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With the development of sequencing technology and the dramatic drop in sequencing cost, the functions of noncoding genes are being characterized in a wide variety of fields (e.g. biomedicine). Enhancers are noncoding DNA elements with vital transcription regulation functions. Tens of thousands of enhancers have been identified in the human genome; however, the location, function, target genes and regulatory mechanisms of most enhancers have not been elucidated thus far. As high-throughput sequencing techniques have leapt forwards, omics approaches have been extensively employed in enhancer research. Multidimensional genomic data integration enables the full exploration of the data and provides novel perspectives for screening, identification and characterization of the function and regulatory mechanisms of unknown enhancers. However, multidimensional genomic data are still difficult to integrate genome wide due to complex varieties, massive amounts, high rarity, etc. To facilitate the appropriate methods for studying enhancers with high efficacy, we delineate the principles, data processing modes and progress of various omics approaches to study enhancers and summarize the applications of traditional machine learning and deep learning in multi-omics integration in the enhancer field. In addition, the challenges encountered during the integration of multiple omics data are addressed. Overall, this review provides a comprehensive foundation for enhancer analysis. [ABSTRACT FROM AUTHOR]

Household traffic surveys are widely used in travel behavior analysis, especially in travel time and distance analysis. Unfortunately, any one kind of household traffic surveys has its own problems. Even all household traffic survey data is accurate, it is difficult to get the trip routes information. To our delight, electric map API (e.g., Google Maps, Apple Maps, Baidu Maps, and Auto Navi Maps) could provide the trip route and time information, which remedies the traditional traffic survey's defect. Thus, we can take advantage of the two kinds of data and integrate them into travel behavior analysis. In order to test the validity of the Baidu electric map API data, a field study on 300 taxi OD pairs is carried out. According to statistical analysis, the average matching rate of total OD pairs is 90.74%, which reflects high accuracy of electric map API data. Based on the fused data of household traffic survey and electric map API, travel behavior on trip time and distance is analyzed. Results show that most purposes' trip distances distributions are concentrated, which are no more than 10 kilometers. It is worth noting that students have the shortest travel distance and company business's travel distance distribution is dispersed, which has the longest travel distance. Compared to travel distance, the standard deviations of all purposes' travel time are greater than the travel distance. Car users have longer travel distance than bus travelers, and their average travel distance is 8.58km., 1. Introduction It is axiomatic that a model can never be better than the data from which it is estimated [1]. Household traffic surveys are mainly used in transport planning [...]

Driving Decision-making Mechanism (DDM) is identified as the key technology to ensure the driving safety of autonomous vehicle, which is mainly influenced by vehicle states and road conditions. However, previous studies have seldom considered road conditions and their coupled effects on driving decisions. Therefore, road conditions are introduced into DDM in this paper, and are based on a Support Vector Machine Regression (SVR) model, which is optimized by a weighted hybrid kernel function and a Particle Swarm Optimization (PSO) algorithm, this study designs a DDM for autonomous vehicle. Then, the SVR model with RBF (Radial Basis Function) kernel function and BP (Back Propagation) neural network model are tested to validate the accuracy of the optimized SVR model. The results show that the optimized SVR model has the best performance than other two models. Finally, the effects of road conditions on driving decisions are analyzed quantitatively by comparing the reasoning results of DDM with different reference index combinations, and by the sensitivity analysis of DDM with added road conditions. The results demonstrate the significant improvement in the performance of DDM with added road conditions. It also shows that road conditions have the greatest influence on driving decisions at low traffic density, among those, the most influential is road visibility, then followed by adhesion coefficient, road curvature and road slope, while at high traffic density, they have almost no influence on driving decisions. [ABSTRACT FROM AUTHOR]