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1. In vivo antidiarrheal activity of the crude extract and solvent fractions of Rhamnus prinoides (Rhamnaceae) leaves

Author

Ayele, Teklie Mengie, Abebe, Endeshaw Chekol, Muche, Zelalem Tilahun, Agidew, Melaku Mekonnen, Yimer, Yohannes Shumet, Addis, Getu Tesfaw, Baye, Nega Dagnaw, Kassie, Achenef Bogale, Alemu, Muluken Adela, Yiblet, Tesfagegn Gobezie, Tiruneh, Gebrehiwot Ayalew, Dagnew, Samuel Berihun, Moges, Tilaye Arega, Tadesse, Tesfaye Yimer, and Zelalem, Amien Ewnetei

Published
2023
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4. Evaluation of Wound Healing Activity of 80% Methanol Root Crude Extract and Solvent Fractions of Stephania abyssinica (Dill. & A. Rich.) Walp. (Menispermaceae) in Mice

Author

Yiblet,Tesfagegn Gobezie, Tsegaw,Asegedech, Ahmed,Nejat, Dagnew,Samuel Berihun, Tadesse,Tesfaye Yimer, Kifle,Zemene Demelash, Yiblet,Tesfagegn Gobezie, Tsegaw,Asegedech, Ahmed,Nejat, Dagnew,Samuel Berihun, Tadesse,Tesfaye Yimer, and Kifle,Zemene Demelash

Abstract

Tesfagegn Gobezie Yiblet,1 Asegedech Tsegaw,2 Nejat Ahmed,3 Samuel Berihun Dagnew,1 Tesfaye Yimer Tadesse,1 Zemene Demelash Kifle2 1Department of Pharmacy, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2University of Gondar, College of Medicine and Health Sciences, School of Pharmacy, Department of Pharmacology, Gondar, Ethiopia; 3Department of Pathology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tesfagegn Gobezie Yiblet, Tel +251935462779, Email tesfaxx@gmail.comBackground: The root of Stephania abyssinica (Dill. and A. Rich.) Walp. (Menispermaceae) is traditionally used to treat wounds. Despite the fact that there have been in vitro studies and claims supporting wound healing, there has been no scientific data on the in vivo wound healing activities of the root of S. Abyssinica.Objective: The aim of the study was to evaluate the wound healing activity of 80% methanol root extract and solvent fractions of S. Abyssinica in mice.Methods: The roots of S. Abyssinica were air dried, ground and macerated by 80% methanol three times successively. The crude extract was fractionated by water, hexane and ethyl acetate separately. The acute dermal toxicity test was done by applying 2000 mg/kg of the 10% w/w crude extract. Wound healing activity of crude extract was evaluated on excision, incision and burn wound models, while the fractions were evaluated on excision wound model only.Results: In mice, an acute dermal toxicity test of 2000 mg/kg of the 10% w/w crude extract was found to be safe. The 10% w/w crude extract ointment (CEO) produced significant (p < 0.001) wound contraction from 4th to 16th post wounding days, and the 5% w/w CEO were significant (p < 0.01) wound contraction on 10th post wounding day as compared to simple ointment (SO) treated group on excision wound. On burn wound models, the CEO showed highly significant (p < 0.001) from the 6t

Published
2022

5. Assessment of COVID-19 vaccination related knowledge, attitude and barriers among health care professionals working at governmental hospitals in South Gondar Zone, Ethiopia

Author

Ayele, Teklie Mengie, primary, Abebe, Endeshaw Chekol, additional, Muche, Zelalem Tilahun, additional, Yimer, Yohannes Shumet, additional, Addis, Getu Tesfaw, additional, Baye, Nega Dagnaw, additional, Kassie, Achenef Bogale, additional, Alemu, Muluken Adela, additional, Yiblet, Tesfagegn Gobezie, additional, Tiruneh, Gebrehiwot Ayalew, additional, and Dagnew, Samuel Berihun, additional

Published
2022
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6. Drug–drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia’s Comprehensive Specialized Hospitals: A multicenter observational study

Author

Dagnew, Samuel Berihun, primary, Tadesse, Tesfaye Yimer, additional, Zeleke, Mulugeta Molla, additional, Yiblet, Tesfagegn Gobezie, additional, Addis, Getu Tesfaw, additional, Mekonnen, Gashaw Binega, additional, Agegnew Wondm, Samuel, additional, and Negash, Erkihun Assefa, additional

Published
2022
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7. Assessment of COVID-19 vaccination-related knowledge, attitude and barriers among healthcare professionals working at governmental hospitals in South Gondar Zone, Ethiopia.

Author

Ayele, Teklie Mengie, Abebe, Endeshaw Chekol, Muche, Zelalem Tilahun, Agidew, Melaku Mekonnen, Yimer, Yohannes Shumet, Addis, Getu Tesfaw, Baye, Nega Dagnaw, Kassie, Achenef Bogale, Alemu, Muluken Adela, Yiblet, Tesfagegn Gobezie, Tiruneh, Gebrehiwot Ayalew, and Dagnew, Samuel Berihun

Subjects
COVID-19 vaccines, ATTITUDES of medical personnel, CROSS-sectional method, VACCINATION coverage, DISEASE incidence
Abstract

Introduction: with COVID-19 vaccines being developed concurrently, it is clear that inadequate knowledge and poor attitudes among communities around the world provide a significant obstacle and continue to prevent the complete population from being immunized against highly contagious illnesses. The study's objective was to evaluate the knowledge, attitude, and barriers that healthcare professionals have towards the COVID-19 vaccine. Methods: a descriptive cross-sectional study was conducted through a self-administered questionnaire that was disseminated to health care professionals working in the South Gondar zone hospitals, in South Gondar Zone, Ethiopia. SPSS Statistics Version 25 was used to enter and evaluate the data that were gathered. To ascertain the relationship between independent and outcome variables, binary logistic analysis was performed. Results: a total of 450 respondents participated in the survey, and 90% of them completed and returned. The majority of the participants (94.44%) were aware of the COVID-19 vaccination. More than half of them (56.22%) had experience with COVID-19 treatment, and 54.7% had sufficient knowledge about COVID-19 immunization. The importance of the vaccine in maintaining population COVID-19 immunization coverage and in reducing COVID-19 incidence to prevent the onset of new epidemics, respectively, was positively viewed by more than two-thirds (74.43%) and 84.4% of the respondents, respectively. Furthermore, only 6.6% of respondents approved of pharmaceutical companies' advertising of the COVID-19 vaccine. Conclusion: according to the current study, healthcare professionals had a promising view of COVID-19 immunization. However, the overall percentage of positive responses to the attitude questions was only 48.34%. Additionally, more than 76.67% of the respondents reported that if the community does not receive the COVID-19 vaccination, the incidence of the virus will greatly grow. However, only about half of the respondents had adequate knowledge about the COVID-19 vaccination. [ABSTRACT FROM AUTHOR]

Published
2022
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