In order to implement the acquisition and processing of signals from imaging systems, a data acquisition system based on FPGA was designed with the requirements of multi-channel, high-resolution and compactness. The data acquisition (DAQ) system uses a quad-channel 12-bit analog-to-digital converter (ADC) AD9228-65 as the front-end core chip, and a series of signal conditioning circuits to form the front-end system. FPGA is used as the data acquisition, logic control, data readout and processing. After preliminary testing, the DAQ system has the advantages of low power, low cost, high-speed, small size.