Search

Your search keyword '"Zhou, Chen-He"' showing total 9 results
Start Over Author "Zhou, Chen-He" Search Limiters Full Text
9 results on '"Zhou, Chen-He"'

3. Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes

Author

Chen, Kun, primary, Lv, Zheng‑Tao, additional, Zhou, Chen‑He, additional, Liang, Shuang, additional, Huang, Wen, additional, Wang, Zheng‑Gang, additional, Zhu, Wen‑Tao, additional, Wang, Yu‑Ting, additional, Jing, Xing‑Zhi, additional, Lin, Hui, additional, Guo, Feng‑Jing, additional, Cheng, Peng, additional, and Chen, An‑Min, additional

Published
2019
Full Text
View/download PDF

4. Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption

Author

Chen, Kun, primary, Lv, Zheng-tao, additional, Cheng, Peng, additional, Zhu, Wen-tao, additional, Liang, Shuang, additional, Yang, Qing, additional, Parkman, Virginia-Jeni Akila, additional, Zhou, Chen-he, additional, Jing, Xing-zhi, additional, Liu, Hui, additional, Wang, Yu-ting, additional, Lin, Hui, additional, Liao, Hui, additional, and Chen, An-min, additional

Published
2018
Full Text
View/download PDF

6. Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption

Author

Zhou, Chen-he, primary, Meng, Jia-hong, additional, Yang, Yu-te, additional, Hu, Bin, additional, Hong, Jian-qiao, additional, Lv, Zheng-tao, additional, Chen, Kun, additional, Heng, Boon Chin, additional, Jiang, Guang-yao, additional, Zhu, Jian, additional, Cheng, Zhao-hui, additional, Zhang, Wei, additional, Cao, Le, additional, Wang, Wei, additional, Shen, Wei-liang, additional, Yan, Shi-gui, additional, and Wu, Hao-bo, additional

Published
2018
Full Text
View/download PDF

7. PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization

Author

Zhou, Chen-he, primary, Meng, Jia-hong, additional, Zhao, Chen-chen, additional, Ye, Chen-yi, additional, Zhu, Han-xiao, additional, Hu, Bin, additional, Heng, Boon Chin, additional, Shen, Yue, additional, Lin, Tiao, additional, Yang, Xiao-bo, additional, Shi, Zhong-li, additional, Shen, Wei-liang, additional, and Yan, Shi-gui, additional

Published
2017
Full Text
View/download PDF

9. FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF- κ B Activation and CXCL10 Expression.

Author

Lv ZT, Liang S, Chen K, Zhang JM, Cheng P, Guo JC, Yang Q, Zhou CH, Liao H, and Chen AM

Subjects
Animals, Bone Resorption, Cell Differentiation, China, Macrophages, Mice, NFATC Transcription Factors, RANK Ligand physiology, Rabbits, Chemokine CXCL10 metabolism, Membrane Proteins physiology, NF-kappa B metabolism, Osteoclasts physiology
Abstract

FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. Considering osteoclast formation is characterized by the activation of inflammation-related pathways, we thus speculated that FNDC4 may play a pivotal role in this process. RT-qPCR analysis was performed to confirm the expression of osteoclast formation related genes in primary murine bone marrow macrophages (BMMs). RANKL-treated BMMs were cultured with FNDC4 to evaluate the effect of FNDC4 on osteoclast differentiation. TRAP staining and bone resorption pits assay were used to assess osteoclast formation and bone resorption, respectively. Luciferase assay and western blotting analysis were conducted to determine whether FNDC4 inhibited osteoclast formation via NF- κ B signaling in RAW 264.7 cells. Furthermore, to identify gene signatures in FNDC4-treated BMMs and to use these to elucidate the underlying molecular mechanisms during osteoclast formation, we adopted a bioinformatics approach by downloading the GSE76172 gene expression profiling dataset from the Gene Expression Omnibus (GEO) database. FNDC4 inhibited RANKL-induced osteoclastogenesis and mature osteoclast resorptive function in a dose-dependent manner. Results of NF- κ B luciferase assay suggested that FNDC4 could significantly suppress the RANKL-induced NF- κ B transcriptional activity. Based on the protein-protein interaction network, CXCL10 was identified as the differentially expressed gene with the highest connectivity degree (degree = 23); it was drastically downregulated in the presence of FNDC4, but supplementation of CXCL10 (10 ng/mL) partially ameliorated the FNDC4-induced inhibition of osteoclast formation. Taken together, we speculated that FNDC4 could suppress osteoclast formation via NF- κ B pathway and downregulation of CXCL10.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results