156 results on '"Yener S"'
Search Results
2. Association between Hashimoto’s Thyroiditis and Papillary Thyroid Cancer: a Single Center Experience
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Canda, T., Calan, M., Solmaz, D., Yalcin, M. M., Gulcu, A., Demir, T., Yener, S., Bayraktar, FIRAT, Comlekci, ABDURRAHMAN, Durak, MERİH, and Danis, NİLAY
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Endocrinology ,Endocrine Care ,Endocrine and Autonomic Systems ,Endocrinology, Diabetes and Metabolism - Abstract
PURPOSE: To investigate the association between papillary thyroid cancer (PTC) and Hashimoto’s thyroiditis (HT). DESIGN: This study is a retrospective study that conducted during 7 consecutive years with a median 119.5 months follow-up. SUBJECTS AND METHOD: Patients who underwent thyroidectomy in Dokuz Eylül University Hospital during 7 consecutive years were included. Patients’ demographics, biochemical, radiological, and pathological results were retrospectively assessed. RESULTS: Four hundred sixty nine patients were evaluated. Among 469 patients who underwent thyroidectomy, 132 (28.1%) were malignant, while 182 patients were diagnosed with HT (38.8%). PTC was ranked first at 92.4% (n: 122). The prevalence of HT was 54.9% in patients with PTC and 33.1% in patients without PTC diagnosis (p
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- 2022
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3. The Early Detection of Second Primary Lung Cancers by Sputum Immunostaining
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Tockman, Melvyn S, Erozan, Yener S, Gupta, Prabodh, Piantadosi, Steven, Mulshine, James L, and Ruckdeschel, John C
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Rare Diseases ,Clinical Research ,Prevention ,Lung Cancer ,Lung ,Cancer ,Aged ,Antibodies ,Monoclonal ,Antigens ,Differentiation ,Antigens ,Neoplasm ,Biomarkers ,Tumor ,Carcinoma ,Non-Small-Cell Lung ,Female ,Humans ,Lung Neoplasms ,Male ,Neoplasms ,Second Primary ,Predictive Value of Tests ,Sputum ,Clinical Sciences ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Study objectiveTo determine whether monoclonal antibody (Mab) detection of tumor-associated antigen expressed on sputum epithelial cells precedes clinical presentation of second primary lung cancer. DESIGN SETTING/PARTICIPANTS: Eleven oncology centers collaborate in the accrual of 1,000 patients with stage I non-small cell lung cancer (NSCLC) who had undergone resection. The Mabs examined in this study (624H12, 703D4) detect two promising oncofetal/differentiation markers (ie, a difucosylated Lewis X and a 31-Kd glycoprotein antigen).InterventionsInduced sputum specimens are evaluated for quality, then are Papanicolaou and immunostained by independent central laboratories at enrollment and annually thereafter. The predictive value of Mab markers is compared with routine morphologic study for detection of second primary lung cancer during an anticipated 3 years of accrual and 1 year of follow-up.Measurements and resultsFive hundred eighty of an anticipated 1,000 patients have been accrued on schedule. Patients are primarily white (88.6%), former smokers (75.9%), men (55.6%), with a median age of 66.7, and joined the study at an average of 3.7 years following resection of a stage 1 NSCLC (34.4% squamous, 43.6% adenocarcinoma). Central laboratories found less dysplasia and more unsatisfactory specimens (27.3%) than do the accrual institution laboratories. Immunostaining identifies more suspicious cells than does morphologic study. However, only two second primary lung cancers (eight total deaths) have occurred to date.ConclusionsHalfway through the accrual, we describe the study design and preliminary observations. This study illustrates rational selection of carcinogenesis markers by linkage of marker expression on preneoplastic specimens with subsequent expression on tumor tissue.
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- 1994
4. THE USE OF LOW DOSE PREDNISOLONE IN PATIENTS WITH SUBACUTE THYROIDITIS AND ITS EFFECT ON IMPAIRED LIFE AND SLEEP QUALITY
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Saydam, B. Ozgen, Comlekci, ABDURRAHMAN, Yener, S., Demir, T., and Adiyaman, S. C.
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Endocrinology ,Endocrine and Autonomic Systems ,Endocrine Care ,Endocrinology, Diabetes and Metabolism - Abstract
CONTEXT: Subacute thyroiditis is an inflammatory thyroid disease, which is treated by nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids. OBJECTIVE: Defining characteristics of patients with subacute thyroiditis at diagnosis and during follow-up. Investigating the efficacies of NSAID and different doses of steroids and their effects on rates of relapse, recurrence, development of hypothyroidism and on quality of life and sleep parameters. DESIGN: A 3-year observational study in a tertiary referral center. SUBJECTS AND METHODS: A total of 63 patients with subacute thyroiditis were included. Clinical outcomes of patients treated with NSAIDs and NSAID unresponsive patients treated with prednisolone with initial doses of 0.5 mg/kg/day and 15 mg/day were evaluated. RESULTS: White blood cell count at diagnosis was an independent predictor of NSAID unresponsiveness. No relapse or recurrence was observed in patients receiving low dose of steroids. Long symptom duration until diagnosis and treatment with NSAIDs were associated with development of hypothyroidism. Subacute thyroiditis caused significant deterioration in quality of life and sleep of patients and low dose of steroid was as effective as higher doses in improving these parameters. CONCLUSIONS: For patients with no response to NSAID therapy, an initial low dose of prednisolone (15 mg/day) is determined as a safe treatment method when dose reduction is performed with appropriate timing.
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- 2022
5. De arboboete gematigd : een onderzoek naar de gronden die kunnen leiden tot matiging van de bestuurlijke boete op grond van de Arbeidsomstandighedenwet- en regelgeving
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Yener, S., Yener, S., Yener, S., and Yener, S.
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- 2020
6. Bovine milk fatty acid and triacylglycerol composition and structure differ between early and late lactation influencing milk fat solid fat content
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Pacheco Pappenheim, S.L., Yener, S., Goselink, R.M.A., Quintanilla-Carvajal, Maria Ximena, van Valenberg, H.J.F., Hettinga, K.A., Pacheco Pappenheim, S.L., Yener, S., Goselink, R.M.A., Quintanilla-Carvajal, Maria Ximena, van Valenberg, H.J.F., and Hettinga, K.A.
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Milk samples were collected in early lactation (8–14 days in milk; DIM) and late lactation (199–326 DIM) from 11 cows to assess the differences in bovine milk fatty acid (FA) and triacylglycerol (TAG) composition, FA positional distribution in the TAG structure, and milk solid fat content (SFC). Cows in early lactation that were in negative energy balance, mobilised C16:0, C18:0, and C18:1cis9 from their body fat stores, increasing the concentrations of these FA in milk fat. These high concentrations of C18:0 and C18:1cis9 enhanced the synthesis of high molecular weight TAG and decreased milk fat SFC in early lactation. For both lactation stages, alterations in the total FA concentrations in the TAG structures resulted in changes in the abundances and the proportions of the FA at the sn-2 and sn-1 (3) positions in the TAG structure, yet without affecting the main esterification preferences of the FA.
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- 2022
7. Microsatellite Alterations as Clonal Markers for the Detection of Human Cancer
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Mao, Li, Lee, Daniel J., Tockman, Melvyn S., Erozan, Yener S., Askin, Frederic, and Sidransky, David
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- 1994
8. Localization of Urinary Lactosylceramide in Cytoplasmic Vesicles of Renal Tubular Cells in Homozygous Familial Hypercholesterolemia
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Chatteriee, Subroto, Kwiterovich, Peter O., Gupta, Prabodh, Erozan, Yener S., Alving, Carl R., and Richards, Roberta L.
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- 1983
9. Bovine milk fat triacylglycerols : Factors influencing their composition and structure, and its effect on milk fat solid fat content
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Hettinga, K.A, Yener, S., Pacheco Pappenheim, Sara Liliana, Hettinga, K.A, Yener, S., and Pacheco Pappenheim, Sara Liliana
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Triacylglycerols (TAG) composition and structure in milk fat determine the physical, nutritional and functional characteristics in milk fat. TAG are composed of three fatty acids (FA) bound to a glycerol molecule. Therefore, changes in milk FA composition are expected to influence milk fat TAG composition and structure. Feed and animal related factors are known to affect milk FA composition. Feed related factors refer to alteration in the dairy cows’ feeding regimes, whereas animal related factors refer to factors such as lactation stage, breed, and genetics. This thesis aimed to assess the effect of feed and animal related factors on the variation in FA and TAG composition and structure and to determine its influence on the milk fat solid fat content (SFC). Milk fat SFC is one of the physical properties that define the suitability of a fat for a specific food product application. Therefore, it was selected as the physical property of study in this thesis to highlight the effect of milk FA and TAG variations.In chapters 2 and 3, the effect of the seasonal feeding regimes on the FA and TAG composition and structure were assessed in a non-seasonal milking system. Both chapters were based on weekly-pooled milk samples collected from fourteen dairy factories in the Netherlands, during one year, from May 2017 to April 2018. Seasonal FA and TAG composition variation were presented in chapter 2, where the largest FA variations were found between summer and winter, while spring and autumn were considered transition periods. The FA variations included a smaller proportion of de novo synthesized FA and an increased proportion of biohydrogenation products and conjugated linoleic acid (CLA) isomer FA in spring and summer. Moreover, the proportion of linolenic acid (ALA) in milk fat was greatest during late spring and summer, reflecting the increased intake of fresh pasture in these periods. The high availability of short-chain FA (SCFA) and C16:0 in winter increased the formati
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- 2021
10. Life on a piece of cake : Performance and fatty acid profiles of black soldier fly larvae fed oilseed by-products
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Schreven, S.J.J., Yener, S., Valenberg, H.J.F., van, Dicke, M., Loon, J.J.A., van, Schreven, S.J.J., Yener, S., Valenberg, H.J.F., van, Dicke, M., and Loon, J.J.A., van
- Abstract
The oilseed crops Crambe abyssinica and Camelina sativa produce oils rich in erucic acid and n-3 polyunsaturated fatty acids (PUFA), respectively. After pressing the oil, a seed cake remains as a protein-rich by-product. Edible insects may convert this seed press cake and the defatted seed meal produced from it into insect biomass suitable for animal feed. Black soldier fly larvae (BSF, Hermetia illucens) can grow on a wide range of organic waste types, but may be hindered by excess protein or the plant toxins characteristic for these two oilseed crops, i.e. glucosinolates and their breakdown products. We tested the effects of 25, 50 and 100% oilseed by-product inclusion in the diet on survival, development, biomass production and fatty acid composition of BSF larvae. Larval performance on diets with up to 50% camelina by-product or 25% crambe by-product was similar to performance on control diet (chicken feed), and decreased with higher inclusion percentages. Larval fatty acid profiles differed significantly among diets, with larvae fed press cake more distinct from control than larvae fed seed meal. Larvae fed camelina press cake had more α-linolenic acid, whereas larvae fed crambe contained most oleic acid. The n-6:n-3 PUFA ratio decreased with increasing proportion of by-product, especially on camelina diets. Lauric acid content was highest in larvae fed 100% camelina meal or 50% crambe meal. These results indicate that BSF larvae can be successfully grown on diets with camelina or crambe oilseed by-products, and that the resulting larval n-6:n-3 PUFA ratio is favourable for animal feed. However, the fate of glucosinolates and their derivatives remains to be determined, to guarantee chemical safety of camelinaor crambe-fed BSF larvae for animal feed.
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- 2020
11. of the Turkish Nationwide Survey of Glycemic and Other Metabolic
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Sonmez, A, Yumuk, V, Haymana, C, Demirci, I, Barcin, C, Kiyici, S, Guldiken, S, Oruk, G, Saydam, BO, Baldane, S, Kutluturk, F, Kucukler, FK, Deyneli, O, Cetinarslan, B, Sabuncu, T, Bayram, F, Satman, I, Ayturk, S, Yilmaz, M, Asik, M, Dinccag, N, Cakmak, R, Turker, F, Idiz, C, Hacisahinogullari, H, Bagdemir, E, Yildiz, B, Haliloglu, O, Sancak, S, Ozsari, L, Cagiltay, E, Imre, E, Sait Gonen, Boysan, SN, Altuntas, Y, Ozturk, FY, Mert, M, Piskinpasa, H, Aydin, H, Imamoglu, S, Ersoy, C, Oz Gul, O, Selek, A, Dogru, T, Kirik, A, Kebapci, N, Efe, B, Kaya, A, Cordan, I, Kirac, CO, Capa, Z, Cesur, M, Yetkin, I, Corapcioglu, D, Canlar, S, Yildiz, OB, Sendur, SN, Cakir, B, Ozdemir, D, Corakci, A, Kutlu, M, Bascil Tutuncu, N, Bozkus, Y, Cakal, E, Demirbas, B, Ertek, S, Altay, M, Dagdeviren, M, Abedi, AH, Cetinkalp, S, Ozisik, H, Yener, S, Guney, E, Unubol, M, Yaylali, GF, Topsakal, S, Hekimsoy, Z, Akbaba, G, Aslan, I, Balci, MK, Dalkiran, S, Akbay, E, Gul, K, Agbaht, K, Yilmaz, MO, Bozkirli, E, Tetiker, BT, Cetinkaya Altuntas, S, Atmaca, A, Durmus, ET, Mete, T, Dikbas, O, Akin, S, Nuhoglu, I, Ersoz, HO, Bayraktaroglu, T, Sisman, P, Sahin, I, Cetin, S, Capoglu, I, Akbas, EM, Ucler, R, Eren, MA, Tuzcu, AK, Pekkolay, Z, Ozkaya, M, Araz, M, Salman, S, Dizdar, OS, Gurkan, E, and Kargili Carlioglu, A
- Abstract
Background: Obesity is the main obstacle for metabolic control in patients with type 2 diabetes. Turkey has the highest prevalence of obesity and type 2 diabetes in Europe. The effect of obesity on the metabolic control, and the macro-and microvascular complications of patients are not apparent. Objectives: This nationwide survey aimed to investigate the prevalence of overweight and obesity among patients with type 2 diabetes and to search for the impact of obesity on the metabolic control of these patients. We also investigated the independent associates of obesity in patients with type 2 diabetes. Methods: We consecutively enrolled patients who were under follow-up for at least 1 year in 69 tertiary healthcare units in 37 cities. The demographic, anthropometric, and clinical data including medications were recorded. Patients were excluded if they were pregnant, younger than 18 years, had decompensated liver disease, psychiatric disorders interfering with cognition or compliance, had bariatric surgery, or were undergoing renal replacement therapy. Results: Only 10% of patients with type 2 diabetes (n = 4,648) had normal body mass indexes (BMI), while the others were affected by overweight (31%) or obesity (59%). Women had a significantly higher prevalence of obesity (53.4 vs. 40%) and severe obesity (16.6 vs. 3.3%). Significant associations were present between high BMI levels and lower education levels, intake of insulin, antihypertensives and statins, poor metabolic control, or the presence of microvascular complications. Age, gender, level of education, smoking, and physical inactivity were the independent associates of obesity in patients with type 2 diabetes. Conclusion: The TEMD Obesity Study shows that obesity is a major determinant of the poor metabolic control in patients with type 2 diabetes. These results underline the importance of prevention and management of obesity to improve health care in patients with type 2 diabetes. Also, the results point out the independent sociodemographic and clinical associates of obesity, which should be the prior targets to overcome, in the national fight with obesity. (c) 2019 The Author(s) Published by S. Karger AG, Basel C1 [Sonmez, Alper; Haymana, Cem; Demirci, Ibrahim] Univ Hlth Sci, Gulhane Sch Med, Dept Endocrinol & Metab, TR-06018 Ankara, Turkey. [Yumuk, Volkan] Istanbul Univ, Cerrahpasa Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey. [Barcin, Cem] Univ Hlth Sci, Gulhane Sch Med, Dept Cardiol, Ankara, Turkey. [Kiyici, Sinem] Univ Hlth Sci, Bursa Yuksek Ihtisas Training & Res Hosp, Dept Endocrinol & Metab, Bursa, Turkey. [Guldiken, Sibel] Trakya Univ, Med Fac, Dept Endocrinol & Metab, Edirne, Turkey. [Oruk, Gonca] Izmir Katip Celebi Univ, Ataturk Educ & Res Hosp, Dept Endocrinol & Metab, Izmir, Turkey. [Saydam, Basak Ozgen] Dokuz Eylul Univ, Med Fac, Dept Endocrinol & Metab, Izmir, Turkey. [Baldane, Suleyman] Selcuk Univ, Med Fac, Dept Endocrinol & Metab, Konya, Turkey. [Kutluturk, Faruk] Gaziosmanpasa Univ, Med Fac, Dept Endocrinol & Metab, Tokat, Turkey. [Kucukler, Ferit Kerim] Hitit Univ, Med Fac, Dept Endocrinol & Metab, Corum, Turkey. [Deyneli, Oguzhan] Marmara Univ, Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey. [Cetinarslan, Berrin] Kocaeli Univ, Med Fac, Dept Endocrinol & Metab, Kocaeli, Turkey. [Sabuncu, Tevfik] Harran Univ, Med Fac, Dept Endocrinol & Metab, Urfa, Turkey. [Bayram, Fahri] Erciyes Univ, Med Fac, Dept Endocrinol & Metab, Kayseri, Turkey. [Satman, Ilhan] Istanbul Univ, Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey. [Ayturk, Semra] Trakya Univ, Sch Med, Dept Endocrinol & Metab, Edirne, Turkey. [Yilmaz, Murat] Corlu REYAP Private Hosp, Dept Endocrinol & Metab, Corlu, Turkey. [Asik, Mehmet] Canakkale 18 March Univ, Sch Med, Dept Endocrinol & Metab, Canakkale, Turkey. [Dinccag, Nevin; Cakmak, Ramazan; Turker, Fulya; Idiz, Cemile; Hacisahinogullari, Hulya; Bagdemir, Elif; Yildiz, Busra; Haliloglu, Ozlem] Istanbul Univ, Sch Med, Dept Endocrinol & Metab, Cerrahpasa, Turkey. [Sancak, Seda] Univ Hlth Sci, Sch Med, Fatih Sultan Mehmet Training & Res Hosp, Dept Endocrinol & Metab, Istanbul, Turkey. [Ozsari, Levent; Cagiltay, Eylem] Univ Hlth Sci, Sch Med, Sultanabdulhamit Training & Res Hosp, Dept Endocrinol & Metab, Istanbul, Turkey. [Imre, Eren] Marmara Univ, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey. [Sait Gonen; Boysan, S. Nur] Istanbul Sci Univ, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey. [Altuntas, Yuksel; Ozturk, Feyza Yener] Univ Hlth Sci, Sch Med, Sisli Hamidiye Etfal Training & Res Hosp, Dept Endocrinol & Metab, Istanbul, Turkey. [Mert, Meral; Piskinpasa, Hamide] Univ Hlth Sci, Istanbul Bakirkoy Dr Sadi Konuk Training & Res Ho, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey. [Aydin, Hasan] Yeditepe Univ, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey. [Ersoy, Canan; Oz Gul, Ozen] Uludag Univ, Sch Med, Dept Endocrinol & Metab, Bursa, Turkey. [Selek, Alev] Kocaeli Univ, Sch Med, Dept Endocrinol & Metab, Kocaeli, Turkey. [Dogru, Teoman; Kirik, Ali] Balikesir Univ, Sch Med, Dept Internal Med, Balikesir, Turkey. [Kebapci, Nur; Efe, Belgin] Eskisehir Osmangazi Univ, Sch Med, Dept Endocrinol & Metab, Odunpazari Eskisehir, Turkey. [Kaya, Ahmet; Cordan, Ilker] Necmettin Erbakan Univ, Sch Med, Dept Endocrinol & Metab, Konya, Turkey. [Kirac, Cem Onur] Selcuk Univ, Sch Med, Dept Endocrinol & Metab, Konya, Turkey. [Capa, Zehra] Univ Hlth Sci, Gulhane Sch Med, Ankara, Turkey. [Capa, Zehra] Gulhane Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Cesur, Mustafa] Private Guven Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Yetkin, Ilhan] Gazi Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Corapcioglu, Demet; Canlar, Sule] Ankara Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Yildiz, Okan Bulent; Sendur, Suleyman Nahit] Hacettepe Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Cakir, Bekir; Ozdemir, Didem] Yildirim Beyazit Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Corakci, Ahmet] Ufuk Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Kutlu, Mustafa] Private Bayindir Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Bascil Tutuncu, Neslihan; Bozkus, Yusuf] Baskent Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Cakal, Erman] Univ Hlth Sci, Sch Med, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Demirbas, Berrin] TOBB Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey. [Ertek, Sibel] Private Mem Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Altay, Mustafa; Dagdeviren, Murat] Univ Hlth Sci, Sch Med, Kecioren Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Abedi, Amir Hassein] Erciyes Univ, Sch Med, Dept Endocrinol & Metab, Kayseri, Turkey. [Cetinkalp, Sevki; Ozisik, Hatice] Ege Univ, Sch Med, Dept Endocrinol & Metab, Izmir, Turkey. [Yener, Serkan] Dokuz Eylul Univ, Sch Med, Dept Endocrinol & Metab, Izmir, Turkey. [Guney, Engin; Unubol, Mustafa] Adnan Menderes Univ, Sch Med, Dept Endocrinol & Metab, Aydin, Turkey. [Yaylali, Guzin Fidan; Topsakal, Senay] Pamukkale Univ, Sch Med, Dept Endocrinol & Metab, Denizli, Turkey. [Hekimsoy, Zeliha] Celal Bayar Univ, Sch Med, Dept Endocrinol & Metab, Manisa, Turkey. [Akbaba, Gulhan] Mugla Univ, Sch Med, Dept Endocrinol & Metab, Mugla, Turkey. [Aslan, Ibrahim] Univ Hlth Sci, Antalya Training & Res Hosp, Sch Med, Dept Endocrinol & Metab, Antalya, Turkey. [Balci, Mustafa Kemal; Dalkiran, Sefika] Akdeniz Univ, Sch Med, Dept Endocrinol & Metab, Antalya, Turkey. [Akbay, Esen] Mersin Univ, Sch Med, Dept Endocrinol & Metab, Mersin, Turkey. [Gul, Kamile] Kahramanmaras Sutcu Imam Univ, Sch Med, Dept Endocrinol & Metab, Kahramanmaras, Turkey. [Agbaht, Kemal] Private Defne Hosp, Dept Endocrinol & Metab, Antalya, Turkey. [Yilmaz, Muge Ozsan] Mustafa Kemal Univ, Sch Med, Dept Endocrinol & Metab, Antakya, Turkey. [Bozkirli, Emre] Baskent Univ, Adana Training Hosp, Dept Endocrinol & Metab, Ankara, Turkey. [Tetiker, B. Tamer; Cetinkaya Altuntas, Seher] Cukurova Univ, Sch Med, Dept Endocrinol & Metab, Adana, Turkey. [Atmaca, Aysegul; Durmus, Elif Tutku] 19 Mayis Univ, Sch Med, Dept Endocrinol & Metab, Samsun, Turkey. [Mete, Turkan] Univ Hlth Sci, Sch Med, Samsun Training & Res Hosp, Dept Endocrinol & Metab, Samsun, Turkey. [Dikbas, Oguz] Giresun Univ, Sch Med, Dept Endocrinol & Metab, Giresun, Turkey. [Akin, Safak] Recep Tayyip Erdogan Univ, Sch Med, Dept Endocrinol & Metab, Rize, Turkey. [Nuhoglu, Irfan; Ersoz, Halil Onder] Karadeniz Tech Univ, Sch Med, Dept Endocrinol & Metab, Trabzon, Turkey. [Bayraktaroglu, Taner] Bulent Ecevit Univ, Sch Med, Dept Endocrinol & Metab, Zonguldak, Turkey. [Sisman, Pinar] Kars Harakani State Hosp, Dept Endocrinol & Metab, Kars, Turkey. [Sahin, Ibrahim; Cetin, Sedat] Inonu Univ, Sch Med, Dept Endocrinol & Metab, Malatya, Turkey. [Capoglu, Ilyas; Akbas, Emin Murat] Erzincan Univ, Sch Med, Dept Endocrinol & Metab, Erzincan, Turkey. [Ucler, Rifki] Yuzuncu Yil Univ, Sch Med, Dept Endocrinol & Metab, Van, Turkey. [Eren, Mehmet Ali] Harran Univ, Sch Med, Dept Endocrinol & Metab, Sanliurfa, Turkey. [Tuzcu, Alpaslan Kemal; Pekkolay, Zafer] Dicle Univ, Sch Med, Dept Endocrinol & Metab, Diyarbakir, Turkey. [Ozkaya, Mesut] Univ Hlth Sci, Sch Med, Gaziantep Ersin Arslan Res & Training Hosp, Gaziantep, Turkey. [Araz, Mustafa] Gaziantep Univ, Sch Med, Dept Endocrinol & Metab, Gaziantep, Turkey. [Salman, Serpil] Liv Hosp Ulus, Dept Endocrinol & Metab, Istanbul, Turkey. [Dizdar, Oguzhan Sitki] Kayseri Educ & Res Hosp, Dept Internal Med, Kayseri, Turkey. [Gurkan, Eren] Mustafa Kemal Univ, Dept Endocrinol & Metab, Antakya, Turkey. [Kargili Carlioglu, Ayse] Erzurum Reg Educ & Res Hosp, Dept Endocrinol & Metab, Erzurum, Turkey.
- Published
- 2019
12. Liraglutide and Renal Outcomes in Type 2 Diabetes
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Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB, LEADER Steering Committee and Investigators. Bergenstal R, Daniels G, Moses AC, Nauck M, Nissen S, Pocock S, Steinberg W, Stockner M, Kristensen P, Ravn LS, Zychma M, Flyvbjerg A, Ford I, Kloos RT, Schactman MJ, Sleight P, Swedberg K, Tenner SM, Akalın S, Arechavaleta R, Bain S, Babkowski MC, Benroubi M, Berard L, Comlekci A, Czupryniak L, Eliasson B, Eriksson M, Fonseca V, Franek E, Gross J, Hafidh K, Haluzik M, Hayes F, Huang YY, Jacob S, Kaddaha G, Khalil A, Kilhovd B, Laakso M, Leiter L, Lalic N, Ji L, Luedemann J, Mannucci E, Marre M, Masmiquel L, Mota M, Omar M, O’Shea D, Pan C, Petrie J, Pieber T, Pratley R, Raz I, Rea R, Rutten G, Satman I, Shestakova M, Simpson R, Smith D, Tack C, Tarnow L, Thomas N, Van Gaal L, Travert F, Vidal J, Warren M, Yoon KH, Tuttle RM, Sheerman SI, Hegedüs L, Baerwald H, Bergenstal M, Celik S, Dias C, Eder M, Fitzgibbons S, Irvhage L, Kloluckova J, Kriulianski R, McDuffie R, Moen S, Paster A, Saalfeld RM, Sankar K, Shehaj E, Swierzewska P, Tiktin M, Tovey S, Gibson CM, Chakrabarti AK, Dashe JF, Hinchey J, Leary MC, Pride Y, Wiviott S, Allen S, Mehr AP, Mutter WP, Parikh S, Ray S, Cheifetz A, Leffler D, Sheth S, Alexander E, Gaglia JL, Goessling W, Mitzner LD, Rosenberg C, Snow KJ, Wagner A, Piazza G, Abell S, Davis T, D'Emden M, Ding SA, Gilfillan C, Greenaway T, Gunawan F, Ho J, Jackson R, Kalra B, Lau SL, Lin J, MacIsaac R, Makepeace A, Malabu U, Marjason J, McCallum R, McLean M, Moin N, Petersons C, Price S, Roberts A, Roberts D, Sangla K, Stranks S, Tan Y, Thynne T, Walters J, Ward G, Wen W, Zhang J, Brix J, Feder A, Höbaus C, Höllerl F, Höller V, Kotter T, Kratz E, Krzizek EC, Leb-Stoeger U, Mader J, Mras N, Novak E, Obendorf F, Peric S, Pesau G, Prager R, Ribitsch A, Schnack C, Schernthaner G, Wascher T, Batens AH, Benhalima K, De Block C, Ernest P, Fouckova A, Jandrain B, Lapauw B, Letiexhe M, Mathieu C, Neven S, Peiffer F, Ruige J, Scheen A, Taes Y, Van Boxelaer I, Vandistel G, Van Durme Y, Verhaegen A, Alencar E, Alencar R, Almeida AC, Alves B, Alves E, Alves G, 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E, Martinez G, Martinez-Miss S, Marx P, Massara L, Mastoor M, Matfin G, Maturu A, Maurides P, May M, Mayfield R, Maynard B, Mazza A, McCann K, McCoy J, McCoy T, McCullen MK, McDaniel C, McDaniel AM, McDermott M, McDonald A, McMasters B, McMurray C, Medlin T, Meinel M, Mendez I, Menefee J, Meredith M, Merriweather M, Mersey J, Messino C, Meyer S, Meyers L, Michael D, Midyett C, Miklius A, Milford E, Miller B, Miller H, Milligan M, Minor A, Miranda-Palma B, Mirarchi N, Mittadodla S, Mittle J, Moffat A, Mohaupt S, Mohiuddin K, Mokshagundam S, Monaco S, Monsaert R, Montano-Pereira C, Montgomery A, Moody K, Moon M, Moore D, Moore L, Morawski E, Moreau C, Morin D, Moscoa C, Motzkin C, Mueller R, Munoz C, Munoz M, Myneni A, Naderi B, Nagireddy P, Naidu J, Naidu R, Naik S, Naimark R, Nardicchi M, Ndukwu I, Neller C, Netten-Foster L, Neumiller J, New T, Newman S, Newton T, Nguyen B, Nicol B, Nicol P, Ninivaggi L, Niswender K, Norman L, Noworatzky G, Nyenwe E, O'Brien H, O'Connell T, Oden W, Odugbesan A, Oliver M, Oliver T, Olmeda C, O'Neil C, Oremus R, Ortega T, Ortiz-Santos S, Osborn T, Padmanabhan S, Papacostea O, Park I, Parker A, Parker K, Parker R, Patel C, Patel M, Patel R, Patino M, Patterson S, Paulson K, Paz A, Pemba R, Pepe C, Perez J, Perez T, Perry D, Phillips B, Phillips J, Pickett A, Pinson M, Pitzer R, Poduri M, Poehls J, Poteat T, Powell L, Prasad S, Prevost J, Price E, Priest D, Prieto L, Purewal T, Purighalla R, Purighalla U, Quadrel M, Qureshi A, Radhamma R, Rafla E, Rajab H, Ramalingam R, Ramirez A, Ramirez J, Ramirez K, Ramirez M, Randall M, Rangaraj U, Rao V, Rasmussen P, Rasouli N, Ray A, Reed J, Rems L, Renaud K, Reno M, Resnick M, Reusch J, Reynolds L, Rhoton K, Rhudy J, Ricci C, Rice L, Richardson A, Richardson L, Rickard H, Rickels M, Riff D, Rightenour N, Risser J, Rizvi A, Robertson J, Robinson A, Robinson R, Rockwell M, Rodriguez JP, Rodriguez M, Rojas M, Rojas W, Rooker-Morris L, Root C, Rose M, Rosenberg R, Rosenstock J, Roth M, Ruby R, Sachson R, Sack P, Sadler RK, Sahai S, Salazar J, Salgam M, Samal A, Samson A, Sanagorski R, Sanchez A, Sandberg J, Sanderson M, Sandoval J, Santiago E, Sapp T, Saunders J, Schill J, Schott C, Schreiman R, Schu D, Schuh K, Schutta M, Schwartz J, Schweppe L, Scofield H, Scribner A, Seal J, Sealock J, Seaton B, Sedlak-Hanslik T, Seekins K, Segal M, Seggelke S, Semenza S, Sentman P, Serra M, Seshadri P, Sevilla E, Shah S, Shaheen K, Shanik M, Shaw J, Sheets M, Shellabarger C, Sher J, Shippey J, Shivaswamy V, Shomali M, Shore D, Shroff P, Siddiqui T, Siegwald A, Silver R, Simmons D, Simons R, Sinan A, Singh M, Sirinvaravong S, Skero J, Slover-Zipf J, Small S, Smith B, Smith K, Smith M, Sohl J, Solarz SH, Soler D, Sood A, Sora N, Souchet A, Soule J, Sparks J, Spector L, Speicher R, Spillers L, Spivey T, Springer N, Sprouse H, St John J, Stacey A, Stacey H, Stafford M, Stagner E, Staples K, Steadman E, Steed R, Steeves G, Steinberg H, Stell C, Stirman E, Straub K, Strock E, Sue M, Suris O, Sutton T, Tabbah I, Talsania M, Tang R, Tapia J, Taylor K, Taylor-Hancher R, Teator R, Tekateka M, Temple B, Temple K, Teodori M, Tharp P, Thethi T, Theuma P, Thomas S, Thottan A, Thrasher J, Thrasher L, Tiemeyer M, Tinney I, Tobin T, Toma S, Tovar M, Townsend J, Trantow C, Traylor H, Trevino M, Troy M, Trumper D, Tryggestad J, Tucker C, Turner J, Turney R, Tuten C, Tyzack J, Ullo L, Underkofler C, Unger J, Urdanetta R, Valdivia V, Valenti S, Vanderheiden A, Vanderlinde-Wood M, Varma C, Vasquez E, Vazquez M, Vickery D, Villafuerte B, Villegas C, Vivar J, Vivekananthan K, Vo G, Vukojicic K, Wachter A, Wahl D, Waitmann J, Walker D, Walsh J, Walsh K, Walton A, Wang A, Wardell K, Watkins S, Watkinson J, Watts M, Watwe V, Weaver N, Weber R, Wedick C, Weeks D, Weeks L, Weindorff K, Weinstein R, Weiss S, Wenger K, Wentworth M, Werner A, West M, Whelan S, White B, White J, Whitmire M, Whittington R, Wical J, Wigley C, Wilkins F, Will K, Williams A, Wilson LE, Wince M, Wine S, Winkle P, Winner C, Wise J, Witte M, Wittenmyer J, Wood C, Wood R, Woodruff C, Worthington B, Wynn D, Wysham C, Xavier P, Yela S, Yenoby L, Young L, Younus N, Yourell V, Zaid M, Zubair I., Mann, Jfe, Ørsted, Dd, Brown-Frandsen, K, Marso, Sp, Poulter, Nr, Rasmussen, S, Tornøe, K, Zinman, B, Buse, Jb, Bergenstal R, LEADER Steering Committee and Investigators., Daniels, G, Moses, Ac, Nauck, M, Nissen, S, Pocock, S, Steinberg, W, Stockner, M, Kristensen, P, Ravn, L, Zychma, M, Flyvbjerg, A, Ford, I, Kloos, Rt, Schactman, Mj, Sleight, P, Swedberg, K, Tenner, Sm, Akalın, S, Arechavaleta, R, Bain, S, Babkowski, Mc, Benroubi, M, Berard, L, Comlekci, A, Czupryniak, L, Eliasson, B, Eriksson, M, Fonseca, V, Franek, E, Gross, J, Hafidh, K, Haluzik, M, Hayes, F, Huang, Yy, Jacob, S, Kaddaha, G, Khalil, A, Kilhovd, B, Laakso, M, Leiter, L, Lalic, N, Ji, L, Luedemann, J, Mannucci, E, Marre, M, Masmiquel, L, Mota, M, Omar, M, O’Shea, D, Pan, C, Petrie, J, Pieber, T, Pratley, R, Raz, I, Rea, R, Rutten, G, Satman, I, 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Madireddy, S, Mae, L, Mahakala, A, Maheshwari, H, Malbari, H, Maldonado, N, Mallitz, M, Mandviwala, M, Mann, K, Mardahay, M, Marino, J, Marney, A, Marshall, L, Martin, A, Martin, E, Martinez, G, Martinez-Miss, S, Marx, P, Massara, L, Mastoor, M, Matfin, G, Maturu, A, Maurides, P, May, M, Mayfield, R, Maynard, B, Mazza, A, Mccann, K, Mccoy, J, Mccoy, T, Mccullen, Mk, Mcdaniel, C, Mcdaniel, Am, Mcdermott, M, Mcdonald, A, Mcmasters, B, Mcmurray, C, Medlin, T, Meinel, M, Mendez, I, Menefee, J, Meredith, M, Merriweather, M, Mersey, J, Messino, C, Meyer, S, Meyers, L, Michael, D, Midyett, C, Miklius, A, Milford, E, Miller, B, Miller, H, Milligan, M, Minor, A, Miranda-Palma, B, Mirarchi, N, Mittadodla, S, Mittle, J, Moffat, A, Mohaupt, S, Mohiuddin, K, Mokshagundam, S, Monaco, S, Monsaert, R, Montano-Pereira, C, Montgomery, A, Moody, K, Moon, M, Moore, D, Moore, L, Morawski, E, Moreau, C, Morin, D, Moscoa, C, Motzkin, C, Mueller, R, Munoz, C, Munoz, M, Myneni, A, Naderi, B, Nagireddy, P, Naidu, J, Naidu, R, Naik, S, Naimark, R, Nardicchi, M, Ndukwu, I, Neller, C, Netten-Foster, L, Neumiller, J, New, T, Newman, S, Newton, T, Nguyen, B, Nicol, B, Nicol, P, Ninivaggi, L, Niswender, K, Norman, L, Noworatzky, G, Nyenwe, E, O'Brien, H, O'Connell, T, Oden, W, Odugbesan, A, Oliver, M, Oliver, T, Olmeda, C, O'Neil, C, Oremus, R, Ortega, T, Ortiz-Santos, S, Osborn, T, Padmanabhan, S, Papacostea, O, Park, I, Parker, A, Parker, K, Parker, R, Patel, C, Patel, M, Patel, R, Patino, M, Patterson, S, Paulson, K, Paz, A, Pemba, R, Pepe, C, Perez, J, Perez, T, Perry, D, Phillips, B, Phillips, J, Pickett, A, Pinson, M, Pitzer, R, Poduri, M, Poehls, J, Poteat, T, Powell, L, Prasad, S, Prevost, J, Price, E, Priest, D, Prieto, L, Purewal, T, Purighalla, R, Purighalla, U, Quadrel, M, Qureshi, A, Radhamma, R, Rafla, E, Rajab, H, Ramalingam, R, Ramirez, A, J, Ramirez, Ramirez, K, Ramirez, M, Randall, M, Rangaraj, U, Rao, V, Rasmussen, P, Rasouli, N, Ray, A, Reed, J, Rems, L, Renaud, K, Reno, M, Resnick, M, Reusch, J, Reynolds, L, Rhoton, K, Rhudy, J, Ricci, C, Rice, L, Richardson, A, Richardson, L, Rickard, H, Rickels, M, Riff, D, Rightenour, N, Risser, J, Rizvi, A, Robertson, J, Robinson, A, Robinson, R, Rockwell, M, Rodriguez, Jp, Rodriguez, M, Rojas, M, Rojas, W, Rooker-Morris, L, Root, C, Rose, M, Rosenberg, R, Rosenstock, J, Roth, M, Ruby, R, Sachson, R, Sack, P, Sadler, Rk, Sahai, S, J, Salazar, Salgam, M, Samal, A, Samson, A, Sanagorski, R, Sanchez, A, Sandberg, J, Sanderson, M, Sandoval, J, Santiago, E, Sapp, T, Saunders, J, Schill, J, Schott, C, Schreiman, R, Schu, D, Schuh, K, Schutta, M, Schwartz, J, Schweppe, L, Scofield, H, Scribner, A, Seal, J, Sealock, J, Seaton, B, Sedlak-Hanslik, T, Seekins, K, Segal, M, Seggelke, S, Semenza, S, Sentman, P, Serra, M, Seshadri, P, Sevilla, E, Shah, S, Shaheen, K, Shanik, M, Shaw, J, Sheets, M, Shellabarger, C, Sher, J, Shippey, J, Shivaswamy, V, Shomali, M, Shore, D, Shroff, P, Siddiqui, T, Siegwald, A, Silver, R, Simmons, D, Simons, R, Sinan, A, Singh, M, Sirinvaravong, S, Skero, J, Slover-Zipf, J, Small, S, Smith, B, Smith, K, Smith, M, Sohl, J, Solarz, Sh, Soler, D, Sood, A, Sora, N, Souchet, A, Soule, J, Sparks, J, Spector, L, Speicher, R, Spillers, L, Spivey, T, Springer, N, Sprouse, H, St John, J, Stacey, A, Stacey, H, Stafford, M, Stagner, E, Staples, K, Steadman, E, Steed, R, Steeves, G, Steinberg, H, Stell, C, Stirman, E, Straub, K, Strock, E, Sue, M, Suris, O, Sutton, T, Tabbah, I, Talsania, M, Tang, R, Tapia, J, Taylor, K, Taylor-Hancher, R, Teator, R, Tekateka, M, Temple, B, Temple, K, Teodori, M, Tharp, P, Thethi, T, Theuma, P, Thomas, S, Thottan, A, Thrasher, J, Thrasher, L, Tiemeyer, M, Tinney, I, Tobin, T, Toma, S, Tovar, M, Townsend, J, Trantow, C, Traylor, H, Trevino, M, Troy, M, Trumper, D, Tryggestad, J, Tucker, C, Turner, J, Turney, R, Tuten, C, Tyzack, J, Ullo, L, Underkofler, C, Unger, J, Urdanetta, R, Valdivia, V, Valenti, S, Vanderheiden, A, Vanderlinde-Wood, M, Varma, C, Vasquez, E, Vazquez, M, Vickery, D, Villafuerte, B, Villegas, C, Vivar, J, Vivekananthan, K, Vo, G, Vukojicic, K, Wachter, A, Wahl, D, Waitmann, J, Walker, D, Walsh, J, Walsh, K, Walton, A, Wang, A, Wardell, K, Watkins, S, Watkinson, J, Watts, M, Watwe, V, Weaver, N, Weber, R, Wedick, C, Weeks, D, Weeks, L, Weindorff, K, Weinstein, R, Weiss, S, Wenger, K, Wentworth, M, Werner, A, West, M, Whelan, S, White, B, White, J, Whitmire, M, Whittington, R, Wical, J, Wigley, C, Wilkins, F, Will, K, Williams, A, Wilson, Le, Wince, M, Wine, S, Winkle, P, Winner, C, Wise, J, Witte, M, Wittenmyer, J, Wood, C, Wood, R, Woodruff, C, Worthington, B, Wynn, D, Wysham, C, Xavier, P, Yela, S, Yenoby, L, Young, L, Younus, N, Yourell, V, Zaid, M, Zubair, I., Mann J.F.E., Orsted D.D., Brown-Frandsen K., Marso S.P., Poulter N.R., Rasmussen S., Tornoe K., Zinman B., Buse J.B., and Buscemi S.
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Male ,Settore MED/09 - Medicina Interna ,Acute Kidney Injury ,Aged ,Albuminuria ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Glucagon-Like Peptide 1 ,Humans ,Hypoglycemic Agents ,Intention to Treat Analysis ,Kidney Failure, Chronic ,Liraglutide ,Middle Aged ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,KIDNEY-FUNCTION ,DISEASE ,law.invention ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Chronic ,RISK ,Kidney ,Acute kidney injury ,11 Medical And Health Sciences ,General Medicine ,medicine.anatomical_structure ,TRIAL ,liraglutide, randomized controlled trial, type 2 diabetes, renal outcomes ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Renal function ,030209 endocrinology & metabolism ,CARDIOVASCULAR OUTCOMES ,Follow-Up Studie ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Intensive care medicine ,Science & Technology ,business.industry ,MORTALITY ,medicine.disease ,INTENSIVE GLUCOSE CONTROL ,INDIVIDUALS ,chemistry ,Diabetic Nephropathie ,LEADER Steering Committee and Investigators ,business - Abstract
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
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- 2017
13. Direct analysis of coffee aroma compounds with Proton Transfer Reaction-Time of Flight-Mass Spectrometry: traceability, perceived quality and processing
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Yener, S.
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Settore CHIM/10 - CHIMICA DEGLI ALIMENTI - Published
- 2016
14. Contents Vol. 55, 2011
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J.C. Ono, Ronald Ghossein, Douglas P. Clark, William C. Faquin, H. Lee, Leslie R. Rowe, Luming Zhou, M. Bongiovanni, Tien-Chun Chang, Satz Mengensatzproduktion, P. Vielh, Agnes Colanta, Yener S. Erozan, Maria E. Arcila, Pei Hui, Edmund S. Cibas, Elke A. Jarboe, Oscar Lin, Christen B. Adkins, Tim Beale, Martin H. Luu, Carl T. Wittwer, J. Yang, Jan-Shun Chang, Joel S. Bentz, Chin-Feng Chang, J.F. Krane, D.C. Wilbur, Manju L. Prasad, Syed Z. Ali, Remmi S. Singh, N. Paul Ohori, G. Denice Smith, Claudia Lobo, Laura Tafe, Barbara Chadwick, Paul A. VanderLaan, Karen E. Schoedel, Marc Ladanyi, Constantine Theoharis, Marluce Bibbo, Helen H. Wang, Jeffrey F. Krane, B. Cochand-Priollet, Kate W. Jordan, Matthew T. Olson, Theresa Scognamiglio, Druck Reinhardt Druck Basel, Talia Mitchell, Latha R. Pisharodi, Thomas J. Stockl, David Chhieng, Khedoudja Nafa, Brian T. Collins, William I. Kuhel, Kevin Schofield, M. Tötsch, Adebowale J. Adeniran, Vickie Y. Jo, Grace C. H. Yang, Ellen Marqusee, Andrew H. Fischer, F.C. Schmitt, Leo L. Cheng, Wei-Shiung Yang, W.C. Faquin, Christopher L. Owens, Gabrijela Kocjan, and Andrew McQueen
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Histology ,Traditional medicine ,business.industry ,Medicine ,General Medicine ,business ,Pathology and Forensic Medicine - Published
- 2011
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15. Bir Hepatit A İnfeksiyonu Olgusunda EDTA’ya Bağlı Pseudotrombositopeni
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AKINCI, B., AKARSU, M., YENER, S., SAYGILI, F., ÖZCAN, M. A., and AKPINAR, H.
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Pseudotrombositopeni,EDTA,hepatit A - Abstract
Pseudotrombositopeni kanama riskinde artışa neden olmayan ve trombosittransfüzyonu gerektirmeyen bir iyatrojenik laboratuar fenomenidir. Etilendiaminotetraasetik asid’e (EDTA) bağlı pseudotrombositopeni, otomatik kan sayımındayalancı olarak trombosit sayısındaki azalmayı tanımlamaktadır. Kan örneklerininEDTA ile antikoagule edilmesi sonucunda normal kişilerde oluşabileceği gibi farklıhastalıkların seyrinde de gözlenebilmektedir. Bu yazıda hepatit A infeksiyonu seyrinde gözlenen bir EDTA bağımlı pseudotrombositopeni olgusu sunulmuştur. Olguhalen devam eden pseudotrombositopeni nedeniyle izlenmektedir
- Published
- 2015
16. A new memristor-based low-pass filter topology and its small-signal solution using MacLaurin series
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Yener, S. C., Resat Mutlu, Hakan Kuntman, H., Yener, SC, Mutlu, R, Kuntman, HH, Sakarya Üniversitesi/Mühendislik Fakültesi/Elektrik-Elektronik Mühendisliği Bölümü, and Yener, Şuayb Çağrı
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Optics - Abstract
In this work, a new memristor-based low-pass filter topology is suggested. Memristor-based filters are nonlinear circuits and many of them cannot be solved analytically. To find an approximate analytical solution of the filter equations, MacLaurin series is used for the first time. Time and frequency domain behavior of the filter are obtained. Also, the frequency domain gain and total harmonic distortion characteristics of the filter are given. Results obtained by the small signal model have been compared with the dynamic model results. It is shown that the small signal model is able to predict the filter behavior very well.
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- 2015
17. Pathologic quiz case: A 54-year-old man with hypertension
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Parwani, Anilm V., Bin Yang, Erozan, Yener S., and Ali, Syed Z.
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Cookery for hypertensives -- Care and treatment ,Cookery for hypertensives -- Case studies ,Cookery for hypertensives -- Research ,Hypertension -- Care and treatment ,Hypertension -- Case studies ,Hypertension -- Research - Published
- 2003
18. Pineal gland lesions
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Syed Z. Ali, Blaire L. Baisden, Anil V. Parwani, Peter C. Burger, and Yener S. Erozan
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Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Adolescent ,Biopsy, Fine-Needle ,Epidermal Cyst ,H&E stain ,Papanicolaou stain ,Astrocytoma ,Pineal Gland ,Diagnosis, Differential ,Humans ,Medicine ,Child ,Pineoblastoma ,Immunoperoxidase ,Cysts ,business.industry ,Pineocytoma ,Infant ,Epidermoid cyst ,Anatomy ,Middle Aged ,medicine.disease ,Oncology ,Cytopathology ,Child, Preschool ,Female ,Germinoma ,business ,Pinealoma - Abstract
BACKGROUND Pineal gland lesions are rare, with only a few cytologic descriptions occurring in the literature, according to the authors' knowledge. The current article describes the cytopathologic characteristics of 20 such lesions with discussion of differential diagnoses. METHODS Cytologic material was obtained either by fine-needle aspiration biopsy (FNAB) under stearotactic radiologic guidance or by touch imprinting (TI) at the time of frozen sectioning. The 20 specimens include pineoblastoma (five specimens), pineocytoma (four specimens), astrocytoma (three specimens), germ cell tumor (three specimens), meningioma (one specimen), epidermoid cyst (three specimens), and pineal cyst (one specimen). Smears were stained with Diff-Quik and with Papanicolaou and hematoxylin and eosin stains. In selected specimens, immunoperoxidase (IPOX) stains were performed on cell block sections using synaptophysin, neuron-specific enolase, placental alkaline phosphatase, glial fibrillary acidic protein, leukocyte common antigen, cytokeratins, and human chorionic gonadotropin antibodies. RESULTS Several cytomorphologic characteristics unique to each lesional category with occasional overlapping features were observed. The unique features included the following: small, hyperchromatic, round to oval cells with frequent rosetting (pineocytoma), with a few specimens in addition showing hypercellularity, crowding, mitoses, and necrosis (pineoblastoma); pleomorphic round cells in a fibrillary background (astrocytoma); large polygonal cells with prominent nucleoli and clear cytoplasm (germ cell tumor); spindled fibroblastic cells (meningioma); anucleate squames and mature squamous cells (epidermoid cyst); and small uniform polygonal cells (pineal cyst). When necessary, IPOX studies supported the morphologic diagnoses. CONCLUSIONS FNAB and TI cytology were found to provide a rapid and reliable diagnosis of pineal lesions. This is particularly important when dealing with minute amounts of tissue material. Both techniques appeared to provide equally good cytomorphology on smears. IPOX studies played an important complementary role in difficult cases when performed on cell blocks. Cancer (Cancer Cytopathol) 2005. © 2005 American Cancer Society.
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- 2005
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19. Molecular Diagnosis of Metastasizing Oligodendroglioma
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William H. Westra, Piotr Kulesza, Alessandro Olivi, Yener S. Erozan, Min Wang, Anthony P. Tufaro, Peter C. Burger, Karin D. Berg, Kimmo J. Hatanpaa, and Kathleen M. Murphy
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Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,medicine.disease ,Pathology and Forensic Medicine ,Parotid gland ,Radiation therapy ,Lesion ,Loss of heterozygosity ,Fine-needle aspiration ,medicine.anatomical_structure ,Endocrinology ,Internal medicine ,Molecular Medicine ,Medicine ,Immunohistochemistry ,Oligodendroglioma ,Differential diagnosis ,medicine.symptom ,business ,neoplasms - Abstract
We report the case of a suspicious parotid mass in which molecular determination of loss of heterozygosity (LOH) of chromosome arms 1p and 19q in combination with cytologic and immunohistochemical analysis defined the tumor to be metastatic oligodendroglioma. The patient was a 41-year-old woman who developed a World Health Organization grade II oligodendroglioma in her right frontal lobe at age 32, for which no adjuvant chemo- or radiotherapy was administered. Five years following this diagnosis, radiological assessment revealed a 10-centimeter mass in the tumor bed, suspicious for a recurrence. Resection of this lesion revealed an anaplastic oligodendroglioma (grade III) and adjuvant radiotherapy was given. Eleven months after this surgery the patient presented with a 5.5-cm subcutaneous, non-mobile, non-tender mass in the region of the right parotid gland. Fine needle aspiration (FNA) yielded highly cellular material, morphologically and immunohistochemically suspicious for oligodendroglioma. Molecular analysis of microsatellite loci residing on chromosome arms 1p and 19q was performed using DNA extracted from the patient's recurrent brain oliogdendroglioma and the FNA specimen. This analysis revealed evidence of LOH at all eight of the microsatellite loci tested. The combination of cytologic and molecular findings defined the extracranial tumor to be metastatic oligodendroglioma.
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- 2004
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20. Dynamics of flavor perception: combining sensory methods and direct injection mass spectrometry
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Yener, S., Charles, M.C., Romano, A., Cappellin, L., Benozzi, E., Miori, S., Biasoli, F., Maerk, T.D., Navarini, L., and Gasperi, F.
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Settore CHIM/10 - CHIMICA DEGLI ALIMENTI - Published
- 2014
21. Ectopic Cervical Thymic Tissue
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Edward G. Weir, Yener S. Erozan, and D. E. Tunkel
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medicine.medical_specialty ,Ectopic thymus ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,General Medicine ,medicine.disease ,Asymptomatic ,Pathology and Forensic Medicine ,Surgery ,Thymectomy ,Medical Laboratory Technology ,Thymic Tissue ,Fine-needle aspiration ,Cytopathology ,Biopsy ,Pharyngeal groove ,Medicine ,medicine.symptom ,business - Abstract
Cervical thymic masses are congenital lesions that result from aberrant thymic migration during embryogenesis. Although most of these masses are asymptomatic, they may cause debilitating symptoms secondary to encroachment on adjacent aerodigestive structures. Preoperative diagnosis of ectopic thymic tissue is rare; most cases are clinically misinterpreted as branchial cleft remnants or cystic hygromas. Definitive diagnosis has relied on histopathologic examination in nearly all reported cases. However, the invasiveness of open incisional or excisional biopsy carries the risk of surgical and anesthetic complications. Inadvertent surgical thymectomy may result in cell-mediated immune deficiencies in infants and young children. The utility of fine needle aspiration is gaining wider acceptance in the diagnostic evaluation of neck masses. We describe an infant with an asymptomatic cervical thymic mass diagnosed by fine needle aspiration.
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- 2001
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22. [Untitled]
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Yener S. Erozan, Elaine W. Gunter, Joseph A. Tangrea, Carol Giffen, Michael J. Barett, Duminda Ratnasinghe, Terry J Hartman, Shu Xiang Yao, Philip R. Taylor, You-Lin Qiao, Michele R. Forman, and Melvyn S. Tockman
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Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Vitamin E ,medicine.medical_treatment ,chemistry.chemical_element ,equipment and supplies ,medicine.disease ,Surgery ,Occupational Cohort ,chemistry ,Internal medicine ,Epidemiology ,medicine ,Alcohol intake ,Lung cancer ,business ,Selenium - Abstract
Objective: To evaluate the association of prediagnostic serum antioxidants and lung cancer risk we conducted a case–control study nested in an occupational cohort of tin miners.
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- 2000
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23. Cytopathology of Liver, Biliary Tract, Kidney and Adrenal Gland
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Erozan, Yener S., Tatsas, Armanda., Erozan, Yener S., and Tatsas, Armanda.
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- 2015
24. Cytopathology of Liver, Biliary Tract, Kidney and Adrenal Gland / by Yener S. Erozan, Armanda Tatsas.
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Erozan, Yener S. author., Tatsas, Armanda. author., SpringerLink (Online service), Erozan, Yener S. author., Tatsas, Armanda. author., and SpringerLink (Online service)
- Abstract
This volume fulfills the need for an easy-to-use and authoritative synopsis of intra-abdominal organ cytopathology. Part of the Essentials in Cytopathology book series, the book is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. The book also fits into the lab coat pocket and is ideal for portability and quick reference. Written by authorities in the field, Cytopathology of the Liver, Biliary Tract, Kidney and Adrenal Glands is a concise and valuable resource to pathologists on the subject of intra-abdominal organ cytopathology.
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- 2015
25. Risk factors and early detection of lung cancer in a cohort of Chinese tin miners
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Qing Yuan Yan, Xue Chang Luo, Yener S. Erozan, Michael J. Barrett, Michele R. Forman, Carol Giffen, Shao Qiang Huang, Melvyn S. Tockman, Michelle M. Maher, You-Lin Qiao, Philip R. Taylor, and Shu Xiang Yao
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Adult ,Male ,China ,medicine.medical_specialty ,Chronic bronchitis ,Lung Neoplasms ,Epidemiology ,Mining ,Tobacco smoke ,Arsenic ,Cohort Studies ,Risk Factors ,Silicosis ,Surveys and Questionnaires ,Internal medicine ,medicine ,Humans ,Lung cancer ,Aged ,business.industry ,Incidence ,Smoking ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Surgery ,Occupational Diseases ,Radon ,Tin ,Cohort ,Sputum ,Female ,medicine.symptom ,business ,Lung cancer screening ,Cohort study - Abstract
PURPOSE: To examine risk factors and establish a biologic specimen and data bank for the study of early markers of lung cancer. METHODS: We designed a dynamic cohort using an ongoing lung cancer screening program among radon- and arsenic-exposed tin miners in Yunnan China. Through the first four years of the study, 8,346 miners aged 40 years and older with over 10 years of occupational exposure have been enrolled, risk factors have been assessed, annual sputum and chest radiographs have been obtained, and numerous biologic specimens have been collected. RESULTS: A total of 243 new lung cancer cases have been identified through 1995. Radon and arsenic exposures are the predominant risk factors, but lung cancer risk is also associated with chronic bronchitis and silicosis, as well as a number of measures of exposure to tobacco smoke, including early age of first use, duration, and cumulative exposure. Tumor and sputum samples are being examined for early markers of lung cancer. CONCLUSION: A cohort of occupationally-exposed tin miners with an extensive biologic specimen repository has been successfully established to simultaneously study the etiology and early detection of lung cancer.
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- 1997
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26. Tocopherol and beta-Carotene Supplements and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: Effects of Base-line Characteristics and Study Compliance
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Juni Palmgren, Yener S. Erozan, Nea Malila, Jarmo Virtamo, Kari Liippo, Tala E, Jaason Haapakoski, Laurence S. Freedman, Eero Taskinen, Jussi K. Huttunen, Michael J. Barrett, Demetrius Albanes, Pirjo Pietinen, Brenda K. Edwards, Peter Greenwald, Philip R. Taylor, Lyly Teppo, Eija Riitta Salomaa, Olli P. Heinonen, Joseph A. Tangrea, Anne M. Hartman, Frederic B. Askin, and Matti Rautalahti
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Male ,Risk ,Vitamin ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Alcohol Drinking ,medicine.medical_treatment ,Gastroenterology ,Antioxidants ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,beta-Carotene ,Internal medicine ,medicine ,Anticarcinogenic Agents ,Humans ,Vitamin E ,Lung cancer ,Aged ,Proportional Hazards Models ,030304 developmental biology ,2. Zero hunger ,0303 health sciences ,Cancer prevention ,business.industry ,Incidence ,Smoking ,Age Factors ,Retinol ,Cancer ,Middle Aged ,beta Carotene ,16. Peace & justice ,medicine.disease ,3. Good health ,Surgery ,Cancer registry ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Food, Fortified ,Multivariate Analysis ,Carcinogens ,Patient Compliance ,business - Abstract
Background Experimental and epidemiologic investigations suggest that alpha-tocopherol (the most prevalent chemical form of vitamin E found in vegetable oils, seeds, grains, nuts, and other foods) and beta-carotene (a plant pigment and major precursor of vitamin A found in many yellow, orange, and dark-green, leafy vegetables and some fruit) might reduce the risk of cancer, particularly lung cancer. The initial findings of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) indicated, however, that lung cancer incidence was increased among participants who received beta-carotene as a supplement. Similar results were recently reported by the Beta-Carotene and Retinol Efficacy Trial (CARET), which tested a combination of beta-carotene and vitamin A. Purpose We examined the effects of alpha-tocopherol and beta-carotene supplementation on the incidence of lung cancer across subgroups of participants in the ATBC Study defined by base-line characteristics (e.g., age, number of cigarettes smoked, dietary or serum vitamin status, and alcohol consumption), by study compliance, and in relation to clinical factors, such as disease stage and histologic type. Our primary purpose was to determine whether the pattern of intervention effects across subgroups could facilitate further interpretation of the main ATBC Study results and shed light on potential mechanisms of action and relevance to other populations. Methods A total of 29,133 men aged 50-69 years who smoked five or more cigarettes daily were randomly assigned to receive alpha-tocopherol (50 mg), beta-carotene (20 mg), alpha-tocopherol and beta-carotene, or a placebo daily for 5-8 years (median, 6.1 years). Data regarding smoking and other risk factors for lung cancer and dietary factors were obtained at study entry, along with measurements of serum levels of alpha-tocopherol and beta-carotene. Incident cases of lung cancer (n = 894) were identified through the Finnish Cancer Registry and death certificates. Each lung cancer diagnosis was independently confirmed, and histology or cytology was available for 94% of the cases. Intervention effects were evaluated by use of survival analysis and proportional hazards models. All P values were derived from two-sided statistical tests. Results No overall effect was observed for lung cancer from alpha-tocopherol supplementation (relative risk [RR] = 0.99; 95% confidence interval [CI] = 0.87-1.13; P = .86, logrank test). beta-Carotene supplementation was associated with increased lung cancer risk (RR = 1.16; 95% CI = 1.02-1.33; P = .02, logrank test). The beta-carotene effect appeared stronger, but not substantially different, in participants who smoked at least 20 cigarettes daily (RR = 1.25; 95% CI = 1.07-1.46) compared with those who smoked five to 19 cigarettes daily (RR = 0.97; 95% CI = 0.76-1.23) and in those with a higher alcohol intake (> or = 11 g of ethanol/day [just under one drink per day]; RR = 1.35; 95% CI = 1.01-1.81) compared with those with a lower intake (RR = 1.03; 95% CI = 0.85-1.24). Conclusions Supplementation with alpha-tocopherol or beta-carotene does not prevent lung cancer in older men who smoke. beta-Carotene supplementation at pharmacologic levels may modestly increase lung cancer incidence in cigarette smokers, and this effect may be associated with heavier smoking and higher alcohol intake. Implications While the most direct way to reduce lung cancer risk is not to smoke tobacco, smokers should avoid high-dose beta-carotene supplementation.
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- 1996
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27. Molecular Detection of Primary Bladder Cancer by Microsatellite Analysis
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David Sidransky, Yener S. Erozan, Adrian Merlo, Li Mao, Mark P. Schoenberg, Donna Schwab, and Marshall S. Scicchitano
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Adult ,Genetic Markers ,Male ,Heterozygote ,Pathology ,medicine.medical_specialty ,Pilot Projects ,Urine ,Biology ,Polymerase Chain Reaction ,Loss of heterozygosity ,Cytology ,medicine ,Humans ,Aged ,Neoplasm Staging ,Urine cytology ,Aged, 80 and over ,Genetics ,Multidisciplinary ,Urinary bladder ,Bladder cancer ,medicine.diagnostic_test ,DNA, Neoplasm ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,Genetic marker ,Microsatellite ,Female ,Chromosome Deletion ,Chromosomes, Human, Pair 9 ,Microsatellite Repeats - Abstract
Microsatellite DNA markers have been widely used as a tool for the detection of loss of heterozygosity and genomic instability in primary tumors. In a blinded study, urine samples from 25 patients with suspicious bladder lesions that had been identified cystoscopically were analyzed by this molecular method and by conventional cytology. Microsatellite changes matching those in the tumor were detected in the urine sediment of 19 of the 20 patients (95 percent) who were diagnosed with bladder cancer, whereas urine cytology detected cancer cells in 9 of 18 (50 percent) of the samples. These results suggest that microsatellite analysis, which in principle can be performed at about one-third the cost of cytology, may be a useful addition to current screening methods for detecting bladder cancer.
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- 1996
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28. Endorectal ultrasound-guided fine-needle aspiration: a useful diagnostic tool for perirectal and intraluminal lesions
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Yener S. Erozan, Susan Geddes, Zahra Maleki, and Qing Kay Li
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Endoscopic ultrasound ,Male ,medicine.medical_specialty ,Histology ,Cytodiagnosis ,Biopsy, Fine-Needle ,Sensitivity and Specificity ,Pathology and Forensic Medicine ,Endosonography ,Prostate ,Neoplasms ,Biopsy ,Medicine ,Humans ,Neoplasm Staging ,Retrospective Studies ,Past medical history ,Urinary bladder ,medicine.diagnostic_test ,business.industry ,Gallbladder ,General Medicine ,medicine.anatomical_structure ,Fine-needle aspiration ,Cytopathology ,Female ,Radiology ,business - Abstract
Objectives: Endorectal endoscopic ultrasound (ERUS) allows highly detailed assessment of the rectal wall layers and visualization of the extraluminal structures. Herein, we study the utility of ERUS fine-needle aspiration (FNA) to evaluate perirectal lesions. Study Design: Forty-nine ERUS-FNAs were retrieved from the cytopathology archives of The Johns Hopkins Hospital. The cytology slides, corresponding histology, immunohistochemistry when available, and clinical data were reviewed. Results: The aspirated material showed malignant (n = 24), benign (n = 19), atypical (n = 3), carcinoid tumor (n = 1), and nondiagnostic conditions (n = 2). The past medical history of 36 cases was significant for carcinomas. The primary site of the tumors included colorectal, urinary bladder, prostate, pancreas, gallbladder, ovary, and female lower genital tract. Statistical analysis for endoscopic ultrasonography FNA showed 87% sensitivity, 100% specificity, diagnostic accuracy of 90%, and a positive predictive value of 100% and a negative predictive value of 77%. Conclusion: ERUS-FNA can be utilized for: (1) accurate staging of colorectal adenocarcinomas by evaluation of nodal metastasis, depth of transmural tumor invasion and local tumor spread to perirectal fat, (2) prevention of aggressive surgical intervention in benign conditions, (3) providing diagnostic material for ancillary studies, and (4) evaluation of perirectal lesions with a more accurate method by combining imaging and histology.
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- 2012
29. Microsatellite alterations as clonal markers for the detection of human cancer
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David Sidransky, Frederic B. Askin, Li Mao, Daniel J. Lee, Yener S. Erozan, and Melvyn S. Tockman
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Lung Neoplasms ,Molecular Sequence Data ,Locus (genetics) ,DNA, Satellite ,Biology ,Polymerase Chain Reaction ,law.invention ,Reference Values ,law ,Carcinoma, Non-Small-Cell Lung ,Neoplasms ,Microsatellite Repeat ,Biomarkers, Tumor ,medicine ,Carcinoma ,Humans ,Neoplasm ,Carcinoma, Small Cell ,Lung cancer ,Polymerase chain reaction ,DNA Primers ,Repetitive Sequences, Nucleic Acid ,Multidisciplinary ,Base Sequence ,Microsatellite instability ,DNA, Neoplasm ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Molecular biology ,Urinary Bladder Neoplasms ,Head and Neck Neoplasms ,Cancer research ,Microsatellite ,Research Article - Abstract
Microsatellite instability has been reported to be an important feature of tumors from hereditary nonpolyposis colorectal carcinoma (HNPCC) patients. The recent discovery of genetic instability in small cell lung carcinoma, a neoplasm not associated with HNPCC, led us to investigate the possible presence of microsatellite alterations in other tumor types. We examined 52 microsatellite repeat sequences in the DNA of normal and tumor pairs from 100 head and neck, bladder, and lung cancer patients by the polymerase chain reaction. Although alterations were rare in dinucleotide repeats, larger (tri- or tetranucleotide) repeats were found to be more prone to expansion or deletion. We screened 100 tumors with a panel of nine tri- and tetranucleotide repeat markers and identified 26 (26%) that displayed alterations in at least one locus. This observation prompted us to examine the possibility of using microsatellite alterations as markers to detect clonal tumor-derived cell populations in pathologic samples. The identical microsatellite alterations detected in the primary tumors were successfully identified in corresponding urine, sputum, and surgical margins from affected patients. This study demonstrates that appropriately selected microsatellite loci are commonly altered in many cancers and can serve as clonal markers for their detection.
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- 1994
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30. Pulmonary Cytopathology
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Erozan, Yener S., Ramzy, Ibrahim, Erozan, Yener S., and Ramzy, Ibrahim
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- 2014
31. Siyah Alaca İneklerde Dış Yapı Özellikleri, Sürüde Kalma Süresi ve Süt Verimi Üzerine Araştırmalar
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URAL, Deniz Alic, YENER, S. Metin, and Adnan Menderes University, Bozdoğan Vocational School, Ankara University, Faculty of Agriculture Department of Animal Science
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Milk Yield ,Dış yapı özellikleri Süt verimi Sürü ömrü ,Conformation Traits ,Herd Life - Abstract
In this study, the relations between conformation traits, herd life and milk yield in Holstein cows were investigated. The material of this study was formed by 247 head Holstein cows in Polatli State Farm and 47 head Holstein cows in Ankara University Agricultural Faculty Research Application Farm. In this study, seventeen linear type traits on a scale of 1 to 9, and 4 general traits on a scale of 65 to 100 were scored in a total of 294 head Holstein cows. Stature was measured by a measuring cane. The relations between traits were investigated by Spearman’s rho coefficient. The best regression equation estimating 305-day milk yield was determined by Stepwise Linear Regression Analysis. The mean values of 305 day milk yield in Ankara University Agricultural Faculty Research Application Farm and Polatli State Farm were ranged between 4862-6559 kg and 6908-7847 kg, respectively. The positive and significant correlations were found between conformation traits and 305-day milk yield in two farms. These correlations indicate that an increase in 305-day milk yield could be achieved through selection on any of the conformation traits. The mean Total score values of Holstein cows that were grown up in Ankara University Agricultural Faculty Research and Application Farm and Polatli State Farm were ranged between 76.1-76.7 and 77.2-78.0, respectively, and cows in both enterprises were classified as medium class. The positive and significant correlations between the final score and categorical type traits constituted showed that an improvement could be seen in the categorical type traits by selection on final score. Bu çalışmada, Siyah Alaca ineklerde dış yapı özellikleri, sürüde kalma süresi ve süt verimi arasındaki ilişkiler incelenmiştir. Çalışmanın materyalini Ankara Üniversitesi Ziraat Fakültesi Araştırma Uygulama Çiftliği’nde yetiştirilen 47 baş ve Polatlı Tarım İşletmesi’nde yetiştirilen 247 baş olmak üzere toplam 294 baş Siyah Alaca inek oluşturmuştur. Çalışmada, toplam 294 baş Siyah Alaca inekte 17 doğrusal özellik 1-9 puanlık skalada ve 4 genel özellik ise 65-100 puanlık bir skalada puanlanmıştır. Sağrı yüksekliği ölçü bastonu ile ölçülmüştür. Özellikler ile süt verimi arasındaki ilişkilerin incelenmesinde Sperman’ın rho katsayısından yararlanılmıştır. 305 günlük süt verimini en iyi şekilde tahmine imkan verecek regresyon denklemini elde etmek için Aşamalı Doğrusal Regresyon Analizi (Stepwise Linear Regression Analysis) yaklaşımından yararlanılmıştır. Ankara Üniversitesi Araştırma Uygulama Çiftliği’nde 305 gün süt verimine ait ortalamalar 4862 ile 6559 kg, Polatlı Tarım İşletmesi’nde ise 6908 ile 7847 kg arasında değişmektedir. Her iki işletmede 305 günlük süt verimi ile bazı dış yapı özellikleri arasında pozitif ve önemli korelasyonlar tespit edilmiş olup bunlar; dış yapı özelliklerinden herhangi birine dayanan seleksiyonla süt veriminde de artış sağlanabileceğini gösterir. Ankara Üniversitesi Araştırma Uygulama Çiftliği ve Polatlı Tarım İşletmesi’nde yetiştirilen Siyah Alaca ineklere ait Toplam puan ortalamaları sırasıyla; 76.1-76.7 ile 77.2-78.0 arasında değişmekte olup, her iki işletmedeki hayvanlar da orta sınıfa girmektedir. Araştırma sonuçları, her iki işletmede de toplam dış yapı puanı ile bunu meydana getiren ana dış yapı özellikleri arasındaki pozitif ve önemli olan ilişkilerden dolayı, toplam dış yapıya göre yapılan seleksiyonla ana dış yapı özelliklerinde de iyileşme olabileceğini göstermektedir.
- Published
- 2009
32. Recovery of Intraocular Toxocara canis by Pars Plana Vitrectomy
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Ronald G. Michels, W. Richard Green, Yener S. Erozan, and Albert M. Maguire
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Male ,Pars plana ,medicine.medical_specialty ,Adolescent ,genetic structures ,Fundus Oculi ,medicine.medical_treatment ,Eye disease ,Visual Acuity ,Vitrectomy ,parasitic diseases ,medicine ,Animals ,Humans ,Eye Infections, Parasitic ,Toxocara ,Toxocariasis ,biology ,business.industry ,Retinal detachment ,medicine.disease ,biology.organism_classification ,eye diseases ,Surgery ,Vitreous Body ,Ophthalmology ,medicine.anatomical_structure ,Chorioretinitis ,Maculopathy ,sense organs ,business ,Follow-Up Studies ,Toxocara canis ,Retinopathy - Abstract
Pars plana vitrectomy has been used in cases of ocular toxocariasis to remove vitreous opacities due to chronic inflammation and to relieve vitreoretinal traction causing macular distortion and retinal detachment. To date, the diagnosis of intraocular Toxocara infection in vitrectomy cases has been presumptive, based on characteristic clinical findings, the presence of eosinophils, and corroborative immunodiagnostic tests. The authors report a case in which a vitrectomy for vitreopapillary traction recovered an intact Toxocara canis organism.
- Published
- 1990
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33. Implementation of Microcontroller-Based Memristive Chaotic Circuit.
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YENER, S. C., BARBAROS, C., MUTLU, R., and KARAKULAK, E.
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- *
ELECTRIC circuit design & construction , *MICROCONTROLLERS , *CHAOS theory , *MEMRISTORS , *CAPACITORS - Abstract
In 1971, Leon Chua theoretically postulated that the memristor is the fourth fundamental circuit element, besides the three well-known circuit elements; namely, resistor, capacitor and inductor. For a long time, because of lack of a simple and practical realization, memristor remained just a theoretical element and rarely appeared in the literature. In 2008, a research team from HP laboratories declared that they had found a physical implementation based on thin films, behaving as a memristor. Memristor can offer new opportunities in circuit design due to its nonlinear behavior and memory. Nevertheless, since a cheap and reliable practical implementation of memristor is yet unavailable on the market, the design of such a realization, which mimics memristor behavior, is vital from the point of view of real-world circuit design. In this paper, a new microcontroller-based memristive chaotic circuit is proposed. Presented design has been implemented using an Ardunio Mega board, which solves numerically the dynamics of the memristor-based chaotic system using Runge-Kutta method. It sends the chaotic signals to the outputs of the circuit, using digital-to-analog converters. Chaotic dynamics and the strange attractors are obtained from the circuit using both, the computer simulations and the lab experiments. Considering both simulation and experimental results, it is shown that the proposed circuit mimics well the dynamics of the memristive chaotic system. [ABSTRACT FROM AUTHOR]
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- 2017
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34. In Memoriam A Tribute to Raj Kumar Gupta
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Yoon Yang Jung, Sule Canberk, André Albergaria, Ozlem Ozen, Zahra Maleki, B. Rekhi, Shuxia Li, Satz Mengensatzproduktion, Helena Barroca, Canser Cakalir, Mi Kyung Kim, S. Kane, Norio Wake, Edmundo Carvalho Mauad, Parvin Ganjei-Azar, Tsunehisa Kaku, K. Deodhar, Andrew M. Schreiner, Fernando Schmitt, Monica T. Garcia-Buitrago, Ali Ayhan, Satoko Nakamura, Chung Hun Lee, Teóclito Saccheto, Qing Kay Li, Tatiana V. Yakoushina, Ana Rita Nobre, S. Joseph, Tae Jin Lee, Toshiaki Saito, Dong Wook Kim, Tomoko Hagiwara, Druck Reinhardt Druck Basel, Hiroaki Kobayashi, Susan Geddes, Tadashi Yoshino, Fatih Gulsen, Soo Jin Jung, Natalia Campacci, Ji Hwa Ryu, Yasuharu Sato, Karen Fried, Merih Tepeoglu, Reni Grimes, Shyouhei Mano, Atay Uludokumaci, David P. Tauro, Han Suk Ryu, Yasumasa Shimoura, Ceyda Sonmez, Syed Z. Ali, José Manuel Lopes, Annapoorna Ferrell, Christopher J. VandenBussche, Young-Wook Kim, Mandana Donoghue, Grace C. H. Yang, Andrea P. Subhawong, José Humberto Tavares Guerreiro Fregnani, D. Ajit, Adhemar Longatto-Filho, Yorihisa Orita, Sumit Agarwal, Merce Jorda, Raphael L. Haikel, Chae Young Lee, Matías Jiménez-Ayala, Huiting Zhu, Yener S. Erozan, Cristovam Scapulatempo, Katsuyoshi Takata, Hyebin Lee, Carmen Gomez-Fernandez, Gulsen Ozbay, S. Gavas, Ashutosh Yadav, Ty K. Subhawong, Hyun Sin In, Jae Wook Eom, Momin T. Siddiqui, and Gatha Singh Yadav
- Subjects
Histology ,business.industry ,Tribute ,Medicine ,General Medicine ,Theology ,business ,Pathology and Forensic Medicine - Published
- 2013
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35. Pathologic quiz case: a 30-year-old man with lower abdominal and back pain. Anaplastic large cell lymphoma (Ki-1 lymphoma) of the pancreas
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Anil V, Parwani, Piotr, Kulesza, Yener S, Erozan, and Syed Z, Ali
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Adult ,Male ,Pancreatic Neoplasms ,Back Pain ,Humans ,Lymphoma, Large-Cell, Anaplastic ,Abdominal Pain - Published
- 2004
36. Cytopathologic grading of hepatocellular carcinoma on fine-needle aspiration
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Piotr Kulesza, Michael Torbenson, Yener S. Erozan, Sheila Sheth, and Syed Z. Ali
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Core needle ,Cancer Research ,medicine.medical_specialty ,Pathology ,Carcinoma, Hepatocellular ,Cytodiagnosis ,Biopsy, Fine-Needle ,Sensitivity and Specificity ,Diagnosis, Differential ,Medicine ,Humans ,Grading (education) ,neoplasms ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Biopsy, Needle ,Liver Neoplasms ,Cancer ,medicine.disease ,digestive system diseases ,Well differentiated ,Fine-needle aspiration ,Oncology ,Pleomorphism (cytology) ,Cytopathology ,Hepatocellular carcinoma ,Radiology ,business - Abstract
BACKGROUND Hepatocellular carcinoma (HCC) is routinely graded histopathologically using a modified Edmondson system (ES). The cytologic grading of HCC has been used predominantly as an adjunct in differential diagnoses (i.e., to help distinguish HCC from other tumors as well as nonneoplastic lesions). However, there are unanswered questions regarding the reliability of the cytologic grading of HCC and its correlation with histologic follow-up. METHODS A total of 106 cases of HCC were identified in the authors' cytopathology files from 1977 to the present. Of these cases, 64 had either a core needle or excisional biopsy sample that was judged to be adequate for histologic grading. From each case smears were graded independently in a blinded fashion by two cytopathologists, and tissue slides were graded by a liver pathologist. The cytopathologists' grading was then adjudicated by considering the histologic diagnosis as the “truth standard”. Finally, after the scores were calculated, a statistical analysis was performed to ascertain the accuracy of the cytopathologic grading. RESULTS The sensitivity for accurate grading was found to be highest for well differentiated (WD) lesions; the specificity was found to be highest for poorly differentiated (PD) HCC for both cytopathologists. Interobserver agreement was highest for WD HCC. WD HCC displayed cohesive fragments, often associated with characteristic vascular/endothelial patterns. In addition, moderately differentiated (MD) HCC demonstrated numerous single cells and atypical naked nuclei, usually with prominent nucleoli. PD HCC displayed loose nests and three-dimensional fragments (often gland-like), pleomorphism, macronucleoli, and focal necrosis. CONCLUSIONS In the authors' experience, the three-tier cytologic grading of HCC was found to be only moderately accurate. The accuracy of cytologic grading was reported to be high for WD/PD HCC and low for MD HCC. The architectural criteria appear to be more useful for WD HCC, whereas marked cellular pleomorphism is specific for PD HCC. The authors propose that a two-tier grading system may be more useful, given the recent studies of HCC recurrence. Cancer (Cancer Cytopathol) 2004. © 2004 American Cancer Society.
- Published
- 2004
37. Pathologic quiz case: a 54-year-old man with hypertension. Primary high-grade leiomyosarcoma of the IVC
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Anil V, Parwani, Bin, Yang, Yener S, Erozan, and Syed Z, Ali
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Leiomyosarcoma ,Male ,Hypertension ,Humans ,Vena Cava, Inferior ,Middle Aged ,Vascular Neoplasms - Published
- 2003
38. Subject Index Vol. 55, 2011
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Oscar Lin, Khedoudja Nafa, Constantine Theoharis, Tien-Chun Chang, Carl T. Wittwer, Grace C. H. Yang, Andrew McQueen, Latha R. Pisharodi, Remmi S. Singh, William I. Kuhel, Wei-Shiung Yang, Chin-Feng Chang, Ellen Marqusee, Ronald Ghossein, Thomas J. Stockl, J. Yang, Christen B. Adkins, Jan-Shun Chang, Barbara Chadwick, Paul A. VanderLaan, Karen E. Schoedel, Satz Mengensatzproduktion, J.C. Ono, H. Lee, Vickie Y. Jo, Luming Zhou, P. Vielh, Talia Mitchell, Yener S. Erozan, William C. Faquin, Leslie R. Rowe, Maria E. Arcila, Elke A. Jarboe, M. Tötsch, Douglas P. Clark, N. Paul Ohori, David Chhieng, M. Bongiovanni, Agnes Colanta, Tim Beale, Adebowale J. Adeniran, Syed Z. Ali, Brian T. Collins, Andrew H. Fischer, Matthew T. Olson, Martin H. Luu, Manju L. Prasad, D.C. Wilbur, Pei Hui, G. Denice Smith, Marluce Bibbo, Helen H. Wang, Theresa Scognamiglio, Claudia Lobo, Jeffrey F. Krane, Edmund S. Cibas, F.C. Schmitt, Kate W. Jordan, Druck Reinhardt Druck Basel, Leo L. Cheng, Kevin Schofield, W.C. Faquin, Christopher L. Owens, Gabrijela Kocjan, Joel S. Bentz, J.F. Krane, Marc Ladanyi, B. Cochand-Priollet, and Laura J. Tafe
- Subjects
Histology ,Index (economics) ,business.industry ,Statistics ,Medicine ,Subject (documents) ,General Medicine ,business ,Pathology and Forensic Medicine - Published
- 2011
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39. Serum carotenoids are associated with increased lung cancer risk among alcohol drinkers, but not among non-drinkers in a cohort of tin miners
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Philip R. Taylor, Michael J. Barrett, Yener S. Erozan, Michele R. Forman, Shu-Xiang Yao, Duminda Ratnasinghe, Elaine W. Gunter, Joseph A. Tangrea, Carol Giffen, Melvyn S. Tockman, and You-Lin Qiao
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,Lung Neoplasms ,Alcohol Drinking ,Mining ,Cohort Studies ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Risk factor ,Lung cancer ,Prospective cohort study ,Aged ,business.industry ,Incidence ,Case-control study ,Cancer ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,beta Carotene ,Endocrinology ,Tin ,Case-Control Studies ,Cohort ,Female ,business ,Cohort study ,Follow-Up Studies - Abstract
To examine the association between pre-diagnostic serum carotenoid levels and lung cancer risk and the effects of alcohol intake on the carotenoid-lung cancer relationship, we conducted a case-control study in an occupational cohort from the Yunnan Tin Corporation in China. During 6 years of follow-up, 339 cases of confirmed lung cancer were diagnosed. Among these cases, those who donated pre-diagnostic blood (n = 108) were eligible for this study. For each case, two individuals alive and free of cancer at the time of case diagnosis, matched on age, sex, and date of blood collection, were selected as controls. Serum beta-carotene (odds ratios (ORs) for tertiles: 1, 1.3, 2.0) and beta-cryptoxanthin (ORs for tertiles: 1, 1.8, 2.9) levels were positively associated with lung cancer risk after adjustment for tobacco use and radon exposure. Among alcohol drinkers, higher serum carotenoid levels were significantly associated with increased lung cancer risk (alpha-carotene OR 2.2, 95% confidence interval (CI) 1.1-4.4, beta-carotene OR 7.6, 95% CI 3.1-18.6, lutein/zeaxanthin OR 2.3, 95% CI 1.2-6.6 and beta-cryptoxanthin OR 7.6, 95% CI 2.7-21.5). Conversely, risk estimates among non-drinkers suggest a possible protective association for higher carotenoid levels.
- Published
- 2000
40. Material Analysis and Application for Radio Frequency Electromagnetic Wave Shielding.
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YENER, S. C. and CEREZCI, O.
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- *
MATERIALS analysis , *ELECTROMAGNETIC shielding , *RADIO frequency , *ELECTROMAGNETIC radiation , *ELECTROMAGNETIC compatibility - Abstract
Our environment is full of radio frequency (RF) electromagnetic radiation due to rapid progress of wireless communication technologies, which have many applications, such as base stations of mobile communication networks and wireless internet antennas. In the context of Electromagnetic Compatibility (EMC) discipline, the word shield is used to describe any sort of metal sheet or material capable of reflecting, refracting or absorbing electromagnetic radiation (EMR), which is custom manufactured for the target electronic device casing, in a way to intervene any radiation passing to and from the device. Examining of electromagnetic shielding effectiveness (SE) is an important part of not only ensuring electromagnetic compatibility and of protecting electrical and electronic equipment but also protection of human beings against electromagnetic energy exposure as well. In this study, after a brief introduction and review on electromagnetic shielding, material selection and their applications for an indoor environment protection against electromagnetic radiation are explained. Potential electromagnetic shielding values of fabrics found in the market have been analyzed and compared by considering various criteria and requirements. Experimental results show that around 20 dB shielding effectiveness values can be obtained using test fabrics for a typical indoor environment. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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41. Breeding Characteristics of Holstein Cows Raiset at Ankara Atatürk Forestry Farm
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ATAY, Okan, YENER, S. Metin, BAKIR, Galip, and KAYGISIZ, Ali
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Holstein,livability,calving rate,abortion rate,number of service per pregnancy,age at first calving,calving interval ,Holstein,yaşama gücü,buzağılama oranı,yavru atma oranı,gebelik başına aşım sayısı,ilkine buzağılama yaşı,buzağılama aralığı - Abstract
Bu çalışmada Ankara Atatürk Orman Çiftliğinde yetiştirilen Holstein sığırların yetiştirme özellikleri incelenmiştir. Ele alınan yetiştirme özelliklerinden gebelik başına aşım sayısı ortalama 1.80 ± 0.06, ineklerin ortalama ayıklanma yaşı 61.66 ± 1.29 ay, ömürboyu buzağı sayısı 3.00 ± 0.16, buzağılarda 6. ay yaşama gücü % 83.65, buzağılama oranı % 94.26, ölü doğum oranı % 3.24, yavru atma oranı % 2.47, sürüde yıllık yenilenme oranı % 30.71, ilkine buzağılama yaşı 29.08 ay, buzağılama aralığı 432 ± 54 gün olarak hesaplanmıştır. İneklerin elden çıkma sebepleri; hastalık (% 27.21) damızlık satışı (% 22.79) ve reforme olma (% 50.00) dır., Breeding characteristics of Holstein cows raised at Ankara Atatürk Forestry Farm were studied. The means for the breeding characteristics were estimated as follows: number of service per pregnancy 1.80 ± 0.06 the mean age of cows on culling 61.66 ± 1.29 months. Lifetime number of calves 3.00 ± 0.16. livability of calves up to the 6 months of age 83.65 %, calving rate 94.26 %, stillbirth rate 3.24 %, abortion rate 2.47 %, age at first calving 29.68 month, calving interval 432 ± 54 days. Yearly replacement in herd 30.71 %. The reason iost of cows rate as follows: 27.21 % disease, breeding sale 22.79 % and reformation 50.00 % respectively
- Published
- 1996
42. Pathologic Quiz Case: A 30-Year-Old Man With Lower Abdominal and Back Pain
- Author
-
Syed Z. Ali, Piotr Kulesza, Anil V. Parwani, and Yener S. Erozan
- Subjects
Medical Laboratory Technology ,medicine.medical_specialty ,business.industry ,Back pain ,Medicine ,General Medicine ,medicine.symptom ,business ,Pathology and Forensic Medicine ,Surgery - Published
- 2004
- Full Text
- View/download PDF
43. The domestic livestock resources of Turkey: cattle local breeds and types and their conservation status
- Author
-
Yilmaz, O., primary, Akin, O., additional, Yener, S. Metin, additional, Ertugrul, M., additional, and Wilson, R. T., additional
- Published
- 2012
- Full Text
- View/download PDF
44. Increased Risk of Unfavorable Metabolic Outcome during Short-Term Follow-Up in Subjects with Nonfunctioning Adrenal Adenomas
- Author
-
Yener, S., primary, Ertilav, S., additional, Secil, M., additional, Akinci, B., additional, Demir, T., additional, Kebapcilar, L., additional, and Yesil, S., additional
- Published
- 2012
- Full Text
- View/download PDF
45. Giant true cyst of the spleen with elevated serum markers, carbohydrate antigen 19-9 and cancer antigen 125
- Author
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Uludag, M., primary, Yetkin, G., additional, Citgez, B., additional, Karakoc, S., additional, Polat, N., additional, and Yener, S., additional
- Published
- 2009
- Full Text
- View/download PDF
46. Effects or Early Weaning On Fattening Performance, Growth And Some Reproductive Traits in Ak Keçi (White Goats)
- Author
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YARGICI, M. Şükrü and YENER, S. Metin
- Subjects
White Goats ,Ak Keçi,Süt - Published
- 1991
47. An Investigation On Repeatability Of Live Weight And Live Weight Gain In Ak Keçi (White Goats)
- Author
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YARGICI, M. Şükrü, ELİÇİN, Ayhan, AKMAN, Numan, YENER, S. Metin, MUTAF, Salim, and ARIK, İ. Zafer
- Subjects
Keçi,Canlı Ağırlık ,Goat,Live Weight - Published
- 1991
48. Pathologic Quiz Case: A 30-Year-Old Man With Lower Abdominal and Back Pain
- Author
-
Parwani, Anil V., primary, Kulesza, Piotr, additional, Erozan, Yener S., additional, and Ali, Syed Z., additional
- Published
- 2004
- Full Text
- View/download PDF
49. The value of immediate cytological evaluation for needle aspiration lung biopsy
- Author
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M. Cheema, Anwar R. Padhani, Yener S. Erozan, and W. Scott
- Subjects
medicine.medical_specialty ,Text mining ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Lung biopsy ,Radiology ,business ,Value (mathematics) - Published
- 1995
- Full Text
- View/download PDF
50. Malignant triton tumor of the gluteal region in a patient unaffected by neurofibromatosis: A case report
- Author
-
Abdullah Merter, Kerem Başarır, Yusuf Yıldız, and Yener Sağlık
- Subjects
Orthopedic surgery ,RD701-811 - Abstract
Malignant triton tumor (MTT) is a rare variant of malignant peripheral nerve sheath tumor (MPNST) made up of both malignant schwannoma cells and malignant rhabdomyoblasts.A 26-years-old male patient was admitted with an asymptomatic gluteal mass. Magnetic resonance imaging showed heterogeneous soft tissue mass and he underwent open biopsy. Malignant peripheral nerve sheath tumor was diagnosed. He was given adjuvant chemotherapy following the removal of the tumor with hip disarticulation. The tumor was diagnosed as “malignant triton tumor” based on pathological examination including immunohistochemical studies. There were no signs of metastasis but recurrence was observed at 9 months follow up.MTT is usually associated with Neurofibromatosis 1 and located in head, neck region. In this case sporadic involvement of gluteal region and aggressive behavior of the lesion despite radical surgery was demonstrated. Keywords: Malignant peripheral nerve sheath tumor, Gluteal region, Triton tumor
- Published
- 2018
- Full Text
- View/download PDF
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