Search

Identifying and discovering drug-target interactions(DTIs) are vital steps in drug discovery and development. They play a crucial role in assisting scientists in finding new drugs and accelerating the drug development process. Recently, knowledge graph and knowledge graph embedding (KGE) models have made rapid advancements and demonstrated impressive performance in drug discovery. However, such models lack authenticity and accuracy in drug target identification, leading to an increased misjudgment rate and reduced drug development efficiency. To address these issues, we focus on the problem of drug-target interactions, with knowledge mapping as the core technology. Specifically, a causal intervention-based confidence measure is employed to assess the triplet score to improve the accuracy of the drug-target interaction prediction model. Experimental results demonstrate that the developed confidence measurement method based on causal intervention can significantly enhance the accuracy of DTI link prediction, particularly for high-precision models. The predicted results are more valuable in guiding the design and development of subsequent drug development experiments, thereby significantly improving the efficiency of drug development.

With the continuous development of business process management technology, the increasing business process models are usually owned by large enterprises. In large enterprises, different stakeholders may modify the same business process model. In order to better manage the changeability of processes, they adopt configurable business process models to manage process variants. However, the process variants will vary with the change in enterprise business demands. Therefore, it is necessary to explore the co-evolution of the process variants so as to effectively manage the business process family. To this end, a novel framework for co-evolution between business process variants through a configurable process model is proposed in this work. First, the mapping relationship between process variants and configurable models is standardized in this study. A series of change operations and change propagation operations between process variants and configurable models are further defined for achieving propagation. Then, an overall algorithm is proposed for achieving co-evolution of process variants. Next, a prototype is developed for managing change synchronization between process variants and configurable process models. Finally, the effectiveness and efficiency of our proposed process change propagation method are verified based on experiments on two business process datasets. The experimental results show that our approach implements the co-evolution of process variants with high accuracy and efficiency., Comment: 18 pages , 11 figures

Gut microbiota plays a crucial role in modulating pig development and health, and gut microbiota characteristics are associated with differences in feed efficiency. To answer open questions in feed efficiency analysis, biologists seek to retrieve information across multiple heterogeneous data sources. However, this is error-prone and time-consuming work since the queries can involve a sequence of multiple sub-queries over several databases. We present an implementation of an ontology-based Swine Gut Microbiota Federated Query Platform (SGMFQP) that provides a convenient, automated, and efficient query service about swine feeding and gut microbiota. The system is constructed based on a domain-specific Swine Gut Microbiota Ontology (SGMO), which facilitates the construction of queries independent of the actual organization of the data in the individual sources. This process is supported by a template-based query interface. A Datalog+-based federated query engine transforms the queries into sub-queries tailored for each individual data source, and an automated workflow orchestration mechanism executes the queries in each source database and consolidates the results. The efficiency of the system is demonstrated on several swine feeding scenarios.

We report the application of the resistive anode readout method on a two dimensional imaging GEM detector. The resistive anode consists of $6\times6$ cells with the cell size $6~\mathrm{mm}\times6~\mathrm{mm}$. New electronics and DAQ system are used to process the signals from the 49 readout channels. The detector has been tested by using the X-ray tube (8~keV). The spatial resolution of the detector is about $103.46~\mathrm{{\mu}m}$ with the detector response part about $66.41~\mathrm{{\mu}m}$. The nonlinearity of the detector is less than $1.5\%$. A quite good two dimensional imaging capability is achieved as well. The performances of the detector show the prospect of the resistive anode readout method for the large readout area imaging detectors., Comment: 6 Pages, 10 figures

In this paper, limitations of the common method measuring intrinsic spatial resolution of the GEM imaging detector are presented. Through theoretical analysis and experimental verification, we have improved the common method to avoid these limitations. Using these improved methods, more precise measurement of intrinsic spatial resolution are obtained., Comment: The manuscript has been submitted to China Physics C on 25th May, 2011