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1. Repairing with Zero Skip Cost

Author

Zhang, Wenqin, Chee, Yeow Meng, Dau, Son Hoang, Etzion, Tuvi, Kiah, Han Mao, and Luo, Yuan

Subjects
Computer Science - Information Theory
Abstract

To measure repair latency at helper nodes, we introduce a new metric called skip cost that quantifies the number of contiguous sections accessed on a disk. We provide explicit constructions of zigzag codes and fractional repetition codes that incur zero skip cost

Published
2024

4. Constructions of Binary Optimal Locally Repairable Codes via Intersection Subspaces

Author

Zhang, Wenqin, Tang, Deng, Ying, Chenhao, and Luo, Yuan

Subjects
Computer Science - Information Theory
Abstract

Locally repairable codes (LRCs), which can recover any symbol of a codeword by reading only a small number of other symbols, have been widely used in real-world distributed storage systems, such as Microsoft Azure Storage and Ceph Storage Cluster. Since binary linear LRCs can significantly reduce coding and decoding complexity, constructions of binary LRCs are of particular interest. The aim of this paper is to construct dimensional optimal binary locally repairable codes with disjoint local repair groups. We introduce how to connect intersection subspaces with binary locally repairable codes and construct dimensional optimal binary linear LRCs with locality $2^b$ ($b\geq 3$) and minimum distance $d\geq 6$ by employing intersection subspaces deduced from the direct sum. This method will sufficiently increase the number of possible repair groups of dimensional optimal LRCs, and thus efficiently expanding the range of the construction parameters while keeping the largest code rates compared with all known binary linear LRCs with minimum distance $d\geq 6$ and locality $2^b$ ($b\geq 3$)., Comment: Accepted for publication in the SCIENCE CHINA Information Sciences

Published
2021

31. Identification of ACSF gene family as therapeutic targets and immune-associated biomarkers in hepatocellular carcinoma

Author

Zhao, Zijin, primary, Liu, Miaomiao, additional, Xu, Zhijie, additional, Cai, Yuan, additional, Peng, Bi, additional, Liang, Qiuju, additional, Yan, Yuanliang, additional, Liu, Wei, additional, Kang, Fanhua, additional, He, Qingchun, additional, Hong, Qianhui, additional, Zhang, Wenqin, additional, Li, Jianbo, additional, Peng, Jinwu, additional, and Zeng, Shuangshuang, additional

Published
2022
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33. Comprehensive analysis of the potential cuproptosis-related biomarker LIAS that regulates prognosis and immunotherapy of pan-cancers

Author

Cai, Yuan, primary, He, Qingchun, additional, Liu, Wei, additional, Liang, Qiuju, additional, Peng, Bi, additional, Li, Jianbo, additional, Zhang, Wenqin, additional, Kang, Fanhua, additional, Hong, Qianhui, additional, Yan, Yuanliang, additional, Peng, Jinwu, additional, Xu, Zhijie, additional, and Bai, Ning, additional

Published
2022
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35. Fabrication of Antibacterial Sponge Microneedles for Sampling Skin Interstitial Fluid.

Author

Chen, Jianmin, Cai, Xiaozhen, Zhang, Wenqin, Zhu, Danhong, Ruan, Zhipeng, and Jin, Nan

Subjects
EXTRACELLULAR fluid, MEDICAL equipment, DISEASE management, WOUND healing, MICROPORES, SILVER nanoparticles
Abstract

Microneedles (MNs) have recently garnered extensive interest concerning direct interstitial fluid (ISF) extraction or their integration into medical devices for continuous biomarker monitoring, owing to their advantages of painlessness, minimal invasiveness, and ease of use. However, micropores created by MN insertion may provide pathways for bacterial infiltration into the skin, causing local or systemic infection, especially with long-term in situ monitoring. To address this, we developed a novel antibacterial sponge MNs (SMNs@PDA-AgNPs) by depositing silver nanoparticles (AgNPs) on polydopamine (PDA)-coated SMNs. The physicochemical properties of SMNs@PDA-AgNPs were characterized regarding morphology, composition, mechanical strength, and liquid absorption capacity. The antibacterial effects were evaluated and optimized through agar diffusion assays in vitro. Wound healing and bacterial inhibition were further examined in vivo during MN application. Finally, the ISF sampling ability and biosafety of SMNs@PDA-AgNPs were assessed in vivo. The results demonstrate that antibacterial SMNs enable direct ISF extraction while preventing infection risks. SMNs@PDA-AgNPs could potentially be used for direct sampling or combined with medical devices for real-time diagnosis and management of chronic diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential.

Author

Zhang, Wenqin, Yan, Yuanliang, Peng, Jinwu, Thakur, Abhimanyu, Bai, Ning, Yang, Keda, and Xu, Zhijie

Subjects
*EXOSOMES, *PATHOGENESIS, *RNA, *IMMUNOMODULATORS, *CELL physiology, *TUMORS, *IMMUNOTHERAPY
Abstract

Simple Summary: The tumor microenvironment (TME) exhibits a pivotal function in the progression of cancer through the bidirectional communication between cellular and noncellular components. During the exchange and interplay of biological signals between immune cells and tumor cells in TME, exosomal lncRNAs are viewed as one of the vital factors, which can interfere with innate and adaptive immune responses to affect the therapeutic efficiency. This review aims to summarize the advance in the roles of exosomal lncRNAs on tumor-immune regulation and propose potential treatment strategies. Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological and pathological processes. Interestingly, a plethora of studies emphasized the mediating role of exosomes in the bidirectional communication between donor and recipient cells. Among the various cargoes of exosomes, long non-coding RNAs (lncRNAs) have been identified as crucial regulators between cancer cells and immune cells in the tumor microenvironment (TME) that can interfere with innate and adaptive immune responses to affect the therapeutic efficiency. Recently, a few major studies have focused on the exosomal lncRNA-mediated interaction between cancer cells and immune cells infiltrated into TME. Nevertheless, a dearth of studies pertains to the immune regulating role of exosomal lncRNAs in cancer and is still in the early stages. Comprehensive mechanisms of exosomal lncRNAs in tumor immunity are not well understood. Herein, we provide an overview of the immunomodulatory function of exosomal lncRNAs in cancer and treatment resistance. In addition, we also summarize the potential therapeutic strategies toward exosomal lncRNAs in TME. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Integrative bioinformatics and experimental analysis revealed TEAD as novel prognostic target for hepatocellular carcinoma and its roles in ferroptosis regulation

Author

Ren, Xinxin, primary, Wang, Xiang, additional, Yan, Yuanliang, additional, Chen, Xi, additional, Cai, Yuan, additional, Liang, Qiuju, additional, Peng, Bi, additional, Xu, Zhijie, additional, He, Qingchun, additional, Kang, Fanhua, additional, Li, Jianbo, additional, Zhang, Wenqin, additional, Hong, Qianhui, additional, Peng, Jinwu, additional, and Xiao, Muzhang, additional

Published
2022
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