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Background: The Node Reporting and Data System (Node-RADS) is a recently proposed classification system for the categorization of lymph nodes in radiological images. This study was conducted to retrospectively evaluate the diagnostic accuracy of the Node-RADS score for metastatic cervical lymph nodes on magnetic resonance imaging (MRI) of patients with nasopharyngeal carcinoma (NPC). Methods: We retrospectively analyzed cervical lymph nodes of NPC cases. Two radiologists independently evaluated each lymph node on the MRI scans using Node-RADS. Interobserver agreement between 2 radiologists for Node-RADS score assessment was evaluated by linear weighted kappa statistics. The correlation between metastasis and the Node-RADS score of each lymph node was analyzed using multivariate regression analysis. To investigate the diagnostic performance of the Node-RADS score, we further conducted receiver operating characteristic curve analysis. Correspondently, the sensitivity, specificity, positive predictive value, and negative predictive value of each different cutoff (>1, >2, >3, and >4) were computed. Results: In all, 119 patients with NPC were assessed, including 203 cervical lymph nodes consisting of 140 (69%) of 203 metastatic and 63 (31%) of 203 benign. The kappa agreement between the 2 readers for the Node-RADS score was 0.863 (95% CI = 0.830-0.897, P <.001). Node-RADS score on MRI scan was shown to be an independent predictive factor of lymph node metastasis after multivariate regression analysis (odds ratio [OR] = 6.745, 95% CI = 3.964-11.474, P <.001). Node-RADS achieved an area under the curve (AUC) of 0.950 (95% CI = 0.921-0.979) in diagnosing metastatic lymph nodes. When Node-RADS >2 was identified as the best cutoff based on balanced values, the sensitivity and positive predictive value were 0.92 and 0.94, respectively. Conclusions: Our study suggests that the Node-RADS score has high accuracy in predicting NPC cervical lymph node metastasis. Nevertheless, this conclusion requires confirmation in a larger cohort of patients with NPC. [ABSTRACT FROM AUTHOR]

Colorectal cancer is the third most prevalent cancer worldwide, and its treatment has been a demanding clinical problem. Beyond traditional surgical therapy and chemotherapy, newly revealed molecular mechanisms diversify therapeutic approaches for colorectal cancer. However, the selection of personalized treatment among multiple treatment options has become another challenge in the era of precision medicine. Artificial intelligence has recently been increasingly investigated in the treatment of colorectal cancer. This narrative review mainly discusses the applications of artificial intelligence in the treatment of colorectal cancer patients. A comprehensive literature search was conducted in MEDLINE, EMBASE, and Web of Science to identify relevant papers, resulting in 49 articles being included. The results showed that, based on different categories of data, artificial intelligence can predict treatment outcomes and essential guidance information of traditional and novel therapies, thus enabling individualized treatment strategy selection for colorectal cancer patients. Some frequently implemented machine learning algorithms and deep learning frameworks have also been employed for long-term prognosis prediction in patients with colorectal cancer. Overall, artificial intelligence shows encouraging results in treatment strategy selection and prognosis evaluation for colorectal cancer patients. [ABSTRACT FROM AUTHOR]

The immunogenicity of SARS-CoV-2 vaccines is poor in kidney transplant recipients (KTRs). The factors related to poor immunogenicity to vaccination in KTRs are not well defined. Here, observational study demonstrated no severe adverse effects were observed in KTRs and healthy participants (HPs) after first or second dose of SARS-CoV-2 inactivated vaccine. Different from HPs with excellent immunity against SARS-CoV-2, IgG antibodies against S1 subunit of spike protein, receptor-binding domain, and nucleocapsid protein were not effectively induced in a majority of KTRs after the second dose of inactivated vaccine. Specific T cell immunity response was detectable in 40% KTRs after the second dose of inactivated vaccine. KTRs who developed specific T cell immunity were more likely to be female, and have lower levels of total bilirubin, unconjugated bilirubin, and blood tacrolimus concentrations. Multivariate logistic regression analysis found that blood unconjugated bilirubin and tacrolimus concentration were significantly negatively associated with SARS-CoV-2 specific T cell immunity response in KTRs. Altogether, these data suggest compared to humoral immunity, SARS-CoV-2 specific T cell immunity response are more likely to be induced in KTRs after administration of inactivated vaccine. Reduction of unconjugated bilirubin and tacrolimus concentration might benefit specific cellular immunity response in KTRs following vaccination. [ABSTRACT FROM AUTHOR]

Lycorine, a natural compound isolated from the traditional Chinese medicinal herb Lycoris radiata, exhibits multiple pharmacological effects, such as anti‐inflammatory, antiviral, and anticancer effects. Accumulating evidence also indicates that lycorine might hold the potential to treat age‐associated Alzheimer's disease. However, whether lycorine is involved in delaying the onset of cellular senescence and its underlying mechanisms has not been determined. Here, we demonstrate that the salt of lycorine, lycorine hydrochloride, significantly suppressed stress‐induced premature cellular senescence (SIPS) by ~2‐fold, as determined by senescence‐associated beta‐galactosidase (SA‐β‐gal) staining and the expression of p16 and p21. In addition, pretreating cells with lycorine hydrochloride significantly inhibited the expression of CXCL1 and IL1α, two factors of the senescence‐associated secreted phenotype (SASP) in SIPS cells. Further experiments revealed that lycorine hydrochloride promoted both the homologous recombination (HR) and nonhomologous end joining (NHEJ) pathways of DNA double‐strand break (DSB) repair. Mechanistic studies suggested that lycorine hydrochloride treatment promoted the transcription of SIRT1 and SIRT6, critical longevity genes positively regulating both HR and NHEJ repair pathways, thereby stimulating DSB repair and stabilizing genomes. Inhibiting SIRT1 enzymatic activity abrogated the protective effect of lycorine hydrochloride on delaying the onset of SIPS, repairing DSBs, and restoring genome integrity. In summary, our work indicates that lycorine hydrochloride might hold therapeutic potential for treating age‐associated diseases or promoting healthy aging by stabilizing genomes. [ABSTRACT FROM AUTHOR]

Understanding the influence of COVID-19 on China's agricultural economy and the Chinese government's emergency measures to ease the economic impacts of viral spread can offer urgently-needed lessons while this virus continues to spread across the globe. Thus, this study collected over 750,000 words upon the topic of COVID-19 and agriculture from the largest two media channels in China: WeChat and Sina Weibo, and employed web crawler technology and text mining method to explore the influence of COVID-19 on agricultural economy and mitigation measures in China. The results show that: (1) the impact of COVID-19 on China's agricultural economy at the very first phase is mainly reflected in eight aspects as crop production, agricultural products supply, livestock production, farmers' income and employment, economic crop development, agricultural products sales model, leisure agriculture development, and agricultural products trade. (2) The government's immediate countermeasures include resuming agricultural production and farmers' work, providing financial support, stabilizing agricultural production and products supply, promoting agricultural products sale, providing subsidies, providing agricultural technology guidance and field management, and providing assistance to poor farmers to reduce poverty. (3) The order of government's immediate countermeasures is not all in line with the order of impact aspects, which indicates that more-tailored policies should be implemented to mitigate the strikes of COVID-19 on China's agricultural economy in the future. [ABSTRACT FROM AUTHOR]

Abstract This paper considers the inverse problem of scattering of time-harmonic acoustic and electromagnetic plane waves by a bounded, inhomogeneous, penetrable obstacle with embedded objects inside. A new method is proposed to prove that the inhomogeneous penetrable obstacle can be uniquely determined from the far-field pattern at a fixed frequency, disregarding its contents. Our method is based on constructing a well-posed interior transmission problem in a small domain associated with the Helmholtz or modified Helmholtz equation and the Maxwell or modified Maxwell equations. A key role is played by the smallness of the domain which ensures that the lowest transmission eigenvalue is large so that a given wave number k is not an eigenvalue of the interior transmission problem. Another ingredient in our proofs is a priori estimates of solutions to the transmission scattering problems with data in L p (1 < p < 2), which are established in this paper by using the integral equation method. A main feature of the new method is that it can deal with the acoustic and electromagnetic cases in a unified way and can be easily applied to deal with inverse scattering by unbounded rough interfaces. [ABSTRACT FROM AUTHOR]

In a two-layered medium, we prove that a buried inhomogeneous scatterer is uniquely determined from the wave field data measured in the upper half-space with respect to many incident point sources. Moreover, we extend the multilevel sampling method in Liu and Zou (2013) to numerically reconstruct the buried scatterer applying only few incident fields and partial scattered data. The extended recovery scheme only involves matrix–vector operations and does not need to solve any large-scale ill-posed linear systems or any optimization process. It is feasible to deal with the scatterers of different features and easy to implement, highly tolerant to noise and computationally quite cheap. We can regard it as an effective yet simple computational method to provide a reliable initial guess for the implementation in existing more accurate and refined optimization-type reconstruction algorithms. [ABSTRACT FROM AUTHOR]

Immunoglobulin A nephropathy (IgAN) has been well studied among young people, but few data on clinicopathological characteristics, treatment response and outcomes for elderly IgAN patients are available. A cohort study of elderly IgAN patients was performed. The combined endpoints of renal outcome were a 50% decline in eGFR compared with the time of renal biopsy, end-stage kidney disease and/or death. Risk factors associated with poor renal outcomes were then determined. The benefits of immunosuppressant therapies were also evaluated by Kaplan-Meier survival curve analysis. This study ultimately included 126 elderly patients with IgAN. Comparison between the endpoint and non-endpoint groups indicated that patients with poor outcomes had more severe clinical features, such as worse kidney function, severe hematuria and lower albumin levels. Cox regression analysis indicated that age (HR 1.15, 95% CI 1.02–1.29, p = 0.021), male gender (HR 9.71, 95% CI 1.00–97.56, p = 0.050), and urine red blood cells (HR 1.003, 95% CI 1.000–1.006, p = 0.029) were independent risk factors for poor renal outcome in elderly IgAN patients. To explore possible reasons accounting for the predictive value of age and sex, patients were divided into two groups based on these two variables. Patients in the geriatric group had lower serum albumin, estimated glomerular filtration rate, hemoglobin and aspartate aminotransferase levels than those in the quinquagenarian group. Male patients tended to have higher hemoglobin, higher alanine aminotransferase, and lower triglycerides and cholesterol levels than female patients. To investigate different treatment responses, patients were classified into two groups depending on treatment strategies (renin-angiotensin system inhibitors and immunosuppressive therapy), and the survival analysis indicated no significant difference in kidney outcome between the two groups (p > 0.05). This result still holds after adjusting for age, sex, eGFR, hematuria, and proteinuria. Advanced age, male, and hematuria might be independently associated with poor kidney outcomes in elderly patients with IgAN. Immunosuppressive therapy might confer no overall benefit to older IgAN patients. [ABSTRACT FROM AUTHOR]

Background: Cancer is a leading global cause of death. Conventional cancer treatments like surgery, radiation, and chemotherapy have associated side effects. Ferroptosis, a nonapoptotic and iron-dependent cell death, has been identified and differs from other cell death types. Research has shown that ferroptosis can promote and inhibit tumor growth, which may have prognostic value. Given the unclear role of ferroptosis in cancer biology, this meta-analysis aims to investigate its impact on cancer prognosis. Methods: This systematic review and meta-analysis conducted searches on PubMed, Embase, and the Cochrane Library databases. Eight retrospective studies were included to compare the impact of ferroptosis inhibition and promotion on cancer patient prognosis. The primary endpoints were overall survival (OS) and progression-free survival (PFS). Studies lacking clear descriptions of hazard ratios (HR) and 95% confidence intervals for OS and PFS were excluded. Random-effects meta-analysis and meta-regression were performed on the included study data to assess prognosis differences between the experimental and control groups. Meta-analysis results included HR and 95% confidence intervals. This study has been registered with PROSPERO, CRD 42023463720 on September 27, 2023. Results: A total of 2,446 articles were screened, resulting in the inclusion of 5 articles with 938 eligible subjects. Eight studies were included in the meta-analysis after bias exclusion. The meta-analysis, after bias exclusion, demonstrated that promoting ferroptosis could increase cancer patients' overall survival (HR 0.31, 95% CI 0.21–0.44) and progression-free survival (HR 0.26, 95% CI 0.16–0.44) compared to ferroptosis inhibition. The results showed moderate heterogeneity, suggesting that biological activities promoting cancer cell ferroptosis are beneficial for cancer patient's prognosis. Conclusions: This systematic review and meta-analysis demonstrated that the promotion of ferroptosis yields substantial benefits for cancer prognosis. These findings underscore the untapped potential of ferroptosis as an innovative anti-tumor therapeutic strategy, capable of addressing challenges related to drug resistance, limited therapeutic efficacy, and unfavorable prognosis in cancer treatment. Registration: CRD42023463720. [ABSTRACT FROM AUTHOR]

Novel BaCa2M3O9 (M = Si, Ge) microwave dielectric ceramics were prepared via solid‐state reaction with sintering at 1125°C–1275°C for 5 h. Single‐phase BaCa2M3O9 (M = Si, Ge) ceramics were obtained according to stoichiometry. The single‐phase BaCa2Ge3O9 ceramic was confirmed through Rietveld refinement and high‐resolution transmission electron microscopy/selected area electron diffraction and synthesized for the first time. The BaCa2M3O9 (M = Si, Ge) exhibited a triclinic structure with a P1¯$\bar 1$ space group and good microwave dielectric properties. The εr, Q × f, and τf values of BaCa2M3O9 (M = Si, Ge) ceramics are mostly dominated by the relative density, ionic polarizability, relative covalence, and bond energy of M–O bond, respectively. A high Q × f value (61 800 GHz at 16.3 GHz) was obtained in BaCa2Ge3O9 ceramic due to its high rc (Ge–O) and low intrinsic dielectric loss. The BaCa2Si3O9 ceramic exhibited small |τf| value (‒36.4 ppm/°C) due to its large ESi‐O. Excellent microwave dielectric properties (εr = 8.31, Q × f = 61 800 GHz, and τf = ‒58.7 ppm/°C) were obtained for the BaCa2Ge3O9 ceramic. [ABSTRACT FROM AUTHOR]

The dielectric properties of a Ga‐based melilite type ceramic Sr2Ga2SiO7 via theoretical prediction based on far‐infrared spectroscopy and experimental measurement by the Hakki–Coleman method were studied in this work. Dense and single‐phase ceramics were fabricated via solid‐state reaction at 1330°C and exhibited comprehensive microwave dielectric properties (εr ∼ 7.6, Q × f ∼ 23 600 GHz, and τf ∼ −35.2 ppm/°C) at 14.3 GHz. Chemical modifications were proposed to adjust the thermal stability and reduce the densification temperature. By adding 10 mol% CaTiO3, the negative τf can be compensated to a near‐zero value of −3.8 ppm/°C. The densification temperature was reduced to 940°C by adding 3 wt.% LiF. A patch antenna was designed using Sr2Ga2SiO7 ceramic with a high radiation efficiency of 99.1% and a gain of 2.788 dBi at the center frequency of 4.371 GHz. All results indicate that the Sr2Ga2SiO7 ceramic has promising application potential for 5G wireless communication technology. [ABSTRACT FROM AUTHOR]

In this paper, we focus on a space–time fractional diffusion equation with the generalized Caputo's fractional derivative operator and a general space nonlocal operator (with the fractional Laplace operator as a special case). A weak Harnack's inequality has been established by using a special test function and some properties of the space nonlocal operator. Based on the weak Harnack's inequality, a strong maximum principle has been obtained which is an important characterization of fractional parabolic equations. With these tools, we establish a uniqueness result of an inverse source problem on the determination of the temporal component of the inhomogeneous term, which seems to be the first theoretical result of the inverse problem for such a general fractional diffusion model. [ABSTRACT FROM AUTHOR]

The elderly usually suffer from many diseases. Improving the quality of life of the elderly is an urgent social issue. In this present study, D-galactose treated aging mice models were used to reveal the effects of different animal sources and different doses of whey protein (WP) on the immune indexes organs and intestinal flora. A total of 9 groups were set up, including normal control (NC), negative control (NS), positive control (Vc), low-, medium- and high-doses of cow WP intervention groups (CL, CM and CH for short, correspondingly) and low-, medium- and high-doses of goat WP intervention groups (GL, GM and GH for short, correspondingly). The body weight gain, thymus/body weight ratio, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, spleen immunoglobulins G (IgG), spleen interleukin-2 (IL-2) and spleen interleukin-2 (IL-6) were measured. Then, the intestinal contents were collected, and 16s genes of intestinal bacteria were sequenced to reveal the changes in bacterial flora structure. WP intervention significantly increased the weight gain, thymus/body ratio and SOD activity, but decrease the content of MDA. WP intervention increased some immune indicators. All the WP treated aging mice showed similar values of physiological indexes to that of the Vc group, even better. The relative abundance of Lactobacillus and Stenotrophomonas was increased and decreased, respectively, by both cow and goat WP. Lactobacillus may be involved in regulating the functional repair of organisms. In contrast, Stenotrophomonas might play a negative role in the immune and antioxidant capacity of the body. Combining physiological indicators and intestinal flora structure, low-concentration WP for cow and goat might be optimal for aging models. [ABSTRACT FROM AUTHOR]