1. Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon–dielectric interactions
- Author
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Huang, Qian, Lee, Joon, Arce, Fernando Teran, Yoon, Ilsun, Angsantikul, Pavimol, Liu, Justin, Shi, Yuesong, Villanueva, Josh, Thamphiwatana, Soracha, Ma, Xuanyi, Zhang, Liangfang, Chen, Shaochen, Lal, Ratnesh, and Sirbuly, Donald J
- Subjects
Physical Sciences ,Classical Physics ,Mathematical Sciences ,Optoelectronics & Photonics ,Mathematical sciences ,Physical sciences - Abstract
Ultrasensitive nanomechanical instruments, including the atomic force microscope (AFM)1-4 and optical and magnetic tweezers5-8, have helped shed new light on the complex mechanical environments of biological processes. However, it is difficult to scale down the size of these instruments due to their feedback mechanisms9, which, if overcome, would enable high-density nanomechanical probing inside materials. A variety of molecular force probes including mechanophores10, quantum dots11, fluorescent pairs12,13 and molecular rotors14-16 have been designed to measure intracellular stresses; however, fluorescence-based techniques can have short operating times due to photo-instability and it is still challenging to quantify the forces with high spatial and mechanical resolution. Here, we develop a compact nanofibre optic force transducer (NOFT) that utilizes strong near-field plasmon-dielectric interactions to measure local forces with a sensitivity of
- Published
- 2017