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As a predominant ecosystem-providing area and distinctive landscape in arid regions, an oasis plays an important role in maintaining land stability, human production, and daily activities. Studying the dynamics of oasis and its driving factors is vital to supporting arid regions' sustainable development. As a typical mountain–desert–oasis landscape, the Turpan–Hami (Tuha) Basin, located in Xinjiang, China, includes complex interactions among different land types. For this study, we revealed the spatio-temporal patterns and transition processes of the oasis using a complex network method between 1990 and 2020 in the Tuha Basin. In the oasis transition network, the degree value, betweenness centrality, and average path length were calculated to express the transition relationship, key oasis type, and oasis structural stability, respectively. Six factors related to climate change and human actives were selected to investigate the driving forces behind oasis transitions, including the average temperature and precipitation in the growing season, the total power of agricultural machinery (TAMP), the production of raw coal (PRC), the total output value of the plantation industry (TPI), and the population (Pop). Our results show that the oasis area of the Tuha Basin, including the natural oasis and artificial oasis, all grew from 1990 to 2020, with the natural oasis expanding more than the artificial oasis. The transitions between oasis types became more frequent as the area of oasis land types increased throughout the study period. Grassland acted as the most important oasis type in the network, with the highest betweenness centrality, but its importance declined due to the increasing complexity of the oasis transition network from 1990 to 2020. The transitions between oasis types became simpler, and the oasis structural stability decreased. Through driving force analysis, the oasis changes showed a positive correlation with the temperature (p-value < 0.05, r = 0.88), and urbanization and industrialization factors prompted transitions to built-up areas and cropland from grassland and shrubland. In summary, our results suggest that to create a harmonious symbiotic relationship between the natural environment in dryland and human activities, preventing grassland degradation and excessive reclamation of land cover is an available way. Meanwhile, the protection of shrubland and water resources is also important. This study provided reference and theory support for promoting the sustainable development of oases. [ABSTRACT FROM AUTHOR]

Inflammation accounts for the process of type II diabetes mellitus (T2DM), the specific mechanism of which is still to be elucidated yet. Nitric oxide (NO), a critical inflammation regulator, the role of which is the inflammation of T2DM, is rarely reported. Therefore, our study is aimed at exploring the effect of NO on the inflammation in T2DM and the corresponding mechanism. We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1 β , TNF- α , IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPAR γ , eNOS, C-reactive protein, heptoglobin, IL-1 β , TNF- α , and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPAR γ . The results showed that excess NO increased the inflammation marker levels in T2DM, which is activated by the PPAR γ /eNOS pathway. These findings will strengthen the understanding of NO in T2DM and provide a new target for the treatment of T2DM., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 Hua Guo et al.)

Radiotherapeutic resistance is a major obstacle for the effective treatment of colorectal cancer (CRC). MicroRNAs (miRNAs) play a critical role in chemoresistance and radioresistance. Here, we aimed to investigate whether miR-590-3p participates in the radioresistance of CRC. High expression of miR-590-3p and low expression of CLCA4 were found in both CRC tissues and cell lines. CLCA4 was indicated to be a target gene of miR-590-3p. CAF-derived exosomes were extracted and co-cultured with CRC cells, which were then exposed to radiation. CRC cells were transfected with plasmids and injected into nude mice to detect the in vivo effect of CAF-derived exosomes. Treatment with CAF-derived exosomes decreased the sensitivity of CRC cells to radiation. CAF-derived exosomes overexpressing miR-590-3p increased cell survival and the ratio of p-PI3K/PI3K and p-AKT/AKT while lowering the expressions of cleaved-PARP, cleaved-caspase 3, and γH2AX in cells. Furthermore, in vivo experimental results confirmed that CAF-derived exosomal miR-590-3p stimulated tumor growth in mice following radiotherapy. Our results demonstrate that miR-590-3p delivery via exosomes derived from CAFs enhances radioresistance in CRC through the positive regulation of the CLCA4-dependent PI3K/Akt signaling pathway., (© 2021 The Authors.)