones, todo ello cntextualizado convenientemente en el periodo artístico correspondiente. Los textos y las creaciones plásticas de los creadores involucrados en la investigación han sido los objetos de estudio. La gran dificultad que el estudio logra superar es la falta de publicaciones sobre el tema del zen y el taoísmo en España, superadas con el manejo de fuentes primarias y secundarias en chino y japonés. Tras el trabajo realizado hay una gran conclusión final que lleva a afirmar que el carácter int, Escuela de Doctorado, Doctorado en Patrimonio Cultural y Natural: Historia, Arte y Territorio

Published
2023

35. Soulages, Michaux, Malraux y Vieira da Silva, amigos e inspiradores de Zao Wou-Ki

Author

Yamada, Satoru

Subjects
Zao Wou-Ki, Vieira da Silva, Soulages, Henri Michaux, 7 Bellas artes::75 - Pintura [CDU]
Abstract

Zao Wou-Ki (1921-2013) fue un pintor chino reconocido internacionalmente. Para alejarse del convencionalismo del arte chino decidió instalarse en París, pero tras conocer la obra de Paul Cézanne y Paul Klee, Zao se reconcilió con la tradición china, con el signo y el qui como elementos clave en su obra. Cuando llegó a París Zao conoció a muchos artistas emergentes que dejarían huella en la Historia de Arte y que serían impulsores de su propio camino artístico, contribuyendo a la recuperación de sus raíces. Hoy nadie ha abordado en profundidad este nexo, motivo por el cual este trabajo se postula como una investigación pionera en la materia. El hecho de que Zao trabajara con numerosos poetas, tras su colaboración con Henri Michaux, nos remite al principio chino de coincidencia entre el poema y la pintura que subyace en su creación, por lo que, en este artículo, vamos a centrarnos en estudiar su colaboración con los poetas para investigar su arte y vincularlo con estudios filológicos sobre poesía. De otra parte, estudiaremos el concepto de qui en el espacio pictórico chino, ya que Zao recogió la idea de Pierre Soulages, que compartía la idea del espacio y la luz con Zao. Zao Wou-Ki (1921-2013) was a Chinese painter with a universal reputation. Because of the conventionalism of art in China, he decided to settle in Paris. It is known that there he started thanks to the art of Cézanne and Klee, and Zao began to sublimate the Chinese tradition: the sign and the qui as his style in his work, but we can guess that there is something more. When he arrived in Paris, got to meet many emerging artists who would leave their mark on the History of Art. They must be the pointers of the artistic path. They also helped him to recover his root in his art through collaboration, but there is not much research done on that. The fact that Zao worked to dedicate the works to numerous poets after the collaboration with Henri Michaux reminds us of the Chinese aesthetic coincidence between poem and painting. We analyze his collaborations with poets to investigate such a concept in his art. Another part to develop the qui, the Chinese pictorial space, we consider that Zao took the spark from Pierre Soulages. Soulages shared the idea of space and light with Zao, so his dialogues are analyzed.

Published
2022

36. Measurement of the $\Omega_c^0$ lifetime at Belle II

Author

Abudinen, Fernando Jesus, Adachi, Ichiro, Aggarwal, Latika, Ahmed, Hossain, Aihara, Hiroaki, Akopov, Norayr, Aloisio, Alberto, Nguyen, Anh-Ky, Asner, David Mark, Aushev, Tagir, Aushev, Volodymyr Ye, Bae, Hanwook, Bambade, Philip, Banerjee, Sw., Banerjee, Swagato, Baudot, Jerome, Bauer, Moritz, Beaubien, Alexandre, Becker, Juergen, Behera, Prafulla Kumar, Bennett, Jake, Bernieri, Enrico, Bernlochner, Florian, Bertacchi, Valerio, Bertemes, Michel, Bertholet, Emilie, Bessner, Martin, Bettarini, Stefano, Bhuyan, Bipul, Bianchi, Fabrizio, Bilka, Tadeas, Biswas, Diptaparna, Bodrov, Denis, Bolz, Arthur, Borah, Jyotirmoi, Bozek, Andrzej, Bracko, Marko, Branchini, Paolo, Briere, R. A., Browder, Thomas Earl, Budano, Antonio, Bussino, Severino, Campajola, Marcello, Cao, Lu, Casarosa, Giulia, Cecchi, Claudia, Chang, Ming-Chuan, Cheema, Priyanka, Chekelian, Vladimir, Chen, Yongqing, Chilikin, Kirill, Chirapatpimol, Khem, Cho, HanEol, Cho, Kihyeon, Cho, Sungjin, Choi, Sookyung, Choudhury, Seema, Cinabro, David, Corona, Luigi, Cunliffe, Samuel Thomas, Das, Sanjeeda Bharati, Dattola, Filippo, De La Cruz Burelo, Eduard, De La Motte, Shanette Anne, de Marino, Gaetano, De Nardo, Guglielmo, De Nuccio, Michael, De Pietro, Giacomo, de Sangro, Riccardo, Destefanis, Marco, Dey, Sourav, De Yta Hernandez, Alejandro, Dhamija, Rashmi, Di Canto, Angelo, Di Capua, Francesco, Dingfelder, Jochen, Dolezal, Zdenek, Dominguez Jimenez, Isabel, Dong, Thanh Van, Dorigo, Mirco, Dort, Katharina, Dreyer, Sascha, Dubey, Shawn, Dujany, Giulio, Ecker, Patrick, Eliachevitch, Michael, Epifanov, Denis Alexandrovich, Feichtinger, Paul, Ferber, Torben, Ferlewicz, Daniel, Fillinger, Tristan, Finocchiaro, Giuseppe, Fodor, Andrea, Forti, Francesco, Fulsom, Bryan Gregory, Ganiev, Eldar, Gaur, Vipin, Gaz, Alessandro, Gellrich, Andreas, Ghevondyan, Gayane, Giordano, Raffaele, Giri, Anjan, Glazov, Alexander, Gobbo, Benigno, Godang, Romulus, Goldenzweig, Pablo, Gradl, Wolfgang, Granderath, Svenja Katharina, Graziani, Enrico, Greenwald, Daniel, Gu, Tianping, Guan, Yinghui, Gudkova, Kristina, Guilliams, Justin, Hayasaka, Kiyoshi, Hayashii, Hisaki, Hazra, Sagar, Hearty, Christopher, Heredia de la Cruz, Ivan, Hernandez Villanueva, Michel, Hershenhorn, Alon David, Higuchi, Takeo, Hill, Ewan Chin, Hirata, Hikari, Hohmann, Marcel, Hsu, Chia-Ling, Iijima, Toru, Inami, Kenji, Inguglia, Gianluca, Ipsita, N. Sushree, Ishikawa, Akimasa, Ito, Shintaro, Itoh, Ryosuke, Iwasaki, Masako, Jackson, Paul Douglas, Jacobs, William Wescott, Jaffe, David, Jang, Eunji, Jia, Sen, Jin, Yifan, Joo, Kyung Kwang, Junkerkalefeld, Henrik, Kaliyar, Abdul Basith, Kang, Kookhyun, Karl, Robert, Karyan, Gevorg, Kiesling, Christian, Kim, Cheolhun, Kim, Doris Yangsoo, Kim, Kyungho, Kim, Yongkyu, Kindo, Haruki, Kinoshita, Kay, Kodys, Peter, Koga, Taichiro, Kohani, Shahab, Kojima, Kazuki, Konno, Tomoyuki, Korobov, Alexandr, Korpar, Samo, Kovalenko, Evgeniy, Kowalewski, Robert, Kraetzschmar, Thomas Michael Gerd, Krizan, Peter, Krokovny, Pavel, Kumar, Jitendra, Kumara, Kospalage Janaka, Kunigo, Takuto, Kuzmin, Alexander, Kwon, Youngjoon, Lacaprara, Stefano, Lam, Tommy, Lanceri, Livio, Lange, Jens Soeren, Laurenza, Martina, Lautenbach, Klemens, Leboucher, Robin, Li, Chunhua, Li, Longke, Libby, James Frederick, Lieret, Kilian Adriano, Liptak, Zachary John, Liu, Qingyuan, Liventsev, Dmitri, Longo, Savino, Lozar, Andrej, Lueck, Thomas, Lyu, Chaoyi, Maggiora, Marco, Maiti, Rajesh Kumar, Manfredi, Riccardo, Manoni, Elisa, Marcello, Simonetta, Marinas, Carlos, Martini, Alberto, Martinov, Tommy, Massaccesi, Ludovico, Masuda, Masataka, Maurya, Shubhangi Krishan, McKenna, Janis Anne, Meier, Frank, Merola, Mario, Metzner, Felix, Milesi, Marco, Miller, Caleb, Miyabayashi, Kenkichi, Mizuk, Roman, Mohanty, G. B., Molina-Gonzalez, N., Molina, Norman Wilfrido, Moneta, Stefano, Moser, Hans-Guenther, Mrvar, Manca, Mussa, Roberto, Nakamura, Isamu, Nakao, Mikihiko, Nakayama, Hiroyuki, Nakazawa, Yu, Narimani Charan, Abtin, Naruki, Megumi, Natkaniec, Zbigniew Marian, Natochii, Andrii, Nayak, Lopamudra, Nayak, Minakshi, Nazaryan, Gevorg, Nellikunnummel, Nisar, Ogawa, Satoru, Ono, Hiroaki, Onuki, Yoshiyuki, Oxford, Emma Rollinson, Paladino, Antonio, Panta, Anil, Paoloni, Eugenio, Pardi, Silvio, Park, Hwanbae, Park, Seokhee, Passeri, Antonio, Paul, Stephan Martin, Pedlar, Todd Kristofer, Peruzzi, Ida Marena, Peschke, Richard, Pestotnik, Rok, Piccolo, Marcello, Piilonen, L. E., Podesta lerma, Pedro Luis Manuel, Podobnik, Tomaz, Pokharel, Saroj, Polat, Leonard, Praz, Cyrille, Prell, Soeren, Prencipe, Elisabetta, Prim, Markus Tobias, Purwar, Harsh, Rad, Navid Khandan, Rados, Petar, Raiz, Sebastiano, Ramirez Morales, Andres, Reif, Markus, Reiter, Simon, Remnev, Mikhail, Ripp-Baudot, Isabelle, Rizzo, Giuliana, Robertson, Steven H., Roney, John Michael, Rostomyan, Armine, Rout, Niharika, Russo, Guido, Sanders, David Alan, Sandilya, Saurabh, Sangal, Aman, Sato, Yo, Savinov, Vladimir, Scavino, Bianca, Schueler, Jeff, Schwanda, Christoph, Schwartz, Alan Jay, Schwenker, Benjamin, Seino, Yoshiaki, Selce, Andrea, Senyo, Katsumi, Serrano, Justine, Sevior, Martin Edmund, Sfienti, Concettina, Shen, Chengping, Shi, Xiaodong, Shillington, Trevor, Sibidanov, Alexei, Singh, Jasbir, Skorupa, Justin, Sobie, Randall, Soffer, Abner, Solovieva, Elena, Spataro, Stefano, Spruck, Bjoern, Staric, Marko, Stefkova, Slavomira, Stottler, Zachary Shaun, Stroili, Roberto, Strube, Jan Fridolf, Sumihama, Mizuki, Sumisawa, Kazutaka, Sutcliffe, William, Suzuki, Soh Yamagata, Svidras, Henrikas, Takizawa, Makoto, Tamponi, Umberto, Tanida, Kiyoshi, Tanigawa, Hikaru, Tenchini, Francesco, Thaller, Arthur, Tiwary, Rahul, Tonelli, Diego, Torassa, Ezio, Toutounji, Nadia Ejlal, Trabelsi, Karim, Uchida, Makoto, Ueda, Ikuo, Uematsu, Yuma, Uglov, Timofey, Unger, Kai Lukas, Unno, Yuji, Uno, Kenta, Uno, Shoji, Ushiroda, Yutaka, Vahsen, Sven Einar, van Tonder, Raynette, Varner, Gary, Varvell, Kevin Ernest, Vinokurova, Anna, Vitale, Lorenzo, Vobbilisetti, Vidya Sagar, Wakeling, Hannah Marie, Wang, Erfei, Wang, Min-Zu, Wang, Xiaolong, Warburton, Andreas, Watanabe, Minori, Watanuki, Shun, Welsch, Maximilian, Wessel, Christian, Won, Eunil, Yabsley, Bruce Donald, Yamada, Satoru, Yan, Wenbiao, Yang, Seongbae, Ye, Hua, Yelton, John, Yin, Junhao, Yook, Youngmin, Yoshihara, Keisuke, Yuan, Changzheng, Zani, Laura, Zhang, Yi, Zhilich, Victor, Zhou, Qi-Dong, Zhou, Xing-Yu, Zhukova, Valentina, Zlebcik, Radek, Belle-II Collaboration, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Belle-II, and HEP, INSPIRE

Subjects
lifetime, Omega, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], hadronic decay [Omega/c0], BELLE, annihilation [electron positron], electron positron: colliding beams, Omega/c0: hadronic decay, electron positron: annihilation, pi+, High Energy Physics - Experiment, KEK-B, Omega/c0: lifetime, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], colliding beams [electron positron], ddc:530, charmed baryon, +Omega-+pi%2B%22">Omega/c0 --> Omega- pi+, lifetime [Omega/c0], experimental results
Abstract

Physical review / D 107, L031103 (2023). doi:10.1103/PhysRevD.107.L031103, We report on a measurement of the $\Omega_c^0$ lifetime using $\Omega_c^0 \to \Omega^-\pi^+$ decays reconstructed in $e^+e^-\to c\bar{c}$ data collected by the Belle II experiment and corresponding to $207~{\rm fb^{-1}}$ of integrated luminosity. The result, $\rm\tau(\Omega_c^0)=243\pm48( stat)\pm11(syst)~fs$, agrees with recent measurements indicating that the $\Omega_c^0$ is not the shortest-lived weakly decaying charmed baryon., Published by Inst., Woodbury, NY

Published
2023
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37. Alignment for the first precision measurements at Belle II

Author

Bilka Tadeas, Abudinen Jesus, Ackermann Karlheinz Georg, Adamczyk Karol Mateusz, Ahlburg Patrick, Aihara Hiroaki, Alonso Oscar, Albalawi Mohammed, Andricek Ladislav, Ayad Rachid, Aziz Tariq, Babu Varghese, Bacher Szymon Grzegorz, Bahinipati Seema, Batignani Giovanni, Baudot Jerome, Behera Prafulla Kumar, Bettarini Stefano, Boronat Marca, Bozek Andrzej, Braun Nils, Buchsteiner Florian, Caldwell Allen, Camien Christian, Casarosa Giulia, Cervenkov Daniel, Chekelian Vladimir, Chen Yeqi, Chilikin Kirill, Corona Luigi, Czank Thomas Rafael, Das Sanjeeda Bharati, Dash Nibedita, de Marino Gaetano, Deschamps Bruno, Dieguez Angel, Dingfelder Jochen, Doležal Zdeněk, Dujany Giulio, Esperante Daniel, Forti Francesco, Fras Markus, Frey Ariane, Friedl Markus, Fuster Juan, Gabriel Miroslav, Gadow Karsten, Ganiev Eldar, Gebauer Uwe, Gessler Thomas, Giakoustidis Georgios, Gioi Luigi Li, Gobbo Benigno, Gomis López Pablo, Greenwald Daniel, Guan Yinghui, Halder Soumen, Hara Koji, Hartbrich Oskar, Hazra Sagar, Heck Martin, Hemperek Tomasz, Hensel Martin, Higuchi Takeo, Hoek Matthias, Huber Stefan, Itoh Ryosuke, Irmler Christian, Ishikawa Akimasa, Jeon Hyebin, Joo Changwoo, Kaleta Mateusz, Kaliyar Abdul Basith, Kandra Jakub, Kang Kookhyun, Kapusta Piotr Julian, Kiesling Christian, Kisielewski Bartlomiej, Kittlinger David, Kleinwort Claus, Klose Daniel, Kodyš Peter, Koffmane Christian, Kohriky T., Kono Tomoyuki, Konorov Igor, Krivokuca Silvia, Krüger Hans, Kuhr Thomas, Kumar Manish, Kumar Rajeev, Kvasnička Peter, Lacasta Carlos, La Licata Chiara, Lalwani Kavita, Lanceri Livio, Lange Jens Sören, Lautenbach Klemens, Lee Seungcheol, Leis Ulrich, Leitl Philipp, Levit Dmytro, Li Chunhua, Li Y. B., Libby James Frederick, Liemann Gerhard, Liu Qingyuan, Liu Zhen’An, Lück Thomas, Luetticke Florian, Macharski Lydia, Maity Souvik, Mariñas Carlos, Mayekar Sukant Narendra, Mccarney Sara, Mohanty Gagan Bihari, Mora Grimaldo Johnny Alejandro, Morii Tomoko, Moser Hans-Günther, Moya David, Müller Felix Johannes, Müller Felix, Nakamura Katsuro, Nakao Mikihiko, Natkaniec Zbigniew Marian, Niebuhr Carsten, Ninkovic Jelena, Onuki Yoshiyuki, Ostrowicz Waclaw, Paladino Antonio, Paoloni Eugenio, Park Hwanbae, Park SeokHee, Paschen Botho, Paul Stephan Martin, Peric Ivan, Poblotzki Frauke, Rabusov Andrei, Rao K. K., Reiter Simon, Richter Rainer Helmut, Ripp-Baudot Isabelle, Ritter Martin, Ritzert Michael, Rizzo Giuliana, Rout Niharika, Sahoo Debashis, Sanchez Javier Gonzalez, Santelj Luka, Sato Nobuhiko, Scavino Bianca, Schaller Gerhard, Schnecke Martina, Schopper Florian, Schreeck Harrison, Schwanda Christoph, Schwenker Benjamin, Sedlmeyer Reinhard, Sfienti Concettina, Simon Frank, Skambraks Sebastian, Soloviev Yuri, Spruck Björn, Stefková Slavomira, Stever Reimer, Stolzenberg Ulf, Suzuki Soh Yamagata, Takahashi Maiko, Tafelmayer Eva, Tanaka Shuji, Tanigawa Hikaru, Thalmeier Richard, Tsuboyama Toru, Uematsu Yuma, Verbycka O., Vila Ivan, Virto Amparo Lopez, Vitale Lorenzo, Vogt Sven, Vos Marcel, Wan Kun, Wang Boqun, Watanuki Shun, Webb James, Wermes Norbert, Wessel Christian, Wiechczyński Jarosław Paweł, Wieduwilt Philipp, Windel Hendrik, Yamada Satoru, Ye Hua, Yin Hao, Zani Laura, and Zhang Tingyu

Subjects
Physics, QC1-999
Abstract

On March 25th 2019, the Belle II detector recorded the first collisions delivered by the SuperKEKB accelerator. This marked the beginning of the physics run with vertex detector. The vertex detector was aligned initially with cosmic ray tracks without magnetic field simultaneously with the drift chamber. The alignment method is based on Millepede II and the General Broken Lines track model and includes also the muon system or primary vertex position alignment. To control weak modes, we employ sensitive validation tools and various track samples can be used as alignment input, from straight cosmic tracks to mass-constrained decays. With increasing luminosity and experience, the alignment is approaching the target performance, crucial for the first physics analyses in the era of Super-BFactories. We will present the software framework for the detector calibration and alignment, the results from the first physics run and the prospects in view of the experience with the first data.

Published
2020
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38. Data quality monitors of vertex detectors at the start of the Belle II experiment

Author

Kodyš Peter, Abudinen Jesus, Ackermann Karlheinz Georg, Adamczyk Karol Mateusz, Ahlburg Patrick, Aihara Hiroaki, Alonso Oscar, Albalawi Mohammed, Andricek Ladislav, Ayad Rachid, Aziz Tariq, Babu Varghese, Bacher Szymon Grzegorz, Bahinipati Seema, Batignani Giovanni, Baudot Jerome, Behera Prafulla Kumar, Bettarini Stefano, Bilka Tadeáš, Boronat Marca, Bozek Andrzej, Braun Nils, Buchsteiner Florian, Caldwell Allen, Camien Christian, Casarosa Giulia, Cervenkov Daniel, Chekelian Vladimir, Chen Yeqi, Corona Luigi, Czank Thomas Rafael, Das Sanjeeda Bharati, Dash Nibedita, de Marino Gaetano, Deschamps Bruno, Dieguez Angel, Dingfelder Jochen, Doležal Zdeněk, Dujany Giulio, Esperante Daniel, Forti Francesco, Fras Markus, Frey Ariane, Friedl Markus, Fuster Juan, Gabriel Miroslav, Gadow Karsten, Ganiev Eldar, Gebauer Uwe, Gessler Thomas, Giakoustidis Georgios, Gioi Luigi Li, Gobbo Benigno, Gomis López Pablo, Greenwald Daniel, Guan Yinghui, Halder Soumen, Hara Koji, Hartbrich Oskar, Hazra Sagar, Heck Martin, Hemperek Tomasz, Hensel Martin, Higuchi Takeo, Hoek Matthias, Huber Stefan, Itoh Ryosuke, Irmler Christian, Ishikawa Akimasa, Jeon Hyebin, Joo Changwoo, Kaleta Mateusz, Kaliyar Abdul Basith, Kandra Jakub, Kang Kookhyun, Kapusta Piotr Julian, Kiesling Christian, Kisielewski Bartlomiej, Kittlinger David, Klose Daniel, Koffmane Christian, Kohriky T., Kono Tomoyuki, Konorov Igor, Krivokuca Silvia, Krüger Hans, Kuhr Thomas, Kumar Manish, Kumar Rajeev, Kvasnicˇka Peter, Lacasta Carlos, La Licata Chiara, Lalwani Kavita, Lanceri Livio, Lange Jens Sören, Lautenbach Klemens, Lee Seungcheol, Leis Ulrich, Leitl Philipp, Levit Dmytro, Li Chunhua, Li Y. B., Libby James Frederick, Liemann Gerhard, Liu Qingyuan, Liu Zhen’An, Lück Thomas, Luetticke Florian, Macharski Lydia, Maity Souvik, Mariñas Carlos, Mayekar Sukant Narendra, Mccarney Sara, Mohanty Gagan Bihari, Mora Grimaldo Johnny Alejandro, Morii Tomoko, Moser Hans-Günther, Moya David, Müller Felix Johannes, Müller Felix, Nakamura Katsuro, Nakao Mikihiko, Natkaniec Zbigniew Marian, Niebuhr Carsten, Ninkovic Jelena, Onuki Yoshiyuki, Ostrowicz Waclaw, Paladino Antonio, Paoloni Eugenio, Park Hwanbae, Park SeokHee, Paschen Botho, Paul Stephan Martin, Peric Ivan, Poblotzki Frauke, Rabusov Andrei, Rao K. K., Reiter Simon, Richter Rainer Helmut, Ripp-Baudot Isabelle, Ritter Martin, Ritzert Michael, Rizzo Giuliana, Rout Niharika, Sahoo Debashis, Sanchez Javier Gonzalez, Santelj Luka, Sato Nobuhiko, Scavino Bianca, Schaller Gerhard, Schnecke Martina, Schopper Florian, Schreeck Harrison, Schwanda Christoph, Schwenker Benjamin, Sedlmeyer Reinhard, Sfienti Concettina, Simon Frank, Skambraks Sebastian, Soloviev Yuri, Spruck Björn, Stefková Slavomira, Stever Reimer, Stolzenberg Ulf, Suzuki Soh Yamagata, Takahashi Maiko, Tafelmayer Eva, Tanaka Shuji, Tanigawa Hikaru, Thalmeier Richard, Tsuboyama Toru, Uematsu Yuma, Verbycka O., Vila Ivan, Virto Amparo Lopez, Vitale Lorenzo, Vogt Sven, Vos Marcel, Wan Kun, Wang Boqun, Watanuki Shun, Webb James, Wermes Norbert, Wessel Christian, Wiechczyński Jarosław Paweł, Wieduwilt Philipp, Windel Hendrik, Yamada Satoru, Ye Hua, Yin Hao, Zani Laura, and Zhang Tingyu

Subjects
Physics, QC1-999
Abstract

The Belle II experiment features a substantial upgrade of the Belle detector and will operate at the SuperKEKB energy-asymmetric e+e− collider at KEK in Tsukuba, Japan. The accelerator completed its first phase of commissioning in 2016, and the Belle II detector saw its first electron-positron collisions in April 2018. Belle II features a newly designed silicon vertex detector based on double-sided strip layers and DEPFET pixel layers. A subset of the vertex detector was operated in 2018 to determine background conditions (Phase 2 operation). The collaboration completed full detector installation in January 2019, and the experiment started full data taking. This paper will report on the final arrangement of the silicon vertex detector part of Belle II with a focus on online monitoring of detector conditions and data quality, on the design and use of diagnostic and reference plots, and on integration with the software framework of Belle II. Data quality monitoring plots will be discussed with a focus on simulation and acquired cosmic and collision data.

Published
2020
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40. Plap-1 lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament

Author

Iwayama, Tomoaki, primary, Iwashita, Mizuho, additional, Miyashita, Kazuya, additional, Sakashita, Hiromi, additional, Matsumoto, Shuji, additional, Tomita, Kiwako, additional, Bhongsatiern, Phan, additional, Kitayama, Tomomi, additional, Ikegami, Kentaro, additional, Shimbo, Takashi, additional, Tamai, Katsuto, additional, Murayama, Masanori A., additional, Ogawa, Shuhei, additional, Iwakura, Yoichiro, additional, Yamada, Satoru, additional, Olson, Lorin E., additional, Takedachi, Masahide, additional, and Murakami, Shinya, additional

Published
2022
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42. Advanced Glycation End Products Are Associated with Diabetes Status and Physical Functions in Patients with Cardiovascular Disease

Author

Hirai, Tomoya, primary, Fujiyoshi, Kazuhiro, additional, Yamada, Satoru, additional, Matsumoto, Takuya, additional, Kikuchi, Junko, additional, Ishida, Kohki, additional, Ishida, Miwa, additional, Yamaoka-Tojo, Minako, additional, Inomata, Takayuki, additional, Shigeta, Kyo, additional, and Tojo, Taiki, additional

Published
2022
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43. Lipase-a single-nucleotide polymorphism rs143793106 is associated with increased risk of aggressive periodontitis by negative influence on the cytodifferentiation of human periodontal ligament cells

Author

1000080909466, Matsumoto, Masahiro, 1000000755358, 0000-0003-0556-9530, Fujihara, Chiharu, Nantakeeratipat, Teerachate, 1000090570292, Kitagaki, Jirouta, 1000080912211, Yamamoto, Yu, 1000040359849, Yamada, Satoru, 1000010243247, Kitamura, Masahiro, 1000070239490, 0000-0002-5230-452X, Murakami, Shinya, 1000080909466, Matsumoto, Masahiro, 1000000755358, 0000-0003-0556-9530, Fujihara, Chiharu, Nantakeeratipat, Teerachate, 1000090570292, Kitagaki, Jirouta, 1000080912211, Yamamoto, Yu, 1000040359849, Yamada, Satoru, 1000010243247, Kitamura, Masahiro, 1000070239490, 0000-0002-5230-452X, and Murakami, Shinya

Abstract

This is the peer reviewed version of the following article: Journal of Periodontal Research, which has been published in final form at https://doi.org/10.1111/jre.13079. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited., Background and Objective: Aggressive periodontitis (AgP) is characterized by general health and rapid destruction of periodontal tissue. The familial aggregation of this disease highlights the involvement of genetic factors in its pathogeny. We conducted a genome-wide association study (GWAS) to identify AgP-related genes in a Japanese population, and the lipid metabolism-related gene, lipase-a, lysosomal acid type (LIPA), was suggested as an AgP candidate gene. However, there is no report about the expression and function(s) of LIPA in periodontal tissue. Hence, we studied the involvement of how LIPA and its single-nucleotide polymorphism (SNP) rs143793106 in AgP by functional analyses of LIPA and its SNP in human periodontal ligament (HPDL) cells. Materials and Methods: GWAS was performed using the genome database of Japanese AgP patients, and the GWAS result was confirmed using Sanger sequencing. We examined the mRNA expression level of LIPA and the protein expression level of the encoded protein lysosomal acid lipase (LAL) in periodontium-composing cells using conventional and real-time polymerase chain reaction (PCR) and western blotting, respectively. Lentiviral vectors expressing LIPA wild-type (LIPA WT) and LIPA SNP rs143793106 (LIPA mut) were transfected into HPDL cells. Western blotting was performed to confirm the transfection. LAL activity of transfected HPDL cells was determined using the lysosomal acid lipase activity assay. Transfected HPDL cells were cultured in mineralization medium. During the cytodifferentiation of transfected HPDL cells, mRNA expression of calcification-related genes, alkaline phosphatase (ALPase) activity and calcified nodule formation were assessed using real-time PCR, ALPase assay, and alizarin red staining, respectively. Results: The GWAS study identified 11 AgP-related candidate genes, including LIPA SNP rs143793106. The minor allele frequency of LIPA SNP rs143793106 in AgP patients was higher than that in healthy subjects.

Published
2022

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